JP6526904B2 - 腎疾患を有する患者の腎臓及び/又は心臓機能の改善方法 - Google Patents
腎疾患を有する患者の腎臓及び/又は心臓機能の改善方法 Download PDFInfo
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
材料及び方法
動物
病原体のない環境下、12/12時間の明暗周期で、食物および水が自由に与えられ、且つ周囲温度を24+2℃、相対湿度を50+20%に設定する条件で、Sprague Dawley ラット (7週齢) を飼養した。本開示の動物研究を含む全ての手順は、「実験動物のケアと使用に関するガイドライン」(中国・台北実験動物科学協会)に準拠している。
5/6腎切除術又は偽手術を受ける予定のSDラット(約10週齢)をZoletil 50/キシラジン(6mg/1.3mg/Kg, i.p.)で麻酔した。その後、左腎臓を露出させ、腎上極及び腎下極を縫合線で結び、次に右腎切除術を行った。次いで、腹膜および皮膚を縫合し、動物をそれぞれのケージに戻した。偽手術を受ける動物は、同様の方法で左腎を露出させたが、それ以上の処理をせずに腹腔内に戻し、腹膜および皮膚を縫合した。偽手術又は5/6腎切除術の2週間後、動物に対して24時間ごとに尿収集、4週間ごとに非侵襲的な尾血圧測定を行った。手術の4週間後、5/6腎切除術又は偽手術を受けたラットを対照群及びテルビブジン群の2群にランダムに割り当てた。対照群は生理食塩水処理を受けた一方、テルビブジン群のラットは、テルビブジン(10mg/mL/Kg)で8又は12週間処理した。次いで、動物を犠牲にし、腎臓および心臓生検試料を得た。
動物を麻酔室内に置き、イソフルランで麻酔した。動物が意識不明になった後、心臓超音波装置(Vivid i, General Electric Company, US)に接続し、拡張期パラメータ(組織速度画像(TVI_V)、E/A比、心筋の歪み(C_歪み)、及び左心室質量(LVMASS))を含む心臓機能パラメータの変化をそれぞれ測定した。
タンパク質同定のために、核抽出タンパク質30μgをSDS-PAGEゲル(8%)の各レーンにロードし、電気泳動により分離したタンパク質をポリビニリデンフルオライド(PVDF)膜(GE Healthcare Bio-Sciences, Little Chalfont, UK)に電気転写し、室温で、5%無脂肪スキムミルク(0.01%Tween-20を含有するTRIS緩衝生理食塩水)で60分間ブロックした。その後、該膜をウサギポリクローナル抗IL-6、TGF-β、TIMP-1及びCOL1-1(1:1000でPBS/5%スキムミルクに希釈;Novus. Biologicals)抗体でそれぞれ4℃で一晩インキュベートした。次いで、HRP結合抗ウサギIgG(Promega)を二次抗体として使用した。免疫反応性タンパク質を化学発光プロトコル(ECL、GE HealthcareBio-Sciences)によって視覚化した。抗アクチンウサギポリクローナル抗体(1:1000; Sigma-Aldrich)をキャリブレーションに使用した。
Trizol試薬(Life Technologies)を用いて、製造者のプロトコルに従って、新鮮な凍結腎臓および心臓組織から全RNAを抽出した。簡単に言えば、腎皮質または心臓組織(150mg)を1mlのTrizolでホモジナイズし、遠心分離によってRNA含有水相を得た。0.5体積部のイソプロパノールでの遠心分離によりRNAを沈殿させ、75%エタノールにより精製した後、抽出された全RNAを80μLのnヌクレアーゼを含まない脱イオン蒸留水に溶解し、-20°Cで保存した。RNAの濃度および純度をNanodrop分光光度計(Thermo Scientific)によって測定した。トランスクリプターファーストストランドcDNA合成キット(Roche)を用いて、製造者のプロトコルに従って、テンプレートRNA (1μg)からファーストストランドcDNAを合成した。20μLの反応液(1μMの各プライマー及び10μLのLightCyclerのファストスタートユニバーサル SYBR Green マスター(ROX) (Roche)を含む)において2μLテンプレートでリアルタイムPCRを行われた。
この実施例において、テルビブジンの治療機能を評価するために、テルビブジンで処理する前に、動物に5/6腎切除術を行うことでインビボ腎不全を誘発した。
図1に示される結果を参照すると、5/6腎切除術を受けた動物のBUN及びCRのレベルは、8週目に対照動物の約4~10倍であり、12週目まで上昇し続けた。その一方で、テルビブジンで8週間処理した動物は、BUN及びCRの両方のレベルが顕著に低下し、テルビブジンで12週間処理したときの効果が最も顕著であった。
まとめると、該データは、テルビブジンが炎症性遺伝子(IL-6、TGF-β、TIMP1、及びCOL-1-A1を含むが、これらに限定されない)の発現レベルを抑制することによりCKDラットの腎機能を改善し得ることを確認した。
実施例1.1と同様に、5/6腎切除術は、CKDラットの心臓組織の線維化をもたらし、テルビブジン処理CKDラットでは、線維化組織の程度が著しく減少した(図5)。
インドキシル硫酸(IS)及びP-クレジルスルフェート(PCS)は、CKD患者の血清中に蓄積する尿毒素であり、CKD被験者において心臓の問題を引き起こす既知の因子である。
図9A、9Cは、CKDラットから採取した血清におけるインドキシル硫酸(IS)及びP-クレジルスルフェート(PCS)の総レベルに対するテルビブジンの影響を示す。IS及びPCSの遊離レベルに対するテルビブジンの影響を図9B、9Dに示す。
この実施例において、肝機能に対するテルビブジンの影響を調べた。
要約すると、本研究のデータは、テルビブジンがCKD被験体を治療、及び/又は、CKDに関連及び/又は続発する心臓問題の発症を防ぐために使用できることを確認する。
Claims (3)
- 有効量のテルビブジン、その塩、溶媒和物及び/又はエステル、並びに、薬学的に許容される賦形剤を含む、AKI又はCKDに罹患している被験体の心臓線維症を改善するための組成物。
- 前記組成物が約0.1〜1,000mg/Kg/日の投与量で前記被験体に投与される請求項1に記載の組成物。
- 前記組成物が約0.5〜500mg/Kg/日の投与量で前記被験体に投与される請求項2に記載の組成物。
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US201562152965P | 2015-04-26 | 2015-04-26 | |
US62/152,965 | 2015-04-26 | ||
PCT/CN2016/080228 WO2016173487A1 (en) | 2015-04-26 | 2016-04-26 | Method for improving kidney and/or heart function in patients with kidney disease |
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US (1) | US10525073B2 (ja) |
EP (1) | EP3288562B1 (ja) |
JP (1) | JP6526904B2 (ja) |
CN (1) | CN107708705A (ja) |
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WO (1) | WO2016173487A1 (ja) |
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US7951789B2 (en) * | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
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EP3288562A4 (en) | 2018-10-31 |
US20180140624A1 (en) | 2018-05-24 |
EP3288562B1 (en) | 2022-03-16 |
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JP2018514585A (ja) | 2018-06-07 |
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