JP6525609B2 - 湿潤状態維持アルゴリズムを備えた粒子操作システム - Google Patents
湿潤状態維持アルゴリズムを備えた粒子操作システム Download PDFInfo
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- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Description
本願は、2013年12月12日に出願された米国特許出願第14/104,084(代理人整理番号:Owl−Backflow)に関連するものであり、当該出願は参照により含まれる。
無し。
無し。
粒子操作装置と、
サンプル流体が流れる、粒子操作装置の上流の1つ以上の微細加工入力チャネル、および、サンプル流体が流れる、粒子操作装置の下流の1つ以上の微細加工出力チャネルと、
1つ以上の微細加工入力チャネルおよび1つ以上の微細加工出力チャネルの1つ以上の内の乾燥状態または間近の乾燥状態(dry or imminently dry condition)を検出し、当該状態を検出したときに信号を発するセンサと、
1つ以上の微細加工入力チャネルと1つ以上の微細加工出力チャネルとの間の制御された順方向の流れを確立し、センサから信号を受信したとき、1つ以上の微細加工出力チャネルと1つ以上の微細加工入力チャネルとの間の流れを逆転させる、流体制御手段と、
を備えている。
10 粒子操作装置、粒子操作段
101 乾燥検出器
110 可動部材、バルブ
112 変向面
120 第1のチャネル、入力チャネル
122 第2のチャネル、分離チャネル
140 廃棄チャネル、出力オリフィス
201 検査領域
400 力発生装置
1100 検出/集光光学素子
1200 ダイクロイックミラー
1250 反射鏡
1300 光検出器
1400、1410 レーザ
1500 制御手段
1900 コントローラ
Claims (18)
- 粒子操作システムであって、
粒子操作装置と、
サンプル流体が流れる、前記粒子操作装置の上流の1つ以上の微細加工入力チャネル、および、サンプル流体が流れる、前記粒子操作装置の下流の1つ以上の微細加工出力チャネルと、
1つ以上の前記微細加工チャネルの乾燥状態または間近の乾燥状態を検出し、当該状態を検出したときに信号を発するセンサと、
前記1つ以上の微細加工入力チャネルと前記1つ以上の微細加工出力チャネルとの間の制御された順方向の流れを確立し、次いで、前記センサから前記信号を受信したとき、前記1つ以上の微細加工出力チャネルと前記1つ以上の微細加工入力チャネルとの間の流れを逆転させる、流体制御手段と、
を備えており、
前記粒子操作装置は、基板表面上に形成された微細加工粒子分離機構部を備えており、前記サンプル流体は、標的粒子および非標的物質を含んでいる、
ことを特徴とする粒子操作システム。 - 前記微細加工粒子分離機構部は、力に応じて、標的粒子を、前記微細加工入力チャネルから1つの微細加工分離出力チャネルに向かわせるように動き、
前記粒子分離機構部の前記標的粒子の向きを変える動きは、実質的に前記基板表面に平行な平面内である、
請求項1記載の粒子操作システム。 - 前記入力チャネル内の流れは、前記微細加工分離出力チャネル内の流れに実質的に逆平行であり、
前記力は磁力であり、
前記入力チャネルおよび前記分離出力チャネルに対して直交した廃棄出力チャネルが設けられており、
前記センサから前記信号が受信されたとき、前記流体制御手段によって前記廃棄チャネルおよび前記入力チャネルとの間で流れが逆転される、
請求項2記載の粒子操作システム。 - 前記微細加工粒子分離機構部はさらに、
前記微細加工粒子分離機構部内に内包された透磁性材料と、
前記微細加工粒子分離機構部の外部の磁束の源と、
前記微細加工粒子分離機構部が形成された基板と、
を備えており、
前記磁束は、前記微細加工粒子分離機構部を動かすよう、前記内包された透磁性材料と相互作用し、
前記微細加工粒子分離機構部は、前記磁束の源が活性化されたとき、第1位置から第2位置に動く、
請求項1記載の粒子操作システム。 - 前記センサは、1つ以上の前記微細加工チャネル内の、流体圧力、光学特性、粘度、キャパシタンスおよび流体抵抗の1つ以上に基づいて乾燥状態または間近の乾燥状態を検出する、請求項1記載の粒子操作システム。
- 前記センサは、入力レザバ、分離レザバないしは廃棄レザバの状態、または、これらのレザバと前記粒子操作装置との間のチャネルの状態、または、分離時間の持続時間、または、前記システムが記録した事象の数、の1つ以上に基づいて、前記乾燥状態または間近の乾燥状態を検出する、請求項1記載の粒子操作システム。
- 前記粒子分離機構部が前記第1位置にあるとき、前記微細加工入力チャネルと廃棄チャネルとの間に流路が形成され、前記粒子分離機構部が前記第2位置にあるとき、前記微細加工入力チャネルと前記微細加工分離出力チャネルとの間に流路が形成される、請求項2記載の粒子操作システム。
- 前記流体制御手段は、前記第1位置にある前記微細加工粒子分離機構部での流体の方向を逆転させる、請求項7記載の粒子操作システム。
- 前記流体制御手段は、前記第2位置にある前記微細加工粒子分離機構部での流体の方向を逆転させる、請求項7記載の粒子操作システム。
- 通常分離の間に順方向の流れ方向を維持するように前記流体制御手段を制御し、前記センサから前記信号を受信したとき、前記流体の方向を逆転させるコントローラをさらに備えている、請求項1記載の粒子操作システム。
- 前記センサから前記信号を受信したとき、前記コントローラは湿潤状態維持アルゴリズムを呼び出す、請求項10記載の粒子操作システム。
- 前記湿潤状態維持アルゴリズムは、
検査レーザの出力の低下、変更または停止、
電源の出力の低下、変更または停止、
ポンプの出力の低下、停止または逆転、
音声アラームの発声、
警告メッセージの送出
の1つ以上を含む、
請求項11記載の粒子操作システム。 - 粒子操作装置を用いた粒子操作方法であって、
粒子操作装置を設けるステップと、
前記粒子操作装置の上流の1つ以上の微細加工入力チャネル、および、前記粒子操作装置の下流の1つ以上の微細加工出力チャネルを設けるステップと、
通常動作の間、微細加工入力チャネルを介して、前記1つ以上の微細加工出力チャネルに流体を流すステップと、
微細加工チャネルが乾燥しているか、または、乾燥間近であるかを検知するステップと、
乾燥状態を示す信号を出力するステップと、
前記信号を受信したときに、前記1つ以上の微細加工入力チャネルと前記1つ以上の微細加工出力チャネルとの間の前記流れを逆転させるステップと、
を含み、
前記粒子操作装置は、基板表面上に形成された微細加工粒子分離機構部を備えており、
前記サンプル流体は、標的粒子および非標的物質を含んでいる、
方法。 - 前記微細加工粒子分離機構部は、力に応じて標的粒子を微細加工入力チャネルから微細加工分離出力チャネルへの向きを変えるよう動き、
前記標的粒子の向きを変える前記粒子分離機構部の動きは、実質的に前記基板表面に平行な面内にあり、
前記微細加工粒子分離機構部は、前記力がかかったときに、前記粒子の向きを変えるよう、第1位置から第2位置に動く、
請求項13記載の方法。 - 前記入力チャネル内の流れは、前記分離出力チャネル内の流れに実質的に逆平行であり、
前記力は磁力であり、
廃棄出力チャネルは前記入力チャネルおよび前記分離出力チャネルに実質的に直交しており、
前記信号を前記センサから受信したとき、前記廃棄チャネルと前記入力チャネルとの間の流れを逆転する、
請求項14記載の方法。 - 前記流れを逆転させるステップの後、検査レーザの出力の低下、変更または停止;電源の出力の低下、変更または停止;ポンプの出力の低下、停止または逆転;音声警告の発生;および警告メッセージの送出の1つ以上を行うステップをさらに含む、請求項13記載の方法。
- 前記のマイクロ流体チャネルが乾燥間近であることの検知は、1つ以上の微細加工チャネル内の流体圧力、光学特性、粘度、キャパシタンス、流体抵抗の1つ以上の変化、または、前記サンプルの量がほぼ枯渇していることを検知するステップを含む、請求項13記載の方法。
- 前記流体制御手段は、前記第1位置にある前記微細加工粒子分離機構部での流体の流れの方向を逆転させる、請求項15記載の方法。
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