JP6509965B2 - 保湿力に優れた皮膚角質除去用化粧料組成物 - Google Patents
保湿力に優れた皮膚角質除去用化粧料組成物 Download PDFInfo
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- JP6509965B2 JP6509965B2 JP2017144275A JP2017144275A JP6509965B2 JP 6509965 B2 JP6509965 B2 JP 6509965B2 JP 2017144275 A JP2017144275 A JP 2017144275A JP 2017144275 A JP2017144275 A JP 2017144275A JP 6509965 B2 JP6509965 B2 JP 6509965B2
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Images
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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Description
下記表1の組成で実施例1及び2の角質除去用組成物を製造した。
ナツメグエキスと尿素を使用しないこと以外は、実施例1と同様にして角質除去用組成物を製造した。
尿素を使用しないこと以外は、実施例1と同様にして角質除去用組成物を製造した。
グルコノデルタラクトン、ナツメグエキス及び尿素を使用しないこと以外は、実施例1と同様にして角質除去用組成物を製造した。
実施例1〜2及び比較例1〜3の組成物で製造された製品に対し、下記条件のように、皮膚刺激試験(Irritation test)及び神経刺激試験(Neurosensory irritation test)を行った。
1)試験部位:Elbow Flex(antecubital fossa:肘前窩)
2)試験面積:横5cm×縦5cm
3)製品への適用回数:2回/1日(午前、午後)
4)製品への適用量:20〜30mg/1回
5)適用期間:1週間(7日)
6)試験物質の除去:水洗(Washing)
7)測定時間:午前製品適用前の測定
<1次皮膚刺激試験の結果>
図1は、1次皮膚刺激試験の結果を示したものである。比較例1の組成物に対する刺激性評価の結果、刺激反応の程度は一般的に示されるレベルであり、心配するレベルの刺激反応はなかったが、3〜4日にわずかな刺激の上昇を示した。比較例3(対照群)と比較したときにも心配するレベルの刺激は示さなかった。
図2は、1次神経刺激試験の結果を示したものである。比較例1の組成物は、実験の全期間中slight stinging/itching/burning potentialを示し、弱い神経刺激症状が現れた。比較例1の組成物中にAHA誘導体が含有されており、若干の神経刺激症状があると予想された。比較例1の組成物の場合、神経の刺激によるトラブル発生の可能性が予想され、製品として適切ではない。
図3は、2次皮膚刺激試験の結果を示したものである。比較例2の組成物に対する刺激性評価の結果、刺激反応の程度は一般に現れるレベルであり、心配するレベルの刺激反応はなかったが、2〜3日にわずかな刺激の上昇を示した。比較例3と比較したときにも心配するレベルの刺激は示さなかった。
図4は、2次神経刺激試験の結果を示したものである。比較例2の組成物は、適用1日目のみslight stinging/itching/burning potentialを示し、その後はnon−stinging/itching/burning potentialを示した。比較例1と神経刺激症状を比較すると、よりマイルドな傾向を示した。比較例3の場合、実験全期間中に心配するほどの神経刺激症状はなく、non−stinging/itching/burning potentialを示した。
図5は、3次神経刺激試験の結果を示したものである。実施例2の組成物は、2日目のみslight stinging/itching potentialを示し、実施例1の組成物は、剤形適用全期間中に心配するレベルの神経刺激症状はなく、non−stinging/itching potentialを示した。
[試験の概要]
5人の被験者を対象に顔面部位に実施例1(製品A)と実施例2(製品B)の角質ケア製品を塗布した後、角質改善程度を評価し、実施例1(製品A)の肌のキメ、透明度の評価も行った。
<角質改善程度の評価結果>
図6は、角質除去効果を示したものである。実施例1(製品A)は、使用直後に有意に角質の改善が認められ、他の時点では有意な改善が認められなかった。実施例2(製品B)は、直後2日、7日後にすべての時点で5人のうち1人の被験者を除いて角質が改善される傾向を示した(製品Aの場合、5人のうち3人だけ改善)。
図7は、肌のキメの改善効果を示したものである。実施例1(製品A)は、製品の使用後、約3.66%の肌のキメが改善され、5人のうち4人が肌のキメが改善される傾向を示し、製品Aは肌のキメの改善に役立つと判断される。
Claims (8)
- ポリヒドロキシ酸(PHA)又はそのラクトン、抗炎症剤混合物及び天然保湿因子を含む皮膚角質除去用化粧料組成物であって、前記抗炎症剤混合物が、ナツメグエキス及びパンテノールを含み、前記天然保湿因子として尿素を含む、皮膚角質除去用化粧料組成物。
- 前記ポリヒドロキシ酸又はそのラクトンは、グルコノラクトン、リボノラクトン、グルコン酸またはラクトビオン酸である、請求項1に記載の皮膚角質除去用化粧料組成物。
- 前記ポリヒドロキシ酸(PHA)又はそのラクトンは、組成物の総重量に対して3〜30重量%で含まれる、請求項1に記載の皮膚角質除去用化粧料組成物。
- 前記抗炎症剤混合物は、ゴボウの種エキス、アラニルグルタミン、アセチルテトラペプチド−15、アルニカ花エキス、褐藻エキス、及びベータ−グルカンからなる群から選択された1種以上をさらに含む、請求項1に記載の皮膚角質除去用化粧料組成物。
- 前記抗炎症剤混合物は、組成物の総重量に対して0.5〜30重量%で含まれる、請求項1に記載の皮膚角質除去用化粧料組成物。
- 前記天然保湿因子は、アミノ酸、ピロリドンカルボン酸(PCA)、ヒアルロン酸ナトリウム、ラクテート、グルコサミン、カリウムイオン、ナトリウムイオン及びカルシウムイオンからなる群から選択された1種以上をさらに含む、請求項1に記載の皮膚角質除去用化粧料組成物。
- 前記天然保湿因子は、組成物の総重量に対して0.001〜10重量%で含まれる、請求項1に記載の皮膚角質除去用化粧料組成物。
- 保湿剤としてポリオールをさらに含む、請求項1に記載の皮膚角質除去用化粧料組成物。
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CN109125107B (zh) * | 2018-09-20 | 2022-02-01 | 深圳市维琪医药研发有限公司 | 一种有效改善和修复面部激素依赖性皮炎的多肽组合物 |
KR102450173B1 (ko) | 2020-08-14 | 2022-10-04 | 주식회사 더마클래스 | 안면부 피부 보습 및 붓기 완화용 화장료 조성물 |
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AU618517B2 (en) * | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
JPH07215832A (ja) * | 1994-01-28 | 1995-08-15 | Shiseido Co Ltd | 皮膚外用剤 |
US6036963A (en) * | 1998-02-26 | 2000-03-14 | Chesebrough-Ponds's Usa Co., Division Of Conopco, Inc. | Gluconolactones and glucarolactones as anti-irritants in cosmetic compositions |
JP2002179528A (ja) * | 2000-12-14 | 2002-06-26 | Japan Natural Laboratory Co Ltd | ピーリング化粧剤およびピーリング石鹸 |
JPWO2002072040A1 (ja) * | 2001-03-13 | 2004-07-02 | 味の素株式会社 | 化粧料または皮膚外用剤 |
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JP2005281135A (ja) * | 2004-03-26 | 2005-10-13 | Shiseido Co Ltd | 皮膚外用剤 |
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