JP6505417B2 - Clinical examination equipment - Google Patents

Description

  Embodiments of the present invention relate to a clinical examination apparatus.

  Clinical examinations are performed to objectively evaluate the condition of a subject. A clinical examination apparatus is mainly used for this clinical examination. An example of a clinical examination apparatus is an automatic analyzer.

  The automatic analyzer dispenses a test sample such as blood or urine and a reagent in a reaction tube, mixes and reacts them, and then measures (tests) changes in color tone or turbidity caused by the reaction. Thereby, the concentration and activity of the substance to be measured in the test sample are measured.

  In addition, an automatic analyzer may perform this measurement by reacting a plurality of types of reagents with a test sample. For example, when the automatic analyzer reacts two types of reagents (a first reagent and a second reagent) with a test sample, a plurality of first reagent bottles containing the first reagent and the second reagent are stored. The plurality of second reagent bottles are stored in the reagent storage. The first reagent and the second reagent are paired according to the item to be measured. Then, during measurement, when the reagent bottle used (the first reagent bottle or the second reagent bottle) is emptied, the automatic analyzer is the same as the reagent contained in the emptied reagent bottle. Continue to use the reagents of the next reagent bottle stored. The amounts of the first reagent and the second reagent used in each measurement are not necessarily the same. Therefore, even if the volumes of the first reagent bottle and the second reagent bottle are the same, the first reagent bottle and the second reagent bottle whose use has been started simultaneously may not necessarily be empty at the same time. Therefore, the timing at which the reagent bottle to be used is changed to the next reagent bottle may be different between the first reagent bottle and the second reagent bottle paired with the first reagent bottle.

  Further, in order to measure the test sample, the automatic analyzer acquires (creates) a calibration curve using a standard sample which is a sample for which the concentration of the substance to be measured is guaranteed. The calibration curve is acquired for each combination (bottle pair) of the first reagent bottle and the second reagent bottle paired with the first reagent bottle. In the calibration curve acquired in units of bottle pairs, the remaining amount of any of the reagents in each of the reagent bottles constituting the bottle pair is smaller than the amount used for one measurement (for convenience, this state is empty of the reagent bottles It is used for the measurement until the state. Then, when one of the reagent bottles constituting the bottle pair becomes empty, a standard sample is used to obtain a calibration curve again. The reagent used at this time was contained in the reagent in another new reagent bottle containing the same reagent as the reagent contained in the emptied reagent bottle and in the emptied reagent bottle A reagent in a reagent bottle which contains a reagent paired with a reagent and which still has an amount of reagent which can be used for one or more measurements.

  Thus, the reagent bottle is changed to a new one until either the reagent bottle containing the first reagent or the reagent bottle containing the second reagent paired with the first reagent becomes empty. If not, each reagent contained in the reagent bottle can be used up.

  However, when one reagent bottle of the pair of reagents contained in different reagent bottles is emptied, if the remaining amount of the reagent in the other reagent bottle is small, the reagent having a small remaining amount The combination of the reagent in the bottle and the reagent in the reagent bottle which is paired with the reagent and contained in a new reagent bottle reduces the number of measurements that can be used for the newly acquired calibration curve. As described above, acquiring a calibration curve having a short effective period for measurement (the number of measurable times is small) increases the ratio of the number of times of acquiring the calibration curve to the number of measurements (the number of examinations) and reduces the efficiency of the measurement. Become. In addition, standard samples are wasted.

JP-A-9-325150

  The problem to be solved by the present invention is to provide a clinical examination apparatus capable of improving the efficiency of measurement.

The clinical examination apparatus according to the embodiment is a clinical examination apparatus that analyzes a first reagent and a sample that has reacted with a second reagent that makes a pair with the first reagent, and the calculation unit, the selection unit, and the analysis control unit It has an analysis part and an analysis data processing part . The calculation unit is configured to perform the first operation based on the number of usable times of the first reagent in the first reagent bottle containing the first reagent and the number of usable times of the second reagent in the second reagent bottle containing the second reagent. The number of remaining uses for each bottle pair, which is a combination of the reagent bottle and the second reagent bottle, is calculated. The selection unit is configured to be able to select the bottle pair excluded from the bottle pair used for the reaction with the sample based on the remaining number of times of use. The analysis control unit receives, from the selection unit, information representing a bottle pair group after the selected bottle pair is excluded. The analysis unit measures a standard sample reacted with the first reagent and the second reagent by the bottle pair group after the selected bottle pair is excluded based on the information received by the analysis control unit. The analysis data processing unit creates a calibration curve for the bottle pair group after the selected bottle pair is excluded, based on the standard sample measurement data from the analysis unit.

FIG. 2 is a block diagram showing a functional configuration of the clinical examination apparatus of the first embodiment. The schematic diagram showing the outline of the analysis part which concerns on the clinical examination apparatus of 1st Embodiment. FIG. 7 is a schematic view schematically showing the usable number of times of the first reagent in the first reagent bottle of the first embodiment and the usable number of times of the second reagent in the second reagent bottle. The schematic diagram showing the outline of the bottle pair of 1st Embodiment. The schematic diagram showing the outline of the number of remaining use of the bottle pair which concerns on 1st Embodiment. FIG. 7 is a schematic view showing the remaining number of use of the bottle pair group and each bottle pair after the bottle pair according to the selection instruction of the first embodiment is excluded. 3 is a flowchart showing the operation of the clinical examination apparatus of the first embodiment. The schematic diagram showing the outline of the number of remaining use of the bottle pair which concerns on embodiment of the modification 1. FIG. FIG. 13 is a schematic view showing a remaining bottle pair group after the removal of the bottle pair according to the selection instruction of Modification Example 1 and the number of remaining usages of each bottle pair. The schematic diagram showing the outline of the number of remaining use of the bottle pair which concerns on embodiment of the modification 2. FIG. FIG. 16 is a schematic view showing a remaining bottle pair group after the removal of a bottle pair according to a selection instruction of Modification Example 2 and the number of remaining usages of each bottle pair. The block diagram showing the functional composition of the clinical examination device of a 2nd embodiment. The schematic diagram showing the remaining frequency of use alert | reported by the alerting | reporting part, the said bottle pair, and the outline of a comparison result. 7 is a flowchart showing the operation of the clinical examination apparatus of the second embodiment. The block diagram showing the functional composition of the clinical examination device of a 3rd embodiment. The flowchart showing the operation | movement of the clinical examination apparatus of 3rd Embodiment.

  Hereinafter, an automatic analyzer will be described with reference to the drawings as an example of the clinical examination apparatus according to the embodiment.

First Embodiment
FIG. 1 is a block diagram showing a functional configuration of the clinical examination apparatus 1 of the first embodiment. The clinical examination apparatus 1 analyzes a first reagent and a sample that has reacted with a second reagent paired with the first reagent. The clinical examination apparatus 1 includes an analysis unit 2, a calculation unit 3, a selection unit 4a, an analysis control unit 4b, an analysis data processing unit 5, an output unit 6, an operation unit 7, and a system control unit 8. Have.

  FIG. 2 is a schematic view showing an outline of the analysis unit 2 according to the clinical examination apparatus 1 of the first embodiment. The analysis unit 2 includes a first reagent bottle 9a, a second reagent bottle 9b, a first reagent rack 10a, a second reagent rack 10b, a first reagent storage 11a, a second reagent storage 11b, a reaction tube 12, a reaction disk 13, and a sample. A container 14, a disk sampler 15, a first dispensing arm 16 a, a second dispensing arm 16 b, a sampling arm 17, a stirring unit 18, a photometric unit 19, and a cleaning unit 20 are provided.

  The first reagent bottle 9a contains a first reagent that reacts with the sample. The second reagent bottle 9 b accommodates a second reagent which is a reagent of a type different from the first reagent. The first reagent rack 10a is installed in the first reagent storage 11a in a state where the plurality of first reagent bottles 9a are accommodated. The second reagent rack 10b is installed in the second reagent storage 11b in a state in which the plurality of second reagent bottles 9b are accommodated.

  The reaction tube 12 is a container used when reacting the sample with the first reagent and the second reagent. A plurality of reaction tubes 12 are arranged in a circle on the reaction disk 13.

  The sample container 14 is a container in which a sample is stored. In one sample container 14, a test sample such as blood or urine, a standard sample which is a sample for which the concentration of the substance to be measured is guaranteed, or a quality control sample used for accuracy control of a calibration curve. Will be stored. A plurality of sample containers 14 are disposed in the disk sampler 15.

  The first reagent in the first reagent bottle 9a is dispensed by the first dispensing arm 16a into the reaction tube 12 in which the sample is dispensed. The second reagent in the second reagent bottle 9b is dispensed by the second dispensing arm 16b into the reaction tube 12 in which the sample and the first reagent are dispensed. The sample in the sample container 14 is dispensed into the reaction tube 12 by the sampling arm 17.

  The reaction tube 12 into which the sample and the first reagent are dispensed, and the reaction tube 12 into which the sample and the first reagent and the second reagent are dispensed, the position of the stirring unit 18 by the rotation of the reaction disk 13 It is moved up. The stirring unit 18 stirs the sample and the first reagent in the reaction tube 12 and also stirs the sample, the first reagent and the second reagent in the reaction tube 12 to obtain the sample, the first reagent and the second reagent. It is a unit for mixing with a reagent.

  The reaction tube 12 including the stirred sample and the first and second reagents is moved to the position of the photometric unit 19 by the rotation of the reaction disk 13. The photometry unit 19 is a unit that emits light to the reaction tube 12 and measures, for example, the change in absorbance of the mixture of the sample and the first and second reagents.

  The cleaning unit 20 is a unit for cleaning the inside of the reaction tube 12 after the liquid mixture in the reaction tube 12 for which the measurement has been completed is discarded.

  The calculation unit 3 is based on the usable number of times of the first reagent in the first reagent bottle 9a containing the first reagent and the usable number of times of the second reagent in the second reagent bottle 9b containing the second reagent. The number of remaining uses for each bottle pair, which is a combination of the first reagent bottle 9a and the second reagent bottle 9b, is calculated.

  FIG. 3 is a schematic view schematically showing the usable number N1 of the first reagent in the first reagent bottle 9a and the usable number N2 of the second reagent in the second reagent bottle 9b according to the first embodiment. The calculation unit 3 stores in advance information representing the usable number N1 of the first reagent in the first reagent bottle 9a and the usable number N2 of the second reagent in the second reagent bottle 9b. The usable number of times N1 of the first reagent is the usable number of times per one first reagent bottle 9a. Here, an example in which the usable number of times N1 of the first reagent before the start of measurement is "330" will be described. When the first dispensing arm 16a performs aspiration N1 times the usable number of times of the first reagent, the first reagent bottle 9a becomes empty. Then, the first dispensing arm 16a starts suctioning from the next first reagent bottle 9a. Each of the first reagent bottles 9a is provided at an arrangement position (9a1, 9a2, 9a3, 9a4,...) In the first reagent storage 11a. In the present embodiment, the first reagent bottle 9a contains the first reagent of the same type. The order in which the first reagent bottles are used is predetermined based on each arrangement position. Here, an example will be described in which this order is determined in the order of arrangement position 9a1, arrangement position 9a2, arrangement position 9a3 and arrangement position 9a4.

  The usable number of times N2 of the second reagent is the usable number of times per one second reagent bottle 9b. Here, an example in which the usable number of times N2 of the second reagent before the start of measurement is "1000" will be described. When the second dispensing arm 16b performs aspiration N2 times the usable number of times of the second reagent, the second reagent bottle 9b becomes empty. Then, the second dispensing arm 16b starts suctioning from the next second reagent bottle 9b. Each of the second reagent bottles 9b is provided at an arrangement position (9b1, 9b2, ...) in the second reagent storage 11b. In the present embodiment, the second reagent bottle 9b contains the second reagent of the same type. Here, an example in which this order is determined in the order of the arrangement position 9b1 and the arrangement position 9b2 will be described.

  FIG. 4 is a schematic view showing an outline of a bottle pair according to the first embodiment. FIG. 5 is a schematic view showing an outline of the number of remaining uses of the bottle pair according to the first embodiment. The bottle pair group shown in FIG. 5 is a list of bottle pairs that can be used for reaction with the sample. The calculation unit 3 determines the number of times of use of the bottle pair, which is the smaller number of times of use when the bottle pair starts to be used, out of the usable number of times N1 of the first reagent and the usable number of times N2 of the second reagent. Calculated as the remaining usage frequency. When the number of usable times N1 of the first reagent and the number of usable times N2 of the second reagent are the same, the number of times of use calculated as the remaining number of times used by the calculation unit 3 is the number N1 of usable times of the first reagent. The number N2 of usable times of the second reagent may be sufficient.

  The bottle pair BP1 of the first reagent bottle 9a at the arrangement position 9a1 and the second reagent bottle 9b at the arrangement position 9b1 is the smaller number of times of the number N1 of usable times of the first reagent and the number N2 of usable times of the second reagent. It is possible to use 330 times. Therefore, the calculation unit 3 calculates the number of available bottle pairs of the bottle pair BP1, that is, the number of remaining usages as “330”. When the first reagent of the first reagent bottle 9a at the arrangement position 9a1 is used 330 times, the first reagent bottle 9a becomes empty, and the first reagent bottle 9a at the arrangement position 9a2 and the second reagent bottle 9b at the arrangement position 9b1 And the bottle pair BP2 will start to be used. At this time, since the second reagent of the second reagent bottle 9b at the arrangement position 9b1 has been used 330 times, when the bottle pair BP2 starts to be used, the second reagent relating to the second reagent bottle 9b can be used The number N2 is "670". Therefore, the calculation unit 3 calculates the number of available bottle pairs of the bottle pair BP2, that is, the number of remaining usage as “330”. Similarly, for the bottle pair BP3 of the first reagent bottle 9a at the arrangement position 9a3 and the second reagent bottle 9b at the arrangement position 9b1, the calculation unit 3 calculates the number of usable bottle pairs, that is, the number of remaining uses as "330".

  When the first reagent of the first reagent bottle 9a at the arrangement position 9a3 is used 330 times, the first reagent bottle 9a becomes empty, and the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b1 And the bottle pair BP4 will start to be used. At this time, since the second reagent of the second reagent bottle 9b at the arrangement position 9b1 has been used 990 times, the number of usable times of the second reagent related to the second reagent bottle 9b when the bottle pair starts to be used N2 is "10". Therefore, the calculation unit 3 calculates the number of available bottle pairs of the bottle pair BP4, that is, the number of remaining usage as “10”. When the second reagent bottle 9b at the arrangement position 9b1 becomes empty, the bottle pair BP5 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b2 starts to be used. At this time, since the first reagent of the first reagent bottle 9a at the arrangement position 9a4 is used ten times, when the bottle pair BP5 starts to be used, the first reagent relating to the first reagent bottle 9a can be used The number N1 is "320". Therefore, the calculation unit 3 calculates the number of available bottle pairs of the bottle pair BP5, that is, the number of remaining usage as “320”. The calculating unit 3 outputs, to the selecting unit 4a, correspondence information representing a correspondence between each bottle pair and the calculated remaining number of times of use. The table information shown in FIG. 5 is given as an example of the correspondence information.

  The selection unit 4a is configured to be able to select a bottle pair excluded from the bottle pair used for the reaction with the sample based on the remaining number of times of use. The selection unit 4 a includes a notification unit 41 and a reception unit 42. The notification unit 41 notifies the remaining number of times of use and the bottle pair. For example, the notification unit 41 includes a display device 411 such as a liquid crystal display or an organic EL (Electro-Luminescence) display. The notification unit 41 causes the display device 411 to display the correspondence information from the calculation unit 3. Thereby, the operator can grasp the remaining number of times of use for each bottle pair. The notification unit 41 may have a printing machine (printer) 412. In this case, the notification unit 41 causes the printing machine 412 to print the correspondence information from the calculation unit 3. Thereby, the operator can grasp the remaining number of times of use for each bottle pair.

  The receiving unit 42 is configured to be able to receive the notified remaining number of times of use and a selection instruction from the operator based on the bottle pair. For example, the reception unit 42 includes an operation device 421 such as a keyboard and a mouse. For example, the operator operates the operation device 421 while grasping the remaining number of uses for each bottle pair, and performs a selection instruction based on the reported number of remaining uses and the bottle pair. When this selection instruction is performed, the operator can perform a selection instruction for a bottle pair with a small number of remaining usages. Here, an example will be described in which selection instructions for the bottle pair BP4 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b1 are performed.

  The selection unit 4a selects a bottle pair BP4 according to the selection instruction received by the reception unit 42 as a bottle pair excluded from the bottle pair used for the reaction with the sample. Thus, the bottle pair BP4 relating to the selection instruction is excluded from the bottle pair group shown in FIG. Then, the selection unit 4a outputs, to the calculation unit 3 and the analysis control unit 4b, information indicating a bottle pair group after the bottle pair BP4 is excluded. When there is no bottle pair that is to be excluded from the bottle pair used for the reaction with the sample, the operator can input an instruction to the effect that "no excluded bottle pair" to the receiving unit 42. In this case, the selection unit 4a outputs information indicating the initial bottle pair group and the remaining number of times of use of the bottle pair group shown in FIG. 5 to the analysis control unit 4b.

  FIG. 6 is a schematic diagram showing the remaining number of use of the bottle pair group and each bottle pair after the bottle pair BP4 according to the selection instruction of the first embodiment is excluded. In the example of FIG. 6, the bottle pair of the selection instruction (the bottle pair BP4 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b1) is excluded from the bottle pair group shown in FIG. The calculation unit 3 receives the information indicating the bottle pair group from the selection unit 4a, and newly calculates the remaining number of times of use. In the example of FIG. 6, the new remaining number of use of the bottle pair BP5 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b2 is calculated as "330". The calculating unit 3 outputs information indicating the newly calculated number of remaining uses to the analysis control unit 4b.

  The analysis control unit 4b controls the analysis unit 2 to measure a standard sample that has reacted with the first reagent and the second reagent for each bottle pair included in the bottle pair group of information received from the selection unit 4a. The analysis control unit 4 b controls the rotation of the first reagent rack 10 a and the second reagent rack 10 b so that the first reagent and the second reagent of each bottle pair included in the bottle pair group are used. The analysis control unit 4 b controls the analysis unit 2 to output the standard sample measurement data obtained by the measurement to the analysis data processing unit 5. The analysis data processing unit 5 creates a calibration curve for each bottle pair included in the bottle pair group of the information received from the selection unit 4a based on the standard sample measurement data from the analysis unit.

  Then, the analysis control unit 4b controls the analysis unit 2 to measure the test sample reacted with the first reagent and the second reagent of each bottle pair included in the bottle pair group from the selection unit 4a. The analysis control unit 4b uses the first reagent and the second reagent of each bottle pair included in the bottle pair group based on the information indicating the bottle pair group from the selecting unit 4a and the information indicating the remaining number of uses from the calculating unit 3. As described above, rotation of the first reagent rack 10a and the second reagent rack 10b is controlled. The analysis control unit 4 b controls the analysis unit 2 to output the test sample measurement data acquired by the measurement to the analysis data processing unit 5. The analysis data processing unit 5 calculates analysis data related to the substance to be measured based on the created calibration curve and the test sample measurement data from the analysis unit 2. The analysis data processing unit 5 outputs the calculated analysis data to the output unit 6.

  The output unit 6 includes, for example, a display device 61 such as a liquid crystal display or an organic EL display. The output unit 6 causes the display device 61 to display the analysis data from the analysis data processing unit 5. As a hardware configuration, the display device 61 and the display device 411 described above may be configured as the same device. The output unit 6 may be configured to include the printing machine 62. In this case, the output unit 6 causes the printer 62 to print the analysis data from the analysis data processing unit 5. As a hardware configuration, the printing machine 62 and the printing machine 412 described above may be configured as the same device. The output unit 6 may be configured to include the communication interface 63. The communication interface 63 is configured to be communicable with a general medical data management server or the like. In this case, the output unit 6 outputs the analysis data from the analysis data processing unit 5 to an external device such as a medical data management server via the communication interface 63.

  The operation unit 7 is used to input various instructions and information to the clinical examination apparatus 1. The operation unit 7 includes, for example, operation devices such as a keyboard and a mouse. As a hardware configuration, the operation unit 7 and the above-described operation device 421 may be configured as the same device.

  The system control unit 8 controls the operation of each unit of the clinical examination apparatus 1. The system control unit 8 includes storage devices such as a read only memory (ROM), a random access memory (RAM), and a hard disc drive (HDD). The storage device stores a computer program for executing the function of each part of the clinical examination apparatus 1. The system control unit 8 is configured to include a processing device such as a central processing unit (CPU), a graphic processing unit (GPU), or an application specific integrated circuit (ASIC). The processing device implements the above functions by executing these computer programs. For example, the system control unit 8 executes a computer program representing the following operation.

  FIG. 7 is a flow chart showing the operation of the clinical examination apparatus 1 of the first embodiment.

  Step S101: The calculating unit 3 calculates the number of times of use of the first reagent in the first reagent bottle 9a containing the first reagent and the number of usable times of the second reagent in the second reagent bottle 9b containing the second reagent. Based on the number of remaining usages for each bottle pair, which is a combination of the first reagent bottle 9a and the second reagent bottle 9b, is calculated. At this time, the calculation unit 3 selects the number of use times of the bottle pair, which is the smaller number of use times when the bottle pair starts to be used, out of the usable number of times N1 of the first reagent and the usable number of times N2 of the second reagent. Calculated as the number of remaining use of the bottle pair. The calculating unit 3 outputs, to the selecting unit 4a, correspondence information indicating a correspondence between the bottle pair and the calculated remaining number of times of use.

  Step S102: The notification unit 41 included in the selection unit 4a notifies the remaining number of times of use and the bottle pair. For example, the notification unit causes the display device 411 to display the correspondence information from the calculation unit 3.

  Step S103: When the accepting unit 42 accepts a selection instruction of a bottle pair to be excluded from the bottle pair used for the reaction with the sample (Yes), this operation proceeds to step S104. When the receiving unit 42 receives an instruction indicating "no excluded bottle pair" (No), this operation proceeds to step S106.

  Step S104: The selection unit 4a selects a bottle pair according to the selection instruction accepted by the acceptance unit 42 as a bottle pair excluded from the bottle pair used for the reaction with the sample. Thereby, a bottle pair relating to the selection instruction is excluded from the bottle pair group that can be used for the reaction with the sample. Then, the selection unit 4a outputs information representing a bottle pair group after the bottle pair is excluded to the calculation unit 3 and the analysis control unit 4b.

  Step S105: The calculating unit 3 calculates the number of remaining uses for the bottle pair group from the selecting unit 4a, that is, the bottle pair group after the bottle pair relating to the selection instruction is excluded. The calculation unit 3 outputs information indicating the newly calculated number of remaining uses to the analysis control unit 4b.

  Step S106: The selection unit 4a outputs, to the analysis control unit 4b, information indicating the bottle pair group that can be used for the reaction with the sample and the remaining use frequency of the bottle pair group.

  Step S107: The analysis control unit 4b controls the analysis unit 2 to measure a standard sample that has reacted with the first reagent and the second reagent for each bottle pair included in the bottle pair group from the selection unit 4a. The analysis data processing unit 5 creates a calibration curve for each bottle pair included in the bottle pair group of the information received from the selection unit 4a based on the standard sample measurement data from the analysis unit.

  Step S108: The analysis control unit 4b controls the analysis unit 2 to measure the test sample reacted with the first reagent and the second reagent of each bottle pair included in the bottle pair group of the information received from the selection unit 4a. Let The analysis data processing unit 5 calculates analysis data related to the substance to be measured based on the created calibration curve and the test sample measurement data from the analysis unit 2.

  The effects of the clinical examination apparatus 1 of the first embodiment will be described. The clinical examination apparatus 1 of this embodiment calculates the number of available bottle pairs as the remaining number of uses, and reports the calculated number of remaining uses. Then, the operator can instruct to select a bottle pair with a small number of remaining usages. The clinical examination apparatus 1 receives the selection instruction and excludes the bottle pair of the selection instruction from the bottle pair used for analysis. The clinical examination apparatus 1 does not use the first reagent and the second reagent of the excluded bottle pair for the preparation of the standard curve and the reaction with the test sample, and the first reagent and the second reagent of the other bottle pairs are Used for preparation and reaction with test sample. Thus, it is possible to prevent the acquisition of a calibration curve having a short effective period (a small number of measurable times) for a bottle pair having a small number of remaining uses. This corresponds to reducing the ratio of the number of acquisitions of the calibration curve to the number of measurements (the number of tests). Therefore, the efficiency of measurement can be improved. In addition, wasteful use of the standard sample can be suppressed.

Modified Example 1 of First Embodiment
A clinical examination apparatus 1 according to a modification 1 of the first embodiment will be described. The clinical examination apparatus 1 differs from the first embodiment in the configuration of the calculation unit 3. Hereinafter, contents different from the first embodiment will be mainly described.

  The calculation unit 3 of Modification 1 is the number of times of use of the first reagent in the first reagent bottle 9a containing the first reagent and the number of usable times of the second reagent in the second reagent bottle 9b containing the second reagent. The remaining number of times of use for each bottle pair, which is a combination of the first reagent bottle 9a and the second reagent bottle 9b, is calculated based on the above. Then, the calculation unit 3 calculates the first measurable number, which is the number obtained by subtracting the number of calibration tests, which is the number of times the first reagent and the second reagent are used to obtain the calibration curve, from the number of bottle pairs available. Calculated as the number of remaining use of the bottle pair.

  FIG. 8 is a schematic view showing an outline of the number of remaining uses of the bottle pair according to the embodiment of the first modification. The number of calibration tests is predetermined. In the example of FIG. 8, the number of calibration tests is set to “5”. The number of calibration tests may be set to the number of times the first and second reagents are used for full calibration, and the number of times the first and second reagents are used for correction calibration. It may be defined. The first reagent and the second reagent of each bottle pair are used together with the standard sample for the number of calibration tests in the measurement for creating a calibration curve.

  The calculation unit 3 subtracts the number of calibration tests from the available number of bottle pairs to obtain the first measurable number, which is the number of times the first reagent and the second reagent can be used after creating the calibration curve, as the remaining use of the bottle pair. Calculated as the number of times. The calculating unit 3 outputs, to the selecting unit 4a, correspondence information indicating a correspondence between the bottle pair and the calculated remaining number of times of use (the first measurable number). The notification unit 41 of the selection unit 4a notifies, based on the correspondence information, the remaining number of uses (the first measurable number) and the bottle pair. Thereby, the operator can grasp the number of remaining usages (first measurable number) of each bottle pair. In addition, the operator can issue a selection instruction for a bottle pair having a small number of remaining usages (first measurable number). Here, an example will be described in which selection instructions for the bottle pair BP4 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b1 are performed.

  The selection unit 4a selects a bottle pair BP4 according to the selection instruction received by the reception unit 42 as a bottle pair excluded from the bottle pair used for the reaction with the sample. The selection unit 4a outputs information representing a bottle pair group after the bottle pair BP4 is excluded to the calculation unit 3 and the analysis control unit 4b.

  FIG. 9 is a schematic diagram showing a remaining bottle pair group after the removal of the bottle pair BP4 according to the selection instruction of the modification 1 and the number of remaining usages (first measurable number of times) of each bottle pair. In the example of FIG. 9, the calculating unit 3 newly calculates the remaining number of times of use (first measurable number) for the bottle pair group from the selecting unit 4a. In the example of FIG. 9, the new remaining number of uses (first measurable number) of the bottle pair BP5 between the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b2 is calculated as "325". ing. The calculating unit 3 outputs information indicating the newly calculated number of remaining uses to the analysis control unit 4b.

  As described above, the clinical examination apparatus 1 of the modification 1 calculates the first measurable number as the remaining number of uses, and reports the calculated number of remaining uses (the first measurable number). Then, the operator can instruct to select a bottle pair with a small number of remaining usages (first measurable number). The clinical examination apparatus 1 receives the selection instruction and excludes the bottle pair of the selection instruction from the bottle pair used for analysis. As a result, it is possible to prevent the acquisition of a calibration curve having a short effective period (a small number of measurable times) for a bottle pair having a small number of remaining uses (the first measurable number). This corresponds to reducing the ratio of the number of acquisitions of the calibration curve to the number of measurements (the number of tests). Therefore, also in the clinical examination apparatus 1 of the modification 1, the efficiency of measurement can be improved. In addition, wasteful use of the standard sample can be suppressed.

Modification 2 of the First Embodiment
A clinical examination apparatus 1 according to a modification 2 of the first embodiment will be described. The clinical examination apparatus 1 differs from the first embodiment in the configuration of the calculation unit 3. Hereinafter, contents different from the first embodiment will be mainly described.

  The calculating unit 3 of the second modification example uses the number of times of use of the first reagent in the first reagent bottle 9a containing the first reagent and the number of usable times of the second reagent in the second reagent bottle 9b containing the second reagent. The remaining number of times of use for each bottle pair, which is a combination of the first reagent bottle 9a and the second reagent bottle 9b, is calculated based on the above. The calculation unit 3 calculates, for each bottle pair, the first measurable number, which is the number obtained by subtracting the number of calibration tests, which is the number of times the first and second reagents are used to obtain the calibration curve, from the number of bottle pairs available. calculate. Then, the calculation unit 3 calculates a second measurable number which is a number obtained by subtracting the number of control tests which is the number of times the first reagent and the second reagent are used for the control measurement from the first measurable number. Calculated as the number of remaining use of the bottle pair.

  FIG. 10 is a schematic view showing an outline of the number of remaining uses of the bottle pair according to the embodiment of the second modification. The number of calibration tests and the number of control tests are predetermined. In the example of FIG. 10, the number of calibration tests is set to "5", and the number of control tests is set to "3". The number of calibration tests may be set to the number of times the first and second reagents are used for full calibration, and the number of times the first and second reagents are used for correction calibration. It may be defined. The first reagent and the second reagent of each bottle pair are used together with the standard sample for the number of calibration tests in the measurement for creating a calibration curve. The number of control tests is determined as the number of times the first and second reagents are used for quality control measurement (control measurement) of the prepared calibration curve. In the quality control measurement, the analysis unit 2 measures the first reagent and the second reagent and the quality control sample. Based on this measurement, the accuracy of the created calibration curve is calculated. A commonly known calculation method may be used as a specific calculation method of this accuracy. The first reagent and the second reagent of each bottle pair are used together with the quality control sample for the number of control tests in the quality control test of the calibration curve.

  The calculation unit 3 subtracts the number of calibration tests from the available number of bottle pairs to obtain the first measurable number, which is the number of times the first reagent and the second reagent can be used after creating the calibration curve, as the remaining use of the bottle pair. Calculated as the number of times. Then, the calculation unit 3 subtracts the number of control tests from the first measurable number of times to obtain the second measurable number of times, which is the number of times the first reagent and the second reagent can be used after quality control measurement. Calculated as the number of remaining usages of The calculating unit 3 outputs, to the selecting unit 4a, correspondence information representing a correspondence between the bottle pair and the calculated remaining number of times of use (the second measurable number). The notification unit 41 of the selection unit 4a notifies, based on the correspondence information, the remaining number of uses (the second measurable number) and the bottle pair. Thus, the operator can grasp the number of remaining uses (second measurable number) for each bottle pair. The operator can issue a selection instruction for a bottle pair having a small number of remaining usages (second measurable number). Here, an example will be described in which selection instructions for the bottle pair BP4 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b1 are performed.

  The selection unit 4a selects a bottle pair BP4 according to the selection instruction received by the reception unit 42 as a bottle pair excluded from the bottle pair used for the reaction with the sample. The selection unit 4a outputs information representing a bottle pair group after the bottle pair BP4 is excluded to the calculation unit 3 and the analysis control unit 4b.

  FIG. 11 is a schematic diagram showing a remaining bottle pair group after the removal of the bottle pair BP4 according to the selection instruction of the modification 2 and the remaining number of times of use of each bottle pair (second measurable number). In the example of FIG. 11, the calculating unit 3 newly calculates the remaining number of times of use (second measurable number) for the bottle pair group from the selecting unit 4a. In the example of FIG. 11, the new number of remaining uses (the first number of measurable times) of the bottle pair BP5 of the first reagent bottle 9a at the arrangement position 9a4 and the second reagent bottle 9b at the arrangement position 9b2 is calculated as "322". ing. The calculating unit 3 outputs information indicating the newly calculated number of remaining uses to the analysis control unit 4b.

  As described above, the clinical examination apparatus 1 of Modification 2 calculates the second measurable number as the remaining number of times of use, and reports the calculated number of remaining uses (second measurable number of times). Then, the operator can instruct to select a bottle pair with a small number of remaining usages (second measurable number). The clinical examination apparatus 1 receives the selection instruction and excludes the bottle pair of the selection instruction from the bottle pair used for analysis. As a result, it is possible to prevent the acquisition of a calibration curve having a short effective period (a small number of measurable times) for a bottle pair having a small number of remaining uses (a second measurable number). This corresponds to reducing the ratio of the number of acquisitions of the calibration curve to the number of measurements (the number of tests). Therefore, also in the clinical examination apparatus 1 of the modification 2, the efficiency of measurement can be improved. In addition, wasteful use of the standard sample can be suppressed.

Second Embodiment
FIG. 12 is a block diagram showing the functional configuration of the clinical examination apparatus 1 of the second embodiment. The clinical examination apparatus 1 differs from the first embodiment in the configuration of the selection unit. Hereinafter, contents different from the first embodiment will be mainly described.

  The selection unit 4c of the second embodiment includes the comparison unit 43, and similarly to the first embodiment, excludes the bottle pair of the selection instruction from the bottle pair used for the reaction with the sample based on the selection instruction (described later). The information representing the set of bottle pairs is output to the analysis control unit 4b. The comparison unit 43 compares, for each bottle pair, the magnitude relationship between the remaining number of uses calculated by the calculation unit 3 and a predetermined threshold value, and outputs information indicating the comparison result for each bottle pair to the notification unit 41. The remaining number of times of use may be any of the above-described number of available bottle pairs, the first number of measurable times, and the second number of measurable times. The threshold is determined, for example, by being input in advance by the operator. For example, in the comparison result by the comparison unit 43, a bottle pair whose remaining use frequency is less than the threshold value or less than or equal to the threshold value can be regarded as a bottle pair used less frequently for measuring the test sample.

  The notification unit 41 notifies the comparison result by the comparison unit 43 together with the remaining number of times of use and the bottle pair. FIG. 13 is a schematic diagram showing the remaining number of times of use notified by the notification unit 41, the bottle pair, and the comparison result. The example of FIG. 13 shows an outline of the comparison result with the second measurable number of times as the remaining number of times of use. The notification unit 41 notifies the magnitude relationship based on the comparison result in a distinguishable manner for each bottle pair. For example, the informing unit 41 represents a bottle pair whose remaining use frequency is equal to or more than the threshold value or more than the threshold value by text information "OK", and represents a bottle pair whose remaining frequency is less than the threshold value or less than or equal to the threshold value ing. Thereby, the operator can grasp the comparison result for each bottle pair. Also, the operator can issue a selection instruction for a bottle pair whose comparison result is smaller than the threshold.

  FIG. 14 is a flow chart showing the operation of the clinical examination apparatus 1 of the second embodiment.

  The processing content of step S201 is the same as the processing content of step S101 in the operation of the clinical examination apparatus 1 of the first embodiment shown in FIG.

  Step S202: The comparing unit 43 compares, for each bottle pair, the magnitude relationship between the number of remaining uses calculated by the calculating unit 3 and a predetermined threshold value. The comparison unit 43 outputs information indicating the comparison result for each bottle pair to the notification unit 41.

  Step S203: The notification unit 41 notifies the comparison result by the comparison unit 43 together with the remaining number of times of use and the bottle pair. At this time, the notification unit 41 notifies the magnitude relationship based on the comparison result in a distinguishable manner for each bottle pair.

  The processing content of step S204 to step S209 is the same as the processing content of step S103 to step S109 in the operation of the clinical examination apparatus 1 of the first embodiment shown in FIG. 7.

  The effects of the clinical examination apparatus 1 of the second embodiment will be described. The clinical examination apparatus 1 of the second embodiment calculates the number of available bottle pairs as the remaining number of uses, and compares the calculated number of remaining uses with a predetermined threshold. Then, the clinical examination apparatus 1 reports the comparison result for each bottle pair. As a result, the operator can easily select a bottle pair with a small number of remaining uses and exclude it from the bottle pair used for analysis. Then, it is prevented that a calibration curve having a short effective period (a small number of measurable times) is obtained for a bottle pair having a small number of remaining usages. This corresponds to reducing the ratio of the number of acquisitions of the calibration curve to the number of measurements (the number of tests). Therefore, the efficiency of measurement can be improved. In addition, wasteful use of the standard sample can be suppressed.

Third Embodiment
FIG. 15 is a block diagram showing a functional configuration of the clinical examination apparatus 1 of the third embodiment. The clinical examination apparatus 1 differs from the first embodiment in the configuration of the selection unit. Hereinafter, contents different from the first embodiment will be mainly described.

  The selection unit 4 d in the third embodiment is configured to include a comparison unit 43 and a selection processing unit 44. The comparison unit 43 compares, for each bottle pair, the magnitude relationship between the number of remaining uses calculated by the calculation unit 3 and a predetermined threshold value. Here, the remaining number of times of use may be any of the above-described number of usable bottle pairs, the first number of measurable times, and the second number of measurable times. The threshold is determined, for example, by being input in advance by the operator. For example, in the comparison result by the comparison unit 43, a bottle pair whose remaining use frequency is less than the threshold value or less than or equal to the threshold value can be regarded as a bottle pair used less frequently for measuring the test sample.

  Based on the comparison result for each bottle pair output from the comparison unit 43, the selection processing unit 44 sets a bottle pair whose remaining usage frequency is less than the threshold or less than the threshold as a bottle pair excluded from the bottle pair used for the reaction with the sample. select. Then, the selection processing unit 44 outputs, to the calculation unit 3 and the analysis control unit 4b, information indicating the bottle pair group after being excluded. In the second embodiment, the notification result from the comparison unit 43 is notified by the notification unit 41, and the final selection instruction is output from the reception unit 42 via the operator. In this third embodiment, bottle pairs with a low remaining usage frequency are automatically excluded from the bottle pairs used for analysis. And the information showing the bottle pair group after the exclusion is automatically output as selection information.

  In addition, in the comparison result by the comparison unit 43, when there is no bottle pair whose remaining use frequency is less than the threshold value or less than the threshold value, the selection processing unit 44 analyzes and controls information representing the original bottle pair group and the remaining use frequency of the bottle pair group. Output to part 4b.

  FIG. 16 is a flow chart showing the operation of the clinical examination apparatus 1 of the third embodiment.

  The processing content of step S301 is the same as the processing content of step S101 in the operation of the clinical examination apparatus 1 of the first embodiment shown in FIG.

  Step S302: The comparing unit 43 compares, for each bottle pair, the magnitude relationship between the number of remaining uses calculated by the calculating unit 3 and a predetermined threshold value.

  Step S303: When there is a bottle pair whose remaining usage frequency is less than the threshold or less than the threshold (Yes), the selecting unit 4d selects a bottle pair whose usage frequency is less than the threshold less than the threshold based on the comparison result by the comparing unit 43. Select as a bottle pair to be excluded from the bottle pair used for reaction with the sample. The selection unit 4d outputs information representing the bottle pair group after the bottle pair is excluded to the calculation unit 3 and the analysis control unit 4b. If there is no bottle pair whose remaining use frequency is less than the threshold value or less than the threshold value (No), the selecting unit 4d outputs information indicating the initial bottle pair group and the remaining use frequency of the bottle pair group to the analysis control unit 4b.

  The processing content of step S304 to step S307 is the same as the processing content of step S105 to step S108 in the operation of the clinical examination apparatus 1 of the first embodiment shown in FIG. 7.

  The effects of the clinical examination apparatus 1 of the third embodiment will be described. The clinical examination apparatus 1 of the third embodiment calculates the number of available bottle pairs as the remaining number of uses, and compares the calculated number of remaining uses with a predetermined threshold. Then, the clinical examination apparatus 1 selects a bottle pair whose remaining use frequency is equal to or less than a threshold value below the threshold as a bottle pair excluded from the bottle pair used for the reaction with the sample. As a result, the clinical examination apparatus 1 can automatically exclude bottle pairs with a low remaining usage frequency from bottle pairs used for analysis. Then, it is prevented that a calibration curve having a short effective period (a small number of measurable times) is obtained for a bottle pair having a small number of remaining usages. This corresponds to reducing the ratio of the number of acquisitions of the calibration curve to the number of measurements (the number of tests). Therefore, the efficiency of measurement can be improved. In addition, wasteful use of the standard sample can be suppressed.

  According to the clinical examination apparatus of at least one embodiment described above, the usage amount of the standard sample is calculated by calculating the remaining number of times of use for each bottle pair and selecting the bottle pair excluded from the bottle pair group used for the reaction with the sample. It is possible to reduce the And control of useless use of a standard sample can be aimed at.

  The configuration described in the above embodiment can be applied to clinical examination devices other than the automatic analysis device.

  Examples of clinical examination devices include clinical chemical analysis devices such as automatic analyzers, blood gas analyzers, electrophoresis devices and liquid chromatography devices, nuclear medicine devices such as radioimmunoassay devices, latex agglutination reaction measurement devices and nephelometers, etc. Immune serum test equipment, blood test equipment such as automatic blood cell counting device, blood coagulation measurement device, bacteria inspection equipment such as microbe classification identification device, blood culture test device, DNA, RNA measurement device, urine analyzer, fecal occult blood measurement device etc Urinary examination equipment, pathological examination equipment such as automatic tissue cell staining apparatus, physiological function examination equipment, other clinical examination equipment such as a micropipette, a washing apparatus dispensing apparatus and a centrifugal separation apparatus, and the like.

  While certain embodiments of the present invention have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the invention. These embodiments can be implemented in other various forms, and various omissions, replacements, and modifications can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the invention described in the claims and the equivalents thereof as well as included in the scope and the gist of the invention.

Reference Signs List 1 clinical examination apparatus 2 analysis unit 3 calculation unit 4a, 4c, 4d selection unit 4b analysis control unit 5 analysis data processing unit 6 output unit 7 operation unit 8 system control unit 9a first reagent bottle 9b second reagent bottle 10a first reagent Rack 10b Second reagent rack 11a First reagent storage 11b Second reagent storage 12 reaction tube 13 reaction disk 14 sample container 15 disk sampler 15a first dispensing arm 16b second dispensing arm 17 sampling arm 18 stirring unit 19 photometric unit 20 Cleaning unit 41 Notification unit 42 Reception unit 43 Comparison unit 44 Selection processing unit 61, 411 Display device 62, 412 Printing machine 63 Communication interface 421 Operation device

Claims (7)

A clinical examination apparatus for analyzing a sample reacted with a first reagent and a second reagent paired with the first reagent,
The first number of usable times of the first reagent in the first reagent bottle containing the first reagent and the second number of usable times of the second reagent in the second reagent bottle containing the second reagent, A calculation unit that calculates the number of remaining usages for each bottle pair, which is a combination of one reagent bottle and the second reagent bottle;
A selection unit capable of selecting the bottle pair excluded from the bottle pair used for the reaction with the sample based on the remaining number of times of use;
An analysis control unit that receives, from the selection unit, information representing a bottle pair group after the selected bottle pair is excluded;
An analysis unit configured to measure a standard sample reacted with the first reagent and the second reagent by the bottle pair group after the selected bottle pair is excluded based on the information received by the analysis control unit;
An analysis data processing unit that creates a calibration curve for a bottle pair group after the selected bottle pair is excluded based on standard sample measurement data from the analysis unit;
Having a clinical examination device.   The calculation unit calculates, as the remaining number of times of use of the bottle pair, the number of times of use of the bottle pair, which is the smaller number of times of use among the number of times of use of the first reagent and the number of times of use of the second reagent. The clinical examination apparatus according to claim 1, characterized in that The calculation unit
The number of usable bottle pairs, which is the smaller number of usages of the number of usable first reagents and the number of usable second reagents, is calculated for each of the bottle pairs,
The first measurable times the calibration test count the number of times that the first reagent and the second reagent is used a number obtained by subtracting from the Botorupea usable count to determine the calibration curve of the Botorupea The clinical examination apparatus according to claim 1, wherein the clinical examination apparatus is calculated as the remaining number of times of use. The calculation unit
The number of usable bottle pairs, which is the smaller number of usages of the number of usable first reagents and the number of usable second reagents, is calculated for each of the bottle pairs,
The first measurable times the calibration test count the number of times that the first reagent and the second reagent is used a number obtained by subtracting from the Botorupea usable count to determine the calibration curve for each of the Botorupea Calculate
The second measurable number, which is the number obtained by subtracting the control test number, which is the number of times the first reagent and the second reagent are used for control measurement, from the first measurable number is the number of times of the bottle pair The clinical examination apparatus according to claim 1, which is calculated as the remaining number of times of use. The selection unit is
A notification unit that notifies the remaining number of times of use and the bottle pair;
A reception unit capable of receiving a selection instruction based on the notified remaining number of times of use and the bottle pair;
Including
The clinical examination apparatus according to any one of claims 1 to 4, wherein the bottle pair corresponding to the selection instruction is selected. The selection unit includes a comparison unit that compares the remaining usage frequency with a predetermined threshold for each bottle pair,
6. The clinical examination apparatus according to claim 5, wherein the notification unit notifies the comparison result by the comparison unit together with the remaining number of times of use and the bottle pair. The selection unit is
A comparison unit that compares the remaining number of times of use with a predetermined threshold value for each of the bottle pairs,
The clinical examination apparatus according to any one of claims 1 to 4, wherein the bottle pair having the available number of times smaller than the threshold or smaller than the threshold is selected based on the comparison result by the comparison unit. .

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