JP2012198237A - Autoanalyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an autoanalyzer by which setting of an analysis parameter is easy.SOLUTION: An autoanalyzer includes: an analysis information storage part 21 which stores reagent information for identifying a reagent usable by an analysis part 18 which is associated with an analysis parameter including an amount of the reagent of the reagent information for performing measurement by using the reagent of the reagent information; a reader which reads the reagent information for identifying the reagent in a reagent container for storing a first reagent described to the reagent container; and an analysis parameter setting part 23 which sets the analysis parameter relevant to the reagent to be used for performing the measurement by the analysis part 18, in which the analysis parameter setting part 23 reads, when the same information as the reagent information read by the reader is stored in the analysis information storage part 21, the analysis parameter relevant to the same information from the analysis information storage part 21 to set the analysis parameter.

Description

The present invention relates to an automatic analyzer that analyzes components of a test sample collected from a subject, and more particularly to an automatic analyzer that analyzes components contained in body fluids such as human blood and urine.

The automatic analyzer is intended for biochemical test items, immunological test items, etc., and the test sample is measured by measuring changes in the color tone caused by the reaction of the mixture of the test sample and the reagent corresponding to each test item. Determine the concentration of various components in the medium and the activity of the enzyme. In the measurement procedure, first, after the reagent container containing the reagent of each inspection item is stored in the set position in the reagent storage, measurement of the inspection item selected according to the inspection is started. A test sample and a reagent are dispensed into a reaction container using a sample and a reagent dispensing probe, and the mixture of the test sample and the reagent dispensed in the reaction container is stirred with a stir bar, and the stirred mixture is removed. Measure with a photometer.

In this automatic analyzer, as the number of test items that can be measured increases, the number of reagent containers to be stored in the reagent store increases. There is a problem that the installation position is wrong when stored in the cabinet. To solve this problem, a barcode label corresponding to the reagent information is attached to the reagent container, and this is read by the barcode reader provided in the reagent container. An automatic analyzer capable of selecting a reagent is known (for example, see Patent Document 1).

In addition, a large number of reagents manufactured by a large number of manufacturers for each inspection item are commercially available. For this reason, in a facility where an automatic analyzer is introduced, a reagent suitable for the facility is selected from a large number of reagents for a large number of inspection items at the time of installation. In addition, even in facilities where inspection is performed by an automatic analyzer, efforts are being made for new inspection items that can be used by the automatic analyzer. In order to enable measurement using a new reagent by the automatic analyzer, it is necessary to set analysis parameters such as the amount of the sample to be used, the amount of the reagent, and the wavelength.
The commercially available reagent is prepared with the optimum analysis parameter for this reagent for each reagent, and each analysis item is measured by setting this analysis parameter in the apparatus.

Japanese Patent No. 3300704

However, it is necessary to manually input the analysis parameters for each reagent, and there is a problem that the input operation takes time. In addition, when using a large number of reagents, there is a risk of making an error in inputting analysis parameters.

The present invention has been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer in which analysis parameters can be easily set.

In order to achieve the above object, an automatic analyzer according to the present invention is an automatic analyzer comprising an analyzing means for measuring a mixed solution of a test sample and a reagent corresponding to a test item set in the test sample. Analysis information storage means for associating and storing reagent information for identifying a reagent usable in the analysis means and an analysis parameter for measurement using the reagent of the reagent information;
When the same reagent information as the reagent information input by the input means is stored in the analysis information storage means, the same reagent information is input to the analysis parameter setting means for setting an analysis parameter related to the same reagent information. When there are a plurality of reagent information including the same test item information among the first output means to output and the plurality of reagent information output from the first output means, a part of the test item information And a second output means for outputting reagent information including the same examination item information.

The block diagram which shows the structure of the automatic analyzer which concerns on the Example of this invention. The perspective view which shows the structure of the analysis part which concerns on the Example of this invention. The figure which shows the structure of the analysis information preserve | saved at the analysis information storage part which concerns on the Example of this invention. The figure which shows an example of the analysis information list screen displayed on the display part which concerns on the Example of this invention. The top view which shows the structure of the 1st reagent store | warehouse | chamber which concerns on the Example of this invention. The figure which shows the external appearance of the reagent container which concerns on the Example of this invention. The flowchart which shows operation | movement of the automatic analyzer which concerns on the Example of this invention. The figure which shows an example of the reagent information registration screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the analysis parameter setting screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the analysis parameter selection screen displayed on the display part which concerns on the Example of this invention.

  Hereinafter, an embodiment of an automatic analyzer according to the present invention will be described with reference to FIGS.

FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. The automatic analyzer 100 uses a standard sample for each inspection item, a management sample for managing data of each inspection item, and a sample such as a test sample collected from the subject using a reagent corresponding to each inspection item. An analysis unit 18 having an analysis unit for measurement, registration of reagent information for identifying a reagent usable in the analysis unit 18, and analysis parameters such as a sample amount and a reagent amount related to the registered reagent information An analysis information unit 20 to be set and an analysis control unit 40 for controlling each analysis unit in the analysis unit 18 based on an analysis parameter set in the analysis information unit 20 are provided.

In addition, a standard curve, management sample data, test sample data, etc. output from the analysis unit 18 by measuring standard samples, control samples, test samples, etc. are processed to create calibration curves and generate analysis data. Data processing unit 50, calibration curve created by data processing unit 50, output unit 60 for outputting generated analysis data, operation unit 70 for inputting various command signals, analysis information unit 20, analysis A system control unit 80 that controls the control unit 40, the data processing unit 50, and the output unit 60 is provided.

FIG. 2 is a perspective view showing the configuration of the analysis unit 18. The analysis unit 18 includes a disk sampler 5 that rotatably holds a sample container 17 containing samples such as a standard sample, a control sample, and a test sample, and one reagent that reacts with components of each test item included in the sample. System and first of two reagent systems
Identification of a test item for identifying a first reagent in the reagent container 6 described in the reagent container 6 held in the rack 1a and the reagent container 6 held in the rack 1a so as to be rotatable. And a first reagent storage 1 having a reader 1b that reads reagent information including a plurality of pieces of identification information including information (inspection item information).

In addition, a rack 2a for rotatably holding a reagent container 7 containing a second reagent paired with the first reagent in the two-reagent system, and the reagent container described in the reagent container 7 held in the rack 2a 7, a second reagent container 2 having a reader 2 b that reads reagent information including a plurality of pieces of identification information including test item information for identifying the second reagent in the sample container 7, and a reaction container by sucking a sample from the sample container 17 A sample dispensing probe 16 for dispensing to 3 and a first reagent dispensing probe 14 for dispensing to dispense the first reagent from the reagent container 6 of the first reagent storage 1 into the reaction container 3; It has.

Further, a first reagent that is aspirated from the reagent container 7 of the second reagent storage 2 and forms a pair with the second reagent
The second reagent dispensing probe 15 for dispensing into the reaction container 3 containing the reagent, the sample dispensing probe 16, and the first and second reagent dispensing probes 14, 15 can be rotated and moved up and down, respectively. The sample dispensing arm 10 and the first and second reagent dispensing arms 8 and 9 are provided. The reagent information read by the readers 1 b and 2 b of the first and second reagent containers 1 and 2 is output to the analysis information unit 20.

Furthermore, a reaction container 3 that accommodates the sample and the first reagent, or the sample, the first reagent, and the second reagent, and a reaction disk 4 that holds a plurality of reaction containers 3 arranged on the circumference in a rotatable manner.
A stirring unit 11 that stirs the mixed liquid of the sample and the first reagent, the mixed liquid of the sample, the first reagent, and the second reagent, and the reaction container 3 that stores the mixed liquid. The photometry unit 13 to be measured and each of the mixed liquids after the measurement in the reaction vessel 3 are sucked and the reaction vessel 3
A cleaning nozzle for cleaning the inside and a cleaning unit 12 for holding the drying nozzle for drying so as to move up and down are provided.

Then, the photometric unit 13 irradiates the reaction container 3 at the photometric position that is rotating and irradiates light, and the absorbance (standard) of the light transmitted through the liquid mixture containing the standard sample at the set observation time (photometric point). Sample data). Moreover, the light absorbency (management sample data and test sample data) in the set wavelength of the light which permeate | transmitted the liquid mixture containing a control sample and a test sample is produced | generated. The generated standard sample data, management sample data, and test sample data are output to the data processing unit 50. Furthermore, the reaction container 3 after the measurement, the sample dispensing probe 16, the first and second reagent dispensing probes 1
Each analysis unit such as 4, 15 and the stirring unit 11 is used for measurement again after being washed.

The analysis information unit 20 in FIG. 1 includes an analysis information storage unit 21 that stores the reagent information of reagents usable in the analysis unit 18 in association with the analysis parameters for measurement using the reagent of the reagent information,
A registration unit 22 for registering reagent information output from the readers 1b and 2b of the first and second reagent storages 1 and 2 in the analysis unit 18, and an analysis unit using the reagent of the reagent information registered in the registration unit 22 1
8 and an analysis parameter setting unit 23 for setting an analysis parameter for measurement.

When analysis data is generated using the reagent of each test item, the analysis data depends on the physical properties such as the viscosity and foaming of the reagent, and the reagent characteristics such as the chemical properties when the reagent reacts with the test item component in the sample. Some reagents deviate from the acceptable range. A reagent that generates such analysis data is a reagent that cannot be used by the analysis unit 18. In addition, a reagent whose analysis data falls within an allowable range is regarded as a usable reagent. The reagent information of the reagent that has been confirmed in advance as to whether or not it can be used and that is determined to be usable by the analysis unit 18 and the analysis parameters that are determined to be usable by the analysis unit 18 are stored in the analysis information storage unit 21. ing.

The registration unit 22 has the same information as reagent information composed of a plurality of pieces of identification information including test item information such as total protein (TP) and aspartate aminotransferase (AST), which are test item names from the readers 1b and 2b. If not stored in the analysis information storage unit 21, warning information for notifying that the reagent of the reagent information cannot be used for measurement is output to the system control unit 80. In the system control unit 80, the warning information from the registration unit 22 is output to the output unit 6.
Output to 0.

The analysis parameter setting unit 23 includes a plurality of pieces of reagent information output from the registration unit 22 and a plurality of pieces of information including the same inspection item information for warning when the same inspection item information includes two or more pieces of reagent information. The reagent information is output to the system control unit 80. The system control unit 80 outputs a plurality of reagent information including the same examination item information, which is warning information from the analysis parameter setting unit 23, to the output unit 60.

The analysis control unit 40 is based on the analysis parameter set by the mechanism unit 41 having a mechanism for driving each analysis unit of the analysis unit 18 and the analysis parameter setting unit 23 of the analysis information unit 20.
And a control unit 42 that drives each mechanism of the mechanism unit 41 to control each analysis unit of the analysis unit 18.

The mechanism 41 includes a mechanism for rotating the rack 1a of the first reagent storage 1, the rack 2a of the second reagent storage 2, and the disk sampler 5, respectively, a mechanism for rotating the reaction disk 4, and the sample dispensing arm 1.
0, a mechanism for rotating and vertically moving the first reagent dispensing arm 8, the second reagent dispensing arm 9, and the stirring unit 11, and a mechanism for vertically moving the cleaning unit 12 are provided.

Also, a mechanism for aspirating and discharging a sample dispensing pump that causes the sample dispensing probe 16 to aspirate and discharge the sample, and the first and second reagent dispensing probes 14 for aspirating and discharging the first and second reagents, A mechanism for driving the first and second reagent pumps to be sucked and discharged, a mechanism for driving the stirrer of the stirring unit 11, and a cleaning nozzle of the cleaning unit 12 for sucking the mixed liquid and discharging and sucking the cleaning liquid. A mechanism for driving the cleaning pump to be performed, a mechanism for driving the drying pump for causing the drying nozzle of the cleaning unit 12 to perform suction, and the like are provided.

The data processing unit 50 includes a calculation unit 51 that generates a calibration curve and generates analysis data from the standard sample data, management sample data, test sample data, and the like output from the analysis unit 18, and the calculation unit 51 generates the data. A data storage unit 52 for storing a calibration curve, generated analysis data, and the like.

The calculation unit 51 creates a calibration curve from the standard sample data of each inspection item output from the photometry unit 13 of the analysis unit 18, stores it in the data storage unit 52, and outputs it to the output unit 60. Strictly speaking, a calibration curve is created for each analysis parameter set by the analysis parameter setting unit 23 of the analysis information unit 20 and stored in the data storage unit 52.

Further, a calibration curve corresponding to the inspection item of the management sample data and the test sample data output from the photometry unit 13 of the analysis unit 18 is read from the data storage unit 52. Then, using the read calibration curve, generate analytical data such as concentration and activity value from the control sample data and test sample data,
The generated analysis data is stored in the data storage unit 52 and output to the output unit 60.

The data storage unit 52 includes a hard disk or the like, stores the calibration curve output from the calculation unit 51 for each inspection item, and stores analysis data of each inspection item output from the calculation unit 51 for each test sample.

The output unit 60 outputs the warning information and the like output from the printing unit 61 and the display unit 62 and prints out the calibration curve and analysis data output from the data processing unit 50 and the system control unit 80. And an audio unit 63. The printing unit 61 includes a printer and prints out the calibration curve, analysis data, and the like output from the data processing unit 50 on printer paper based on a preset format.

The display unit 62 includes a monitor such as a CRT or a liquid crystal panel, and displays a calibration curve and analysis data output from the data processing unit 50. In addition, an analysis information list screen composed of reagent information and analysis parameters stored in the analysis information storage unit 21 of the analysis information unit 20, the analysis information unit 20
A reagent information registration screen composed of reagent information registered in the registration unit 22 of FIG.
An analysis parameter setting screen composed of analysis parameters set by the analysis parameter setting unit 23, an analysis parameter selection screen for selecting an analysis parameter set by the analysis parameter setting unit 23 for each management sample or test sample, etc. Is displayed. Further, the system control unit 80
The warning information of the registration unit 22 and the analysis parameter setting unit 23 output from is displayed.

The voice unit 63 includes a speaker, a buzzer, and the like, and outputs warning information output from the system control unit 80 by voice or buzzer sound.

The operation unit 70 includes input devices such as a keyboard, a mouse, a button, and a touch panel, and includes various command signals, subject information such as a subject ID and a subject name of the subject from which the subject sample is collected, a management sample and a subject. Input information on inspection items selected for each sample.

The system control unit 80 includes a CPU and a storage circuit, and stores a command signal supplied from the operation unit 70, subject information, information on a test sample selected for each management sample or test sample, and the like. Based on these information and the analysis parameters set by the analysis parameter setting unit 23 of the analysis information unit 20, control of the entire system such as control of operating each unit of the analysis unit 18 under a predetermined condition of a certain analysis cycle is performed. Do.

Hereinafter, an example of the operation of the automatic analyzer 100 will be described with reference to FIGS. 1 to 10. FIG.
These are figures which show an example of the analysis information comprised by the reagent information preserve | saved at the analysis information storage part 21 of the analysis information part 20, and an analysis parameter. FIG. 4 is a diagram illustrating an example of the analysis information list screen displayed on the display unit 62. FIG. 5 is a top view showing the configuration of the first reagent storage 1 in the analysis unit 18. FIG. 6 is a view showing the appearance of the reagent container 6. FIG. 7 is a flowchart showing the operation of the automatic analyzer. FIG. 8 is a diagram illustrating an example of a reagent information registration screen displayed on the display unit 62. FIG. 9 is a diagram illustrating an example of the analysis parameter setting screen displayed on the display unit 62. FIG. 10 is a diagram illustrating an example of the analysis parameter selection screen displayed on the display unit 62.

First, analysis information stored in the analysis information storage unit 21 of the analysis information unit 20 will be described.
In FIG. 3, the analysis information storage unit 21 stores each inspection item A to N classified by inspection item.
The analysis information A1 to N1 encoded in the column is stored. The analysis information newly available in the analysis unit 18 can be further stored via a network, a storage medium such as a floppy (R) disk, an optical disk, or the like.

In the column of the inspection item A, for example, k types of reagent analysis information A1 to A corresponding to the inspection item A are displayed.
k is stored. The analysis information A1 includes, for example, inspection item information a10a that is information on the inspection item name of the inspection item A, and manufacturer information a10 that is information on the name of the manufacturer that manufactures the reagent of the inspection item A.
b, and when the test item A is a two-reagent system, for example, the first reagent information a10c that is information on the first reagent of the manufacturer and the second reagent information a that is information on the second reagent paired with the first reagent
It is composed of reagent information such as 10d. Also, the first and second reagent information a10c, a10d
Sample information a11 which is information on the amount of sample when the reagent is used, first reagent amount information a12 which is information on the amount of the first reagent, and second reagent amount information a13 which is information on the amount of the second reagent.
It is composed of analysis parameters such as first wavelength information a14 that is information of the first wavelength when measuring with two wavelengths, second wavelength information a15 that is information of the second wavelength, and photometric information a16 that is information of the photometry point. The

The analysis information A2 includes reagent information such as inspection item information a10a, manufacturer information a20b that is information of a manufacturer name different from the manufacturer of the analysis information A1, first reagent information a20c, and second reagent information a20d. Further, sample information a21, first reagent amount information a22, second reagent amount information a23, and first wavelength information a corresponding to the first and second reagent information a20c and a20d.
24, analysis parameters such as second wavelength information a25 and photometric information a26.

Further, the analysis information Ak includes maker information aka, maker information ak0b, first reagent information ak0c, second reagent information ak0d, and the like, which are different from the maker of the inspection item information a10a, inspection items A1 to A (k-1). Consists of reagent information. Also, the first and second reagent information ak0c,
Sample information ak1, first reagent amount information ak2, second reagent amount information ak3 corresponding to ak0d
, First wavelength information ak4, second wavelength information ak5, photometric information ak6, and other analysis parameters.

In the column of the inspection item N, for example, one type of analysis information N1 corresponding to the inspection item A is stored. The analysis information N1 includes inspection item information n10a which is information on the inspection item name of the inspection item N, manufacturer information n10b, first reagent information n10c which is information on the first reagent when the inspection item N is one reagent system, and the like. Consists of reagent information. Further, sample information n11 corresponding to the first reagent information nk0c, first reagent amount information n12, and second reagent amount information n13 which is information with a reagent amount of 0.
, First wavelength information n14, second wavelength information n15, photometric information n16, and other analysis parameters.

Each piece of analysis information stored in the analysis information storage unit 21 is displayed on the display unit 62 by an operation from the operation unit 70. After performing the analysis information display operation from the operation unit 70, at least one is selected from, for example, an inspection item, a manufacturer, and an analysis parameter. When an inspection item is selected, a desired inspection item name is selected. When a manufacturer is selected, a desired manufacturer name is selected. Furthermore, when an analysis parameter is selected, desired parameters such as a sample amount and a first reagent amount included in the analysis parameter are selected.

Here, after an analysis information display operation is performed from the operation unit 70, an inspection item and a manufacturer are selected. Next, when an inspection item name such as “TP” or “AST” is selected for the inspection item, and a manufacturer name such as “WJ company” or “DS company” is selected for the manufacturer, an operation is performed. Then, an analysis information list screen including the reagent information of each selected inspection item corresponding to each selected manufacturer is displayed on the display unit 62.

FIG. 4 is a diagram showing an example of the analysis information list screen displayed on the display unit 62. The analysis information list screen 64 is composed of columns of “item” and “manufacturer”, and “TP”, “AST”, and the like as inspection item names are displayed in the “item” column. In the “manufacturer” column, “WJ company”, “DS company”, and the like, which are manufacturer names, are displayed.

Furthermore, in the “TP” area of the “Item” column corresponding to “WJ Company” in the “Manufacturer” column, reagent information “4810131... 2” is displayed, and “WJ Company” corresponding to “WJ Company” is displayed. In the “AST” area, “4810331... 5” is displayed. In addition, "DS company" corresponding to "
In the “TP” area, “5030131... 4” is displayed, and “AS” corresponding to “DS Company” is displayed.
In the “T” area, “50303331... 3” is displayed.

In this manner, reagent information and analysis parameters of a desired test item can be displayed on the display unit 62 from the analysis information stored in the analysis information storage unit 21 and viewed.

Next, details of the configuration of the first reagent storage 1 will be described.
FIG. 5 is a top view showing the configuration of the first reagent storage 1. The first reagent storage 1 is arranged inside the inner periphery of the reaction disk 4 of the analysis unit 18, and is a disk that holds a plurality of reagent containers 6 that are radially placed on the circumference so as to be rotatable in the direction of arrow R1. -Shaped rack 1a, reagent container 6 and reagent case 1c that accommodates rack 1a, and a reader such as a barcode reader that is arranged outside reagent case 1c and reads reagent information from reagent container 6 held in rack 1a 1b. As shown in FIG. 6, a label 6a on which reagent information of the reagent in the reagent container 6 is displayed, for example, as a one-dimensional or two-dimensional barcode is attached to the outer peripheral surface of the reagent container 6.

The second reagent store 2 is different from the first reagent store 1 in that the second reagent store 2 is disposed outside the outer periphery of the reaction disk 4 and accommodates the reagent container 7. Since the 2nd reagent storage 2 is comprised similarly to the 1st reagent storage 1, description of the structure is abbreviate | omitted. The reagent container 7 held in the rack 2 a of the second reagent storage 2 is affixed with a label on which reagent information is displayed in the same manner as the reagent container 6.

Next, the operation of the automatic analyzer 100 will be described.
FIG. 7 is a flowchart showing the operation of the automatic analyzer 100. Automatic analyzer 100
The reagent container 6 containing the first reagent to be used for the first time and the reagent container 7 containing the second reagent are used in the first reagent storage, such as when adding inspection items, changing the reagent of each inspection item, etc. When a reagent information registration operation is performed from the operation unit 70 after placing the rack 1a on the first rack 1a or the rack 2a of the second reagent storage 2, the automatic analyzer 100 starts operation (step S1).

The system control unit 80 controls the analysis information unit 20, the analysis control unit 40, and the output unit 60 to perform a registration operation. In addition, since the analysis information part 20 and the output part 60 operate | move similarly to the case of the 1st reagent storage 1 according to the operation | movement of the 2nd reagent storage 2, the analysis information according to the operation | movement of the 2nd reagent storage 2 below. Description of the operation of the unit 20 and the output unit 60 is omitted.

The control unit 42 of the analysis control unit 40 operates the mechanism unit 41 to control the analysis unit 18. The rack 1a of the first reagent storage 1 in the analysis unit 18 rotates in the R1 direction. The reader 1b reads the reagent information from the labels 6a of all the reagent containers 6 on the rack 1a that passes while rotating and outputs it to the registration unit 22 of the analysis information unit 20 (step S2).

For example, the registration unit 22 outputs, for example, inspection item information, manufacturer information, and first information output from the reader 1b.
The same information as the reagent information of the reagent information is searched from each analysis information stored in the analysis information storage unit 21. When the same information as the reagent information output from the reader 1b is stored in the analysis information storage unit 21 (Yes in step S3), the reagent information is stored in the analysis parameter setting unit 23.
And the reagent of the reagent information is stored and registered in the internal memory as a reagent that can be used by the analysis unit 18 (step S4). When the same information as the reagent information output from the reader 1b is stored in the internal memory and already registered, the reagent information output from the reader 1b is not registered. Further, it is not output to the analysis parameter setting unit 23.

As described above, the reagent container 6 containing the reagent to be used for the first time is placed on the rack 1a of the first reagent storage 1, and unregistered reagent information is registered by a simple operation by simply performing a registration operation from the operation unit 70. can do.

In addition, when the same information as the reagent information output from the reader 1b is not stored in the analysis information storage unit 21 (No in step S3), it is used to notify that measurement cannot be performed using the reagent of the reagent information. The warning information is output to the display unit 62 and the voice unit 63 of the output unit 60 (step S5). Thereafter, the process returns to step S2.

An analysis information storage device including an analysis information storage unit 21 that stores reagent information and analysis parameters of reagents that can be used in the analysis unit 18 is provided outside the automatic analysis device 100, so that the analysis information storage device and the automatic analysis device 100 Connect to the network. And you may implement so that it may communicate via a network and step S3 may be performed.

When a registration information display operation is performed from the operation unit 70 after the registration operation is completed, reagent information registered by the registration unit 22 is displayed on the display unit 62.

FIG. 8 is a diagram showing an example of a reagent information registration screen displayed on the display unit 62. The reagent information registration screen 65 is composed of columns of “item” and “manufacturer”. In the “item” column, registered inspection item names such as “TP” and “AST” are displayed. Also,
In the “manufacturer” column, registered manufacturer names such as “WJ company” and “DS company” are displayed.

In addition, reagent information “4810131... 2” is displayed in the “TP” area of the “item” column corresponding to “WJ company” in the “manufacturer” column, and “AST” corresponding to “WJ company”. "-" Indicating that the information is not registered is displayed in the "" area. In addition, “?” Indicating that it is not registered is displayed in the “TP” area corresponding to “DS company”, and reagent information “50303031” is displayed in the “AST” area corresponding to “DS company”.・ ・ 3 ”is displayed.

In addition, by performing an update operation from the operation unit 70, the reagent information displayed on the reagent information registration screen 65 displayed on the display unit 62 is updated, and the updated reagent information is stored in the internal memory of the registration unit 22. Can do.

Thus, the reagent information registered in the registration unit 22 can be displayed, and the reagent information used in the analysis unit 18 can be confirmed.

After step S4, the analysis parameter setting unit 23 sets analysis parameters related to the reagent information based on the reagent information output from the registration unit 22. And the registration part 22
When there is a plurality of reagent information output from the information and two or more reagent information includes the same inspection item information (Yes in step S6 in FIG. 7), a plurality of reagents including the same inspection item information to warn Information is output to the display unit 62 (step S7 in FIG. 7).

Further, when there is only one reagent information output from the registration unit 22 or when there are a plurality of reagent information output from the registration unit 22 and all pieces of test item information included in the plurality of reagent information are different (
Step S6 in FIG. 7) proceeds to Step S9.

After step S7, when an operation item name change operation included in the reagent information is performed from the operation unit 70 so that all the inspection item information included in the plurality of reagent information displayed on the display unit 62 is different, analysis parameter setting is performed. The unit 23 changes the test item information of the reagent information including the same test item information (step S8 in FIG. 7).

Note that when the analysis parameter set by the analysis parameter setting unit 23 is output to the output unit 60, it is difficult to identify the parameter other than the inspection item information, and therefore before the output to the output unit 60 is enabled. Steps S6 to S8 are executed. As an example that requires execution of this step, when introducing a test item that has not been tested until now into the automatic analyzer 100, for example, after evaluating reagents from a plurality of manufacturers for one test item. One type of reagent may be selected. At this time, it is possible to prevent the same inspection item name from being output for a plurality of analysis parameters.

After “No” in Step S6 or Step S8, the analysis parameter setting unit 23 outputs the reagent information output from the registration unit 22 in the case of “No” in Step S6, or Step S6.
The analysis parameters related to the reagent information that does not include the same examination item information in “Yes” and the reagent information after the reagent information displayed on the display unit 62 is changed from the analysis information storage unit 21 are displayed. read out. Next, reagent information output from the registration unit 22 or modified reagent information so that the analysis parameter can be identified together with the read analysis parameter is stored in an internal memory and used in the analysis unit 18. This is set as a reagent analysis parameter (step S9 in FIG. 6).

Next, for example, “WJ” “" displayed on the reagent information registration screen 65 of FIG.
When an operation for displaying the “AST” analysis parameter setting screen is performed, the analysis parameter and inspection item information set by the analysis parameter setting unit 23 are displayed on the analysis parameter setting screen of the display unit 62.

FIG. 9 is a diagram showing an example of an analysis parameter setting screen displayed on the display unit 62. This analysis parameter setting screen 66 includes “item”, “sample amount”, “reagent amount”, “wavelength”,
And “photometry points” and the like, and dialog boxes 661 to 668 for displaying the analysis parameters set by the analysis parameter setting unit 23 in the respective columns. In addition,
The analysis parameters displayed in the dialog boxes 661 to 668 are displayed on the operation unit 70.
It can be changed by the operation from.

In the dialog box 661 in the “Item” column, for example, “AST”, which is inspection item information included in the reagent information set by the analysis parameter setting unit 23, is displayed.

In the dialog box 662 in the “sample amount” column, the sample amount (μL) to be dispensed into the reaction container 3 by the sample dispensing probe 16 when measurement is performed using the “AST” reagent of “WJ”. A certain “5.0” is displayed.

In the “first reagent” column in the “reagent amount” column, in the dialog box 663, “150” is the amount (μL) of the first reagent dispensed into the reaction container 3 by the first reagent dispensing probe 14.
Is displayed. In the dialog box 664 in the “second reagent” column, “50” that is the amount (μL) of the second reagent dispensed into the reaction container 3 by the second reagent dispensing probe 15 is displayed. .

A dialog box 665 in the “wavelength 1” column in the “wavelength” column has “WJ”
“340”, which is the first wavelength (nm) corresponding to the change in color tone of “AST”, is displayed. In the dialog box 666 in the “wavelength 2” column, “380” that is the second wavelength (nm) is displayed.

“20” is displayed in the dialog box 667 in the “photometric point” column, and “29” is displayed in the dialog box 668. Here, for example, when the test sample is dispensed into the reaction vessel 3 and then the reaction vessel 3 rotates and passes through the photometric position of the analysis unit 18 for the first time, the first photometric point is set. Then, the reaction container 3 containing the mixed liquid containing the test sample passes through the photometry position from the 20th to the 29th time, and is generated by the photometry unit 13 by the measurement at each of the 20th to 29th photometry points. Analysis data is generated based on the test sample data.

As described above, it is possible to set as an analysis parameter for measurement by the analysis unit 18 using the reagent of the registered reagent information by a simple operation only by performing a registration operation from the operation unit 70.

Next, based on the analysis parameter set by the analysis parameter setting unit 23, the standard curve of each inspection item corresponding to this analysis parameter is measured, so that the created calibration curve is stored in the data storage unit of the data processing unit 50. 52 is stored. And, for example, after setting a control sample on the sample information setting screen as a sample for confirming the reagent of the registered reagent information,
When an operation for displaying the analysis parameter selection screen is performed from the operation unit 70, the analysis parameter selection screen is displayed on the display unit 62.

FIG. 10 is a diagram illustrating an example of the analysis parameter selection screen displayed on the display unit 62.
This analysis parameter selection screen 67 is included in the column of “ID” for displaying, for example, the sample ID of the control sample set on the sample information setting screen, and the reagent information related to the analysis parameter set by the analysis parameter setting unit 23. “Item” field for displaying inspection item information to be displayed, and “I”
The inspection item to be measured for each sample ID displayed in the “D” column is configured by a measurement item setting area 67a for selecting and setting from the “item” column.

In the “ID” column, for example, “1” and “2” sample IDs set on the sample information setting screen are displayed. In the “item” column, inspection item names such as “TP” and “AST” are displayed.

In the measurement item setting area 67a, “◯” is displayed in the area of the selected inspection item name in the “item” column corresponding to the selected sample ID in the “ID” column, and “•” is displayed in the non-selected area. Is displayed. Then, from the operation unit 70, the sample ID “1” is “TP”
Is selected as “1” in the “ID” column in the measurement item setting area 67a.
“◯” corresponding to the first test is displayed in the “TP” area in the “Item” column corresponding to “”. When the inspection item “AST” is selected for the sample ID “2”, “ID”
“◯” of the second test is displayed in the “AST” area of the “item” column corresponding to “2” of the column.

After the selection on the analysis parameter selection screen 67, when a measurement start operation for measuring the management sample is performed from the operation unit 70, the system control unit 80 instructs the control unit 42 to measure the management sample. The analysis unit 18 measures the examination items set on the analysis parameter selection screen 67 based on each analysis parameter set by the analysis parameter setting unit 23 under the control of the control unit 42.

The sample dispensing probe 16 of the analysis unit 18 dispenses the management sample corresponding to the first test and the second test set on the analysis parameter selection screen 67 from each sample container 17 to the reaction container 3. After dispensing the control sample, the first reagent dispensing probe 14 removes the first reagent corresponding to the test item of the first test and the second test from the reagent container 6 of the first reagent storage 1 and the first test and the second test. Dispense into the reaction container 3 containing the control sample. After dispensing the first reagent, the agitating unit 11 agitates the mixed liquid in the reaction container 3 containing the first and second test management samples and the first reagent. After the mixture is stirred, the second reagent dispensing probe 15 receives the second reagent corresponding to the inspection item of the two reagent system from the reagent container 7 of the second reagent storage 2 and contains the control sample and the first reagent. Dispense into container 3. After dispensing the second reagent, the stirring unit 11 stirs the mixed solution in the reaction container 3 containing the management sample, the first reagent, and the second reagent. After stirring the mixed solution, the photometric unit 13 measures the mixed solution in the reaction vessel 3 corresponding to the first test and the second test. Then, the generated management sample data is output to the calculation unit 51 of the data processing unit 50.

The calculation unit 51 reads out a calibration curve for each inspection item created in advance from the data storage unit 52.
Next, analysis data is generated from the management sample data output from the photometry unit 13 using the read calibration curve, and the generated analysis data is stored in the data storage unit 52 and output to the output unit 60.

The cleaning unit 12 aspirates the mixed liquid that has been measured in the reaction container 3 and cleans and dries the reaction container 3. Cleaning and drying of all reaction vessels 3 are completed, and sample ID “1”
When the analysis data of each inspection item “2” and “2” are output to the output unit 60, the automatic analyzer 100 ends the operation (step S10 in FIG. 7).

According to the embodiment of the present invention described above, the analysis information storage unit 21 that stores the reagent information of the reagents that can be used in the analysis unit 18 in association with the analysis parameters for measurement using this reagent is provided. By the operation of registering the reagent container 6 containing the reagent used in 18, the reagent information written on the label 6a of the reagent container 6 can be read by the reader 1b.

Then, when the same information as the reagent information read by the reader 1 b is stored in the analysis information storage unit 21 and not registered in the registration unit 22, the reagent information can be registered. Further, the same information as the reagent information read by the reader 1b is stored in the analysis information storage unit 21.
If it is not stored, warning information for informing that measurement cannot be performed using the reagent of the reagent information can be output to the output unit 60.

Next, when there are a plurality of reagent information registered in the registration unit 22 and two or more pieces of reagent information include the same inspection item information, a plurality of reagent information including the same inspection item information is displayed for warning. 62 can be output. As a result, it is possible to prevent the presence of a plurality of pieces of inspection item information for identifying the analysis parameters set by the analysis parameter setting unit 23.

Moreover, when the reagent information registered by the registration unit 22 is one or there are a plurality of reagent information,
When the test item information included in the plurality of reagent information is all different, the analysis parameter related to the registered reagent information is read from the analysis information storage unit 21 and set as a reagent parameter used for measurement by the analysis unit 18 can do.

Thereby, the trouble of registering the reagent information of the reagent used in the analysis unit 18 and the trouble of setting the analysis parameter related to the reagent can be reduced. Further, it becomes possible to prevent an input error when registering the reagent information, and the reagent information can be managed correctly. Furthermore, it becomes possible to prevent input mistakes when setting analysis parameters, and measurement can be performed with high accuracy.

18 analysis unit 20 analysis information unit 21 analysis information storage unit 22 registration unit 23 analysis parameter setting unit 40 analysis control unit 41 mechanism unit 42 control unit 50 data processing unit 51 calculation unit 52 data storage unit 60 output unit 61 printing unit 62 display unit 63 Voice unit 70 Operation unit 80 System control unit

Claims (6)

In an automatic analyzer comprising an analysis means for measuring a mixed solution of a test sample and a reagent corresponding to a test item set for the test sample,
Analysis information storage means for associating and storing reagent information for identifying a reagent usable in the analysis means and an analysis parameter for measurement using the reagent of the reagent information;
When the same reagent information as the reagent information input by the input means is stored in the analysis information storage means, the same reagent information is input to the analysis parameter setting means for setting an analysis parameter related to the same reagent information. First output means for outputting;
Of the plurality of reagent information output from the first output means, when there are a plurality of reagent information containing the same test item information, the same test is performed to change a part of the test item information. Second output means for outputting reagent information including item information;
An automatic analyzer characterized by comprising: 2. The automatic analyzer according to claim 1, wherein a part of the inspection item information is an inspection item name. 3. The automatic analyzer according to claim 1, further comprising a change operation unit capable of changing the test item information of the reagent information including the same test item information. 4. The automatic analyzer according to claim 1, wherein the reagent information includes a plurality of pieces of identification information including inspection item information for identifying the inspection item. Analysis parameter selection means for selecting an analysis parameter set by the analysis parameter setting means,
5. The analysis unit according to claim 1, wherein the analysis unit measures a mixture of reagents related to the analysis parameter based on the analysis parameter selected by the analysis parameter selection unit. Automatic analyzer. The input reagent information is input by reading means for reading reagent information for identifying a reagent in the reagent container described in a reagent container containing the reagent. Item 6. The automatic analyzer according to Item 5.

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