JP2007198991A - Autoanalyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve the problem, wherein since a specimen is diluted or increased for remeasurement in a conventional autoanalyzer, when the measuring result of a substance to be inspected exceeds the measuring limit of the autoanalyzer by a first measurement, a time twice that is the normal time is required in the measurement of the specimen, when remeasurement is performed that becomes the cause for delaying clinical decision of specimen requiring urgency in report. <P>SOLUTION: The autoanalyzer is provided with a means for indicating analysis, in a combination of the different amount of the specimen, with respect to the specific substance to be inspected of a preliminarily indicated specific specimen and a function for continuously measuring the same substance to be inspected in a different amount of the specimen, according to the indication, without waiting for the measuring result in the first amount of the specimen. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an automatic analyzer, and more particularly to an automatic analyzer used for measurement of a patient sample that requires urgent reporting of results.

  Automatic analyzers are broadly divided into biochemical analyzers and immune analyzers. All are the same until the test substance in the biological sample such as blood, urine, and body fluid and the reagent that reacts with the test substance are mixed in the reaction container to generate the reaction substance. Utilizes the fact that the color changes depending on the reaction, irradiates light and measures the absorbance to quantitatively analyze the test substance, and converts the measured value into a concentration and outputs it. On the other hand, the immunoanalyzer includes a fluorescent labeling substance contained in the reagent, and chemically or electrically emits the labeling substance, and measures the amount of luminescence with a photomultiplier tube or the like.

  The measurement takes about 3 to 10 minutes for biochemical analysis and about 20 minutes for immunoassay depending on the characteristics of each test substance.

  When measuring, if the concentration of the sample is higher or lower than expected, the measurement range of the photometer or photomultiplier may be exceeded. In that case, the sample is diluted or increased and measured again, and the liquid volume is corrected for the diluted or increased amount when converting the concentration, and the result is output. Such a technique is described in Patent Documents 1 and 2, for example.

JP-A-5-99930 JP 2001-228158 A

  When measuring a normal sample, the first measurement is performed, and after confirming that the measurement result is over the range, the measurement is performed again. However, when measuring a patient sample that requires urgent treatment such as surgery, if the absorbance exceeds the measurement limit of the apparatus in the first measurement and re-measurement is performed, the measurement time is doubled and requires 6 to 20 minutes. This is a factor that delays clinical judgment of specimens that require urgent reporting.

  An object of the present invention is to provide an automatic analyzer that can quickly output a measurement result even when measuring an urgent sample.

  A means for instructing analysis with a combination of different sample amounts for a specific test substance of a specific sample specified in advance, and waiting for a measurement result with the first sample amount with a different sample amount for the same test substance in accordance with the instruction Provide a function for continuous measurement.

  There are also provided means for individually confirming the measurement results for the respective sample amounts and means for selecting which sample amount results are to be adopted as patient data.

  Compared with the case where remeasurement is performed after the first measurement result is output, the waiting time required for remeasurement (about 3 to 10 minutes) can be shortened, and more rapid reporting is possible.

  Also, by providing this function, simultaneous measurement of the same test substance with different sample amounts can be performed by the control sample for quality control, and verification of data accuracy can be easily performed.

  Embodiments of the present invention will be described below with reference to the accompanying drawings.

  FIG. 1 is a schematic diagram illustrating the overall structure of the automatic analyzer. In FIG. 1, reference numeral 101 denotes an operation unit. The operation unit is connected to a keyboard 102 for inputting data, a mouse 103, a display device 104 for displaying data, a printing device 105 for printing data, and an analysis unit. And a peripheral device such as a storage device 107 for storing analysis instruction information and measurement results.

  An analysis unit 108 is connected to the operation unit 101 via the interface 106.

  In the analysis unit, reference numeral 109 denotes a reaction disk, and a plurality of reaction vessels 110 are installed on the concentric circumference. 111 is a reagent disk, and a plurality of reagent bottles 112 containing various reagents are installed on the concentric circle. Around the reaction disk 109, a sample dispensing probe 113, a stirring device 114, a cleaning device 115, a light source 116, and a multiwavelength photometer 117 are arranged. A reagent dispensing probe 118 is disposed between the reaction disk 109 and the reagent disk 111. A rack transport belt 119 is installed on the rotation circumference of the sample dispensing probe 113. The rack 120 moves on the rack transport belt 119. A plurality of specimen containers 121 containing specimens are installed in the rack 120.

  All of these mechanism operations are controlled by the computer 123 via the interface 122.

  The operator gives an analysis instruction to the analysis apparatus using the display device 104 of the operation unit 101, the keyboard 102, or the mouse 103. The analysis instruction is stored in the storage device 107 and transmitted to the analysis unit 108 via the interface 106. The analysis unit 108 performs the analysis operation as follows in accordance with the received analysis instruction.

The sample dispensing probe 113 dispenses a predetermined amount of the sample contained in the sample container 121 into the reaction container 110. When dispensing for one sample container 121 is completed, the rack transport belt 119 moves on the rack 120 so that the next sample container 121 is directly below the sample dispensing probe 113. When the dispensing of all the sample containers 121 on the rack 120 is completed, the rack 120 is carried out by the rack transport belt 119. The reaction container 110 into which the sample is dispensed rotates on the reaction disk 109 by the rotation operation of the reaction disk 109. Meanwhile, with respect to the specimen in the reaction container 110, the reagent in the reagent bottle 112 is dispensed by the reagent dispensing probe 118, the reaction liquid is stirred by the stirring device 114, and the absorbance is measured by the light source 116 and the multiwavelength photometer 117. After that, the reaction vessel 110 that has been analyzed is washed by the washing device 115 later. The measured absorbance signal enters the computer 123 via the interface 122 via the A / D converter 124. From this absorbance signal, based on the analysis method set for each test substance in advance, calibration curve data is calculated from the set concentration data in the case of a standard solution sample, and in the case of a patient sample and a control sample, Concentration data is calculated from calibration curve data obtained by measurement. These data are transmitted as measurement results to the operation unit 101 via the interface 106 after adding information symbolizing the type of specimen.

  The operation unit 101 stores the received measurement result in the storage device 107 and outputs it to the display device 104 and the printing device 105.

  FIG. 2 is a comparison diagram of measurement sequences after applying the prior art and the invention. The case where the test substance A is measured again is taken as an example. In the measurement sequence 201 in the conventional technique, the second sample dispensing 203 is performed after the first measurement result output 202, and therefore the measurement result output waiting time 205 until the measurement result output result 204 of the remeasurement is shown in FIG. As shown, it is approximately twice the measurement result output waiting time 206 per one time. On the other hand, in the measurement sequence 207 after application of the invention, the second sample dispensing 209 is performed after the first sample dispensing 208, so that the measurement result output waits until the measurement result output result 210 of the remeasurement. The time 211 can be shortened to substantially the same time as the measurement result output waiting time 206 per time as shown in the figure.

  FIG. 3 is an analysis instruction screen of the operation unit 101. This screen is a screen for registering analysis instruction information for each sample. The name of the test substance is displayed on the test substance request key 301, and the analysis is instructed by selecting with the keyboard 102 or the mouse 103. The sample amount / dilution rate 302 is an input area for designating the sample amount or dilution rate when analyzing the test substance, and includes “standard”, “decrease”, “increase”, “3 times dilution”, It is a method of selecting one from “5-fold dilution”,. The operator inputs the sample identification 303, the sample type 304, the sample number 305, the patient ID 306, and the sample cup type 307, which are sample attribute information, and then gives an instruction of the test substance to be analyzed, the sample amount / dilution rate 302, And by selecting the test substance request key 301. In the example of FIG. 3, the test substance AST is instructed to be analyzed by a combination of the standard sample amount and the increased sample amount, and the test substance ZTT is instructed by a combination of the standard sample amount, the reduced sample amount, and the 3-fold diluted sample amount. Is shown. When the operator finally presses the registration button 308, the analysis instruction information is confirmed, stored in the storage device 107, and transmitted to the analysis unit 108 during sample analysis.

FIG. 4 is a measurement result screen of the operation unit 101. This screen is a screen for displaying the measurement result received from the analysis unit 108 by the operation unit 101, and includes a sample list box 401 and an item list box 402. When the operator selects an arbitrary sample from the sample list box 401, the measurement result of each test substance of the selected sample is displayed in the item list box 402. The item list box 402 includes a test substance name 403, a measurement result 404, and a measurement result data alarm 405. When analysis is performed with a combination of different specimen amounts for one specific test substance, the measurement result is displayed using a plurality of lists in the item list box 402. In the example of FIG. 4, for the test substance name AST, the first measurement result is “34”, the first measurement result data alarm is “H”, the second measurement result is “24”, The data alarm of the second measurement result indicates “None”.

1 is an overall configuration schematic diagram of an analyzer. Comparison diagram of measurement sequence after application of conventional technology and invention. Analysis instruction screen. Measurement result screen.

Explanation of symbols

DESCRIPTION OF SYMBOLS 101 ... Operation part, 102 ... Keyboard, 103 ... Mouse, 104 ... Display apparatus, 105 ... Printing apparatus, 106, 122 ... Interface, 107 ... Memory | storage device, 108 ... Analysis part, 109 ... Reaction disk, 110 ... Reaction container, 111 DESCRIPTION OF SYMBOLS ... Reagent disc, 112 ... Reagent bottle, 113 ... Sample dispensing probe, 114 ... Stirring device, 115 ... Cleaning device, 116 ... Light source, 117 ... Multi-wavelength photometer, 118 ... Reagent dispensing probe, 119 ... Rack transport belt, 120 ... rack,
121 ... Sample container, 123 ... Computer, 124 ... A / D converter, 201 ... Measurement sequence in the prior art, 202,204,210 ... Measurement result output timing, 203,208,209 ... Sample dispensing timing, 205, 211 ... Measurement result output waiting time, 206 ... Measurement result output waiting time per time, 207 ... Measurement sequence after application of the invention, 301 ... Test substance request key, 302 ... Sample amount / dilution ratio, 303 ... Sample identification, 304 ... Sample type, 305 ... Sample number, 306 ... Patient ID, 307 ... Sample cup type, 308 ... Register button, 401 ... Sample list box, 402 ... Item list box, 403 ... Test substance name, 404 ... Measurement result, 405 ... Measurement result data alarm.

Claims (9)

A sample designating means for designating a specific analysis item of a specific sample in advance;
An analysis condition designating means capable of designating two or more analysis conditions to be performed on the test substance designated by the designating means,
When analyzing the sample designated by the sample designating means, control means for controlling two or more kinds of analyzes designated by the analysis condition designating means to measure in parallel without waiting for the first measurement result; ,
An automatic analyzer characterized by comprising: The automatic analyzer according to claim 1,
At least one of the sample designating unit and the analysis condition designating unit has a function that can be designated on an input screen of an operation unit. The automatic analyzer according to claim 1,
At least one of the sample designating unit and the analysis condition designating unit has a function capable of designating based on information from a HOST computer. The automatic analyzer according to claim 1,
Equipped with urgent sample designation means to designate as an urgent sample requiring urgent reporting of results,
An automatic function comprising a function for displaying on the screen a display capable of instructing at least one of the sample designating means and the analysis condition designating means when designated as an emergency sample by the emergency sample designating means. Analysis equipment. The automatic analyzer according to claim 1,
An automatic analyzer having a function of displaying on a screen a display capable of instructing at least one of the sample designating unit and the analysis condition designating unit when a sample is loaded from an emergency loading position. The automatic analyzer according to claim 1,
An automatic analyzer provided with a function capable of designating a control sample for quality control by the sample designating means. The automatic analyzer according to claim 1,
The analysis condition designated by the analysis condition designating means is a sample dilution ratio, and the automatic analysis is provided with a function that allows the dilution ratio to be designated in advance for each analysis item designated by the sample designating means. apparatus. The automatic analyzer according to claim 1,
An automatic analyzer characterized in that the analysis condition designating unit has a function of designating the number of times of measurement for each sample amount by a combination of different sample amounts. The automatic analyzer according to claim 1,
An automatic analyzer having a function capable of designating which sample amount to be used as patient data from among the measurement results at different sample amounts designated by the analysis condition designating means.

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