JP6505079B2 - 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 - Google Patents
補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 Download PDFInfo
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- JP6505079B2 JP6505079B2 JP2016505600A JP2016505600A JP6505079B2 JP 6505079 B2 JP6505079 B2 JP 6505079B2 JP 2016505600 A JP2016505600 A JP 2016505600A JP 2016505600 A JP2016505600 A JP 2016505600A JP 6505079 B2 JP6505079 B2 JP 6505079B2
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361806687P | 2013-03-29 | 2013-03-29 | |
| US61/806,687 | 2013-03-29 | ||
| PCT/US2014/032209 WO2014160958A1 (en) | 2013-03-29 | 2014-03-28 | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018080510A Division JP6505288B2 (ja) | 2013-03-29 | 2018-04-19 | 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520542A JP2016520542A (ja) | 2016-07-14 |
| JP2016520542A5 JP2016520542A5 (enExample) | 2017-04-27 |
| JP6505079B2 true JP6505079B2 (ja) | 2019-04-24 |
Family
ID=50686201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016505600A Active JP6505079B2 (ja) | 2013-03-29 | 2014-03-28 | 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
| JP2018080510A Active JP6505288B2 (ja) | 2013-03-29 | 2018-04-19 | 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018080510A Active JP6505288B2 (ja) | 2013-03-29 | 2018-04-19 | 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20160051673A1 (enExample) |
| EP (2) | EP2978451B1 (enExample) |
| JP (2) | JP6505079B2 (enExample) |
| CA (1) | CA2897334A1 (enExample) |
| ES (1) | ES2768648T3 (enExample) |
| WO (1) | WO2014160958A1 (enExample) |
Families Citing this family (25)
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| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| PT2970974T (pt) | 2013-03-14 | 2017-11-29 | Alnylam Pharmaceuticals Inc | Composições de irna de componente do complemento c5 e métodos para a sua utilização |
| WO2016040589A1 (en) | 2014-09-12 | 2016-03-17 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| EA201791366A1 (ru) | 2014-12-19 | 2018-02-28 | Чугаи Сейяку Кабусики Кайся | Антитела к c5 и способы их применения |
| CN114773469B (zh) | 2015-02-05 | 2025-12-19 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
| WO2016209956A1 (en) * | 2015-06-26 | 2016-12-29 | Alexion Pharmaceuticals, Inc. | A method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| EP3328885A1 (en) * | 2015-09-11 | 2018-06-06 | Bruce Andrien | Recombinant glycosylated eculizumab and eculizumab variants |
| IL263481B2 (en) | 2016-06-14 | 2024-06-01 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| SG10201800265UA (en) * | 2016-06-17 | 2018-02-27 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| CN116271014A (zh) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| US11965884B2 (en) | 2016-10-19 | 2024-04-23 | Alexion Pharmaceuticals, Inc. | Method of quantitating unbound C5 in a sample |
| WO2018075761A1 (en) * | 2016-10-19 | 2018-04-26 | Alexion Pharmaceuticals, Inc. | A method of quantitating unbound c5a in a sample |
| TWI828672B (zh) * | 2017-01-31 | 2024-01-11 | 日商中外製藥股份有限公司 | 用於治療或預防c5相關疾病的醫藥組合物以及治療或預防c5相關疾病的方法 |
| JP7209637B2 (ja) * | 2017-04-21 | 2023-01-20 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | 自己免疫性水疱症の治療のためのコバーシン |
| AU2018383751B2 (en) | 2017-12-13 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibody combinations and uses thereof |
| EP3597222A1 (en) * | 2018-07-16 | 2020-01-22 | Easemedcontrol R & D GmbH & Co KG | Treatment and diagnosis of unresolved inflammatory diseases |
| CN113038967B (zh) | 2018-09-06 | 2026-07-14 | 宾夕法尼亚大学理事会 | 人源化抗c5抗体及其用途 |
| JP7629394B2 (ja) * | 2018-09-10 | 2025-02-13 | ヴォリューション イミュノ ファーマシューティカルズ エスエイ | リウマチ性疾患の治療に使用するためのコバーシン |
| US20220204602A1 (en) * | 2019-04-24 | 2022-06-30 | The Trustees Of The University Of Pennsylvania | Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof |
| WO2021154941A1 (en) * | 2020-01-31 | 2021-08-05 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als) |
| WO2023064809A1 (en) * | 2021-10-12 | 2023-04-20 | Vanqua Bio, Inc. | Oligonucleotides for targeting complement c5 |
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| PY09026846A (es) | 2008-08-05 | 2015-09-01 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5 |
| JP6223659B2 (ja) | 2008-11-10 | 2017-11-01 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| US20100291106A1 (en) | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| NZ597259A (en) | 2009-06-23 | 2014-04-30 | Alexion Pharma Inc | Bispecific antibodies that bind to complement proteins |
| WO2011109338A1 (en) * | 2010-03-01 | 2011-09-09 | Alexion Pharmaceuticals Inc. | Methods and compositions for treating degos' disease |
| PT2970974T (pt) | 2013-03-14 | 2017-11-29 | Alnylam Pharmaceuticals Inc | Composições de irna de componente do complemento c5 e métodos para a sua utilização |
-
2014
- 2014-03-28 JP JP2016505600A patent/JP6505079B2/ja active Active
- 2014-03-28 ES ES14722916T patent/ES2768648T3/es active Active
- 2014-03-28 CA CA2897334A patent/CA2897334A1/en not_active Abandoned
- 2014-03-28 EP EP14722916.5A patent/EP2978451B1/en not_active Revoked
- 2014-03-28 WO PCT/US2014/032209 patent/WO2014160958A1/en not_active Ceased
- 2014-03-28 EP EP18211716.8A patent/EP3473272A1/en not_active Withdrawn
- 2014-03-28 US US14/779,605 patent/US20160051673A1/en not_active Abandoned
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2018
- 2018-04-19 JP JP2018080510A patent/JP6505288B2/ja active Active
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- 2019-05-29 US US16/425,402 patent/US20200023060A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| US20200023060A1 (en) | 2020-01-23 |
| JP2018111728A (ja) | 2018-07-19 |
| WO2014160958A1 (en) | 2014-10-02 |
| ES2768648T3 (es) | 2020-06-23 |
| JP6505288B2 (ja) | 2019-04-24 |
| JP2016520542A (ja) | 2016-07-14 |
| EP2978451B1 (en) | 2019-11-27 |
| CA2897334A1 (en) | 2014-10-02 |
| EP3473272A1 (en) | 2019-04-24 |
| US20160051673A1 (en) | 2016-02-25 |
| US20240293540A1 (en) | 2024-09-05 |
| EP2978451A1 (en) | 2016-02-03 |
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