CA2897334A1 - Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 - Google Patents
Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 Download PDFInfo
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- CA2897334A1 CA2897334A1 CA2897334A CA2897334A CA2897334A1 CA 2897334 A1 CA2897334 A1 CA 2897334A1 CA 2897334 A CA2897334 A CA 2897334A CA 2897334 A CA2897334 A CA 2897334A CA 2897334 A1 CA2897334 A1 CA 2897334A1
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Landscapes
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| PCT/US2014/032209 WO2014160958A1 (en) | 2013-03-29 | 2014-03-28 | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
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| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| WO2014160129A2 (en) | 2013-03-14 | 2014-10-02 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| EP3191591A1 (en) | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
| IL278014B2 (en) | 2014-12-19 | 2023-10-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use |
| AR103162A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-c5 y métodos para su uso |
| US20180142010A1 (en) * | 2015-06-26 | 2018-05-24 | Alexion Pharmaceuticals, Inc. | Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| EP3328885A1 (en) * | 2015-09-11 | 2018-06-06 | Bruce Andrien | Recombinant glycosylated eculizumab and eculizumab variants |
| LT3468990T (lt) | 2016-06-14 | 2024-06-25 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antikūnai ir jų panaudojimas |
| TWI807666B (zh) * | 2016-06-17 | 2023-07-01 | 日商中外製藥股份有限公司 | 抗c5抗體及使用方法 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| US11828683B2 (en) | 2016-10-19 | 2023-11-28 | Alexion Pharmaceuticals, Inc. | Method of quantitating unbound C5a in a sample |
| ES2848206T3 (es) * | 2016-10-19 | 2021-08-05 | Alexion Pharma Inc | Un método de cuantificar C5 sin unir en una muestra |
| WO2018143266A1 (en) * | 2017-01-31 | 2018-08-09 | Chugai Seiyaku Kabushiki Kaisha | A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease |
| KR102656199B1 (ko) * | 2017-04-21 | 2024-04-09 | 볼루션 이뮤노 파마슈티컬스 에스에이 | 자가면역 수포 질환의 치료를 위한 코버신 |
| MX2020006113A (es) | 2017-12-13 | 2020-08-24 | Regeneron Pharma | Combinaciones de anticuerpos anti-c5 y usos de las mismas. |
| EP3597222A1 (en) * | 2018-07-16 | 2020-01-22 | Easemedcontrol R & D GmbH & Co KG | Treatment and diagnosis of unresolved inflammatory diseases |
| MX2021002710A (es) * | 2018-09-06 | 2021-09-23 | Univ Pennsylvania | Anticuerpos anti-c5 humanizados y usos de los mismos. |
| SG11202111419QA (en) * | 2019-04-24 | 2021-11-29 | Univ Pennsylvania | Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof |
| WO2021154941A1 (en) * | 2020-01-31 | 2021-08-05 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als) |
| US20240417725A1 (en) * | 2021-10-12 | 2024-12-19 | Vanqua Bio, Inc. | Oligonucleotides for targeting complement c5 |
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| ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
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| US20100291106A1 (en) | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| KR20120105405A (ko) | 2009-06-23 | 2012-09-25 | 알렉시온 파마슈티칼스, 인코포레이티드 | 보체 단백질에 결합하는 이중특이적 항체 |
| AU2011223866B2 (en) * | 2010-03-01 | 2015-05-21 | Alexion Pharmaceuticals Inc. | Methods and compositions for treating Degos' disease |
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| JP6505079B2 (ja) | 2019-04-24 |
| JP2018111728A (ja) | 2018-07-19 |
| ES2768648T3 (es) | 2020-06-23 |
| JP2016520542A (ja) | 2016-07-14 |
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