JP6490512B2 - Inner surface decontamination apparatus and inner surface decontamination method using the same - Google Patents

Description

  The present invention relates to an inner surface decontamination device for decontaminating an inner surface of a work glove or a half suit installed from a wall surface such as an isolator device or a glove box, that is, a surface in contact with an external environment side. . The present invention also relates to an inner surface decontamination apparatus combined with a glove or half suit leak inspection apparatus.

  When working in a clean atmosphere, such as pharmaceutical manufacturing or semiconductor or electronic component manufacturing, keep the interior sterile and dust-free to prevent contaminants from entering the external environment. Work is done in a clean working environment. As such a work environment, a clean room is generally used. In this clean room, a worker wearing a dust-free garment performs work. However, in order to raise the sterility assurance level and the dust-free assurance level, work is performed with a more advanced clean area in the clean room.

  As one method for configuring an advanced clean region, an isolator device or a glove box (hereinafter, referred to as “isolator device” collectively) is used. This isolator device uses a chamber sealed from the outside environment, and an operator performs work from outside the chamber through a work glove and a half suit. As another method for configuring an advanced clean area, an RABS (Access Restriction Barrier System) is used. This RABS is provided with a region surrounded by a wall whose lower part is released in a part of the clean room, and a laminar flow of laminar flow of a one-way flow that flows downward from above to the inside of the RABS, It is intended to perform strict access restrictions for workers. In this RABS, the worker performs work through work gloves and half suits provided on the wall surface.

  In general, the interior of an isolator device or RABS that manufactures pharmaceuticals or the like has completed advanced decontamination validation according to GMP (Good Manufacturing Practice), and guarantees Grade A (Ministry of Health, Labor and Welfare, Guidelines for Aseptic Drug Production). In this case, the isolator device and the outside of the RABS are maintained in a state of grade B, grade C, D or the like. As described above, it is important to maintain not only an isolator device or RABS that requires a high level of sterility assurance but also a sterilization environment of the external environment.

  Here, at the boundary between the inside and outside of the isolator device or RABS, in order to maintain a highly sterile environment inside, it is considered to be particularly important that the work gloves, the half suit itself, or the airtightness of the wearing part thereof are airtight. is there. In work gloves and half suits frequently used by workers, holes (pinholes) and tears occur in the main body, or the airtightness of these wearing parts breaks down, so that the internal highly sterile environment Cannot be maintained.

  On the other hand, the inner surfaces of work gloves and half suits, that is, the surfaces in contact with the external environment side (grades B, C, D) are the most difficult parts to maintain an aseptic environment on the external environment side. That is, these inner surfaces are portions where the operator frequently puts and removes hands and half body, and it is because the inside of the bag shape is difficult to maintain the effect of decontamination. Therefore, the inner surfaces of the work gloves and the half suit are particularly carefully decontaminated when the external environment is regularly decontaminated. Furthermore, it should be decontaminated more frequently than regular decontamination of the external environment. If the aseptic environment in this part is lower than the aseptic environment (grade B, C, D) outside the isolator device or RABS, there will be holes (pinholes) or tears in the work gloves or half suit. If it occurs, the degree of contamination of the internal environment (grade A) increases.

  Therefore, various devices for airtightness inspection (hereinafter referred to as “leakage inspection”) have been proposed and actually used in order to manage the airtightness of the work gloves or the half suit itself or its mounting portion. For example, Patent Document 1 below proposes a negative pressure glove tightness inspection device that inspects the air tightness of a work glove and its mounting portion in a state where the work glove is attached to an isolator device.

JP 2002-280277 A

  By the way, the leak inspection apparatus such as the negative pressure type glove airtightness inspection apparatus proposed in the above-mentioned Patent Document 1 is a device that periodically inspects the airtightness of the work glove and its mounting portion, and is airtight. The purpose is to detect abnormalities early. Therefore, when an abnormality in airtightness is detected, if the inner surface of work gloves or half suits is contaminated, the degree of contamination of the internal environment (grade A) of the isolator device and RABS is prevented from increasing. Not what you want.

  Accordingly, the present invention addresses the above-mentioned problems and easily decontaminates the inner surface of a work glove or the like that is most difficult to maintain a sterile environment on the external environment side such as an isolator device while the isolator device or the like is attached. It is an object to provide an inner surface decontamination apparatus and an inner surface decontamination method using the same.

  In solving the above-mentioned problems, the present inventors, as a result of diligent research, injected compressed air or the like into a work glove attached to an isolator device or the like to expand the work glove, and at the same time, It has been found that the object of the present invention can be achieved by spraying a decontamination solution on the inner surface, and the present invention has been completed.

That is, the inner surface decontamination apparatus according to the present invention is as described in claim 1.
A connection port provided in a work opening (3) opened in the wall surface (2) of the work room in order for an operator located in the external environment to work inside the work room (1) maintained in a sterile environment. A device (20) for decontaminating the surface (inner surface) (11b) in contact with the external environment side of the working member (11) attached while maintaining airtightness from (10) to the inside of the working chamber. , 30, 40, 50)
A connection port closing member (21, 31, 41, 51) for sealing the connection port from the external environment side to form a closed space (14) surrounded by the connection port and the inner surface of the working member; ,
Decontamination liquid supply means (22, 32, 42, 52) for supplying a decontamination liquid to the inside of the closed space via the connection port closing member;
A decontamination liquid spraying means (23, 33, 43, 53) for atomizing the decontamination liquid supplied to the inside of the closed space and spraying it on the inner surface of the working member. Features.

According to the description of claim 2, the present invention provides the inner surface decontamination device (20, 40) according to claim 1,
The decontamination liquid spraying means (23, 43) includes a compressed air generator (23a, 43a) that generates compressed air, and the connection port closing member (21, 43a) between the compressed air generator and the inside of the closed space. 41) and compressed air supply pipes (23b, 43b) communicating with each other through the air, and an extended end portion of the compressed air supply pipe opening toward the inner surface of the working member inside the closed space. Forming discharge ports (23c, 43c);
The decontamination liquid supply means (22, 42) includes a decontamination liquid tank (22a, 42a) for storing the decontamination liquid, the decontamination liquid tank, and the inside of the closed space as the connection port closing member. And a decontamination liquid supply pipe (22b, 42b) communicating with each other, and an extended end portion of the decontamination liquid supply pipe is opened in a direction intersecting a discharge direction of the air discharge port in the closed space. Forming a decontamination liquid supply port (22c, 42c),
The air from the air discharge port is discharged to the upper part of the decontamination liquid supply port, so that the decontamination liquid supplied from the decontamination liquid supply port is sucked up by the air discharged from the air discharge port. And sprayed in the form of a mist toward the inner surface of the working member.

According to a third aspect of the present invention, there is provided the inner surface decontamination device (30) according to the first aspect,
The decontamination liquid supply means (32) connects the decontamination liquid tank (32a) containing the decontamination liquid, the decontamination liquid tank, and the inside of the closed space via the connection port closing member (31). A decontamination liquid supply pipe (32b) communicating with each other, and an extended end portion of the decontamination liquid supply pipe opens toward the inner surface of the working member inside the closed space. (32c)
The decontamination liquid spraying means (33) includes an injection nozzle (33c) disposed in the decontamination liquid supply port, a compressed air generator (33a) that generates compressed air, the compressed air generator, and the A compressed air supply pipe (33b) communicating with the inside of the decontamination tank,
Compressed air supplied from the compressed air generator through the compressed air supply pipe pressurizes the inside of the decontamination liquid tank, so that the decontamination liquid in the decontamination liquid tank is converted into the decontamination liquid. It is supplied to the said injection nozzle through liquid supply piping, and is injected in the shape of a mist toward the inner surface of the said working member from the said injection nozzle.

Moreover, this invention is the inner surface decontamination apparatus as described in any one of Claims 1-3 according to description of Claim 4, Comprising:
Work member pressure setting means (53a, 53b), work member pressure detection means (54), and control means,
Compressed air is supplied to the inside of the closed space through the connection port closing member, and the pressure inside the closed space is maintained constant by the pressure setting means in the working member, and the pressure in the working member is detected. By detecting pressure changes over time by means,
It also has the function of a work member leak inspection device for inspecting defects such as pinholes in the work member.

Moreover, this invention is the inner surface decontamination apparatus as described in any one of Claims 1-4 according to the description of Claim 5,
The working member is a working glove or a half suit.

Moreover, this invention is the inner surface decontamination apparatus as described in any one of Claims 1-5 according to description of Claim 6,
The decontamination liquid is an alcohol for disinfection such as ethanol or 2-propanol.

Moreover, according to the description of claim 7, the inner surface decontamination method according to the present invention is as follows.
With inner surface decontamination apparatus according to any one of claims 1 to 6, within the spray amount of 1μL / cm ² ~5μL / cm ² of the decontamination liquid to the inner surface of the working member It is characterized by.

  According to the above configuration, the inner surface decontamination apparatus according to the present invention includes the connection port closing member, the decontamination liquid supply unit, and the decontamination liquid spray unit. The connection port closing member seals the connection port provided on the wall surface of the working room maintaining the aseptic environment from the external environment side. A working member is attached to the connection port while maintaining airtightness toward the inside of the working chamber. Therefore, a portion surrounded by the connection port and the inner surface of the working member forms a hermetically closed space. The inner surface of the working member in this closed space is the most difficult part to maintain a sterile environment on the external environment side of the working chamber.

  On the other hand, the decontamination liquid supply means supplies the decontamination liquid to the inside of the closed space surrounded by the connection port and the inner surface of the working member. The decontamination liquid supplied to the inside of the closed space is atomized by the decontamination liquid spraying means and sprayed on the inner surface of the working member. The atomized decontamination liquid is decontaminated by covering the inner surface of the working member (the surface in contact with the external environment side of the working chamber). As a result, the inner surface of the working member that is most difficult to maintain the aseptic environment is easily decontaminated while being attached to the connection port.

  Moreover, according to the said structure, the decontamination liquid spraying means has comprised the compressed air generator and the compressed air supply piping. Compressed air generated by the compressed air generator is supplied to the inside of the closed space via the compressed air supply pipe, and is discharged from the air outlet opening at the extended end of the compressed air supply pipe toward the inner surface of the working member. Is done. On the other hand, the decontamination liquid supply means includes a decontamination liquid tank and a decontamination liquid supply pipe. The decontamination liquid accommodated in the decontamination liquid tank is supplied to the inside of the closed space via the decontamination liquid supply pipe, and the decontamination liquid supply port that opens at the extended end of the decontamination liquid supply pipe has an air discharge. Open to the exit.

  According to this configuration, the air discharge port and the decontamination liquid supply port are opened in a direction crossing each other, and high-speed compressed air discharged from the air discharge port is blown onto the upper portion of the decontamination liquid supply port. As a result, a negative pressure due to the venturi effect is generated, and the decontamination liquid is sucked up from the decontamination liquid supply port. The decontamination liquid sucked up from the decontamination liquid supply port rides on compressed air discharged at a high speed and is sprayed in the form of a mist toward the inner surface of the working member. As a result, the decontamination liquid is sprayed on each part of the inner surface of the working member that is most difficult to maintain an aseptic environment, and the inner surface of the working member attached to the connection port is easily decontaminated.

  Moreover, according to the said structure, the decontamination liquid supply means comprises the decontamination liquid tank and the decontamination liquid supply piping. The decontamination liquid stored in the decontamination liquid tank is supplied to the inside of the closed space via the decontamination liquid supply pipe, and is supplied to the decontamination liquid supply port that opens at the extended end of the decontamination liquid supply pipe. The On the other hand, the decontamination liquid spraying means includes an injection nozzle, a compressed air generator, and a compressed air supply pipe that are disposed in the decontamination liquid supply port. Compressed air generated by the compressed air generator is supplied to the decontamination liquid tank via the compressed air supply pipe, and pressurizes the inside of the decontamination liquid tank.

  According to this configuration, the decontamination liquid in the decontamination liquid tank pressurized with compressed air is supplied to the injection nozzle via the decontamination liquid supply pipe, and is sprayed from the injection nozzle toward the inner surface of the working member. Is injected into. As a result, the decontamination liquid is sprayed on each part of the inner surface of the working member that is most difficult to maintain an aseptic environment, and the inner surface of the working member attached to the connection port is easily decontaminated.

  Further, according to the above configuration, the inner surface decontamination apparatus according to the present invention includes, in addition to each of the above configurations, a work member internal pressure setting unit, a work member internal pressure detection unit, and a control unit, You may make it have the function of the leak inspection apparatus for working members. As a result, it is possible to inspect for defects such as pinholes in the working member attached to the connection port and to easily decontaminate the inner surface of the working member.

Moreover, according to the said structure, the inner surface decontamination method concerning this invention uses each inner surface decontamination apparatus of the said structure, and the spraying amount of a decontamination liquid is 1 microliter / cm < ² >-with respect to the inner surface of a working member. Spray within a range of 5 μL / cm ² . As a result, the decontamination liquid is sprayed on each part of the inner surface of the working member that is most difficult to maintain an aseptic environment, and the inner surface of the working member attached to the connection port is easily decontaminated.

  Therefore, according to each of the above configurations, the inner surface decontamination can be easily decontaminated while the inner surface of a work glove or the like that is most difficult to maintain a sterile environment on the external environment side such as the isolator device is attached to the isolator device or the like. An apparatus and an inner surface decontamination method using the same can be provided.

It is sectional drawing which looked at the state which attached the work glove to the isolator apparatus from the side. It is sectional drawing which looked at the state which attached the inner surface decontamination apparatus which concerns on 1st Embodiment of this invention to the work glove of the isolator apparatus from the side surface. It is process drawing explaining operation of the inner surface decontamination apparatus of FIG. It is sectional drawing which looked at the state which attached the inner surface decontamination apparatus which concerns on 2nd Embodiment of this invention to the work glove of the isolator apparatus from the side surface. It is sectional drawing which looked at the state which attached the inner surface decontamination apparatus which concerns on 3rd Embodiment of this invention to the work glove of the isolator apparatus from the side surface. It is sectional drawing which looked at the state which attached the inner surface decontamination apparatus which concerns on 4th Embodiment of this invention to the work glove of the isolator apparatus from the side surface. It is process drawing explaining operation of the inner surface decontamination apparatus of FIG.

  Hereinafter, the present invention will be described in detail. Here, FIG. 1 is a cross-sectional view of a state in which a work glove is attached to the isolator device as seen from the side. In FIG. 1, the inner surface decontamination apparatus according to the present invention is not attached.

  In FIG. 1, the interior of a chamber 1 of an isolator device (not shown) installed in a clean room (not shown) that maintains a sterile environment (grade B) maintains a highly sterile environment (grade A). . A transparent glass window 2 is provided on the front wall of the chamber 1 (FIG. 1 is a side view). This glass window 2 has two circular working openings 3 that allow communication between the outside environment (in a clean room: grade B) and the inside of the chamber 1 (grade A) (FIG. 1 is a side view and only one is shown). Show).

  A connection port 10 for airtightly attaching the work glove and a work glove 11 made of synthetic resin attached to the connection port 10 are attached to these work openings 3. The connection port 10 is formed of a cylindrical body that is inserted into the work opening 3 and fixed to the glass window 2, and an inner peripheral side portion of the connection port 10 is an insertion portion in which an operator located in the clean room inserts an arm. Form. On the other hand, on the outer peripheral side of the connection port 10 on the inner side (left side in the figure) of the chamber 1, the base end portion (upper arm portion) 12 of the working glove 11 attached to the cylinder is airtight with two O-rings 13. It is fixed to. In FIG. 1, the work glove 11 is shown horizontally and expanded for convenience.

  The outer surface 11a of the working glove 11 fixed to the connection port 10 (inside the chamber 1) is decontaminated at the same time when the interior of the chamber 1 of the isolator device is highly decontaminated, and is maintained at grade A. Yes. On the other hand, the inner surface 11b (external environment side) of the work glove 11 is decontaminated at the same time when the inside of the clean room is decontaminated, and is maintained at grade B.

  However, the inner surface 11b of the work glove 11 is a portion where the operator frequently puts in and out his hand, and since it is formed in a bag shape, the decontamination effect is difficult to maintain. In addition, this portion is also a portion where a hole (pinhole) or a tear is likely to occur because the operator frequently puts in and out the hand. Therefore, when a hole (pinhole) or tear occurs in this part, the highly sterile environment (grade A) of the chamber 1 of the isolator device is immediately contaminated, and the degree of contamination increases.

  Hereinafter, an inner surface decontamination apparatus according to the present invention will be described according to each embodiment. The present invention is not limited to the following embodiments.

<< First Embodiment >>
FIG. 2 is a cross-sectional view of a state in which the inner surface decontamination apparatus according to the first embodiment is attached to a work glove of an isolator device disposed in a clean room, as viewed from the side. In FIG. 2, a clean room (not shown) maintaining an aseptic environment (grade B), an isolator device (not shown) maintaining an aseptic environment (grade A), a chamber 1, and a glass window 2 of the chamber 1. The opened circular work opening 3, the connection port 10 attached to the work opening 3, and the synthetic resin work glove 11 attached to the connection port 10 are the same as in FIG. .

  In FIG. 2, the inner surface decontamination apparatus 20 according to the first embodiment includes a connection port closing member 21, a decontamination liquid supply unit 22, and a decontamination liquid spray unit 23. The connection port closing member 21 is a lid that hermetically seals the inner peripheral opening of the connection port 10 attached to the working opening 3, and the lid that seals the inner peripheral opening from the external environment side. 21a, a cylindrical portion 21b inserted into the inner peripheral side portion of the connection port 10, and a packing 21c that hermetically seals the inner peripheral side portion of the connection port 10 and the outer peripheral side portion of the cylindrical portion 21b. Yes. The connection port closing member 21 hermetically seals the inner peripheral opening of the connection port 10, so that a portion surrounded by the inner surface 11 b of the work glove 11 and the cylindrical portion 21 b of the connection port closing member 21 is an external environment. A closed space 14 that is airtightly closed is formed.

  The decontamination liquid supply means 22 includes a decontamination liquid tank 22a and a decontamination liquid supply pipe 22b. The decontamination liquid tank 22 a stores a decontamination liquid for decontaminating the inner surface 11 b of the work glove 11. The decontamination solution is not particularly limited, but it is preferable to employ a decontamination solution that does not affect the human body and does not damage the inner surface 11b of the work glove 11. In the first embodiment, it is preferable to use a disinfecting alcohol such as ethanol or 2-propanol as the decontamination solution. Further, the decontamination liquid supply pipe 22b passes through the lid part 21a and the cylinder part 21b of the connection port 10 and communicates the decontamination liquid tank 22a with the closed space 14. Further, the extended end portion on the closed space 14 side of the decontamination liquid supply pipe 22 b opens the decontamination liquid supply port 22 c in the closed space 14. The position of the decontamination liquid supply port 22c will be described later.

  The decontamination liquid spraying means 23 includes a compressed air generator 23a and a compressed air supply pipe 23b. The compressed air generator 23a is not particularly limited as long as it can supply the compressed air required by the first embodiment, and may be a compressor, a blower fan, a compressed air cylinder, or the like. In the first embodiment, a compressor is used as the compressed air generator 23a. In addition, the compressed air supply pipe 23 b passes through the lid portion 21 a and the cylindrical portion 21 b of the connection port 10 and communicates the compressed air generator 23 a and the closed space 14. The extended end of the compressed air supply pipe 23 b on the closed space 14 side opens an air discharge port 23 c in the closed space 14. The air discharge port 23c is a tip portion of the compressed air supply pipe 23b extending from the tube portion 21b of the connection port 10, and is directed from the tube portion 21b side to the inner surface 11b of the finger portion 11c at the tip of the work glove 11. Open.

  On the other hand, the decontamination liquid supply port 22c of the decontamination liquid supply pipe 22b opens in a direction intersecting with the air discharge port 23c of the compressed air supply pipe 23b. In FIG. 2, the air discharge port 23 c opens leftward in the horizontal direction toward the tip of the work glove 11. On the other hand, in FIG. 2, the decontamination liquid supply port 22c opens upward in the vertical direction toward the air discharge port 23c. Such a positional relationship between the air discharge port 23c and the decontamination liquid supply port 22c constitutes a venturi effect.

  Specifically, high-speed compressed air discharged from the air discharge port 23c is blown onto the upper portion of the decontamination liquid supply port 22c. As a result, a negative pressure due to the venturi effect is generated in this portion, and the decontamination liquid is sucked up from the decontamination liquid supply port 22c. The decontamination liquid sucked up from the decontamination liquid supply port 22c rides on the compressed air discharged at a high speed and moves the inner surface 11b of the work glove 11 from the base end (upper arm) 12 to the finger 11c at the front end. It is sprayed in the form of a mist toward the entire surface (15 in FIG. 2). As a result, the decontamination liquid is sprayed on each part of the inner surface 11b of the working glove 11 that is most difficult to maintain the aseptic environment, and the inner surface 11b of the working glove 11 attached to the connection port 10 is easily decontaminated. The

Here, the amount of the decontamination liquid sprayed into the closed space 14 varies depending on the capacity of the work glove 11 to be decontaminated and the area of the inner surface 11b. Further, the discharge pressure and the air flow rate of the compressed air discharged from the air discharge port 23 c vary depending on the capacity and length of the work glove 11. In the first embodiment, ethanol is used as the decontamination liquid, and in the case of the working glove 11 having an inner diameter of 210 mm for the upper arm and an arm length of 800 mm, the discharge pressure is 200 to 400 kPa and the air flow rate is 18 to 38 L / min. Within the range, by setting the spray amount of the decontamination liquid within the range of 0.20 to 0.95 μL / cm ² , the base end part (upper arm part) 12 of the work glove 11 to the finger part 11c at the front end is good. The decontamination effect was confirmed.

  Here, the decontamination operation by the inner surface decontamination apparatus 20 according to the first embodiment will be described. FIG. 3 is a process diagram for explaining the operation of the inner surface decontamination apparatus 20 according to the first embodiment (refer to FIG. 2 for symbols of respective parts). FIG. 3A shows a state in which the inner space decontamination device 20 is attached to the connection port 10 to which the work glove 11 is attached, and the closed space 14 is configured. In this state, the internal pressure of the closed space 14 is the same as the external environment, and the work glove 11 is in a suspended state. In this state, a part of the inner surface 11b of the finger part 11c at the tip of the work glove 11 may be partially in contact. Although the decontamination solution may be sprayed from this state, in the first embodiment, the decontamination solution is sprayed after the working glove 11 is inflated to some extent.

  Therefore, in the state of FIG. 3A, compressed air is supplied from the compressed air generator 23a to the inside of the closed space 14 via the compressed air supply pipe 23b. At this time, the supply valve (not shown) of the decontamination liquid supply pipe 22 b is closed, and the decontamination liquid is not supplied into the closed space 14. As a result, the internal pressure of the closed space 14 increases, and the work glove 11 expands as shown in FIG. In this state, the work glove 11 rises in the left direction in the figure and has no contact with the inner surface 11b of the finger portion 11c at the tip.

  Next, in the state of FIG. 3 (3), the supply plug (not shown) of the decontamination liquid supply pipe 22 b is opened while compressed air is supplied from the compressed air generator 23 a into the closed space 14. . Thus, the decontamination liquid is supplied from the decontamination liquid tank 22a to the inside of the closed space 14 via the decontamination liquid supply pipe 22b. The supply of the decontamination liquid is based on the above-mentioned Venturi effect, and the supplied decontamination liquid is sprayed on the inner surface 11b of the work glove 11 in the form of a mist.

  When the decontamination liquid is supplied into the closed space 14 together with the compressed air and sprayed in the form of a mist, the working glove 11 is further expanded as shown in FIG. In this state, the work glove 11 is greatly inflated and maintained horizontally in the left direction in the figure, and the fog is spread over the entire surface from the base end part (upper arm part) 12 of the work glove 11 to the inner surface 11b of the finger part 11c at the front end. A decontamination liquid is injected. By continuing this state for a predetermined time, the decontamination liquid necessary for decontamination of the inner surface 11b of the work glove 11 is supplied uniformly.

  Next, the supply plug (not shown) of the decontamination liquid supply pipe 22b is closed, and the supply of compressed air from the compressed air generator 23a is stopped. Thereafter, the inner surface decontamination device 20 is removed from the connection port 10, and the decontamination of the inner surface 11 b of the work glove 11 is completed.

  From the above, in the inner surface decontamination apparatus 20 according to the first embodiment, the inner surface of a work glove or the like that is most difficult to maintain a sterile environment on the external environment side such as an isolator apparatus is mounted on the isolator apparatus or the like. It can be easily decontaminated.

<< Second Embodiment >>
The inner surface decontamination apparatus according to the second embodiment is attached to a work glove of an isolator device arranged in a clean room, as in the first embodiment. FIG. 4 is a cross-sectional view of a state in which the inner surface decontamination apparatus according to the second embodiment is attached to a work glove as viewed from the side. In FIG. 4, a clean room (not shown) maintaining an aseptic environment (grade B), an isolator device (not shown) maintaining an aseptic environment (grade A), and a glass window 2 of the chamber 1 are shown. The opened circular work opening 3, the connection port 10 attached to the work opening 3, and the synthetic resin work glove 11 attached to the connection port 10 are the same as in FIG. .

  In FIG. 4, the inner surface decontamination apparatus 30 according to the second embodiment includes a connection port closing member 31, a decontamination liquid supply unit 32, and a decontamination liquid spray unit 33. The connection port closing member 31 is a lid that hermetically seals the inner peripheral opening of the connection port 10 attached to the work opening 3, and the lid closes the inner peripheral opening from the external environment side. 31a, a cylindrical portion 31b inserted into the inner peripheral side portion of the connection port 10, and a packing 31c that hermetically seals the inner peripheral side portion of the connection port 10 and the outer peripheral side portion of the cylindrical portion 31b. Yes. The connection port closing member 31 hermetically seals the inner peripheral opening of the connection port 10, so that a portion surrounded by the inner surface 11 b of the work glove 11 and the cylindrical portion 31 b of the connection port closing member 31 is an external environment. A closed space 14 that is airtightly closed is formed.

  The decontamination liquid supply means 32 includes a decontamination liquid tank 32a and a decontamination liquid supply pipe 32b. The decontamination liquid tank 32 a stores a decontamination liquid for decontaminating the inner surface 11 b of the work glove 11. In the second embodiment, it is preferable to use a disinfecting alcohol such as ethanol or 2-propanol as the decontamination solution as in the first embodiment. In addition, the decontamination liquid supply pipe 32 b passes through the lid part 31 a and the cylinder part 31 b of the connection port 10 and communicates the decontamination liquid tank 32 a with the closed space 14. Further, the extended end portion of the decontamination liquid supply pipe 32 b on the closed space 14 side opens a decontamination liquid supply port 32 c in the closed space 14. The decontamination liquid supply port 32c will be described later.

  The decontamination liquid spraying means 33 includes a compressed air generator 33a, a compressed air supply pipe 33b, and an injection nozzle 33c. The compressed air generator 33a is not particularly limited as long as it can supply the compressed air required by the second embodiment. In the second embodiment, a compressor is used as in the first embodiment. To do. The compressed air supply pipe 33b communicates the compressed air generator 33a with the air layer inside the decontamination liquid tank 32a. The injection nozzle 33c is a nozzle having a very small opening, and sprays the decontamination liquid supplied at a predetermined flow rate and pressure in the form of a mist. The spray nozzle 33c is attached to the decontamination liquid supply port 32c of the decontamination liquid supply pipe 32b described above, and is arranged from the cylindrical part 31b side toward the inner surface 11b of the finger part 11c at the tip of the work glove 11. Yes.

  In such a configuration, the compressed air supplied from the compressed air generator 33a to the decontamination liquid tank 32a via the compressed air supply pipe 33b pressurizes the decontamination liquid tank 32a. As a result, the decontamination liquid in the decontamination liquid tank 32a is supplied to the decontamination liquid supply port 32c in the closed space 14 through the decontamination liquid supply pipe 32b in a pressurized state. The above-described spray nozzle 33c is attached to the decontamination liquid supply port 32c, and the decontamination liquid moves from the spray nozzle to the inner surface 11b of the work glove 11 from the base end portion (upper arm portion) 12 to the tip finger portion 11c. Is sprayed in the form of a mist toward the entire surface (15 in FIG. 4). As a result, the decontamination liquid is sprayed on each part of the inner surface 11b of the working glove 11 that is most difficult to maintain the aseptic environment, and the inner surface 11b of the working glove 11 attached to the connection port 10 is easily decontaminated. The

Here, the amount of the decontamination liquid sprayed into the closed space 14 varies depending on the capacity of the work glove 11 to be decontaminated and the area of the inner surface 11b. Further, the flow rate and pressure of the decontamination liquid supplied to the spray nozzle 33c are not particularly limited, but when the decontamination liquid is ethanol as in the first embodiment, the decontamination liquid is sprayed. The amount is preferably in the range of 0.20 to 0.95 μL / cm ² . The decontamination operation by the inner surface decontamination apparatus 30 according to the first embodiment is basically the same as that of the first embodiment, and the description thereof is omitted here. However, in the second embodiment, the decontamination liquid is sprayed from when the working glove 11 is in a suspended state (a state corresponding to FIG. 3 (1)).

  From the above, also in the inner surface decontamination apparatus 30 according to the second embodiment, the inner surface of the work glove or the like that is most difficult to maintain a sterile environment on the external environment side such as the isolator apparatus is mounted on the isolator apparatus or the like. It can be easily decontaminated.

<< Third Embodiment >>
The inner surface decontamination apparatus according to the third embodiment is attached to a work glove of an isolator device arranged in a clean room, as in the first embodiment. FIG. 5 is a cross-sectional view of a state in which the inner surface decontamination apparatus according to the third embodiment is attached to a work glove as viewed from the side. In FIG. 5, a clean room (not shown) maintaining an aseptic environment (grade B), an isolator device (not shown) maintaining an aseptic environment (grade A), and a glass window 2 of the chamber 1 are shown. The opened circular work opening 3, the connection port 10 attached to the work opening 3, and the synthetic resin work glove 11 attached to the connection port 10 are the same as in FIG. .

  In FIG. 5, the inner surface decontamination apparatus 40 according to the third embodiment includes a connection port closing member 41, a decontamination liquid supply means 42, and a decontamination liquid spray means 43, but the decontamination liquid supply means. 42 and the decontamination liquid spraying means 43 are integrated devices in which the connection port closing member 41 is incorporated. The connection port closing member 41 is a lid that hermetically seals the inner peripheral opening of the connection port 10 attached to the work opening 3, and the lid closes the inner peripheral opening from the external environment side. 41a, a cylindrical portion 41b inserted into the inner peripheral side portion of the connection port 10, and a packing 41c that hermetically seals the inner peripheral side portion of the connection port 10 and the outer peripheral side portion of the cylindrical portion 41b. Yes. The connection port closing member 41 hermetically seals the inner peripheral opening of the connection port 10, so that a portion surrounded by the inner surface 11 b of the work glove 11 and the cylindrical portion 41 b of the connection port closing member 41 is an external environment. A closed space 14 that is airtightly closed is formed.

  The decontamination liquid supply means 42 includes a decontamination liquid tank 42 a and a decontamination liquid supply pipe 42 b, which are housed inside the lid portion 41 a of the connection port closing member 41. The decontamination liquid tank 42 a stores a decontamination liquid for decontaminating the inner surface 11 b of the work glove 11. In the third embodiment, it is preferable to use a disinfecting alcohol such as ethanol or 2-propanol as the decontamination solution as in the first embodiment. Further, the decontamination liquid supply pipe 42 b penetrates the cylinder part 41 b from the inside of the lid part 41 a of the connection port 10 and communicates the decontamination liquid tank 42 a with the closed space 14. Further, the extended end portion of the decontamination liquid supply pipe 42 b on the closed space 14 side opens a decontamination liquid supply port 42 c in the closed space 14. The position and structure of the decontamination liquid supply port 42c are the same as those in the first embodiment.

  The decontamination liquid spraying means 43 includes a compressed air generator 43 a and a compressed air supply pipe 43 b, and these are housed in the lid portion 41 a of the connection port closing member 41. The compressed air generator 43a is not particularly limited as long as it can supply the compressed air required by the third embodiment. However, since the inner surface decontamination device 40 is an integrated device, In 3 embodiment, a small ventilation fan is used. In addition, the compressed air supply pipe 43 b passes through the cylinder portion 41 b from the inside of the lid portion 41 a of the connection port 10 and communicates the compressed air generator 43 a and the closed space 14. Further, the extended end portion of the compressed air supply pipe 43 b on the closed space 14 side opens an air discharge port 43 c in the closed space 14. The position and structure of the air discharge port 43c are the same as those in the first embodiment, and the venturi effect is configured by the combination with the decontamination liquid supply port 42c.

  Specifically, high-speed compressed air discharged from the air discharge port 43c is blown onto the upper portion of the decontamination liquid supply port 42c. As a result, a negative pressure due to the venturi effect is generated in this portion, and the decontamination liquid is sucked up from the decontamination liquid supply port 42c. The decontamination liquid sucked up from the decontamination liquid supply port 42c rides on the compressed air discharged at a high speed and moves the inner surface 11b of the work glove 11 from the base end (upper arm) 12 to the tip finger 11c. It is sprayed in the form of a mist toward the entire surface (15 in FIG. 5). As a result, the decontamination liquid is sprayed on each part of the inner surface 11b of the working glove 11 that is most difficult to maintain the aseptic environment, and the inner surface 11b of the working glove 11 attached to the connection port 10 is easily decontaminated. The

Here, the amount of the decontamination liquid sprayed into the closed space 14 varies depending on the capacity of the work glove 11 to be decontaminated and the area of the inner surface 11b. Further, the discharge pressure and the air flow rate of the compressed air discharged from the air discharge port 23 c vary depending on the capacity and length of the work glove 11. Also in the third embodiment, when the decontamination liquid is ethanol as in the first embodiment, the spray amount of the decontamination liquid should be within the range of 0.20 to 0.95 μL / cm ^2. Is preferred. The decontamination operation performed by the inner surface decontamination apparatus 30 according to the third embodiment is basically the same as that of the first embodiment, and a description thereof is omitted here.

  From the above, also in the inner surface decontamination apparatus 40 according to the third embodiment, the inner surface of the work glove or the like that is most difficult to maintain a sterile environment on the external environment side such as the isolator apparatus is mounted on the isolator apparatus or the like. It can be easily decontaminated.

<< 4th Embodiment >>
The inner surface decontamination device according to the fourth embodiment is attached to a work glove of an isolator device arranged in a clean room, as in the first embodiment. FIG. 6 is a cross-sectional view of a state in which the inner surface decontamination apparatus according to the fourth embodiment is attached to a work glove as viewed from the side. In FIG. 6, a clean room (not shown) maintaining an aseptic environment (grade B), an isolator device (not shown) maintaining an advanced aseptic environment (grade A), and a glass window 2 of the chamber 1 are shown. The opened circular work opening 3, the connection port 10 attached to the work opening 3, and the synthetic resin work glove 11 attached to the connection port 10 are the same as in FIG. .

  In FIG. 6, the inner surface decontamination apparatus 50 according to the fourth embodiment includes a connection port closing member 51, a decontamination liquid supply means 52, and a decontamination liquid spraying means 53 similar to those in the first embodiment, It has an internal pressure sensor 54 with data transmission function (hereinafter referred to as “pressure sensor 54”) and a control device (not shown), and also has a function of leak inspection of work gloves.

  The connection port closing member 51 is a lid that hermetically seals the inner peripheral opening of the connection port 10 attached to the working opening 3, and the lid that seals the inner peripheral opening from the external environment side. 51a, a cylindrical portion 51b inserted into the inner peripheral side portion of the connection port 10, and a packing 51c that hermetically seals the inner peripheral side portion of the connection port 10 and the outer peripheral side portion of the cylindrical portion 51b. Yes. The connection port closing member 51 hermetically seals the inner peripheral opening of the connection port 10, so that a portion surrounded by the inner surface 11 b of the work glove 11 and the cylindrical portion 51 b of the connection port closing member 51 is an external environment. A closed space 14 that is airtightly closed is formed.

  The decontamination liquid supply means 52 includes a decontamination liquid tank 52a and a decontamination liquid supply pipe 52b. The decontamination liquid tank 52 a stores a decontamination liquid for decontaminating the inner surface 11 b of the work glove 11. In the fourth embodiment, it is preferable to use a disinfecting alcohol such as ethanol or 2-propanol as the decontamination solution as in the first embodiment. In addition, the decontamination liquid supply pipe 52 b passes through the lid part 51 a and the cylinder part 51 b of the connection port 10 and communicates the decontamination liquid tank 52 a with the closed space 14. Further, the extended end portion on the closed space 14 side of the decontamination liquid supply pipe 52 b opens the decontamination liquid supply port 52 c in the closed space 14. The position and structure of the decontamination liquid supply port 52c are the same as those in the first embodiment.

  The decontamination liquid spraying means 53 includes a compressed air generator 53a and a compressed air supply pipe 53b. The compressed air generator 53a is not particularly limited as long as it can supply the compressed air required by the fourth embodiment. In the fourth embodiment, a compressor is used as in the first embodiment. To do. The compressed air supply pipe 53b passes through the lid portion 41a and the cylinder portion 41b of the connection port 10 and communicates the compressed air generator 53a with the closed space 14. Further, the extended end portion of the compressed air supply pipe 53 b on the closed space 14 side opens an air discharge port 53 c in the closed space 14. The position and structure of the air discharge port 53c are the same as those in the first embodiment, and the venturi effect is configured by combination with the decontamination liquid supply port 52c.

  Specifically, high-speed compressed air discharged from the air discharge port 53c is blown onto the upper portion of the decontamination liquid supply port 52c. As a result, a negative pressure due to the venturi effect is generated in this portion, and the decontamination liquid is sucked up from the decontamination liquid supply port 52c. The decontamination liquid sucked up from the decontamination liquid supply port 52c rides on the compressed air discharged at high speed, and moves the inner surface 11b of the work glove 11 from the base end part (upper arm part) 12 to the tip finger part 11c. It is sprayed in the form of a mist toward the entire surface (15 in FIG. 6). As a result, the decontamination liquid is sprayed on each part of the inner surface 11b of the working glove 11 that is most difficult to maintain the aseptic environment, and the inner surface 11b of the working glove 11 attached to the connection port 10 is easily decontaminated. The

Here, the amount of the decontamination liquid sprayed into the closed space 14 varies depending on the capacity of the work glove 11 to be decontaminated and the area of the inner surface 11b. Further, the discharge pressure and the air flow rate of the compressed air discharged from the air discharge port 23 c vary depending on the capacity and length of the work glove 11. Also in the fourth embodiment, when the decontamination liquid is ethanol as in the first embodiment, the spray amount of the decontamination liquid should be in the range of 0.20 to 0.95 μL / cm ^2. Is preferred.

  Here, the function of the leak inspection of the working glove, which is a feature of the inner surface decontamination apparatus 50 according to the fourth embodiment, will be described. The leak inspection for managing the airtightness of the work gloves or the half suit itself or its mounting portion is generally performed as described in the above-mentioned Patent Document 1. In the inner surface decontamination apparatus 50 according to the fourth embodiment, the compressed air generating device included in the connection port closing member 51, the pressure sensor 54, the control device (not shown), and the decontamination liquid spraying means 53 has a leak inspection function. It can be operated by 53a and compressed air supply piping 53b.

  In FIG. 6, the pressure sensor 54 is housed inside the lid portion 51 a and the cylinder portion 51 b of the connection port closing member 51. The closed space 14 has a pressure sensor portion 54a for measuring the pressure change, and the external environment side has an antenna portion 54b for transmitting the measured pressure change to the control device.

  In such a configuration, compressed air is supplied from the compressed air generator 53a to the inside of the closed space 14 sealed with the connection port closing member 51 via the compressed air supply pipe 53b. At this time, the supply of the decontamination liquid is stopped. When the inside of the closed space 14 reaches a predetermined pressure (for example, 3 kPa), the supply of compressed air is stopped. Thereafter, a change in pressure inside the closed space 14 is detected by the pressure sensor unit 54a for a predetermined time, and the data is transmitted from the antenna unit 54b to a control device (not shown). At this time, if the pressure drop within a predetermined time is larger than the set value, it can be seen that the airtightness of the work glove itself or its mounting portion is broken. In the inner surface decontamination apparatus 50 according to the fourth embodiment, the leak inspection and the decontamination operation are preferably performed as separate operations.

  Here, the decontamination operation by the inner surface decontamination apparatus 50 according to the fourth embodiment will be described. FIG. 7 is a process diagram for explaining the operation of the inner surface decontamination apparatus 50 according to the fourth embodiment (refer to FIG. 6 for symbols of respective parts). FIG. 7A shows a state where the inner surface decontamination device 50 is attached to the connection port 10 to which the work glove 11 is attached, and the leak inspection (the above-described operation) of the closed space 14 is completed. If no leak is found in the leak test, the internal pressure of the closed space 14 remains at the leak test pressure or a slight drop, and the work glove 11 is in a greatly expanded state.

  Next, in the state shown in FIG. 7A, a part of the air inside the closed space 14 is extracted to reduce the internal pressure. This is an operation for smoothly spraying the subsequent decontamination liquid, but is not required when the discharge pressure of the compressed air is large. When a part of the air inside the closed space 14 is extracted, the internal pressure of the closed space 14 is lowered, and the working glove 11 is slightly deflated as shown in FIG. However, even in this state, the work glove 11 rises in the left direction in the figure, and there is no portion in contact with the inner surface 11b of the finger portion 11c at the tip.

  Next, in the state of FIG. 7 (3), the supply plug (not shown) of the decontamination liquid supply pipe 52 b is opened while supplying the compressed air from the compressed air generator 53 a into the closed space 14. Thus, the decontamination liquid is supplied from the decontamination liquid tank 52a to the inside of the closed space 14 through the decontamination liquid supply pipe 52b. The supply of the decontamination liquid is based on the above-mentioned Venturi effect, and the supplied decontamination liquid is sprayed on the inner surface 11b of the work glove 11 in the form of a mist.

  When the decontamination liquid is supplied into the closed space 14 together with the compressed air and sprayed in the form of a mist, the work glove 11 expands again as shown in FIG. 7 (4). In this state, the work glove 11 is greatly inflated and maintained horizontally in the left direction in the figure, and the fog is spread over the entire surface from the base end part (upper arm part) 12 of the work glove 11 to the inner surface 11b of the finger part 11c at the front end. A decontamination liquid is injected. By continuing this state for a predetermined time, the decontamination liquid necessary for decontamination of the inner surface 11b of the work glove 11 is supplied uniformly.

  Next, a supply plug (not shown) of the decontamination liquid supply pipe 52b is closed, and the supply of compressed air from the compressed air generator 53a is stopped. Thereafter, the inner surface decontamination device 50 is removed from the connection port 10, and the decontamination of the inner surface 11 b of the work glove 11 is completed.

  From the above, in the inner surface decontamination apparatus 50 according to the fourth embodiment, the inner surface of the work glove or the like that is most difficult to maintain a sterile environment on the external environment side such as the isolator apparatus is mounted on the isolator apparatus or the like. It can be easily decontaminated.

In carrying out the present invention, not only the above-described embodiments but also the following various modifications can be mentioned.
(1) In each of the above embodiments, the decontamination is performed with the inner surface of the working glove attached to the connection port being attached, but the present invention is not limited to this, and the inner surface of the half suit attached to the connection port You may make it decontaminate in the state which mounted | wore.
(2) In each of the above embodiments, the decontamination is performed with the inner surface of the working glove attached to the connection port of the isolator device being attached, but the present invention is not limited to this. ) May be decontaminated in a state where the work gloves attached to the connection port on the wall surface or the inner surface of the half suit are attached.
(3) In each of the above embodiments, ethanol was used as the decontamination solution, and the appropriate spray amount was described, but this is not a limitation, and 2-propanol or other decontamination solution is used, You may make it spray the quantity suitable for a decontamination liquid.
(4) The integrated inner surface decontamination apparatus according to the third embodiment employs the same venturi effect as that of the first embodiment as a spray mechanism, but is not limited thereto, and the second embodiment. You may make it employ | adopt the same injection nozzle.
(5) The inner surface decontamination apparatus having a leak inspection function according to the fourth embodiment employs the same venturi effect as that of the first embodiment as a spray mechanism, but is not limited to this. You may make it employ | adopt the same injection nozzle as embodiment.
(6) The inner surface decontamination apparatus having a leak inspection function according to the fourth embodiment has a decontamination liquid supply means and a decontamination liquid injection means outside the connection port closing member as in the first embodiment. However, the present invention is not limited to this, and an inner surface decontamination apparatus having the same integrated leak inspection function as that of the third embodiment may be used.

DESCRIPTION OF SYMBOLS 1 ... Chamber, 2 ... Glass window, 3 ... Work opening, 10 ... Connection port,
11 ... Work gloves, 11a ... outer surface, 11b ... inner surface, 11c ... finger part,
12 ... Proximal end (upper arm), 13 ... O-ring, 14 ... enclosed space, 15 ... mist-like jet,
20, 30, 40, 50 ... inner surface decontamination device,
21, 31, 41, 51 ... connection port closing member,
21a, 31a, 41a, 51a ... lid,
21b, 31b, 41b, 51b ... cylinder part,
21c, 31c, 41c, 51c ... packing,
22, 32, 42, 52 ... decontamination liquid supply means,
22a, 32a, 42a, 52a ... decontamination tank,
22b, 32b, 42b, 52b ... decontamination liquid supply piping,
22c, 32c, 42c, 52c ... decontamination liquid supply port,
23, 33, 43, 53 ... decontamination liquid spraying means,
23a, 33a, 43a, 53a ... compressed air generator,
23b, 33b, 43b, 53b ... compressed air supply piping,
23c, 43c, 53c ... air discharge port, 33c ... injection nozzle,
54 ... Pressure sensor, 54a ... Sensor part, 54b ... Antenna part.

Claims (7)

In order for an operator located in an external environment to work inside a work room maintained in an aseptic environment, a connection port provided in a work opening opened in the wall surface of the work room is directed toward the inside of the work room. A device for decontaminating a surface (inner surface) that contacts the external environment side of a working member that is attached with airtightness,
A connection port closing member that seals the connection port from the external environment side and forms a closed space surrounded by the connection port and the inner surface of the working member;
A decontamination liquid supply means for supplying a decontamination liquid into the closed space via the connection port closing member;
An inner surface decontamination apparatus comprising decontamination liquid spraying means for atomizing the decontamination liquid supplied to the inside of the closed space and spraying the decontamination liquid on the inner surface of the working member. The decontamination liquid spraying means includes a compressed air generator that generates compressed air, and a compressed air supply pipe that communicates the compressed air generator and the inside of the closed space via the connection port closing member. Along with this, in the closed space, an extended end of the compressed air supply pipe forms an air outlet opening toward the inner surface of the working member,
The decontamination liquid supply means includes a decontamination liquid tank that accommodates the decontamination liquid, a decontamination liquid supply pipe that communicates the decontamination liquid tank and the inside of the closed space via the connection port closing member. And an end portion of the decontamination liquid supply pipe in the closed space forms a decontamination liquid supply port that opens in a direction intersecting the discharge direction of the air discharge port,
The air from the air discharge port is discharged to the upper part of the decontamination liquid supply port, so that the decontamination liquid supplied from the decontamination liquid supply port is sucked up by the air discharged from the air discharge port. The inner surface decontamination apparatus according to claim 1, wherein the inner surface decontamination apparatus is sprayed in a mist toward the inner surface of the working member. The decontamination liquid supply means includes a decontamination liquid tank that accommodates the decontamination liquid, a decontamination liquid supply pipe that communicates the decontamination liquid tank and the inside of the closed space via the connection port closing member. And an extended end portion of the decontamination liquid supply pipe in the closed space forms a decontamination liquid supply port that opens toward the inner surface of the working member,
The decontamination liquid spraying unit communicates an injection nozzle disposed in the decontamination liquid supply port, a compressed air generation device that generates compressed air, and the compressed air generation device and the inside of the decontamination liquid tank. Compressed air supply piping
Compressed air supplied from the compressed air generator through the compressed air supply pipe pressurizes the inside of the decontamination liquid tank, so that the decontamination liquid in the decontamination liquid tank is converted into the decontamination liquid. 2. The inner surface decontamination apparatus according to claim 1, wherein the inner surface decontamination apparatus is supplied to the injection nozzle through a liquid supply pipe and sprayed in a mist form toward the inner surface of the working member from the injection nozzle. It has working member pressure setting means, working member pressure detection means, and control means,
Compressed air is supplied to the inside of the closed space through the connection port closing member, and the pressure inside the closed space is maintained constant by the pressure setting means in the working member, and the pressure in the working member is detected. By detecting pressure changes over time by means,
The inner surface decontamination apparatus according to any one of claims 1 to 3, which also has a function of a work member leak inspection apparatus for inspecting defects such as pinholes in the work member.   5. The inner surface decontamination apparatus according to claim 1, wherein the working member is a working glove or a half suit.   The inner surface decontamination apparatus according to any one of claims 1 to 5, wherein the decontamination liquid is an alcohol for disinfection such as ethanol or 2-propanol. With inner surface decontamination apparatus according to any one of claims 1 to 6, within the spray amount of 1μL / cm ² ~5μL / cm ² of the decontamination liquid to the inner surface of the working member An internal decontamination method characterized by the above.