JP5412188B2 - Pass box and isolator device - Google Patents

Description

  The present invention relates to a pass box for delivering an article between two environments having different air cleanliness, and further relates to an isolator device including the pass box.

  In operations that deal with substances harmful to the human body, such as pharmaceutical manufacturing or R & D work, the workers are protected from contamination with harmful chemical substances, and these harmful chemical substances are removed from the work environment to the external environment. It is necessary to prevent leakage. Therefore, the work environment in which such work is performed is sealed as a work room, and the worker wears protective clothing inside the work room to perform work. This work chamber is also called a containment chamber. By controlling the intake and exhaust devices, the air pressure in the containment chamber is always negative with respect to the external environment to prevent leakage of chemicals and other substances handled in the containment chamber to the external environment. Yes.

  On the other hand, for work that is smaller than the work in the containment room, a small chamber is used as the work room, and an isolator device that allows workers to work from outside the chamber through gloves and half suits is used. Is done. The chamber of the isolator device is provided with an intake / exhaust device for filtering chemical substances harmful to the human body from the air in the chamber. These isolator devices are called containment isolator devices, and even in this containment isolator device, the chemical substance that is handled inside the chamber with the air pressure inside the chamber being always negative with respect to the external environment by the control of the intake / exhaust device To prevent leakage to the external environment.

  Here, in work using containment chambers and containment isolator devices that handle substances harmful to the human body, it is necessary to carry out necessary equipment and containers containing chemical substances during work, etc., from the outside to the work room. It may become. However, from the viewpoint of preventing leakage of chemical substances to the external environment, the external environment and the work room cannot be opened directly. Therefore, in such a case, a spare room called a pass box is installed between the inside and outside of the containment chamber, or between the chamber and outside of the containment isolator device, and the instrument is passed through this pass box. And containers containing chemical substances are carried into the work chamber.

  Specifically, first, the outer carry-in door of the pass box is opened, and the object is carried into the pass box. Next, the outer carry-in door of the pass box is closed, and this time, the inner carry-in door between the pass box and the work chamber is opened, and the object is moved into the work chamber. Then, the object can be carried into the work chamber by closing the inner carry-in door.

  Here, in the containment chamber and the containment isolator device, the pass box has an outer carry-in door that is opened to the external environment. Therefore, the air pressure in the pass box must always be negative with respect to the external environment. . Especially when the outside entrance door of the pass box is opened, the air pressure in the pass box becomes the same as the air pressure in the external environment, and harmful chemical substances handled in the work room do not leak to the external environment through the pass box. It is necessary to do so.

  For this purpose, in containment chambers and containment isolator devices that handle substances that are highly harmful to the human body, the inside of the pass box is independent of the intake / exhaust devices provided in the work chamber and the external environment. In addition, it is conceivable to provide an intake / exhaust device for filtering chemical substances harmful to the human body from the air in the pass box.

  As described above, when an independent intake / exhaust device is provided in the work chamber, the external environment, and the pass box, the air pressure in the pass box is set lower than the air pressure in the external environment, and the air pressure in the work chamber is set in the pass box. Set lower than air pressure. This makes it difficult for the air in the work chamber to flow into the pass box, and also makes it difficult for the air in the pass box to flow out to the external environment.

  By such air filtration and air pressure control by the triple intake and exhaust device, the pollution degree in the pass box is maintained lower than the pollution degree in the work room, and chemical substances that are harmful to the human body are kept in the external environment. It is thought that it is possible to prevent leakage.

  However, in addition to the air intake / exhaust device in the work chamber, independent air intake / exhaust devices are provided for the pass box and the external environment, respectively. And the balance control of air pressure in the external environment is difficult.

  In particular, the volume of the pass box is considerably smaller than the volume of the work chamber, and when the inner carry-in door between the pass box and the work chamber is opened, the air pressure balance between the work chamber and the pass box tends to be lost. Similarly, when opening the outer carry-in door of the pass box, the air pressure balance between the external environment and the pass box tends to be lost. Therefore, in such a case, a substance harmful to the human body contaminates the inside of the pass box and leaks to the external environment via the outer carry-in door of the pass box.

  In order to cope with such a case, when a plurality of target rooms are provided, and each target room is equipped with an intake / exhaust device, and the air pressure in each target room is set to a different set pressure, An air conditioning system disclosed in Patent Document 1 below proposes a device that constantly monitors the air pressure of each air and controls the intake and exhaust devices to constantly control the amount of air that is sucked and exhausted into each target room.

JP 2008-14523 A

  By the way, the air conditioning system described in Patent Document 1 includes a chamber pressure (pneumatic pressure) monitoring device in each target room, and performs centralized control of each intake and exhaust device based on the information of the chamber pressure monitoring device. The displacement from the engine is changed independently. In other words, when the doors between the target rooms are opened, the target chambers with high air pressure settings are set so that the air pressure balance in the target rooms does not collapse and the air pressure in the target rooms does not become uniform or reverse. The exhaust amount from the target chamber is decreased, while the exhaust amount from the target chamber having a low air pressure set value is increased.

  Such an air conditioning system includes a chamber pressure monitor device and an intake / exhaust device capable of controlling the intake / exhaust amount in each target room, and requires a centralized control device or the like linked to these. Therefore, the air conditioning system described in Patent Document 1 is an effective method in a large-scale clean laboratory that controls the air pressure balance between a plurality of large work rooms.

  However, there is a limit to providing the air conditioning system described in Patent Document 1 in a containment chamber having a small space such as a pass box, or in a containment isolator device that is a smaller facility. There was also a problem that was difficult.

  Therefore, the present invention addresses the above-mentioned problems, and in a pass box provided in a containment chamber or a containment isolator device, the present invention has only a simple facility and structure, and the air pressure in the work chamber and the air pressure in the pass box The balance with the air pressure of the external environment can be maintained. This ensures that the air flow from the inside of the pass box to the work room is always maintained, and harmful chemical substances etc. handled in the work room through the pass box. The purpose is to provide a pass box that does not leak to the external environment.

  Furthermore, an object of this invention is to provide the isolator apparatus provided with the said pass box.

  In solving the above problems, the present inventors, as a result of diligent research, provided an intake port for sucking outside air from the external environment in the pass box, and an outer carry-in port provided between the pass box and the external environment, An opening / closing member made of a flexible material was provided. As a result, the flow of air from the inside of the pass box to the work room is always maintained by negative pressure control by intake / exhaust of the containment chamber or exhaust by the exhaust device provided in the chamber of the isolator device. As a result, it was found that the object of the present invention can be achieved by securing the containment state of the present invention.

That is, the pass box according to the present invention, according to claim 1,
Provided on the peripheral wall of the working chamber (10, 120) that maintains the internal containment state by making the internal air exhausted by the exhaust means (30, 40) to a negative pressure state than the external environment, In a pass box having an outer carry-in port (80, 180) for delivering an article between the inner wall and an inner carry-in port (70, 170) for delivering an article between the work chambers on the peripheral wall,
Flexible opening and closing members (72, 82, 172, 182) provided to close the respective carry-in ports at the outer carry-in port (80, 180) and the inner carry-in port (70, 170),
An outer carry-in door (81, 181) provided at the outer carry-in port (80, 180) so as to be opened and closed;
The other part of the peripheral wall or the upper wall is provided with air inlets (53, 153) for sucking air in the external environment into the inside by suction by the exhaust means ,
The flexible opening and closing members (72, 82, 172, 182) are provided with vent holes (72b, 72c, 82b, 82c, 172b, 172c, 182b, 182c) ,
When delivering goods from the external environment to the work room via this pass box, the negative pressure state is maintained more than the external environment by suction by the exhaust means, and the positive pressure state is maintained more than the work room. Thus, the one-way air flowing from the external environment to the work chamber via the pass box is always maintained .

The pass box having the above-described configuration is attached to a containment chamber or a chamber of a containment isolator device (referred to as a “working room”) that handles chemical substances harmful to the human body. In order to prevent harmful chemical substances and the like handled inside these working chambers from leaking to the outside environment, the air pressure in the chambers is negative with respect to the outside air. As a result, the working chamber can always be kept in a containment state.

  Here, when a necessary instrument or the like is carried into the work chamber from the outside while maintaining the containment state, it passes through a pass box. For this purpose, the pass box having the above-described configuration has two carry-in ports on the peripheral wall, the outer carry-in port is open to the external environment, and the inner carry-in port is attached to the work chamber.

  Moreover, the pass box by the said structure provides the outer carrying-in door which can be opened and closed in an outer carrying-in entrance. By closing this outer carry-in door, harmful chemical substances and the like are prevented from leaking to the external environment. On the other hand, by opening the outer carry-in door, an instrument or the like to be carried into the work chamber can be carried into the pass box.

  In the present invention, an intake port is provided in the other part or the upper wall of the peripheral wall of the pass box. Here, since the air pressure in the working chamber is maintained at a negative pressure, the air in the external environment is sucked into the inside of the pass box through the intake port, and further, is sucked into the working chamber from the inside of the pass box. The Therefore, the air pressure in the work chamber and in the pass box is always kept low on the work chamber side. This is brought about by suction by the suction / exhaust means on the working chamber side, and it is not necessary to provide a dedicated exhaust means in the pass box.

  In the present invention, flexible opening and closing members are provided at the outer carry-in port and the inner carry-in port, respectively.

  First, since the flexible opening and closing member provided at the inner carry-in port is provided so as to close the inner carry-in port, the work chamber and the inside of the pass box are simply partitioned. Therefore, harmful chemical substances or the like handled in the work chamber are prevented from flowing into the pass box, and the degree of contamination in the pass box is kept lighter than the degree of contamination in the work chamber.

  In addition, the opening / closing member is provided with a vent, and the flow of air from the inside of the pass box to the work chamber is restricted to have a flow velocity above a certain level. The flow is always kept stable.

  Further, the opening / closing member has flexibility, and a part of the opening / closing member bends, thereby facilitating the work of bringing an instrument or the like carried into the pass box from the outside into the work chamber. That is, the operator can insert the instrument or the like into the work chamber from the inside of the pass box while pressing and opening the opening / closing member provided at the inner carry-in port with the instrument or the like to be carried in. After carrying in, the bending of the opening / closing member is eliminated and the opening / closing member is closed, whereby the original simple section is restored.

  As described above, even when the opening / closing member provided at the inner carry-in port is expanded, the air flow from the inside of the pass box to the working chamber is always stably maintained without being disturbed.

  Similarly, since the flexible opening and closing member provided at the outer carry-in port is provided so as to close the outer carry-in port, the outer carry-in door is opened and an instrument or the like is to be carried into the pass box. Sometimes, the external environment and the pass box are simply partitioned, so that harmful chemical substances and the like can be prevented from flowing out of the pass box into the external environment. Therefore, the external environment can be protected from leakage of chemical substances harmful to the human body.

  In addition, this opening / closing member is provided with a vent, and when the outer carry-in door is opened, it is generated and sealed at a flow rate above a certain level with the air flow from the outside environment to the inside of the pass box restricted. The state is kept stable. This is because the flow of air from the inside of the pass box to the working chamber is always maintained, and the air pressure in the pass box is negative.

  Furthermore, this opening / closing member is also flexible, and a part of the opening / closing member bends, thereby facilitating loading of an instrument or the like from the outside into the pass box. That is, the operator can insert the instrument into the pass box while pressing and opening the opening / closing member provided at the outer carry-in port with the instrument to be carried in. After carrying in, the bending of the opening / closing member is eliminated, and the original simple section is restored by closing the opening / closing member. As described above, the instrument or the like carried into the pass box is carried into the work chamber via the inner opening / closing member provided at the inner carry-in port.

  Thus, even when the opening / closing member provided at the outer carry-in port is expanded, the air flow from the external environment to the inside of the pass box is always stably maintained without being disturbed.

  According to the above configuration, the air flow from the inside of the pass box to the work room can be stably maintained, and the outside entrance door of the pass box for carrying instruments and the like into the work room via the pass box. Even when the door is opened, air flows from the outside to the inside of the pass box, so that harmful chemical substances or the like handled in the work chamber through the pass box do not leak to the outside environment.

  Therefore, the present invention can keep the balance between the air pressure in the working chamber, the air pressure in the pass box, and the air pressure in the external environment only by having a simple equipment and structure. It is possible to provide a pass box that maintains a flow of air into the work chamber and prevents harmful chemical substances or the like handled in the work chamber from leaking to the outside environment via the pass box.

According to the description of claim 2, the present invention is the pass box according to claim 1,
Inner carry-in doors (71, 171) provided to be openable and closable at the inner carry-in entrances (70, 170),
The inner carry-in door is provided with vent holes (78, 178) , and the one-way air flowing to the work chamber via the inner carry-in port is always maintained .

  According to the said structure, the inner side entrance door is newly provided in the pass box of Claim 1. The inner carry-in door is provided with a vent, and the vent communicates between the work chamber and the inside of the pass box. Therefore, even when the inner carry-in door is closed, the work can be performed from inside the pass box through the vent provided in the flexible opening / closing member provided in the inner carry-in door and the vent provided in the inner carry-in door. The air flow into the room can be maintained.

  Further, by providing the inner carry-in door at the inner carry-in port, the inside of the pass box is further prevented from being contaminated by harmful chemical substances and the like handled in the work chamber, and the degree of contamination in the pass box is further reduced.

  This inner carry-in door is provided so as to be openable and closable, and is opened when an instrument or the like is carried into the work chamber from the inside of the pass box. By opening the inner carry-in door, it is possible to carry in an instrument or the like via a flexible opening / closing member as described above.

  Therefore, also in the invention of the second aspect, the same effect as that of the first aspect of the invention can be achieved.

Moreover, according to the description of Claim 3 , this invention is the pass box of Claim 1 or 2 , Comprising:
The flexible opening and closing member is made of a flexible sheet (72, 82, 172, 182),
The flexible sheet (72, 82, 172, 182) is formed by cutting (72b, 72c, 82b, 82c, 172b, 172c, 182b, 182c) from the central part toward the peripheral part. And

  According to the above configuration, a flexible sheet may be used as the flexible opening / closing member. This flexible sheet is cut and cut from the central part toward the peripheral part. This cutting acts as a vent provided in the opening / closing member. Moreover, by cutting, a part of the flexible sheet bends, thereby facilitating the carrying-in of instruments and the like. That is, the operator can insert an instrument or the like while pressing and expanding the flexible sheet with the instrument or the like that is carried in. After the carry-in, the flexure of the flexible sheet is eliminated and the original simple section is restored by closing the flexible sheet.

Therefore, also in the invention described in claim 3 , the same effect as that of the invention described in claim 1 or 2 can be achieved.

  In the present invention, the shape and thickness of the flexible opening / closing member or flexible sheet is flexible and maintains the above simple section, and is expanded by pressing, and thereafter Any data can be used as long as it can be easily restored. For example, as a material used for the flexible opening / closing member or the flexible sheet, various rubber sheets having good elasticity can be used.

Moreover, according to the description of claim 4 , an isolator device according to the present invention is provided.
A chamber (10) having an inlet (14) for inhaling outside air;
Exhaust means (30, 40) for exhausting air inside the chamber (10);
In an isolator device including a pass box (C) externally attached to the peripheral wall of the chamber,
The said pass box (C) is a pass box as described in any one of Claims 1-3 ,
The outer carry-in port (80) is provided to communicate the inside of the pass box (C) with the outside air,
The inner carry-in port (70) is formed in an external portion (55) between the chamber (10) and the pass box (C), and the inside of the chamber (10) and the inside of the pass box (C). Is provided to communicate,
The intake port (53) provided in the pass box (C) is provided so as to communicate the inside of the pass box (C) with the outside air.

  According to the above configuration, the isolator device sucks outside air from the air inlet provided in the chamber, exhausts the air in the chamber by the exhaust means, and sets the air pressure in the chamber to a negative pressure. This negative pressure maintains the containment state in which harmful chemical substances and the like handled in the chamber do not leak to the external environment. Here, when a necessary instrument or the like is carried into the chamber from the outside while maintaining the containment state, it passes through a pass box.

In the isolator apparatus which concerns on this invention, the pass box as described in any one of Claims 1-3 is used as a pass box. Of the two inlets that the pass box has on its peripheral wall, the outer inlet is open to the outside environment, while the inner inlet is attached to open into the chamber.

  In addition, an outer carry-in door is provided at the outer carry-in port of the pass box so that it can be opened and closed. By closing the outer carry-in door, harmful chemical substances and the like are prevented from leaking to the external environment. On the other hand, by opening the outer carry-in door, an instrument or the like to be carried into the chamber can be carried into the pass box.

  The pass box used in the isolator device according to the present invention is provided with the intake port as described above, and the intake port provided in the pass box communicates the inside of the pass box with the outside air. The air sucked from the air inlet is sucked into the chamber from the inside of the pass box by maintaining the air pressure in the chamber at a negative pressure.

  Therefore, the air pressure in the chamber and in the pass box can always be kept low on the chamber side. This is brought about by suction by the exhaust means on the chamber side, and it is not necessary to provide a dedicated exhaust means in the pass box.

  In the isolator device according to the present invention, in order to maintain a sufficient containment state, the air pressure in the chamber is preferably lower than −10 Pa and further lower than −30 Pa with respect to the air pressure of the external environment. May be. By making the air pressure in the chamber lower than -10 Pa, the flow of air from the inside of the pass box to the inside of the chamber is stabilized. In particular, the outside of the pass box is opened and the inside of the pass box is exposed to the external environment. In this case, the air flow from the inside of the pass box to the inside of the chamber can be maintained, and harmful chemical substances and the like can be prevented from leaking to the outside environment through the pass box.

The air flow through the pass box in the isolator device according to the present invention is the same as described in the first to third aspects.

  Therefore, the present invention can maintain the balance between the air pressure in the chamber, the air pressure in the pass box, and the air pressure in the external environment only by having a simple equipment and structure. It is possible to provide an isolator device including a pass box that maintains a flow of air into the chamber and does not leak harmful chemical substances or the like handled in the chamber through the pass box to the external environment.

  In addition, the code | symbol in the bracket | parenthesis of each said means shows the correspondence with the specific means as described in each embodiment mentioned later.

It is a front view which shows 1st Embodiment of the isolator apparatus provided with the pass box which concerns on this invention, and the said pass box. (A) is the front view which looked at the inner side entrance of the pass box shown in FIG. 1 from the inner side of a carrying-in room, (B) is sectional drawing along XX in front view (A). is there. It is a perspective view which shows the structure which attaches a rubber sheet to the inner side entrance of the pass box shown in FIG. 1 with an exploded view. It is a perspective view which shows the state which looked at the inner side entrance of the pass box shown in FIG. 1 from the inner side of a chamber, and opened the inner side entrance door. (A) is the front view which looked at the outer side entrance of the pass box shown in FIG. 1 from the inner side of the carrying-in room, (B) is sectional drawing along the YY line in front view (A). is there. FIG. 2 is a cross-sectional view showing a normal working state in the isolator device shown in FIG. 1. In the isolator apparatus shown in FIG. 1, it is sectional drawing which shows the state which opened the outer carrying-in door in order to carry in an instrument into the inside of a carrying-in chamber from the outside. In the isolator apparatus shown in FIG. 1, it is sectional drawing which shows the state which carried in the inside of the carrying-in room from the outside. In the isolator apparatus shown in FIG. 1, it is sectional drawing which shows the state which carried in the inside of the carrying-in room, and closed the outer carrying-in door. In the isolator apparatus shown in FIG. 1, in order to carry in an instrument from the inside of a carrying-in room to the inside of a chamber, it is sectional drawing which shows the state which opened the inner carrying-in door. In the isolator apparatus shown in FIG. 1, it is sectional drawing which shows the state which carried in the instrument into the inside of the chamber from the inside of a carrying-in room. In the isolator apparatus shown in FIG. 1, it is sectional drawing which shows the state which carried in the inside of the chamber and closed the inner carrying-in door. It is a front view which shows 2nd Embodiment of the pass box which concerns on this invention. It is the schematic which shows the state which provided the pass box shown in FIG. 13 in the containment chamber. It is a perspective view which shows the state which looked at the inner side entrance of the pass box shown in FIG. 13 from the inner side of the containment chamber, and opened the inner side entrance door. It is a perspective view which shows the state which looked at the outer side entrance of the pass box shown in FIG. 13 from the inner side of a preparation room, and opened the outer side entrance door. It is a front view which shows roughly the different structures (A)-(F) of the flexible sheet which concerns on the modification of each said embodiment.

Hereinafter, the present invention will be described with reference to embodiments.
(First embodiment)
1st Embodiment of the isolator apparatus provided with the pass box which concerns on this invention, and the said pass box is described according to drawing. As shown in FIG. 1, the isolator device is joined to a gantry A placed on the floor surface, an isolator main body B mounted on the gantry A, and a right side wall portion of the isolator main body B. Pass box C.

  The gantry A is covered with a wall material made of a stainless steel metal plate. The interior of the gantry A serves as an electrical component and a machine room. A control panel D is incorporated in the front wall of the gantry A.

  The isolator body B is composed of a chamber 10, an intake filter unit 20, an exhaust filter unit 30, and a blower 40 for exhausting the air in the chamber to the outside after being filtered by the filter unit 30. Yes.

  The chamber 10 is made of a stainless steel box and is hermetically shielded from the external environment in which the operator works. The chamber 10 has a spray nozzle for cleaning liquid and a drain groove (both shown in the figure). Not shown).

  A transparent glass window 11 is provided on the front wall of the chamber 10 so that the inside can be visually recognized. The glass window 11 has four working openings 12a, 12b, 12c, and 12d that allow communication between the outside and the inside of the chamber 10. Resin gloves 13a, 13b, 13c, 13d (not shown) are airtightly attached to these working openings 12a, 12b, 12c, 12d, respectively.

  An air inlet 14 (not shown) for taking outside air into the chamber 10 is opened in the wall portion on the upper surface of the chamber 10. A filter unit 20 is connected to the intake port 14 in the vertical direction to the outside of the chamber 10. The inside of the filter unit 20 is filled with a filter 21 composed of a HEPA filter for filtering air that is sucked into the chamber 10 from the outside.

  An exhaust port 15 (not shown) is opened in the left side wall of the chamber 10. A filter unit 30 is connected to the exhaust port 15 in the horizontal direction outside the chamber. The filter unit 30 is filled with filters 31 a and 31 b made of HEPA filters for filtering air exhausted from the inside of the chamber 10 to the outside. The filter unit 30 is communicated with a blower 40 installed on a wall portion on the upper surface of the chamber 10 by a pipe 41.

  Here, the filter unit 30 houses two filters 31a and 31b in series. This is because the exhaust gas from the chamber 10 contains a lot of chemical substances that are harmful to the human body, and is necessary to remove this and maintain the containment state.

  An external outlet 16 is provided on the left side wall of the chamber 10. The external take-out port 16 has an outer bag 17 attached to the outside of the chamber, and is used for taking out used instruments and used filters out of the chamber.

  The pass box C includes a carry-in chamber 50 made of a stainless steel box and an intake filter unit 60.

  The carry-in chamber 50 is hermetically shielded from the external environment in which the operator works, and the wall portion on the front surface of the carry-in chamber 50 is used for one work that communicates the outside with the inside of the carry-in chamber 50. The opening 51 opens. A resin globe 52 (not shown) is airtightly attached to the working opening 51.

  An intake port 53 (not shown) is opened in the upper wall of the carry-in chamber 50. A filter unit 60 is connected to the intake port 53 in the vertical direction to the outside of the carry-in chamber 50. The filter unit 60 is filled with a filter 61 composed of a HEPA filter for filtering air that is taken into the carry-in chamber 50 from the outside.

  Further, the left side wall portion of the carry-in chamber 50 is externally attached to the right side wall portion of the chamber 10, and the external carry-in port that communicates the inside of the carry-in chamber 50 with the inside of the chamber 10 is connected to the external portion. 70 is open. The inner carry-in entrance 70 is provided with an inner carry-in door 71 (described later) that can be opened and closed on the inner side of the chamber 10. The inner carry-in port 70 is provided with a rubber sheet 72 (described later) at a position facing the inner carry-in door 71 on the inner side of the carry-in chamber 50 so as to close the inner carry-in port 70. This rubber sheet 72 corresponds to the flexible sheet in the present invention.

  On the other hand, an outer carry-in port 80 that allows the outside air to communicate with the inside of the carry-in chamber 50 is opened in the right side wall portion of the carry-in chamber 50. The outer carry-in port 80 is airtightly provided with an outer carry-in door 81 (described later) that can be opened and closed outside the carry-in chamber 50. The outer carry-in port 80 is provided with a rubber sheet 82 (described later) at a position facing the outer carry-in door 81 on the inner side of the carry-in chamber 50 so as to close the outer carry-in port 80. The rubber sheet 82 corresponds to the flexible sheet in the present invention.

  Here, the inner carry-in door 71 and the rubber sheet 72 provided at the inner carry-in port 70 will be described. In FIG. 2, the wall 18 on the side surface of the chamber 10 and the wall 54 on the side surface of the pass box C are joined to externally attach the pass box C to the chamber 10. An inner carry-in entrance 70 is opened in the wall portion 18 of the external attachment portion 55. The inner carry-in entrance 70 is provided with an inner carry-in door 71 on the inner side of the chamber 10, while a rubber sheet 72 is provided on the inner side of the carry-in chamber 50 at a position facing the inner carry-in door 71.

  Here, examples of the rubber used for the flexible rubber sheet include ethylene-propylene-diene copolymer rubber (EPDM), acrylonitrile-butadiene rubber (NBR), butyl rubber (IIR), chloroprene rubber (CR), natural rubber, and the like. Rubber (NR), Isoprene rubber (IR), Styrene-butadiene rubber (SBR), Butadiene rubber (BR), Acrylic rubber (ACM), Fluoro rubber, Silicone rubber, Epichlorohydrin rubber, NBR hydride, Polysulfide rubber, Urethane Among these, ethylene-propylene-diene copolymer rubber (EPDM), butyl rubber (IIR), chloroprene rubber (CR), and silicone rubber are more preferable. These rubbers can be used alone or in admixture of two or more.

  In the first embodiment, the rubber sheet 72 is a chloroprene rubber (CR) sheet having a thickness of 3 mm.

  As shown in FIG. 3, the rubber sheet 72 is composed of four pieces of a substantially trapezoidal rubber sheet, and is fixed and integrated by a bolt 73c and a nut 73d while being sandwiched between two fixing frames 73a and 73b. . In this fixed state, a small circular opening 72b surrounded by four tip portions 72a is formed in the central portion of the rubber sheet 72, and four slits 72c are formed from the opening 72b toward the peripheral portion. Is formed.

  The small circular opening 72b and the four slits 72c correspond to the vents of the inner opening / closing member in the present invention. This vent (opening 72b and slit 72c) maintains a flow of air from the inside of the carry-in chamber 50 to the inside of the chamber 10, and is a harmful chemical substance that is handled inside the chamber 10 via the carry-in chamber 50. Etc. are prevented from leaking to the external environment.

  The rubber sheet 72 is attached to the wall 18 in the above-described integrated state, and opens and closes in a swing manner to the inside of the carry-in chamber 50 via the support shaft 74. Thus, by opening and closing the rubber sheet 72 in an integrated state, when cleaning the interior of the chamber 10 and the carry-in chamber 50, there are no cleaning defects inside the apparatus and no retention of cleaning liquid, which is effective.

  On the other hand, as shown in FIGS. 3 and 4, the inner carry-in door 71 includes a door plate 75, a packing 76, and a handle 77, and a vent hole 78 is provided in the lower portion of the door plate 75. The air vent 78 allows air to flow from the inside of the carry-in chamber 50 to the inside of the chamber 10 through the vents (opening 72b and slit 72c) of the rubber sheet 72 even when the inner carry-in door 71 is closed. It is effective to maintain.

  The inner carry-in door 71 is attached to the wall portion 18 by packing 76 and opens and closes in a swing manner on the inner side of the chamber 10 via a support shaft 79. The operator opens the inner carry-in door 71 when carrying an instrument or the like from the carry-in chamber 50 into the chamber 10. Moreover, the opening and closing of the inner carry-in door 71 is also effective when cleaning the inside of the chamber 10 and the carry-in chamber 50.

  Next, the outer carry-in door 81 and the rubber sheet 82 provided at the outer carry-in port 80 will be described. In FIG. 5, an outer carry-in port 80 is opened in the side wall portion 56 of the pass box C. The outer carry-in port 80 is provided with an outer carry-in door 81 on the outer side of the carry-in chamber 50, while a rubber sheet 82 is provided on the inner side of the carry-in chamber 50 at a position facing the outer carry-in door 81. In the first embodiment, the rubber sheet 82 is a chloroprene rubber (CR) sheet having a thickness of 3 mm, which is the same as the rubber sheet 72.

  The rubber sheet 82 is composed of four substantially trapezoidal rubber sheets, like the rubber sheet 72 (see FIG. 3) provided at the inner carry-in entrance 70 described above, and is sandwiched between the two fixed frames 83a and 83b. Thus, the bolt 83c and the nut 83d are fixed and integrated. In this fixed state, a small circular opening 82b surrounded by four tip portions 82a is formed in the central portion of the rubber sheet 82, and four slits 82c are formed from the opening 82b toward the peripheral portion. Is formed.

  The small circular openings 82b and the four slits 82c correspond to the vents of the outer opening / closing member in the present invention. This vent (opening 82b and slit 82c) generates an air flow from the outside to the inside of the carry-in chamber 50 when the outer carry-in door 81 is opened in order to carry instruments or the like into the carry-in chamber 50. In addition, harmful chemical substances and the like handled inside the chamber 10 through the carry-in chamber 50 are prevented from leaking to the external environment.

  The rubber sheet 82 is attached to the wall portion 56 in an integrated state in the same manner as the rubber sheet 72 (see FIG. 3) described above, and opens and closes in a swing manner to the inside of the carry-in chamber 50 via the support shaft 84. Thus, by opening and closing the rubber sheet 82 in an integrated state, when cleaning the inside of the carry-in chamber 50, there is no cleaning defect inside the apparatus and no cleaning liquid is retained.

  On the other hand, as shown in FIG. 5 (B), the outer carry-in door 81 includes a door plate 85, a packing 86, and a handle 87. Unlike the above-described inner carry-in door 71 (see FIGS. 2 and 3), The door plate 85 is not provided with a vent hole. Accordingly, the outer carry-in door 81 is hermetically attached to the wall portion 56 by the packing 86, and opens and closes in a swing manner to the outside of the carry-in chamber 50 via a support shaft (not shown). Therefore, the outer carry-in door 81 is opened when an instrument or the like is carried into the carry-in chamber 50 from the outside.

  Here, in the isolator device according to the first embodiment configured as described above, an operation for carrying an instrument into the chamber through the pass box from the outside of the chamber will be described with reference to FIGS. To do.

  FIG. 6 is a cross-sectional view schematically showing the front of the isolator device (see FIG. 1) according to the first embodiment, and this state indicates a normal working state by the isolator device. In FIG. 6, the inner carry-in door 71 provided at the inner carry-in port 70 of the pass box C and the outer carry-in door 81 provided at the outer carry-in port 80 are both closed, and the chamber 10 and the carry-in chamber 50 are Both are kept in containment.

  At this time, outside air is filtered into the chamber 10 through the filter unit 20 for suction and is sucked by the filter 21. On the other hand, outside air is filtered and sucked into the carry-in chamber 50 by a filter 61 through a filter unit 60 for intake. The air sucked into the carry-in chamber 50 is sucked into the chamber 10 through the vent holes (opening 72b and slit 72c) of the rubber sheet 72 and the vent holes 78 of the inner carry-in door 71. The air sucked into the interior of the chamber 10 is exposed to chemical substances that are harmful to the human body handled inside the chamber 10. The air is filtered by the filters 31a and 31b through the exhaust filter unit 30, and then exhausted to the outside environment as safe air.

  This series of intake and exhaust air movements is performed by suction by an exhaust blower 40 installed on the upper wall of the chamber 10. In the first embodiment, in the state where the inner carry-in door 71 and the outer carry-in door 81 shown in FIG. 6 are both closed, the air pressure inside the chamber 10 is −30 Pa with respect to the atmospheric pressure. At this time, the air pressure inside the carry-in chamber 50 is −25 Pa with respect to the atmospheric pressure, and the state in which air flows from the high-pressure carry-in chamber 50 into the low-pressure chamber 10 is maintained.

  The air pressure of −30 Pa inside the chamber 10 is brought about by the suction force of the exhaust blower 40, and the air pressure of −25 Pa inside the carry-in chamber 50 is the vent of the rubber sheet 72 (opening 72 b and This is caused by the air resistance due to the slit 72c) and the vent 78 of the inner carry-in door 71.

  Thus, in a normal working state (see FIG. 6) by the isolator device, air resistance by the filter unit 20 for intake and the filter unit 60, and air resistance by the vent (opening 72b and slit 72c) and the vent 78. In addition, the air resistance by the exhaust filter unit 30 is balanced with the suction force by the exhaust blower 40 to maintain the air pressure of −30 Pa inside the chamber 10 and the air pressure of −25 Pa inside the carry-in chamber 50. doing.

  As described above, the air pressure inside the chamber 10 and the inside of the carry-in chamber 50 is balanced, so that the air inside the carry-in chamber 50 flows into the chamber 10 from the inside of the carry-in chamber 50. Therefore, chemical substances and the like harmful to the human body are maintained in a state of being contained in the chamber 10 and the carry-in chamber 50. Further, the contamination level inside the loading chamber 50 having the outer loading door 81 that opens to the outside is lower than the contamination level inside the chamber 10, and chemical substances that are harmful to the human body contaminate the external environment. There is nothing to do.

  Here, in a state where the containment of the isolator device is maintained, the operator prepares the instrument E to be carried into the chamber outside the outer carry-in door 81 (see FIG. 6).

  Next, the worker opens the outer carry-in door 81 (see FIG. 7). Even in this state, the air pressure inside the chamber 10 is maintained at −30 Pa by the suction force of the exhaust blower 40. On the other hand, the air pressure inside the carry-in chamber 50 changes between −5 Pa and −10 Pa when the outer carry-in door 81 is opened, but still maintains a negative pressure. This is caused by the air resistance due to the vents (opening 82b and slit 82c) of the rubber sheet 82 provided at the outer carry-in port 80, and the chamber 10 from the inside of the carry-in chamber 50 at the inner carry-in port 70 described above. This is because the air flow into the interior of the interior is always maintained through the ventilation holes (openings 72b and slits 72c) of the rubber sheet 72 and the ventilation holes 78 of the inner carry-in door 71.

  Here, the air pressure inside the carry-in chamber 50 changes from −25 Pa to −5 Pa to −10 Pa because the air is directly sucked from outside through the vents (opening 82 b and slit 82 c) of the rubber sheet 82. This is because the intake through the filter unit 60 is reduced. This is because the air resistance by the filter unit 60 is larger than the air resistance of the vent (opening 82b and slit 82c).

  In this state (see FIG. 7), the outer carry-in door 81 is open, but the outer carry-in port 80 is simply closed by the rubber sheet 82, and the outer carry-in port 80 is completely opened to atmospheric pressure. Exposure is avoided. Further, since the air pressure inside the carry-in chamber 50 maintains a negative pressure, the air flow in the vent holes (opening 82b and slit 82c) flows into the carry-in chamber 50 at a predetermined flow rate.

  Other movements of the intake and exhaust air are performed in the same manner as in a normal working state (see FIG. 6), and are filtered by the filters 31a and 31b through the filter unit 30 and exhausted to the external environment. Therefore, the balance between the air pressure inside the chamber 10 and the inside of the carry-in chamber 50 and the external atmospheric pressure causes the external air to flow into the carry-in chamber 50, and the air inside the carry-in chamber 50 It flows into the chamber 10 from the inside of the carry-in chamber 50. Therefore, chemical substances and the like that are harmful to the human body are maintained in a state of being contained in the chamber 10 and the carry-in chamber 50.

  Next, the operator inserts the tool E into the carry-in chamber 50 while pressing and expanding the rubber sheet 82 from the outside of the carry-in chamber 50. On the other hand, the worker receives the instrument E from the inside of the carry-in chamber 50 via the globe 52 (not shown) provided on the front wall portion of the carry-in chamber 50 and carries it into the carry-in chamber 50 (see FIG. 8).

  The other intake and exhaust air movements are the same as in the state shown in FIG. 7, and the air pressure inside the chamber 10 is maintained at −30 Pa, while the air pressure inside the carry-in chamber 50 is − 5 Pa to -10 Pa. Therefore, even in this state (see FIG. 8), the air pressure inside the chamber 10 and the inside of the carry-in chamber 50 and the external atmospheric pressure balance, so that the external air flows into the carry-in chamber 50, and The air inside the carry-in chamber 50 flows from the inside of the carry-in chamber 50 into the chamber 10. Therefore, chemical substances and the like that are harmful to the human body are maintained in a state of being contained in the chamber 10 and the carry-in chamber 50.

  Next, the operator closes the outer carry-in door 81 in a state where the instrument E is carried into the carry-in chamber 50 (see FIG. 9). Thereby, the intake from the outside through the rubber sheet 82 stops, and instead, the intake through the filter unit 60 that has been reduced increases. In this state, the air pressure inside the chamber 10 is maintained at −30 Pa by the suction force of the exhaust blower 40, while the air pressure inside the carry-in chamber 50 is − It changes to 25Pa.

  This state is the same as the normal working state (see FIG. 6) by the isolator device. Therefore, even in this state (see FIG. 9), the air pressure inside the chamber 10 and the inside of the carry-in chamber 50 is balanced, so that the air inside the carry-in chamber 50 is changed from the inside of the carry-in chamber 50 to the inside of the chamber 10. Flow into. Therefore, chemical substances and the like that are harmful to the human body are maintained in a state of being contained in the chamber 10 and the carry-in chamber 50.

  Next, the operator opens the inner carry-in door 71 to the inside of the chamber 10 (see FIG. 10). Even in this state, the air pressure inside the chamber 10 is maintained at −30 Pa by the suction force of the exhaust blower 40. On the other hand, the air pressure inside the carry-in chamber 50 does not change even when the inner carry-in door 71 is opened, and is maintained at −25 Pa. This is because the air inlet 78 is always open in the inner carry-in door 71, and the air flow from the inside of the carry-in chamber 50 to the inside of the chamber 10 is not greatly affected by the opening / closing of the inner carry-in door 71. Because. Even in a state where the inner carry-in door 71 is opened, the rubber sheet 72 prevents harmful chemical substances and the like handled inside the chamber 10 from contaminating the carry-in chamber 50.

  This state does not change from the normal working state (see FIG. 6) by the isolator device, and even in this state (see FIG. 10), the air pressures in the chamber 10 and the loading chamber 50 are balanced. The air inside the carry-in chamber 50 flows from the inside of the carry-in chamber 50 into the chamber 10. Therefore, chemical substances and the like that are harmful to the human body are maintained in a state of being contained in the chamber 10 and the carry-in chamber 50.

  Next, the operator presses and expands the rubber sheet 72 from the inside of the carry-in chamber 50 with the instrument E through a globe 52 (not shown) provided on the front wall of the carry-in chamber 50. The instrument E is inserted into the chamber 10. On the other hand, the operator receives the instrument E from the inside of the chamber 10 via the globe 13a (not shown) provided in the glass window 11 on the front wall of the chamber 10 and carries it into the chamber 10 ( (See FIG. 11).

  The movement of the intake and exhaust air in this state is the same as that shown in FIG. 10, and the air pressure inside the chamber 10 is maintained at −30 Pa, while the air pressure inside the carry-in chamber 50 is − 25 Pa. Therefore, even in this state (see FIG. 11), the air pressure inside the chamber 10 and the inside of the carry-in chamber 50 is balanced, so that the air inside the carry-in chamber 50 is changed from the inside of the carry-in chamber 50 to the inside of the chamber 10. Flow into. Therefore, chemical substances and the like that are harmful to the human body are maintained in a state of being contained in the chamber 10 and the carry-in chamber 50.

  Finally, the operator closes the inner carry-in door 71 in a state where the instrument E is carried into the chamber 10 (see FIG. 12). This state is the same as the normal working state (see FIG. 6) by the isolator device, and the air pressure inside the chamber 10 is maintained at −30 Pa by the suction force by the exhaust blower 40, while the carry-in chamber 50 The air pressure inside is maintained at −25 Pa.

In this state (see FIG. 12), the air pressure inside the chamber 10 and the inside of the carry-in chamber 50 is balanced, so that the air inside the carry-in chamber 50 flows into the chamber 10 from the inside of the carry-in chamber 50. To do. Therefore, chemical substances that are harmful to the human body will be kept in the chamber 10 and the carry-in chamber 50, and the chemical substances that are harmful to the human body will not contaminate the external environment, so that the appliance E can be used. It can be carried into the chamber 10.
(Second Embodiment)
Next, 2nd Embodiment of the pass box based on this invention with which the containment chamber was equipped is described according to drawing. In the second embodiment, the pass box is provided at the boundary between the containment chamber 120 that handles chemical substances harmful to the human body and the preparation chamber 130 adjacent to the containment chamber 120 (see FIG. 14). ).

  As shown in FIG. 13, the pass box includes a gantry 110 that is placed on the floor surface, and a pass box main body 100 that is placed on the gantry 110. The gantry 110 includes four columns 111 for installing the pass box main body 100 at a predetermined height on the floor and a connecting member 112 that connects the columns to stabilize the column.

  At the boundary between the containment chamber 120 and the preparation chamber 130, there is a wall portion 140 that hermetically shields both the chambers. The opening 141 that opens to the wall portion 140 has the pass box body 100 in each chamber. It arrange | positions so that it may protrude and it is mounted on the floor surface of the preparation chamber 130 by the mount frame 110 (refer FIG. 14).

  The containment chamber 120 is airtightly shielded from the preparation chamber 130, and inside the containment chamber 120, a worker 121 wearing protective clothing is working to handle chemical substances that are harmful to the human body. An intake / exhaust device 122 having a filter unit is provided on the upper wall of the containment chamber 120. The intake / exhaust device 122 sucks and exhausts air inside the containment chamber 120, and the air pressure of the containment chamber 120 is always maintained in the preparation chamber. The air pressure is controlled to be negative rather than the air pressure of 130. The intake / exhaust device 122 is filled with a filter (not shown) made of a HEPA filter for filtering air to be intake / exhaust. This prevents chemical substances that are harmful to the human body handled in the containment chamber 120 from leaking to the preparation chamber 130 or the external environment.

  In the preparation room 130, a worker 131 who does not wear protective clothing is preparing to carry in the containment room 120 instruments and the like used in the containment room 120. An intake / exhaust device 132 having a filter unit is provided on the upper wall of the preparation chamber 130. The intake / exhaust device 132 sucks and exhausts air inside the preparation chamber 130, and the air pressure of the preparation chamber 130 is always contained in the containment chamber. The pressure is controlled so as to be more positive than 120 air pressure. In addition, in FIG. 14, the entrance / exit of the containment chamber 120 and the preparation chamber 130, a work implement, etc. are not shown in figure.

  As shown in FIG. 13, the pass box main body 100 includes a carry-in chamber 150 made of a stainless steel box and an intake filter unit 160.

  An intake port 153 (not shown) is opened in the upper wall of the carry-in chamber 150. A filter unit 160 is connected to the intake port 153 in the vertical direction to the outside of the carry-in chamber 150. The filter unit 160 is filled with a filter 161 made of a HEPA filter for filtering the air sucked from the preparation chamber 130 into the carry-in chamber 150.

  In addition, an inner carry-in port 170 that allows communication between the inside of the containment chamber 120 and the inside of the carry-in chamber 150 is opened in the wall portion 151 on the left side surface of the carry-in chamber 150 (see FIG. 13). The inner carry-in port 170 is provided with an inner carry-in door 171 that can be opened and closed on the inner side of the containment chamber 120. The inner carry-in port 170 is provided with a rubber sheet 172 at a position facing the inner carry-in door 171 on the inner side of the carry-in chamber 150 so as to close the inner carry-in port 170.

  As shown in FIG. 15, the inner carry-in door 171 includes a door plate 175, a packing 176, and a handle 177 (not shown), and a vent 178 is provided at the lower portion of the door plate 175. The vent 178 is effective for maintaining the air flow from the inside of the carry-in chamber 150 to the inside of the containment chamber 120 even when the inner carry-in door 171 is closed.

  The inner carry-in door 171 is attached to the wall portion 151 on the left side surface of the carry-in chamber 150 by a packing 176, and opens and closes in a swing manner to the inner side of the containment chamber 120 through the support shaft 179. Therefore, the worker 121 working inside the containment chamber 120 can carry in an instrument or the like from the inside of the carry-in chamber 150 into the containment chamber 120 by opening the inner carry-in door 171.

  The rubber sheet 172 corresponds to a flexible sheet in the present invention, and a chloroprene rubber (CR) sheet having a thickness of 3 mm was used as the rubber sheet 172. The structure of the rubber sheet 172 according to the second embodiment is the same as the structure of the rubber sheet 72 according to the first embodiment (see FIGS. 2 and 3). In a state of being fixed and integrated in a state of being sandwiched between two fixed frames, it is attached to the wall portion 151 on the left side surface of the carry-in chamber 150, and the inner side of the carry-in chamber 150 via a support shaft 174 (not shown). Open and close in a swing manner.

  The small circular opening 172b and the four slits 172c formed in the rubber sheet 172 correspond to the vent hole of the inner opening / closing member in the present invention (see FIG. 15). This vent maintains the air flow from the inside of the carry-in chamber 150 to the inside of the containment chamber 120, and harmful chemical substances handled inside the containment chamber 120 leak to the outside environment via the carry-in chamber 150. Is prevented.

  On the other hand, an outer carry-in port 180 that connects the inside of the preparation chamber 130 and the inside of the carry-in chamber 150 is opened in the wall portion 152 on the right side surface of the carry-in chamber 150 (see FIG. 13). This outer carry-in port 180 is airtightly provided with an outer carry-in door 181 that can be opened and closed inside the preparation chamber 130. Further, a rubber sheet 182 is provided at the outer carry-in port 180 at a position facing the outer carry-in door 181 on the inner side of the carry-in chamber 150 so as to close the outer carry-in port 180.

  As shown in FIG. 16, the outer carry-in door 181 includes a door plate 185, a packing 186, and a handle 187 (not shown). Unlike the above-described inner carry-in door 171 (see FIG. 15), the door plate 185 is provided. There are no vents. Therefore, the outer carry-in door 181 is hermetically attached to the wall portion 152 on the right side surface of the carry-in chamber 150 by the packing 186 and opens and closes in a swing manner to the inside of the preparation chamber 130 via the support shaft 189. Accordingly, the worker 131 working inside the preparation chamber 130 can carry in an instrument or the like from the inside of the preparation chamber 130 to the inside of the loading chamber 150 by opening the outer carry-in door 181.

  The rubber sheet 182 corresponds to a flexible sheet in the present invention, and a chloroprene rubber (CR) sheet having a thickness of 3 mm was used as the rubber sheet 182. The structure of the rubber sheet 182 according to the second embodiment is the same as the structure of the rubber sheet 82 according to the first embodiment (see FIGS. 3 and 5). In a state of being fixed and integrated in a state of being sandwiched between two fixed frames, it is attached to the wall portion 152 on the right side surface of the carry-in chamber 150, and the inner side of the carry-in chamber 150 via a support shaft 184 (not shown). Open and close in a swing manner.

  The small circular opening 182b and the four slits 182c formed in the rubber sheet 182 correspond to the vent hole of the outer opening / closing member in the present invention (see FIG. 16). This vent hole generates an air flow from the preparation chamber 130 to the inside of the carry-in chamber 150 when the outer carry-in door 181 is opened in order to carry instruments or the like into the carry-in chamber 150. In this way, harmful chemical substances and the like handled inside the containment chamber 120 are prevented from leaking into the preparation chamber 130.

  In the containment chamber equipped with the pass box configured as described above, the work of carrying instruments and the like from the preparation room into the containment chamber through the pass box is carried out in the first embodiment (FIGS. 6 to 6). 12).

  However, in the second embodiment, the operation of opening the outer carry-in door 181 and carrying instruments and the like from the preparation chamber 130 into the carry-in chamber 150 is performed by the worker 131 of the preparation chamber 130, while the inner carry-in is performed. The worker 121 of the containment chamber 120 performs the work of opening the door 171 and carrying instruments and the like from the carry-in chamber 150 into the containment chamber 120.

  The pass box according to each embodiment configured as described above or the isolator device including the pass box has a simple facility and structure. In addition, these pass boxes or isolator devices maintain a balance between the air pressure in the work chamber, the air pressure in the carry-in chamber of the pass box, and the air pressure in the external environment, so that air is always supplied from the inside of the pass box carry-in chamber to the work chamber. It can be made to flow.

  In particular, when the outer carry-in door is opened in the work of carrying in the equipment necessary for work into the work chamber from the outside through the pass box carry-in chamber, the rubber sheet vent provided in the outer carry-in port from the outside The flow of air into the work chamber is generated through the door, and the air flow from the inside of the carry-in chamber to the work chamber can always be maintained even when the inner carry-in door is opened. Therefore, harmful chemical substances handled in the work room are not leaked to the outside environment.

  Therefore, according to the present invention, a highly toxic chemical substance or the like is contained in the work room, the worker is protected from contamination of the harmful chemical substance, and the harmful chemical substance is prevented from leaking to the external environment. In the work in the containment chamber used for this purpose or in the work using the containment isolator device, the work to carry in the work room from the outside the container containing the equipment and chemical substances required during the work through the pass box It can be done safely.

In carrying out the present invention, not only the above-described embodiments but also the following various modifications can be mentioned.
1. In each of the above embodiments, as the flexible opening and closing member, a flexible sheet consisting of four pieces, which employs a rubber sheet having a small circular opening at the center, is used. For example, a flexible sheet having the structure shown in FIG. 17 or a flexible opening / closing member having another structure may be adopted. In FIG. 17, (A) is a front view of a flexible sheet having the same structure as the rubber sheet according to each of the above embodiments. On the other hand, (B) replaces the central opening with a small circle and makes it a quadrangle. (C) does not have a central opening. In (D), four pieces of flexible sheets form a partial overlapping portion, and have a square opening at the center. (E) has four X-shaped slits in the center of one flexible sheet. (F) has eight slits in the center of one flexible sheet. Here, the flexible sheet is not composed of four pieces, but may be a flexible sheet composed of several pieces. Further, the number of slits included in one flexible sheet may not be four or eight, and may be any number.
2. In each of the above embodiments, the size of the vent hole provided in the inner carry-in door is fixed. By adopting a structure in which the opening area of the vent hole can be changed, the inside of the carry-in chamber can be moved into the work chamber. The air pressure in the working chamber may be adjusted by adjusting the flow rate of the flowing air.
3. In each of the above embodiments, the vent provided in the inner carry-in door is provided in the lower part of the inner carry-in door, but is not limited to this, and any other position such as the central portion of the inner carry-in door You may make it provide in.
4). In each of the above embodiments, swing doors are adopted as the inner carry-in door and the outer carry-in door. However, the present invention is not limited to this, and any type such as a shutter-type door may be adopted. Good.
5. In each of the above embodiments, both the inner carry-in door and the rubber sheet as the flexible sheet are provided at the inner carry-in port between the work chamber and the carry-in chamber, but without providing the inner carry-in door. Only a flexible sheet may be provided.
6). In each of the above embodiments, both the inner carry-in door and the rubber sheet as the flexible sheet are provided at the inner carry-in port between the work chamber and the carry-in chamber, but the flexible sheet is not provided. In addition, only the inner carry-in door may be provided.
7). In the first embodiment, the air pressure in the chamber of the isolator device is maintained at −30 Pa by the suction force of the exhaust blower, while the air pressure in the carry-in chamber of the pass box is maintained at −25 Pa. The air pressure in these rooms is not limited to this, and may be appropriately changed depending on the output of the exhaust blower.
8). The isolator device according to the first embodiment and another isolator device may be connected to perform a series of operations continuously.
9. In the first embodiment, four gloves are attached to the chamber, and one globe is attached to the carry-in chamber. However, the number of gloves attached to the chamber and the carry-in chamber is not limited to these. Absent. Further, a half suit or the like may be worn instead of the glove.
10. In the said 1st Embodiment, although the door of the surrounding wall of a chamber is not demonstrated, it can be set as the door which can open and close the front glass window, the side surface, or the wall part of a back surface. By providing the door in this way, it is possible to easily perform work such as internal maintenance and inspection when the containment state is opened.
11. In the first embodiment, the positions of the filter units for intake and exhaust may be provided at other positions on the side wall or upper wall of the chamber.
12 The number of filters attached to the filter unit for intake or exhaust is not limited to one set or two sets, and three or more sets may be used. Moreover, it is not limited to the combination of 1 set and 2 sets.
13. The filter attached to the filter unit for intake or exhaust may not be a HEPA filter, and may be appropriately selected according to harmful substances such as chemical substances used in the work room.

  The pass box according to the present invention or the isolator device including the pass box can maintain a balance between the air pressure in the work chamber, the air pressure in the pass box, and the air pressure in the external environment only with simple equipment and structure. In this way, it is possible to always maintain the air flow from the inside of the pass box to the work room, and to prevent the harmful chemical substances handled in the work room from leaking to the outside environment through the pass box. it can.

  As a result, the containment state is maintained, such as the handling of chemical substances that are harmful to the human body during the manufacturing or R & D stage of pharmaceuticals, the handling of highly toxic microorganisms in medical and biological experiments, or the handling of radioactive substances. The present invention can be used effectively for many tasks that need to be performed.

  A: Base, B: Isolator body, C: Pass box, D: Control panel, E: Instrument, 10: Chamber, 20, 30, 60, 160 ... Filter unit, 40: Blower, 50, 150 ... Loading room, 70 , 170 ... inner carry-in port, 80, 180 ... outer carry-in port, 71, 171 ... inner carry-in door, 81, 181 ... outer carry-in door, 72, 82, 172, 182 ... rubber sheet, 100 ... pass box body, 110 ... Pass box frame, 120 ... containment room, 130 ... preparation room.

Claims (4)

Outer side for delivering goods to and from the external environment, provided on the peripheral wall of the working chamber that maintains the internal containment state by making the internal air exhausted by the exhaust means to a negative pressure state than the external environment In a pass box having an inner carry-in port on the peripheral wall for transferring articles between the carry-in port and the work room ,
A flexible opening and closing member provided at each of the outer carry-in port and the inner carry-in port to close each carry-in port;
An outer carry-in door provided to be openable and closable at the outer carry-in entrance;
The other part of the peripheral wall or the upper wall is provided with an intake port for sucking air from the outside environment by suction by the exhaust means ,
The flexible opening and closing member is provided with a vent ,
When delivering goods from the external environment to the work room via this pass box, the negative pressure state is maintained more than the external environment by suction by the exhaust means, and the positive pressure state is maintained more than the work room. A pass box characterized by always maintaining a one-way air flowing from the external environment to the work room via the pass box. An inner carry-in door provided to be openable and closable at the inner carry-in entrance,
2. The pass box according to claim 1 , wherein a ventilation port is provided in the inner carry-in door, and the one-way air flowing to the work chamber via the inner carry-in port is always maintained. . The flexible opening / closing member is made of a flexible sheet,
  The pass box according to claim 1 or 2, wherein the flexible sheet is cut and cut from a central part toward a peripheral part. A chamber having an inlet for taking in outside air;
  Exhaust means for exhausting air inside the chamber;
  In an isolator device including a pass box externally attached to the peripheral wall of the chamber,
  The pass box is the pass box according to any one of claims 1 to 3,
  The outer carry-in port is provided to allow communication between the inside of the pass box and the outside air,
  The inner carry-in port is formed at an external portion of the chamber and the pass box, and is provided to communicate the inside of the chamber and the inside of the pass box,
  An isolator device, wherein an intake port provided in the pass box is provided so as to allow communication between the inside of the pass box and the outside air.

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