JP6478333B2 - ポイント・オブ・ケア・センサ・システムのためのカートリッジ、および当該システムにより分析物を検出する方法 - Google Patents

ポイント・オブ・ケア・センサ・システムのためのカートリッジ、および当該システムにより分析物を検出する方法 Download PDF

Info

Publication number
JP6478333B2
JP6478333B2 JP2016503001A JP2016503001A JP6478333B2 JP 6478333 B2 JP6478333 B2 JP 6478333B2 JP 2016503001 A JP2016503001 A JP 2016503001A JP 2016503001 A JP2016503001 A JP 2016503001A JP 6478333 B2 JP6478333 B2 JP 6478333B2
Authority
JP
Japan
Prior art keywords
cartridge
sample
implementations
reader
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016503001A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016512339A5 (https=
JP2016512339A (ja
Inventor
エヌ． ジョンソン、ブラッドレイ
エヌ． ジョンソン、ブラッドレイ
ヤン、ジュイ−ミン
エー． ジョシ、カンチャン
エー． ジョシ、カンチャン
アール． ラドキー、レイ
アール． ラドキー、レイ
グリューナー、ガレット
スカルポ、セルゲイ
Original Assignee
ナノミックス、インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ナノミックス、インコーポレイテッド filed Critical ナノミックス、インコーポレイテッド
Publication of JP2016512339A publication Critical patent/JP2016512339A/ja
Publication of JP2016512339A5 publication Critical patent/JP2016512339A5/ja
Application granted granted Critical
Publication of JP6478333B2 publication Critical patent/JP6478333B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/27—Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ecology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2016503001A 2013-03-15 2014-03-14 ポイント・オブ・ケア・センサ・システムのためのカートリッジ、および当該システムにより分析物を検出する方法 Expired - Fee Related JP6478333B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/844,334 US9458488B2 (en) 2013-03-15 2013-03-15 Point of care sensor systems
US13/844,334 2013-03-15
PCT/US2014/029162 WO2014144660A1 (en) 2013-03-15 2014-03-14 Point of care sensor systems

Publications (3)

Publication Number Publication Date
JP2016512339A JP2016512339A (ja) 2016-04-25
JP2016512339A5 JP2016512339A5 (https=) 2017-04-20
JP6478333B2 true JP6478333B2 (ja) 2019-03-06

Family

ID=51528833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016503001A Expired - Fee Related JP6478333B2 (ja) 2013-03-15 2014-03-14 ポイント・オブ・ケア・センサ・システムのためのカートリッジ、および当該システムにより分析物を検出する方法

Country Status (5)

Country Link
US (3) US9458488B2 (https=)
EP (1) EP2967451B1 (https=)
JP (1) JP6478333B2 (https=)
CN (3) CN105163661B (https=)
WO (1) WO2014144660A1 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD739553S1 (en) * 2013-03-15 2015-09-22 Nanomix, Inc. Chemical sensor cartridge
US9458488B2 (en) 2013-03-15 2016-10-04 Nanomix, Inc. Point of care sensor systems
SG11201601668PA (en) * 2013-09-04 2016-04-28 Credo Biomedical Pte Ltd Assay test device, kit and method of using
US11033898B2 (en) 2014-02-01 2021-06-15 Ezmems Ltd. Fluidic microelectromechanical sensors/devices and fabrication methods thereof
WO2015114635A1 (en) * 2014-02-01 2015-08-06 Ezmems Ltd. Chip device for monitoring and regulating fluid flow, and methods of manufacture thereof
JP7068822B2 (ja) 2014-09-08 2022-05-17 インディアン インスティテゥート オブ サイエンス 電気化学的バイオセンサ及びアルブミンとその複合体の検出方法
US10001449B2 (en) * 2014-12-15 2018-06-19 Church & Dwight Co., Inc. Systems, devices and methods for a hydroscopic based lateral flow assay
TWI547694B (zh) * 2015-01-30 2016-09-01 國立陽明大學 微流道生物反應器及其套組和使用方法
EP3250505A4 (en) * 2015-01-30 2018-07-11 Hewlett-Packard Development Company, L.P. Microfluidics sensing system
GB201511039D0 (en) 2015-06-23 2015-08-05 Karhiniemi Marko And Medigoo Oy And Karilahti Mika In-vitro-analyser
US9922525B2 (en) * 2015-08-14 2018-03-20 Gregory J. Hummer Monitoring system for use with mobile communication device
US11340210B2 (en) * 2020-07-11 2022-05-24 Matthew Hummer Method and devices for detecting viruses and bacterial pathogens
US11179061B1 (en) * 2020-07-11 2021-11-23 Gregory J. Hummer Method and devices for detecting viruses and bacterial pathogens
US11896372B2 (en) * 2021-05-18 2024-02-13 Matthew Hummer Device for reading, processing and transmitting test result data for pathogens or viruses in fluid test samples
EP3472616B1 (en) 2016-06-21 2020-01-01 Koninklijke Philips N.V. Analyte detection system and method
GB201615320D0 (en) * 2016-09-09 2016-10-26 Invitron Ltd Point of care platform test
EP3552015B1 (en) * 2016-12-07 2023-01-18 Radiometer Medical ApS System and method for estimating a temperature of a liquid sample
US11213819B2 (en) * 2017-01-30 2022-01-04 Noavaran Payesh Ani Salamat (AZSense) Integrated patient monitor system
WO2018160216A1 (en) 2017-03-03 2018-09-07 Polymer Technology Systems, Inc. Systems and methods for enzymatic a1c detection and quantification
CN108686721B (zh) * 2017-04-06 2021-04-20 美康生物科技股份有限公司 用于全血样品分离检测的微流控芯片及其检测方法
EP3607327A4 (en) * 2017-04-07 2020-03-11 James D. Kurkowski SERVICE POINT TEST CARTRIDGE
US11714083B2 (en) * 2017-05-11 2023-08-01 Arizona Board Of Regents On Behalf Of Arizona State University Point-of-care apparatus and methods for analyte detections using electrochemical impedance or capacitance
US11703513B2 (en) 2017-08-07 2023-07-18 Polymer Technology Systems, Inc. Systems and methods for enzymatic A1C detection and quantification
US11067526B2 (en) * 2017-08-17 2021-07-20 Abbott Point Of Care Inc. Devices, systems, and methods for performing optical and electrochemical assays
US20200246795A1 (en) * 2017-10-05 2020-08-06 Boehringer Ingelheim Vetmedica Gmbh Cartridge, analysis system and method for testing a sample
WO2019099855A1 (en) * 2017-11-17 2019-05-23 Siemens Healthcare Diagnostics Inc. Sensor assembly and method of using same
AU2018367618B2 (en) 2017-11-20 2020-12-03 Siemens Healthcare Diagnostics Inc. User interface for managing a multiple diagnostic engine environment
ES2927989T3 (es) 2017-11-21 2022-11-14 Mx3 Diagnostics Inc Sistema y procedimiento de análisis de saliva
KR102812840B1 (ko) * 2018-05-08 2025-05-26 인피콘, 인크. 화학 분석 장치 및 방법
CN108828231A (zh) * 2018-06-21 2018-11-16 微粒云科技（北京）有限公司 一种心肺功能标志物磁微粒微流控生物芯片、检测方法
CN108845146A (zh) * 2018-06-21 2018-11-20 微粒云科技（北京）有限公司 一种用于心肌五项标志物检测的生物芯片、检测方法
CN112119311B (zh) * 2018-07-27 2024-12-20 泽普托生命技术股份有限公司 用于处理基于gmr的生物标志物检测中的分析物信号的系统和方法
CN109061130A (zh) * 2018-08-06 2018-12-21 张岩锐 一种带有尿液分析试纸条的装置
US10753986B2 (en) 2018-10-04 2020-08-25 Genmark Diagnostics, Inc. Systems and methods for assessing electrical connectivity between elements of assay devices
US10352983B1 (en) * 2018-10-04 2019-07-16 Genmark Diagnostics, Inc. Systems and methods for assessing electrical connectivity between elements of assay devices
CA3060849C (en) 2018-11-02 2022-06-14 Cardiai Technologies Ltd. Portable electrochemical-sensor system for analyzing user health conditions and method thereof
CN113543882A (zh) * 2018-12-31 2021-10-22 本-古里安大学B.G.内盖夫技术和应用公司 捕获流测定装置和方法
US20200400695A1 (en) * 2019-02-07 2020-12-24 Giner, Inc. Method and system for detection and/or quantification of delta-9-tetrahydrocannabinol in saliva
US11723553B2 (en) 2019-02-11 2023-08-15 Giner, Inc. Method and system for detection and/or quantification of delta-9-tetrahydrocannabinol in exhaled breath
CN118604090A (zh) * 2019-03-01 2024-09-06 南京岚煜生物科技有限公司 一种具有五层结构的多通道微流体凝血检测芯片
US11982682B2 (en) 2019-05-06 2024-05-14 University Of Prince Edward Island Portable field testing apparatus and method
US12320771B2 (en) 2019-06-12 2025-06-03 Siemens Healthcare Diagnostics Inc. System and method of measurement and calibration of analyte testing
GB2585227B (en) * 2019-07-04 2023-05-17 Mint Diagnostics Ltd Saliva testing
US11701036B2 (en) * 2019-07-10 2023-07-18 MX3 Diagnostics, Inc. Saliva test strip and method
WO2021016140A1 (en) 2019-07-19 2021-01-28 Micropoint Bioscience, Inc. Micro-assay cartridges
FR3100890B1 (fr) * 2019-09-17 2024-02-16 Innopsys Méthode et lecteur portable d’analyse d’échantillon de liquide biologique
US11703436B2 (en) 2020-01-30 2023-07-18 MX3 Diagnostics, Inc. Biological fluid sample assessment
CN111307794A (zh) * 2020-03-30 2020-06-19 上海舒爽材料科技有限公司 嘴动式口腔检测机构及相应的智能口腔检测仪
IL297098A (en) 2020-04-08 2022-12-01 The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo Systems and methods for determining the prevalence of sars cov 2 in the population
WO2021252923A1 (en) 2020-06-12 2021-12-16 Genmark Diagnostics, Inc. Systems and methods for assessing bays on diagnostic devices
US12000823B2 (en) * 2020-07-11 2024-06-04 Matthew Hummer Simultaneous disease detection system method and devices
JP2022019626A (ja) * 2020-07-15 2022-01-27 エコセンス 被験者の肝臓の健康状態に関係するパラメータを決定するためのシステムおよび方法
JP2022032479A (ja) * 2020-08-12 2022-02-25 株式会社ファーストスクリーニング 電気化学センサユニット
CN112113955B (zh) * 2020-09-15 2022-03-18 四川行之智汇知识产权运营有限公司 血红蛋白检测卡
WO2022094707A1 (en) * 2020-11-04 2022-05-12 Pelican Diagnostics Inc. Portable devices and methods for detecting and identifying compounds in a fluid sample
JP7842108B2 (ja) 2021-01-22 2026-04-07 アナログ・ディヴァイシス・インターナショナル・アンリミテッド・カンパニー 検知アセンブリ
CN115735005B (zh) * 2021-04-29 2025-07-08 京东方科技集团股份有限公司 芯片装载结构、分析装置及分析系统
WO2022245542A2 (en) * 2021-05-18 2022-11-24 Matthew Hummer Method and devices for detecting viruses and bacterial pathogens
US11892425B2 (en) * 2021-05-18 2024-02-06 Matthew Hummer Device for reading, processing and transmitting test result data for pathogens or viruses in fluid test samples
US12553675B2 (en) 2021-07-16 2026-02-17 Siemens Healthcare Diagnostics Inc. Detection of abnormal heat exchanger operating condition
US12455258B2 (en) * 2022-04-19 2025-10-28 Lg Electronics Inc. Biosensor chip and biosensor cartridges having the same
US20230408438A1 (en) * 2022-06-15 2023-12-21 Oregon State University Electrocatalytic polymer device for biological detection
CA3262807A1 (en) * 2022-07-19 2024-01-25 Hylid Diagnostics Inc. DELOCAL BLOOD ANALYSIS SYSTEM
GB2631113A (en) * 2023-06-20 2024-12-25 Tachmed Holdings Ltd Sensor unit
EP4671772A2 (en) * 2024-03-14 2025-12-31 Leica Microsystems CMS GmbH FLUID DISTRIBUTOR FOR SUPPLYING FLUID TO A MICROFLUID SYSTEM AND FLUID CONTAINER
EP4650049A3 (en) * 2024-05-15 2026-02-25 Summa Finland Oy An analyzer and a sensor disc assembly for the analyzer

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1179585B1 (en) * 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6893552B1 (en) 1997-12-29 2005-05-17 Arrowhead Center, Inc. Microsensors for glucose and insulin monitoring
CA2333875C (en) 1998-06-01 2005-10-11 Roche Diagnostics Corporation Redox reversible bipyridyl osmium complex conjugates
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
US20030224371A1 (en) 2002-06-04 2003-12-04 Thomas Bradley S. Integrated cartridge for sample manipulation
AU2003297214A1 (en) * 2002-12-16 2004-07-22 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
CA2772050C (en) * 2002-12-26 2016-09-06 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US7887750B2 (en) * 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
US7776583B2 (en) 2004-06-03 2010-08-17 Meso Scale Technologies, Llc Methods and apparatuses for conducting assays
WO2007070093A2 (en) * 2005-12-09 2007-06-21 Flexible Medical Systems, Llc. Flexible apparatus and method for monitoring and delivery
KR101637140B1 (ko) 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US20060275852A1 (en) 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US20070081920A1 (en) * 2005-10-12 2007-04-12 Murphy R S Semi-disposable optoelectronic rapid diagnostic test system
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
WO2008044530A1 (en) * 2006-10-05 2008-04-17 Panasonic Corporation Multicomponent analysis sensor and method of measuring multiple components
US8506908B2 (en) * 2007-03-09 2013-08-13 Vantix Holdings Limited Electrochemical detection system
CA2700507C (en) 2007-09-24 2018-05-29 Bayer Healthcare Llc Multi-region and potential test sensors, methods, and systems
GB0820817D0 (en) * 2008-11-13 2008-12-24 Wireless Biodevices Ltd Electrode, electrochemical sensor and apparatus, and methods for operating the same
US9212995B2 (en) * 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
EP3586945A3 (en) * 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
ES2649559T3 (es) * 2009-11-23 2018-01-12 Cyvek, Inc. Método y aparato para realizar ensayos
EP4060325B1 (en) 2009-12-07 2024-08-21 Meso Scale Technologies, LLC. Assay cartridge reader
GB201014805D0 (en) * 2010-09-07 2010-10-20 Multi Sense Technologies Ltd Microfluidics based assay device
GB201102037D0 (en) * 2011-02-07 2011-03-23 Multi Sense Technologies Ltd Microfluidics based assay device
AU2012288554B2 (en) * 2011-07-22 2015-08-20 Biosensia Patents Limited Reader device for luminescent immunoassays
WO2013015822A1 (en) 2011-07-25 2013-01-31 Mikhail Briman Cartridge for diagnostic testing
US9772310B2 (en) * 2011-07-28 2017-09-26 Kyocera Corporation Biosensor
CN104081208A (zh) 2012-02-10 2014-10-01 美艾利尔瑞士公司 用于确定胰岛素抗性的化验和方法
US20150060272A1 (en) 2013-03-15 2015-03-05 Nanomix, Inc. Amperometric detection of limulus amebocyte lysate activation by endotoxin and/or 1-3-beta-d-glucan
US9458488B2 (en) 2013-03-15 2016-10-04 Nanomix, Inc. Point of care sensor systems

Also Published As

Publication number Publication date
US20200232981A1 (en) 2020-07-23
CN109991296B (zh) 2021-10-15
US10520501B2 (en) 2019-12-31
CN113758980A (zh) 2021-12-07
CN109991296A (zh) 2019-07-09
EP2967451A1 (en) 2016-01-20
US20170153230A1 (en) 2017-06-01
CN105163661B (zh) 2019-01-22
WO2014144660A1 (en) 2014-09-18
EP2967451B1 (en) 2019-05-15
US11965883B2 (en) 2024-04-23
US20140273187A1 (en) 2014-09-18
US9458488B2 (en) 2016-10-04
JP2016512339A (ja) 2016-04-25
EP2967451A4 (en) 2016-09-14
CN105163661A (zh) 2015-12-16

Similar Documents

Publication Publication Date Title
JP6478333B2 (ja) ポイント・オブ・ケア・センサ・システムのためのカートリッジ、および当該システムにより分析物を検出する方法
US10261047B2 (en) Cartridge for diagnostic testing
AU2019401601B2 (en) Handheld impedance-based diagnostic test system for detecting analytes
CN112782393B (zh) 用于检测和量化分析物的系统和方法
JP5127878B2 (ja) アッセイカートリッジ及び同アッセイカートリッジを用いた方法
JP4461393B2 (ja) 改善した試料クロージャを有する免疫測定装置
JP4891079B2 (ja) 免疫参照電極を有する免疫測定装置
KR20220075375A (ko) 폴리뉴클레오티드-함유 샘플들의 향상된 증폭을 위한 미세유체 카트리지
KR20190066037A (ko) 샘플을 테스트하기 위한 분석 시스템 및 방법
RU2839388C1 (ru) Микрофлюидные картриджи для повышенной амплификации полинуклеотидсодержащих проб
HK40064466A (en) Handheld impedance-based diagnostic test system for detecting analytes

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170314

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170314

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180227

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180525

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180727

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180823

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190108

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190201

R150 Certificate of patent or registration of utility model

Ref document number: 6478333

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees