JP6468611B2 - キナーゼ阻害のためのヘテロアリール化合物 - Google Patents

キナーゼ阻害のためのヘテロアリール化合物 Download PDF

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JP6468611B2
JP6468611B2 JP2016567502A JP2016567502A JP6468611B2 JP 6468611 B2 JP6468611 B2 JP 6468611B2 JP 2016567502 A JP2016567502 A JP 2016567502A JP 2016567502 A JP2016567502 A JP 2016567502A JP 6468611 B2 JP6468611 B2 JP 6468611B2
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amino
alkyl
methyl
compound
dihydro
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JP2016567502A
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JP2017518282A5 (cg-RX-API-DMAC7.html
JP2017518282A (ja
Inventor
ウェイ−シェン フアン，
ウェイ−シェン フアン，
フェン リ，
フェン リ，
デイビッド シー． ダルガルノ，
デイビッド シー． ダルガルノ，
ヨンジン ゴン，
ヨンジン ゴン，
アレクシー ブイ． イシュチェンコ，
アレクシー ブイ． イシュチェンコ，
アナ コールマン，
アナ コールマン，
ウィリアム シー． シェイクスピア，
ウィリアム シー． シェイクスピア，
アンジェラ ブイ． ウエスト，
アンジェラ ブイ． ウエスト，
ヨンジン シュー，
ヨンジン シュー，
ウィルメン ヤングセイ，
ウィルメン ヤングセイ，
ユン ザン，
ユン ザン，
ティアンジュン ゾウ，
ティアンジュン ゾウ，
シャオティアン ズー，
シャオティアン ズー，
Original Assignee
アリアド ファーマシューティカルズ， インコーポレイテッド
アリアド ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2016567502A 2014-05-13 2015-05-13 キナーゼ阻害のためのヘテロアリール化合物 Expired - Fee Related JP6468611B2 (ja)

Applications Claiming Priority (3)

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US201461992742P 2014-05-13 2014-05-13
US61/992,742 2014-05-13
PCT/US2015/030522 WO2015175632A1 (en) 2014-05-13 2015-05-13 Heteroaryl compounds for kinase inhibition

Publications (3)

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JP2017518282A JP2017518282A (ja) 2017-07-06
JP2017518282A5 JP2017518282A5 (cg-RX-API-DMAC7.html) 2018-06-21
JP6468611B2 true JP6468611B2 (ja) 2019-02-13

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US (1) US20170166598A1 (cg-RX-API-DMAC7.html)
EP (1) EP3143015B1 (cg-RX-API-DMAC7.html)
JP (1) JP6468611B2 (cg-RX-API-DMAC7.html)
CN (1) CN106687457B (cg-RX-API-DMAC7.html)
WO (1) WO2015175632A1 (cg-RX-API-DMAC7.html)

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Publication number Publication date
CN106687457B (zh) 2020-01-10
EP3143015A4 (en) 2017-11-01
EP3143015B1 (en) 2019-02-20
EP3143015A1 (en) 2017-03-22
CN106687457A (zh) 2017-05-17
US20170166598A1 (en) 2017-06-15
JP2017518282A (ja) 2017-07-06
WO2015175632A1 (en) 2015-11-19

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