JP6460991B2 - 抗菌剤として使用するための三環式ジャイレース阻害剤 - Google Patents
抗菌剤として使用するための三環式ジャイレース阻害剤 Download PDFInfo
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- JP6460991B2 JP6460991B2 JP2015532025A JP2015532025A JP6460991B2 JP 6460991 B2 JP6460991 B2 JP 6460991B2 JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015532025 A JP2015532025 A JP 2015532025A JP 6460991 B2 JP6460991 B2 JP 6460991B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700159P | 2012-09-12 | 2012-09-12 | |
| US61/700,159 | 2012-09-12 | ||
| PCT/US2013/059310 WO2014043272A1 (en) | 2012-09-12 | 2013-09-11 | Tricyclic gyrase inhibitors for use as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528502A JP2015528502A (ja) | 2015-09-28 |
| JP2015528502A5 JP2015528502A5 (https=) | 2016-11-04 |
| JP6460991B2 true JP6460991B2 (ja) | 2019-01-30 |
Family
ID=49226575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532025A Active JP6460991B2 (ja) | 2012-09-12 | 2013-09-11 | 抗菌剤として使用するための三環式ジャイレース阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10865216B2 (https=) |
| EP (1) | EP2895488B1 (https=) |
| JP (1) | JP6460991B2 (https=) |
| CN (1) | CN105189505B (https=) |
| AR (1) | AR092538A1 (https=) |
| TW (1) | TWI639602B (https=) |
| WO (1) | WO2014043272A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2617339T3 (es) | 2010-12-16 | 2017-06-16 | Calchan Limited | Derivados de pirrolopirimidina inhibidores de ASK1 |
| EP2686320B1 (en) * | 2011-03-15 | 2016-05-18 | Merck Sharp & Dohme Corp. | Tricyclic gyrase inhibitors |
| CN105899511B (zh) * | 2013-09-11 | 2019-06-07 | 默沙东公司 | 三环促旋酶抑制剂 |
| WO2016067009A1 (en) * | 2014-10-28 | 2016-05-06 | Redx Pharma Plc | Compounds with activity against bacteria and mycobacteria |
| WO2017205977A1 (en) | 2016-06-01 | 2017-12-07 | Universite De Montreal | Selection of human hematopoetic stem cells using epcr |
| CN106588731B (zh) * | 2016-12-08 | 2018-06-29 | 河北桑迪亚医药技术有限责任公司 | 环丙基二苯基锍三氟甲磺酸盐的合成方法 |
| CA3057431A1 (en) | 2017-03-24 | 2018-09-27 | Taisho Pharmaceutical Co., Ltd. | 2(1h)-quinolinone derivative |
| CN110475777B (zh) | 2017-03-30 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物 |
| HRP20220790T1 (hr) | 2017-05-04 | 2022-09-16 | Bayer Cropscience Aktiengesellschaft | Derivati 2-{[2-(feniloksimetil)piridin-5-il]oksi}etanamina i srodni spojevi kao pesticidi, primjerice namijenjeni zaštiti bilja |
| WO2018226976A1 (en) * | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
| EP3684361A4 (en) | 2017-09-20 | 2021-09-08 | Kura Oncology, Inc. | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHOD OF USING |
| CN112135618A (zh) | 2018-02-20 | 2020-12-25 | 蒙特利尔大学 | 体内介导免疫应答的nk和dc细胞的扩增 |
| WO2020064661A1 (en) * | 2018-09-26 | 2020-04-02 | F. Hoffmann-La Roche Ag | Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| WO2020127624A1 (en) * | 2018-12-20 | 2020-06-25 | F. Hoffmann-La Roche Ag | Oxopyrido[1,2-a]pyrimidine compounds for the treatment and prophylaxis of bacterial infection |
| WO2020225077A1 (en) * | 2019-05-03 | 2020-11-12 | Idorsia Pharmaceuticals Ltd | Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors |
| UA129778C2 (uk) | 2019-10-28 | 2025-07-30 | Мерк Шарп Енд Доум Елелсі | Низькомолекулярні інгібітори g12c-мутантного kras |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| KR20220146458A (ko) | 2020-01-23 | 2022-11-01 | 마이오포르테 테라퓨틱스 인코포레이티드 | Pgdh 억제제 및 그의 제조 및 사용 방법 |
| CN112552222B (zh) * | 2020-12-18 | 2022-08-23 | 南通药明康德医药科技有限公司 | 一种2-(2-(叔-丁氧羰基)-2-氮杂螺[3.4]辛烷-5-基)乙酸的制备方法 |
| CN112574085A (zh) * | 2020-12-18 | 2021-03-30 | 南通药明康德医药科技有限公司 | 一种5-氨基-2-氮杂螺[3.4]辛烷-2-羧酸叔丁酯的制备方法 |
| CN114763357B (zh) * | 2021-01-15 | 2024-06-18 | 中国科学院上海药物研究所 | 吲哚并嘧啶三环类化合物及其制备方法和用途 |
| CN113372352B (zh) * | 2021-06-10 | 2022-08-26 | 青岛农业大学 | 吲哚3,4位并九元中环化合物及其制备方法 |
| KR20250073215A (ko) * | 2022-09-21 | 2025-05-27 | 브리스톨-마이어스 스큅 컴퍼니 | tert-부틸 (2-아자비시클로[2.2.1]헵탄-4-일)카르바메이트 및 관련 화합물을 제조하는 방법 |
| WO2024103010A1 (en) * | 2022-11-11 | 2024-05-16 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| EP4709371A1 (en) * | 2023-05-09 | 2026-03-18 | Merck Sharp & Dohme LLC | Small molecule inhibitors of kras g12d mutant |
| AU2024361909A1 (en) | 2023-10-20 | 2026-03-26 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2025240742A1 (en) * | 2024-05-15 | 2025-11-20 | Merck Sharp & Dohme Llc | Protein degraders of kras g12d mutant |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN157280B (https=) | 1983-07-15 | 1986-02-22 | Hoechst India | |
| DE4030059A1 (de) | 1990-09-22 | 1992-03-26 | Bayer Ag | Verfahren zur herstellung von 5-hydroxy-3,4,5,6-tetrahydro-pyrimidin-derivaten |
| DE4032560A1 (de) | 1990-10-13 | 1992-04-16 | Bayer Ag | 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate |
| US5279359A (en) | 1992-06-26 | 1994-01-18 | Erickson Donald C | Rotary trisorption heat pump |
| US5527910A (en) | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
| SK10572002A3 (sk) | 2000-01-24 | 2003-10-07 | Warner-Lambert Company | 3-Aminochinazolín-2,4-diónové antibakteriálne činidlá |
| US20080051414A1 (en) | 2003-10-14 | 2008-02-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| JP4845736B2 (ja) * | 2003-10-14 | 2011-12-28 | アリゾナ ボード オブ リージェンツ オン ビハーフ ザ ユニバーシティー オブ アリゾナ | プロテインキナーゼ阻害剤 |
| US20090143399A1 (en) | 2003-10-14 | 2009-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US7776855B2 (en) | 2006-07-27 | 2010-08-17 | Janssen Pharmaceutica N.V. | Antimicrobial oxazolidinone prodrugs |
| US9481675B2 (en) * | 2009-09-11 | 2016-11-01 | Merck Sharp & Dohme Corp. | Gyrase inhibitors |
| EP2686320B1 (en) * | 2011-03-15 | 2016-05-18 | Merck Sharp & Dohme Corp. | Tricyclic gyrase inhibitors |
| CN105899511B (zh) * | 2013-09-11 | 2019-06-07 | 默沙东公司 | 三环促旋酶抑制剂 |
-
2013
- 2013-09-11 CN CN201380058803.6A patent/CN105189505B/zh active Active
- 2013-09-11 JP JP2015532025A patent/JP6460991B2/ja active Active
- 2013-09-11 US US14/427,611 patent/US10865216B2/en active Active
- 2013-09-11 EP EP13765905.8A patent/EP2895488B1/en active Active
- 2013-09-11 WO PCT/US2013/059310 patent/WO2014043272A1/en not_active Ceased
- 2013-09-11 TW TW102132841A patent/TWI639602B/zh active
- 2013-09-12 AR ARP130103259A patent/AR092538A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN105189505B (zh) | 2019-03-22 |
| CN105189505A (zh) | 2015-12-23 |
| TWI639602B (zh) | 2018-11-01 |
| EP2895488A1 (en) | 2015-07-22 |
| AR092538A1 (es) | 2015-04-22 |
| WO2014043272A1 (en) | 2014-03-20 |
| TW201425314A (zh) | 2014-07-01 |
| JP2015528502A (ja) | 2015-09-28 |
| EP2895488B1 (en) | 2024-12-11 |
| US10865216B2 (en) | 2020-12-15 |
| US20150246934A1 (en) | 2015-09-03 |
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