JP6449822B2 - 歯の状態を処置するための組成物および方法 - Google Patents
歯の状態を処置するための組成物および方法 Download PDFInfo
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- JP6449822B2 JP6449822B2 JP2016161421A JP2016161421A JP6449822B2 JP 6449822 B2 JP6449822 B2 JP 6449822B2 JP 2016161421 A JP2016161421 A JP 2016161421A JP 2016161421 A JP2016161421 A JP 2016161421A JP 6449822 B2 JP6449822 B2 JP 6449822B2
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Description
本願は、2011年12月13日に出願された米国仮出願第61/570,121号に対する優先権を主張し、該仮出願は引用により本明細書中に組み込まれる。
本発明は、動物における歯の状態、特にコンパニオンアニマルにおける歯の状態を処置または緩和するのに有用な方法および組成物に関する。
実質的に、家庭向けのコンパニオンアニマル、例えばイヌ科の動物およびネコ科の動物のコンパニオンアニマル、ならびに多くの他の動物は歯牙プラークおよび歯石(calculus)(タータ(tartar))を蓄積する。これらの蓄積は、歯肉炎による動物の苦痛をもたらし、それは、典型的には歯周炎に進行し、次いで、重篤な全身性疾患および状態に至る。これらの歯の状態に苦しむ動物はまた、一般に口臭および口内炎に苦しむ。
本明細書では、動物における歯の状態を処置または緩和する方法であって、該処置または緩和の必要のある動物に、少なくとも0.8%の乳酸を含有する組成物の有効量を与えることを含む方法を提供する。特定の実施形態において、歯の状態は、歯牙プラーク、歯石、歯の汚れ、口臭、口内炎、歯肉炎、歯周炎およびそれらの組合せからなる群より選択される。
実施例1:ネコ科動物(ネコ)における歯牙プラーク、歯石および汚れに関する乳酸阻害:12ヶ月の食餌(Feeding)試験
本試験は、ネコにおける経口のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)に対する乳酸の効果を評価するために設計された。最初に、すべてのネコは、標準的な広く確立された手順を用いた専門の歯科予防をベースラインに受けた。6ヶ月および12ヵ月後に、歯のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)を、Logan−Boyce定量法(Logan EI, Boyce. Oral health assessment in dogs: parameters and methods. J. Vet Dent; 11(2):58-63.を参照のこと)を用いて定量した。
本試験は、イヌにおける口腔サブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)に対する乳酸の効果を評価するように設計された。最初に、すべてのイヌは、一般的な広く確立された手順を用いた専門の歯科予防をベースラインに受けた。28日後に、歯のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)を、上記で参照し説明したLogan−Boyce定量法を用いて定量化した。
本試験は、口腔サブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)に対する食餌の乳酸の効果を評価し、細菌の形跡(evidence)を実際に示すように設計された。高および低歯牙プラーク形成が試験群と対照群間に均一に割り当てられたことを保証するために、試験の前に、較正試験を行った。最初に、すべての猫は、標準的な広く確立された手順を用いた専門の歯科予防をこの較正ベースラインに受けた。28日後に、歯のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)を、上記で参照し説明したLogan−Boyce定量法を用いて定量化した。ネコは、次いで歯牙プラーク蓄積に基づいて試験群または対照群に割り当てた。1つの対照群(乳酸サプリメントを含まない食べ物を与える)および2つの試験群(乳酸サプリメントを含む食べ物を与える)を用い、各群は15匹のネコを含んだ。
Claims (12)
- 歯牙プラーク、歯石、歯の汚れ、口臭、口内炎、歯肉炎、歯周炎およびそれらの組合せからなる群より選択される、動物における歯の症状の防止における乳酸の使用であって、
前記動物はイヌ科の動物またはネコ科の動物であり、
乳酸は1.0〜1.5重量%で乾燥組成物に含有され、
前記組成物は、栄養上完全なコンパニオンアニマル・ペットフード組成物であり、10%〜50%のタンパク質、4%〜25%の脂肪、20%〜70%の炭水化物および4%〜20%の粗繊維を含み、かつ抗菌脂質を含まず、
前記使用は、乳酸を含む前記組成物を、食物摂取の成分として、前記動物に食餌することを含む使用。 - 前記組成物は、乳酸を1.0〜1.2重量%又は1.1〜1.5重量%で含む請求項1に記載の乳酸の使用。
- 歯の症状が歯牙プラークである請求項1又は2の乳酸の使用。
- 歯の症状が歯石である請求項1又は2の乳酸の使用。
- 歯の症状が歯の汚れである請求項1又は2の乳酸の使用。
- 歯の症状が歯肉炎である請求項1又は2の乳酸の使用。
- 歯の症状が歯周炎である請求項1又は2の乳酸の使用。
- 前記組成物が、少なくとも1つの酸化防止剤をさらに含み、該酸化防止剤は、ビタミンC、ビタミンE、ビタミンA、リポ酸、アスタキサンチン、ベータ−カロチン、L−カルニチン、コエンザイムQ10、グルタチオン、リコピン、ルテイン、N−アセチルシステイン、大豆イソフラボン、S−アデノシルメチオニン、タウリン、トコトリエノール、ホウレンソウ、トマト、柑橘果実、ブドウ、ニンジン、ブロッコリー、緑茶、イチョウ葉エキス、トウモロコシ・グルテン・ミール、米ぬか、海草、クルクミン、魚油、果実、野菜、酵母、カロチノイド、フラボノイド、ポリフェノール及びそれらの混合物からなる群より選択される請求項1〜7のいずれか1つに記載の乳酸の使用。
- 前記動物は、少なくとも1ヶ月、少なくとも2ヶ月または少なくとも3ヶ月間、前記組成物を食餌される請求項1〜8のいずれか1つに記載の乳酸の使用。
- 前記組成物が、
30%〜40%のタンパク質、15%〜25%の脂肪、25%〜35%の炭水化物および5%〜10%の粗繊維、または
20%〜30%のタンパク質、8%〜12%の脂肪、40%〜60%の炭水化物および10%〜14%の粗繊維の1つを含む請求項1〜9のいずれか1つに記載の乳酸の使用。 - 前記組成物が、1.1%の乳酸、33%のタンパク質、30%の炭水化物、20%の脂肪および8%の粗繊維を含む請求項1〜10のいずれか1つに記載の乳酸の使用。
- 前記組成物が、1.5%の乳酸、25%のタンパク質、50%の炭水化物、10%の脂肪および12%の粗繊維を含む請求項1〜10のいずれか1つに記載の乳酸の使用。
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