JP2017000161A - 歯の状態を処置するための組成物および方法 - Google Patents
歯の状態を処置するための組成物および方法 Download PDFInfo
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- JP2017000161A JP2017000161A JP2016161421A JP2016161421A JP2017000161A JP 2017000161 A JP2017000161 A JP 2017000161A JP 2016161421 A JP2016161421 A JP 2016161421A JP 2016161421 A JP2016161421 A JP 2016161421A JP 2017000161 A JP2017000161 A JP 2017000161A
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Abstract
Description
本願は、2011年12月13日に出願された米国仮出願第61/570,121号に対する優先権を主張し、該仮出願は引用により本明細書中に組み込まれる。
本発明は、動物における歯の状態、特にコンパニオンアニマルにおける歯の状態を処置または緩和するのに有用な方法および組成物に関する。
実質的に、家庭向けのコンパニオンアニマル、例えばイヌ科の動物およびネコ科の動物のコンパニオンアニマル、ならびに多くの他の動物は歯牙プラークおよび歯石(calculus)(タータ(tartar))を蓄積する。これらの蓄積は、歯肉炎による動物の苦痛をもたらし、それは、典型的には歯周炎に進行し、次いで、重篤な全身性疾患および状態に至る。これらの歯の状態に苦しむ動物はまた、一般に口臭および口内炎に苦しむ。
本明細書では、動物における歯の状態を処置または緩和する方法であって、該処置または緩和の必要のある動物に、少なくとも0.8%の乳酸を含有する組成物の有効量を与えることを含む方法を提供する。特定の実施形態において、歯の状態は、歯牙プラーク、歯石、歯の汚れ、口臭、口内炎、歯肉炎、歯周炎およびそれらの組合せからなる群より選択される。
実施例1:ネコ科動物(ネコ)における歯牙プラーク、歯石および汚れに関する乳酸阻害:12ヶ月の食餌(Feeding)試験
本試験は、ネコにおける経口のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)に対する乳酸の効果を評価するために設計された。最初に、すべてのネコは、標準的な広く確立された手順を用いた専門の歯科予防をベースラインに受けた。6ヶ月および12ヵ月後に、歯のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)を、Logan−Boyce定量法(Logan EI, Boyce. Oral health assessment in dogs: parameters and methods. J. Vet Dent; 11(2):58-63.を参照のこと)を用いて定量した。
本試験は、イヌにおける口腔サブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)に対する乳酸の効果を評価するように設計された。最初に、すべてのイヌは、一般的な広く確立された手順を用いた専門の歯科予防をベースラインに受けた。28日後に、歯のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)を、上記で参照し説明したLogan−Boyce定量法を用いて定量化した。
本試験は、口腔サブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)に対する食餌の乳酸の効果を評価し、細菌の形跡(evidence)を実際に示すように設計された。高および低歯牙プラーク形成が試験群と対照群間に均一に割り当てられたことを保証するために、試験の前に、較正試験を行った。最初に、すべての猫は、標準的な広く確立された手順を用いた専門の歯科予防をこの較正ベースラインに受けた。28日後に、歯のサブストレート蓄積(歯牙プラーク、歯石および歯の汚れ)を、上記で参照し説明したLogan−Boyce定量法を用いて定量化した。ネコは、次いで歯牙プラーク蓄積に基づいて試験群または対照群に割り当てた。1つの対照群(乳酸サプリメントを含まない食べ物を与える)および2つの試験群(乳酸サプリメントを含む食べ物を与える)を用い、各群は15匹のネコを含んだ。
Claims (1)
- 歯垢、歯石、歯の汚れ、口臭、口内炎、歯肉炎、歯周炎およびそれらの組合せからなる群より選択される、非ヒト動物における歯の状態を処置または緩和する方法であって、
該処置または緩和の必要のある非ヒト動物に、0.8重量%〜1.5重量%の量で乳酸を含有するフード組成物の有効量を与えることを含む方法。
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