JP6449777B2 - 抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法 - Google Patents

抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法 Download PDF

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JP6449777B2
JP6449777B2 JP2015549834A JP2015549834A JP6449777B2 JP 6449777 B2 JP6449777 B2 JP 6449777B2 JP 2015549834 A JP2015549834 A JP 2015549834A JP 2015549834 A JP2015549834 A JP 2015549834A JP 6449777 B2 JP6449777 B2 JP 6449777B2
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antibody
seq
cdr
amino acid
domain
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JP2016503067A5 (cg-RX-API-DMAC7.html
JP2016503067A (ja
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ティム ルイス，
ティム ルイス，
チェ−リュン ロー，
チェ−リュン ロー，
Original Assignee
シアトル ジェネティックス， インコーポレイテッド
シアトル ジェネティックス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015549834A 2012-12-21 2013-12-20 抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法 Expired - Fee Related JP6449777B2 (ja)

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US201261745239P 2012-12-21 2012-12-21
US61/745,239 2012-12-21
PCT/US2013/077264 WO2014100740A1 (en) 2012-12-21 2013-12-20 Anti-ntb-a antibodies and related compositions and methods

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JP2016503067A JP2016503067A (ja) 2016-02-01
JP2016503067A5 JP2016503067A5 (cg-RX-API-DMAC7.html) 2017-01-12
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JP2018203019A Expired - Fee Related JP6817674B2 (ja) 2012-12-21 2018-10-29 抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法
JP2019238780A Withdrawn JP2020055870A (ja) 2012-12-21 2019-12-27 抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法
JP2022038055A Withdrawn JP2022066565A (ja) 2012-12-21 2022-03-11 抗ｎｔｂ－ａ抗体ならびに関連する組成物および方法

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JP2019238780A Withdrawn JP2020055870A (ja) 2012-12-21 2019-12-27 抗ｎｔｂ−ａ抗体ならびに関連する組成物および方法
JP2022038055A Withdrawn JP2022066565A (ja) 2012-12-21 2022-03-11 抗ｎｔｂ－ａ抗体ならびに関連する組成物および方法

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US (4) US9708404B2 (cg-RX-API-DMAC7.html)
EP (1) EP2934585B1 (cg-RX-API-DMAC7.html)
JP (4) JP6449777B2 (cg-RX-API-DMAC7.html)
CN (2) CN105188749B (cg-RX-API-DMAC7.html)
AU (1) AU2013364043B2 (cg-RX-API-DMAC7.html)
CA (1) CA2893977C (cg-RX-API-DMAC7.html)
EA (1) EA031025B1 (cg-RX-API-DMAC7.html)
HK (1) HK1216850A1 (cg-RX-API-DMAC7.html)
IL (2) IL239211B (cg-RX-API-DMAC7.html)
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CA2893977A1 (en) 2014-06-26
HK1216850A1 (zh) 2016-12-09
EA201591191A1 (ru) 2015-11-30
IL271305A (en) 2020-01-30
CN105188749B (zh) 2017-12-19
CN107880126A (zh) 2018-04-06
AU2013364043A1 (en) 2015-06-18
US10435468B2 (en) 2019-10-08
EP2934585A4 (en) 2016-07-13
JP6817674B2 (ja) 2021-01-20
WO2014100740A1 (en) 2014-06-26
EP2934585A1 (en) 2015-10-28
US9708404B2 (en) 2017-07-18
EA031025B1 (ru) 2018-11-30
IL271305B (en) 2021-01-31
IL239211B (en) 2020-08-31
CN105188749A (zh) 2015-12-23
US20170320944A1 (en) 2017-11-09
JP2022066565A (ja) 2022-04-28
EP2934585B1 (en) 2018-06-13
US20150376276A1 (en) 2015-12-31
IL239211A0 (en) 2015-07-30
JP2020055870A (ja) 2020-04-09
US20190375841A1 (en) 2019-12-12
CN107880126B (zh) 2021-03-30
JP2019014752A (ja) 2019-01-31
CA2893977C (en) 2024-02-13
US20230105802A1 (en) 2023-04-06
JP2016503067A (ja) 2016-02-01
AU2013364043B2 (en) 2018-01-04

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