JP6445046B2 - １，１’−（１，６−ジオキソ−１，６−ヘキサンジイル）ビス−ｄ−プロリンのプロドラッグ - Google Patents

１，１’−（１，６−ジオキソ−１，６−ヘキサンジイル）ビス−ｄ−プロリンのプロドラッグ Download PDF

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Publication number
JP6445046B2
JP6445046B2 JP2016565212A JP2016565212A JP6445046B2 JP 6445046 B2 JP6445046 B2 JP 6445046B2 JP 2016565212 A JP2016565212 A JP 2016565212A JP 2016565212 A JP2016565212 A JP 2016565212A JP 6445046 B2 JP6445046 B2 JP 6445046B2
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Japan
Prior art keywords
sap
compound
disease
formula
amyloidosis
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JP2016565212A
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English (en)
Japanese (ja)
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JP2017514829A (ja
JP2017514829A5 (enExample
Inventor
アレクシ、ドニ
オリビエ、ミルゲ
ジェローム、トゥム
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2016565212A 2014-04-29 2015-04-27 １，１’−（１，６−ジオキソ−１，６−ヘキサンジイル）ビス−ｄ−プロリンのプロドラッグ Expired - Fee Related JP6445046B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1407506.3 2014-04-29
GBGB1407506.3A GB201407506D0 (en) 2014-04-29 2014-04-29 Novel compound
PCT/EP2015/058998 WO2015165833A1 (en) 2014-04-29 2015-04-27 A prodrug of 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-d-proline

Publications (3)

Publication Number Publication Date
JP2017514829A JP2017514829A (ja) 2017-06-08
JP2017514829A5 JP2017514829A5 (enExample) 2018-06-14
JP6445046B2 true JP6445046B2 (ja) 2018-12-26

Family

ID=50972033

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016565212A Expired - Fee Related JP6445046B2 (ja) 2014-04-29 2015-04-27 １，１’−（１，６−ジオキソ−１，６−ヘキサンジイル）ビス−ｄ−プロリンのプロドラッグ

Country Status (26)

Country Link
US (3) US9701668B2 (enExample)
EP (1) EP3137457B1 (enExample)
JP (1) JP6445046B2 (enExample)
KR (1) KR20160145617A (enExample)
CN (1) CN106459016B (enExample)
AR (1) AR100204A1 (enExample)
AU (1) AU2015252184B2 (enExample)
BR (1) BR112016025129A2 (enExample)
CA (1) CA2947060C (enExample)
CL (1) CL2016002721A1 (enExample)
CR (1) CR20160508A (enExample)
DO (1) DOP2016000292A (enExample)
EA (1) EA032129B1 (enExample)
ES (1) ES2731253T3 (enExample)
GB (1) GB201407506D0 (enExample)
IL (2) IL248249A0 (enExample)
MA (1) MA39406B1 (enExample)
MX (1) MX2016014246A (enExample)
MY (1) MY191088A (enExample)
PE (1) PE20161558A1 (enExample)
PH (1) PH12016502006B1 (enExample)
SG (1) SG11201608371RA (enExample)
TW (1) TWI676624B (enExample)
UA (1) UA119871C2 (enExample)
UY (1) UY36098A (enExample)
WO (1) WO2015165833A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9737505B2 (en) 2014-04-29 2017-08-22 Glaxosmithkline Intellectual Property Development Limited Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
GB201518950D0 (en) * 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound
GB202213162D0 (en) 2022-09-08 2022-10-26 Cambridge Entpr Ltd Prodrugs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2182203T3 (es) 1997-10-31 2003-03-01 Hoffmann La Roche Derivados de d-prolina.
US6903129B2 (en) * 2001-12-14 2005-06-07 Hoffman-La Roche Inc. D-proline prodrugs
JP2006526612A (ja) 2003-06-05 2006-11-24 ファイザー・プロダクツ・インク ベータ−ラクタマーゼ阻害剤・プロドラッグ
GB0313386D0 (en) 2003-06-10 2003-07-16 Univ London Treatment of disease
KR20080004571A (ko) 2005-04-12 2008-01-09 메이지 세이카 가부시키가이샤 2-티오에테닐 카바페넴 유도체
GB0712503D0 (en) 2007-06-27 2007-08-08 Therapeutics Pentraxin Ltd Use
UA108227C2 (xx) 2010-03-03 2015-04-10 Антигензв'язуючий білок
US9737505B2 (en) 2014-04-29 2017-08-22 Glaxosmithkline Intellectual Property Development Limited Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline

Also Published As

Publication number Publication date
TWI676624B (zh) 2019-11-11
WO2015165833A1 (en) 2015-11-05
CA2947060A1 (en) 2015-11-05
CN106459016A (zh) 2017-02-22
UA119871C2 (uk) 2019-08-27
US20180099955A1 (en) 2018-04-12
US20170267665A1 (en) 2017-09-21
CR20160508A (es) 2017-03-10
DOP2016000292A (es) 2017-11-15
IL279120A (en) 2021-01-31
ES2731253T3 (es) 2019-11-14
EA201692185A1 (ru) 2017-06-30
IL248249A0 (en) 2016-11-30
US9873686B2 (en) 2018-01-23
EP3137457B1 (en) 2019-04-17
US20160075694A1 (en) 2016-03-17
EP3137457A1 (en) 2017-03-08
AU2015252184B2 (en) 2017-11-02
MA39406B1 (fr) 2018-04-30
JP2017514829A (ja) 2017-06-08
GB201407506D0 (en) 2014-06-11
US10597385B2 (en) 2020-03-24
CL2016002721A1 (es) 2017-01-20
EA032129B1 (ru) 2019-04-30
BR112016025129A2 (pt) 2017-08-15
PH12016502006A1 (en) 2016-12-19
TW201625598A (zh) 2016-07-16
PE20161558A1 (es) 2017-01-06
UY36098A (es) 2015-11-30
MX2016014246A (es) 2017-02-06
AU2015252184A1 (en) 2016-10-27
AR100204A1 (es) 2016-09-21
US9701668B2 (en) 2017-07-11
KR20160145617A (ko) 2016-12-20
MA39406A1 (fr) 2017-07-31
CN106459016B (zh) 2019-11-01
MY191088A (en) 2022-05-30
CA2947060C (en) 2023-09-26
PH12016502006B1 (en) 2016-12-19
SG11201608371RA (en) 2016-11-29

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