MA39406A1 - Promédicament de la 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-d-proline - Google Patents

Promédicament de la 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-d-proline

Info

Publication number
MA39406A1
MA39406A1 MA39406A MA39406A MA39406A1 MA 39406 A1 MA39406 A1 MA 39406A1 MA 39406 A MA39406 A MA 39406A MA 39406 A MA39406 A MA 39406A MA 39406 A1 MA39406 A1 MA 39406A1
Authority
MA
Morocco
Prior art keywords
bis
hexanediyl
dioxo
prodrug
proline
Prior art date
Application number
MA39406A
Other languages
English (en)
Other versions
MA39406B1 (fr
Inventor
Alexis Denis
Olivier Mirguet
Jérôme Toum
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MA39406A1 publication Critical patent/MA39406A1/fr
Publication of MA39406B1 publication Critical patent/MA39406B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne le composé qu'est le (2r,2'r)-bis(((((tétrahydro-2h-pyran-4-yl)oxy)carbonyl)oxy)méthyl)1,1'-adipoylbis(pyrrolidine-2-carboxylate), des compositions pharmaceutiques en contenant et leur utilisation en vue du traitement de maladies ou de troubles dans lesquels la déplétion en composant p de l'amyloïde sérique (sap) serait bénéfique, cela comprenant l'amylose, la maladie d'alzheimer, le diabète de type 2 et l'arthrose.
MA39406A 2014-04-29 2015-04-27 Promédicament de la 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-d-proline MA39406B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1407506.3A GB201407506D0 (en) 2014-04-29 2014-04-29 Novel compound
PCT/EP2015/058998 WO2015165833A1 (fr) 2014-04-29 2015-04-27 Promédicament de la 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-d-proline

Publications (2)

Publication Number Publication Date
MA39406A1 true MA39406A1 (fr) 2017-07-31
MA39406B1 MA39406B1 (fr) 2018-04-30

Family

ID=50972033

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39406A MA39406B1 (fr) 2014-04-29 2015-04-27 Promédicament de la 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-d-proline

Country Status (26)

Country Link
US (3) US9701668B2 (fr)
EP (1) EP3137457B1 (fr)
JP (1) JP6445046B2 (fr)
KR (1) KR20160145617A (fr)
CN (1) CN106459016B (fr)
AR (1) AR100204A1 (fr)
AU (1) AU2015252184B2 (fr)
BR (1) BR112016025129A2 (fr)
CA (1) CA2947060C (fr)
CL (1) CL2016002721A1 (fr)
CR (1) CR20160508A (fr)
DO (1) DOP2016000292A (fr)
EA (1) EA032129B1 (fr)
ES (1) ES2731253T3 (fr)
GB (1) GB201407506D0 (fr)
IL (2) IL248249A0 (fr)
MA (1) MA39406B1 (fr)
MX (1) MX2016014246A (fr)
MY (1) MY191088A (fr)
PE (1) PE20161558A1 (fr)
PH (1) PH12016502006B1 (fr)
SG (1) SG11201608371RA (fr)
TW (1) TWI676624B (fr)
UA (1) UA119871C2 (fr)
UY (1) UY36098A (fr)
WO (1) WO2015165833A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9737505B2 (en) 2014-04-29 2017-08-22 Glaxosmithkline Intellectual Property Development Limited Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
GB201518950D0 (en) * 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound
GB202213162D0 (en) 2022-09-08 2022-10-26 Cambridge Entpr Ltd Prodrugs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE224366T1 (de) 1997-10-31 2002-10-15 Hoffmann La Roche D-prolinderivate
US6903129B2 (en) * 2001-12-14 2005-06-07 Hoffman-La Roche Inc. D-proline prodrugs
BRPI0410936A (pt) 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase
GB0313386D0 (en) 2003-06-10 2003-07-16 Univ London Treatment of disease
CA2604206A1 (fr) 2005-04-12 2006-10-19 Meiji Seika Kaisha, Ltd. Derives de carbapenem substitues par 2-thioethenyle
GB0712503D0 (en) 2007-06-27 2007-08-08 Therapeutics Pentraxin Ltd Use
UA108227C2 (xx) 2010-03-03 2015-04-10 Антигензв'язуючий білок
US9737505B2 (en) 2014-04-29 2017-08-22 Glaxosmithkline Intellectual Property Development Limited Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline

Also Published As

Publication number Publication date
GB201407506D0 (en) 2014-06-11
AR100204A1 (es) 2016-09-21
SG11201608371RA (en) 2016-11-29
MA39406B1 (fr) 2018-04-30
CR20160508A (es) 2017-03-10
IL279120A (en) 2021-01-31
JP6445046B2 (ja) 2018-12-26
TWI676624B (zh) 2019-11-11
PE20161558A1 (es) 2017-01-06
DOP2016000292A (es) 2017-11-15
CA2947060C (fr) 2023-09-26
US9873686B2 (en) 2018-01-23
CN106459016B (zh) 2019-11-01
UY36098A (es) 2015-11-30
AU2015252184A1 (en) 2016-10-27
AU2015252184B2 (en) 2017-11-02
IL248249A0 (en) 2016-11-30
KR20160145617A (ko) 2016-12-20
PH12016502006A1 (en) 2016-12-19
CN106459016A (zh) 2017-02-22
CL2016002721A1 (es) 2017-01-20
US10597385B2 (en) 2020-03-24
MX2016014246A (es) 2017-02-06
UA119871C2 (uk) 2019-08-27
WO2015165833A1 (fr) 2015-11-05
EP3137457A1 (fr) 2017-03-08
TW201625598A (zh) 2016-07-16
EA201692185A1 (ru) 2017-06-30
US9701668B2 (en) 2017-07-11
EP3137457B1 (fr) 2019-04-17
MY191088A (en) 2022-05-30
CA2947060A1 (fr) 2015-11-05
BR112016025129A2 (pt) 2017-08-15
US20170267665A1 (en) 2017-09-21
ES2731253T3 (es) 2019-11-14
PH12016502006B1 (en) 2016-12-19
US20160075694A1 (en) 2016-03-17
EA032129B1 (ru) 2019-04-30
JP2017514829A (ja) 2017-06-08
US20180099955A1 (en) 2018-04-12

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