JP6444857B2 - ファイバー無し透過反射型プローブを使用した分析物濃度の非侵襲測定 - Google Patents
ファイバー無し透過反射型プローブを使用した分析物濃度の非侵襲測定 Download PDFInfo
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- JP6444857B2 JP6444857B2 JP2015504720A JP2015504720A JP6444857B2 JP 6444857 B2 JP6444857 B2 JP 6444857B2 JP 2015504720 A JP2015504720 A JP 2015504720A JP 2015504720 A JP2015504720 A JP 2015504720A JP 6444857 B2 JP6444857 B2 JP 6444857B2
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Images
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Description
12、14 レーザーダイオード
16 LED
18 試料検出器、信号検出器
20 光学式透過反射型プローブ
21 リムーバブルメモリカード
22 測定部位
23 プロセッサ
24 レーザーコントローラモジュール
25 メモリ
26 線形アクチュエータ
27 画面
28 Optical Bridge信号
29 PC
30 検出器出力電圧
31 プリンタ
34 副放射線源
40 光学ロッド
42 光学ロッドの遠位端
44 検出窓の円形穴
45 光学ロッドの磨かれた外面
46 検出窓
49 検出窓の遠位面
50 テーパの付いた管状ハウジング
52 ハウジング内面
54 ハウジング遠位端
56 ハウジング近位端
60 ヒートシンク
62 位置決め板
Claims (22)
- 標的分析物の量を測定するために標的領域を非侵襲的に調べるための装置において、
異なった波長を有している少なくとも2つの反復する放射期間を含む組み合わされた電磁放射線ビームを生成するための源であって、前記波長の少なくとも2つは前記標的分析物について異なった吸収係数を有している、組み合わされた電磁放射線ビームを生成するための源と、
前記標的領域によって後方散乱した前記放射線の一部を検出するように配列されている検出器であって、前記2つの反復する放射期間の各期間における前記組み合わされたビームの検出強度に比例する出力信号を生成する検出器と、
前記電磁放射線ビームを前記標的領域へ方向付けるとともに前記後方散乱放射線を前記検出器へ導くためのファイバー無し透過反射型プローブと、を備えており、
前記ファイバー無し透過反射型プローブは、内反射面を有して前記標的領域に近いほど小さくなるようにテーパの付いた管状ハウジングと、外反射面を有する円筒状光学ロッドと、前記電磁放射線ビームを前記標的領域へ透過させる検出窓と、を備えており、
前記管状ハウジングは、前記源の数に応じたファセット面を内面に有し、当該ファセット面は前記円筒状光学ロッドの周りに配置されており、
前記検出窓の前記標的領域に近い面である遠位面と、前記光学ロッドの前記標的領域に近い端部である遠位端とが整列されている、装置。 - 前記標的領域は流体を備えている、請求項1に記載の装置。
- 前記標的領域内の前記流体の量を制御するために当該標的領域を圧迫及び圧迫解除するための手段を更に備えている、請求項2に記載の装置。
- 前記標的領域を圧迫及び圧迫解除するための前記手段は制御可能な機械式デバイスである、請求項3に記載の装置。
- 測定中の前記試料マトリクス内の前記流体の量の推定を得るための手段を更に備えている、請求項2に記載の装置。
- 前記流体の量の推定を得るための前記手段は、前記流体の成分によって差別的に吸収される波長を有する放射線を前記標的領域目がけて方向付けるための源を備えている、請求項5に記載の装置。
- 前記放射線は緑色光である、請求項6に記載の装置。
- 前記標的領域内の前記流体の脈動の位相を測定するための手段を更に備えている、請求項2に記載の装置。
- 前記標的領域内の前記流体の脈動の位相を測定するための前記手段は、前記流体の成分によって差別的に吸収される波長を有する放射線を前記標的領域目がけて方向付けるための源を備えている、請求項8に記載の装置。
- 前記装置は、前記標的分析物の前記濃度を計算するための搭載プロセッサを備える手持ち式ユニットである、請求項1に記載の装置。
- グラフィックディスプレイ画面を更に備えている、請求項10に記載の装置。
- 再充電式バッテリを更に備えている、請求項10に記載の装置。
- ユーザー命令及び測定結果を記憶するためのメモリを更に備えている、請求項10に記載の装置。
- 前記メモリは参照データベースを備えている、請求項13に記載の装置。
- 前記手持ち式ユニットは無線通信リンクを使用して外部機器と通信している、請求項10に記載の装置。
- 前記円筒状光学ロッドは前記検出窓の中心に垂直に配置されている、請求項1に記載の装置。
- 前記流体は血液であり、前記測定される標的分析物は糖である、請求項2に記載の装置。
- 標的分析物の量を測定するために標的領域を非侵襲的に調べる方法において、
内反射面を有して前記標的領域に近いほど小さくなるようにテーパの付いた管状ハウジングと、検出窓と、前記検出窓に垂直に配置されている外反射面を有する光学ロッドと、を備えるファイバー無し透過反射型プローブを提供する段階と、
少なくとも2つの時分割成分から成る放射線ビームを生成するための2つの異なった波長で作動する少なくとも2つの光源を提供する段階と、
前記放射線ビームを、前記管状ハウジングの前記内面及び前記光学ロッドの前記外面で反射させることによって、前記検出窓を通じて標的領域へ透過させる段階と、
前記標的領域からの後方散乱ビームを、前記光学ロッドの内面で反射させることによって、前記検出器へ導く段階と、
前記後方散乱ビームを検出し前記標的領域による前記2つの波長の差分吸収を指し示す出力信号を発生させる検出器を提供する段階と、を備えており、
前記管状ハウジングは、前記源の数に応じたファセット面を内面に有し、当該ファセット面は前記光学ロッドの周りに配置されており、
前記検出窓の前記標的領域に近い面である遠位面と、前記光学ロッドの前記標的領域に近い端部である遠位端とが整列されている、方法。 - 前記差分吸収信号は前記標的分析物の濃度を計算するのに使用される、請求項18に記載の方法。
- 前記測定される分析物は糖である、請求項18に記載の方法。
- 前記2つの波長は1380nm及び1620nmである、請求項20に記載の方法。
- 前記2つの波長は1380+/−20nm及び1620+/−20nmである、請求項20に記載の方法。
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US13/441,467 US20130267799A1 (en) | 2012-04-06 | 2012-04-06 | Noninvasive measurement of analyte concentration using a fiberless transflectance probe |
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PCT/US2013/035250 WO2013152177A1 (en) | 2012-04-06 | 2013-04-04 | Noninvasive measurement of analyte concentration using a fiberless transflectance probe |
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GB201812766D0 (en) * | 2018-08-06 | 2018-09-19 | Res & Innovation Uk | Optical multi-pass cells |
US20210093252A1 (en) * | 2019-10-01 | 2021-04-01 | Avid Najdahmadi | Light-based medical device |
WO2021233560A1 (en) * | 2020-05-20 | 2021-11-25 | Diamontech Ag | Method and apparatus for analyte measurement including real-time quality assessment and improvement |
WO2021233561A1 (en) * | 2020-05-20 | 2021-11-25 | Diamontech Ag | Method and apparatus for analyzing a material with asymmetric or harmonic intensity modulation of excitation radiation |
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US3986777A (en) * | 1974-08-22 | 1976-10-19 | Weber Dental Mfg. Co., Div. Of Sterndent Corporation | Tristimulus colorimeter for use in the fabrication of artificial teeth |
US5183042A (en) | 1989-05-23 | 1993-02-02 | Vivascan Corporation | Electromagnetic method and apparatus to measure constituents of human or animal tissue |
US5137023A (en) | 1990-04-19 | 1992-08-11 | Worcester Polytechnic Institute | Method and apparatus for monitoring blood analytes noninvasively by pulsatile photoplethysmography |
US5112124A (en) | 1990-04-19 | 1992-05-12 | Worcester Polytechnic Institute | Method and apparatus for measuring the concentration of absorbing substances |
DE68902738T2 (de) | 1989-05-23 | 1993-01-28 | Biosensors Technology Inc | Verfahren zur bestimmung mittels strahlungsabsorption von substanzen in absorbierenden und streuenden matrixmaterialien. |
US5178142A (en) | 1989-05-23 | 1993-01-12 | Vivascan Corporation | Electromagnetic method and apparatus to measure constituents of human or animal tissue |
CA2112577C (en) * | 1991-07-03 | 2003-03-25 | Hannu Harjunmaa | Electromagnetic method and apparatus to measure constituents of human or animal tissue |
US5277181A (en) | 1991-12-12 | 1994-01-11 | Vivascan Corporation | Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis |
AU2245092A (en) | 1991-12-31 | 1993-07-28 | Vivascan Corporation | Blood constituent determination based on differential spectral analysis |
US5851178A (en) * | 1995-06-02 | 1998-12-22 | Ohmeda Inc. | Instrumented laser diode probe connector |
US6174424B1 (en) * | 1995-11-20 | 2001-01-16 | Cirrex Corp. | Couplers for optical fibers |
US5830137A (en) * | 1996-11-18 | 1998-11-03 | University Of South Florida | Green light pulse oximeter |
US6070093A (en) * | 1997-12-02 | 2000-05-30 | Abbott Laboratories | Multiplex sensor and method of use |
US8175666B2 (en) * | 2002-04-26 | 2012-05-08 | Grove Instruments, Inc. | Three diode optical bridge system |
US7003337B2 (en) * | 2002-04-26 | 2006-02-21 | Vivascan Corporation | Non-invasive substance concentration measurement using and optical bridge |
JP2004081427A (ja) * | 2002-08-26 | 2004-03-18 | Kenji Yoshikawa | 生体内水分測定装置 |
JP2004290545A (ja) * | 2003-03-28 | 2004-10-21 | Citizen Watch Co Ltd | 血液分析装置 |
WO2007028233A1 (en) * | 2005-09-06 | 2007-03-15 | Nir Diagnostics Inc. | Method and apparatus for measuring analytes |
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HK1201325A1 (en) | 2015-08-28 |
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IL234976A0 (en) | 2014-12-31 |
US20130267799A1 (en) | 2013-10-10 |
AU2013243441A1 (en) | 2014-10-30 |
CA2869607A1 (en) | 2013-10-10 |
WO2013152177A1 (en) | 2013-10-10 |
JP2015512326A (ja) | 2015-04-27 |
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EP2834620A1 (en) | 2015-02-11 |
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