JP6431538B2 - エストロゲン受容体ベータアイソフォームの選択的アゴニストとしての置換（４’−ヒドロキシフェニル）シクロアルカン化合物およびその使用 - Google Patents

エストロゲン受容体ベータアイソフォームの選択的アゴニストとしての置換（４’−ヒドロキシフェニル）シクロアルカン化合物およびその使用 Download PDF

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JP6431538B2
JP6431538B2 JP2016533043A JP2016533043A JP6431538B2 JP 6431538 B2 JP6431538 B2 JP 6431538B2 JP 2016533043 A JP2016533043 A JP 2016533043A JP 2016533043 A JP2016533043 A JP 2016533043A JP 6431538 B2 JP6431538 B2 JP 6431538B2
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compounds
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agonist
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JP2017504567A (ja
JP2017504567A5 (enExample
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ウィリアム エイ． ドナルドソン
ウィリアム エイ． ドナルドソン
ダニエル エス． セム
ダニエル エス． セム
テレンス エス． ニューマン
テレンス エス． ニューマン
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マーケット ユニバーシティー
マーケット ユニバーシティー
コンコーディア ユニバーシティー インコーポレイテッド
コンコーディア ユニバーシティー インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016533043A 2013-11-21 2014-11-21 エストロゲン受容体ベータアイソフォームの選択的アゴニストとしての置換（４’−ヒドロキシフェニル）シクロアルカン化合物およびその使用 Active JP6431538B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361963031P 2013-11-21 2013-11-21
US61/963,031 2013-11-21
PCT/US2014/066896 WO2015077611A1 (en) 2013-11-21 2014-11-21 Substituted (4'-hydroxyphenyl)cycloalkane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform

Publications (3)

Publication Number Publication Date
JP2017504567A JP2017504567A (ja) 2017-02-09
JP2017504567A5 JP2017504567A5 (enExample) 2017-06-08
JP6431538B2 true JP6431538B2 (ja) 2018-11-28

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JP2016533043A Active JP6431538B2 (ja) 2013-11-21 2014-11-21 エストロゲン受容体ベータアイソフォームの選択的アゴニストとしての置換（４’−ヒドロキシフェニル）シクロアルカン化合物およびその使用

Country Status (6)

Country Link
US (1) US10570077B2 (enExample)
EP (1) EP3071541B1 (enExample)
JP (1) JP6431538B2 (enExample)
AU (1) AU2014352830B2 (enExample)
CA (1) CA2931313C (enExample)
WO (1) WO2015077611A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210340155A1 (en) * 2017-03-30 2021-11-04 Marquette University Substituted (4-Hydroxyphenyl)Cycloalkane and (4-Hydroxyphenyl)Cycloalkene Compounds and Uses Thereof as Selective Agonists of the Estrogen Receptor Beta Isoform for Enhanced Memory Consolidation
CN112341320A (zh) * 2020-11-02 2021-02-09 烟台丰鲁精细化工有限责任公司 一种对（反式-4-羟基环己基）酚的新型合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1086530A (en) 1965-08-04 1967-10-11 Du Pont 4-phenyl and 4-substituted phenyl bicyclo[2,2,2]octane-amines
US3564060A (en) 1967-12-08 1971-02-16 Du Pont Pharmaceutically active derivatives of 4 - phenyl - bicyclo (2,2,2)octane and oct-2-ene-1-carbinols and carboxaldehydes
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6288050B1 (en) 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB9810862D0 (en) 1998-05-20 1998-07-22 Hoechst Schering Agrevo Gmbh Substitutedn pyridine and pyrimidines, processes for their preparation and their use as pesticides
EP1278716B1 (en) 2000-04-26 2006-08-23 Warner-Lambert Company LLC Trans-n-¬4-(4-hydroxyphenyl)cyclohexyl|-3-phenylpropionamide as subtype selective nmda receptor antagonist
JP5662803B2 (ja) * 2007-12-20 2015-02-04 アストラゼネカ アクチボラグ Ｄｇａｔ１阻害剤としてのカルバモイル化合物１９０
MX2010011408A (es) * 2008-04-16 2010-12-20 Karobio Ab Ligandos de receptor de estrogeno novedosos.
AU2010209545A1 (en) * 2009-01-28 2011-08-18 Sanofi Thiadiazole and oxadiazole derivatives, preparation thereof, and therapeutic use thereof
CN102482242B (zh) * 2009-09-03 2014-07-16 住友化学株式会社 二环氧化合物、其制造方法和含有该二环氧化合物的组合物
WO2012112364A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Lactam derivatives as dgat-1 inhibitors
WO2013119040A1 (en) * 2012-02-07 2013-08-15 Kainos Medicine, Inc. Compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme

Also Published As

Publication number Publication date
EP3071541A4 (en) 2017-07-19
CA2931313A1 (en) 2015-05-28
EP3071541B1 (en) 2023-06-07
US20160340279A1 (en) 2016-11-24
US10570077B2 (en) 2020-02-25
JP2017504567A (ja) 2017-02-09
EP3071541A1 (en) 2016-09-28
WO2015077611A1 (en) 2015-05-28
AU2014352830B2 (en) 2018-12-13
AU2014352830A1 (en) 2016-07-07
CA2931313C (en) 2022-04-05

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