JP6404213B2 - ホスホランバンのプロテインホスファターゼ１媒介の脱リン酸化抑制用デコイペプチド｛ＤｅｃｏｙＰｅｐｔｉｄｅｓＩｎｈｉｂｉｔｉｎｇＰｒｏｔｅｉｎＰｈｏｓｐｈａｔａｓｅ１−ＭｅｄｉａｔｅｄＤｅｐｈｏｓｐｈｏｒｙｌａｔｉｏｎｏｆＰｈｏｓｐｈｏｌａｍｂａｎ｝ - Google Patents

ホスホランバンのプロテインホスファターゼ１媒介の脱リン酸化抑制用デコイペプチド｛ＤｅｃｏｙＰｅｐｔｉｄｅｓＩｎｈｉｂｉｔｉｎｇＰｒｏｔｅｉｎＰｈｏｓｐｈａｔａｓｅ１−ＭｅｄｉａｔｅｄＤｅｐｈｏｓｐｈｏｒｙｌａｔｉｏｎｏｆＰｈｏｓｐｈｏｌａｍｂａｎ｝ Download PDF

Info

Publication number
JP6404213B2
JP6404213B2 JP2015520069A JP2015520069A JP6404213B2 JP 6404213 B2 JP6404213 B2 JP 6404213B2 JP 2015520069 A JP2015520069 A JP 2015520069A JP 2015520069 A JP2015520069 A JP 2015520069A JP 6404213 B2 JP6404213 B2 JP 6404213B2
Authority
JP
Japan
Prior art keywords
peptide
plb
polypeptide
amino acid
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015520069A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016500647A (ja
JP2016500647A5 (https=
Inventor
ジン パク・ウ
ジン パク・ウ
ロジャー・ジェイ・ハヤール
ギュン オ・ジェ
ギュン オ・ジェ
Original Assignee
グワンジュ インスティテュート オブ サイエンス アンド テクノロジー
グワンジュ インスティテュート オブ サイエンス アンド テクノロジー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グワンジュ インスティテュート オブ サイエンス アンド テクノロジー, グワンジュ インスティテュート オブ サイエンス アンド テクノロジー filed Critical グワンジュ インスティテュート オブ サイエンス アンド テクノロジー
Publication of JP2016500647A publication Critical patent/JP2016500647A/ja
Publication of JP2016500647A5 publication Critical patent/JP2016500647A5/ja
Application granted granted Critical
Publication of JP6404213B2 publication Critical patent/JP6404213B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2015520069A 2012-07-05 2013-07-05 ホスホランバンのプロテインホスファターゼ１媒介の脱リン酸化抑制用デコイペプチド｛ＤｅｃｏｙＰｅｐｔｉｄｅｓＩｎｈｉｂｉｔｉｎｇＰｒｏｔｅｉｎＰｈｏｓｐｈａｔａｓｅ１−ＭｅｄｉａｔｅｄＤｅｐｈｏｓｐｈｏｒｙｌａｔｉｏｎｏｆＰｈｏｓｐｈｏｌａｍｂａｎ｝ Active JP6404213B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261668034P 2012-07-05 2012-07-05
US61/668,034 2012-07-05
PCT/KR2013/006009 WO2014007584A1 (en) 2012-07-05 2013-07-05 Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban

Publications (3)

Publication Number Publication Date
JP2016500647A JP2016500647A (ja) 2016-01-14
JP2016500647A5 JP2016500647A5 (https=) 2016-04-21
JP6404213B2 true JP6404213B2 (ja) 2018-10-10

Family

ID=49882272

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015520069A Active JP6404213B2 (ja) 2012-07-05 2013-07-05 ホスホランバンのプロテインホスファターゼ１媒介の脱リン酸化抑制用デコイペプチド｛ＤｅｃｏｙＰｅｐｔｉｄｅｓＩｎｈｉｂｉｔｉｎｇＰｒｏｔｅｉｎＰｈｏｓｐｈａｔａｓｅ１−ＭｅｄｉａｔｅｄＤｅｐｈｏｓｐｈｏｒｙｌａｔｉｏｎｏｆＰｈｏｓｐｈｏｌａｍｂａｎ｝

Country Status (6)

Country Link
US (3) USRE48636E1 (https=)
EP (1) EP2870171B1 (https=)
JP (1) JP6404213B2 (https=)
KR (1) KR101516791B1 (https=)
ES (1) ES2639121T3 (https=)
WO (1) WO2014007584A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3530278A4 (en) * 2016-10-24 2019-10-30 Gwangju Institute of Science and Technology COMPOSITION WITH PROTEIN-PHOSPHATASE-1-INHIBITING PEPTIDE FOR THE TREATMENT OF VASCULAR DISEASES
KR20240173703A (ko) * 2023-06-05 2024-12-13 (주)벳바젠 포스포람반의 단백질 포스파타아제 1-매개 탈인산화 억제용　데코이 펩타이드를 암호화하는 뉴클레오타이드 및 ccn5 단백질 또는 이의 단편을 암호화하는 뉴클레오타이드를 포함하는 유전자 컨스트럭트 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025804A2 (en) * 1998-11-02 2000-05-11 The Regents Of The University Of California A method for inhibition of phospholamban activity for the treatment of cardiac disease and heart failure
US20040121942A1 (en) 1999-11-02 2004-06-24 Kenneth Chien Method for inhibition of phospholamban activity for the treatment of cardiac disease and heart failure
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
US20040214760A1 (en) * 2001-01-15 2004-10-28 Ramesh Gupta Inhibition pf protein-phosphatases for the treatment of heart failure
US7989606B2 (en) 2006-02-10 2011-08-02 The University Of Cincinnati Phosphatase inhibitor protein-1 as a regulator of cardiac function
WO2008137681A2 (en) 2007-05-02 2008-11-13 Intrexon Corporation Pp1 ligands
EP4012714A1 (en) * 2010-03-23 2022-06-15 Iogenetics, LLC. Bioinformatic processes for determination of peptide binding
US9046530B2 (en) * 2011-12-02 2015-06-02 Board Of Regents, The University Of Texas System Methods and compositions for chlamydial antigens as reagents for diagnosis of tubal factor infertility and chlamydial infection

Also Published As

Publication number Publication date
USRE48636E1 (en) 2021-07-13
JP2016500647A (ja) 2016-01-14
EP2870171B1 (en) 2017-06-28
ES2639121T3 (es) 2017-10-25
EP2870171A4 (en) 2015-05-13
US10479816B2 (en) 2019-11-19
KR20140010889A (ko) 2014-01-27
EP2870171A1 (en) 2015-05-13
US20190112338A1 (en) 2019-04-18
KR101516791B1 (ko) 2015-05-04
US20150166603A1 (en) 2015-06-18
US10208085B2 (en) 2019-02-19
WO2014007584A1 (en) 2014-01-09

Similar Documents

Publication Publication Date Title
US7902154B2 (en) Pharmaceutical composition for alleviation and treatment of ischemic conditions and method for delivering the same
JP6203215B2 (ja) プロミニン−１ペプチド断片およびその使用
JP6941605B2 (ja) 望まれない細胞増殖の除去又は破壊を必要とする疾患を治療するための組み合わせ組成物
JP6877349B2 (ja) 細胞の破壊又は除去を必要とする疾患を治療する方法
US12351609B2 (en) Use of a small native peptide activator of SERCA pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload
JP6046493B2 (ja) プロミニン−１の血管新生促進フラグメントおよびその使用
US10688153B2 (en) Peptides and method for treatment of cardiac arrest
US10479816B2 (en) Decoy peptides inhibiting protein phosphatase 1-medicated dephosphorylation of phospholamban
JP2010239971A (ja) 細胞におけるペルオキシソームカタラーゼ機能の促進
HUP0401865A2 (hu) Protein-hisztidin-foszfatáz alkalmazása
EP3849582A1 (en) Peptides and medical uses thereof
JP2006515168A5 (https=)
ES2220736T3 (es) Uso de inhibidores de caspasa-3 o desoxirribonucleasa activada por caspasa (cad) para tratar enfermedades cardiacas.
WO2005017151A1 (ja) アポトーシスを誘導するip3受容体タンパク質の末端切断型変異体
WO2000044395A1 (en) Methods and compositions for modulating fertility
WO2020053773A1 (en) Peptides and medical uses thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160301

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160301

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170110

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170609

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171121

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180402

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180904

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180912

R150 Certificate of patent or registration of utility model

Ref document number: 6404213

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250