JP6389124B2 - Ｒｅｔ蛋白質のｃ−末端ドメインを含む融合蛋白質及びその診断マーカーとしての用途 - Google Patents

Ｒｅｔ蛋白質のｃ−末端ドメインを含む融合蛋白質及びその診断マーカーとしての用途 Download PDF

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JP6389124B2
JP6389124B2 JP2014538724A JP2014538724A JP6389124B2 JP 6389124 B2 JP6389124 B2 JP 6389124B2 JP 2014538724 A JP2014538724 A JP 2014538724A JP 2014538724 A JP2014538724 A JP 2014538724A JP 6389124 B2 JP6389124 B2 JP 6389124B2
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fusion
ret
kif5b
seq
protein
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JP2015504299A (ja
JP2015504299A5 (enExample
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ヨン−ソク・ジュ
ジョン−スン・セオ
ウン−ヒ・キム
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マクロジェン・インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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JP2014538724A 2011-10-31 2012-10-31 Ｒｅｔ蛋白質のｃ−末端ドメインを含む融合蛋白質及びその診断マーカーとしての用途 Active JP6389124B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161553483P 2011-10-31 2011-10-31
US61/553,483 2011-10-31
US13/663,565 US10023855B2 (en) 2011-10-31 2012-10-30 Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker
US13/663,565 2012-10-30
PCT/KR2012/009056 WO2013066047A1 (en) 2011-10-31 2012-10-31 Fusion protein comprising c-terminal domain of ret protein and use thereof as a diagnosing marker

Publications (3)

Publication Number Publication Date
JP2015504299A JP2015504299A (ja) 2015-02-12
JP2015504299A5 JP2015504299A5 (enExample) 2015-12-03
JP6389124B2 true JP6389124B2 (ja) 2018-09-12

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JP2014538724A Active JP6389124B2 (ja) 2011-10-31 2012-10-31 Ｒｅｔ蛋白質のｃ−末端ドメインを含む融合蛋白質及びその診断マーカーとしての用途

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Country Link
US (1) US10023855B2 (enExample)
EP (1) EP2773673B1 (enExample)
JP (1) JP6389124B2 (enExample)
KR (2) KR101625139B1 (enExample)
WO (1) WO2013066047A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013028817A1 (en) 2011-08-23 2013-02-28 Foundation Medicine , Inc. Novel kif5b-ret fusion molecules and uses thereof
US20140121239A1 (en) * 2012-09-07 2014-05-01 Exelixis, Inc. Method of treating lung adenocarcinoma
SG11201502211QA (en) 2012-09-25 2015-05-28 Chugai Pharmaceutical Co Ltd Ret inhibitor
US10202365B2 (en) 2015-02-06 2019-02-12 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
EA038890B1 (ru) 2015-11-02 2021-11-03 Блюпринт Медсинс Корпорейшн Ингибиторы ret
AR107912A1 (es) 2016-03-17 2018-06-28 Blueprint Medicines Corp Inhibidores de ret
WO2018017983A1 (en) 2016-07-22 2018-01-25 Blueprint Medicines Corporation Compounds useful for treating disorders related to ret
MY201941A (en) * 2017-08-21 2024-03-25 Taiho Pharmaceutical Co Ltd Fusion protein of dctn1 protein with ret protein
CA3096043A1 (en) 2018-04-03 2019-10-10 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
KR20230017234A (ko) 2020-05-29 2023-02-03 블루프린트 메디신즈 코포레이션 프랄세티닙의 고체 형태

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69736428T2 (de) 1996-05-08 2007-08-30 Biogen Idec Ma Inc., Cambridge RET-LIGAND 3 (RetL3), UM NEURALES UND RENALES WACHSTUM ZU STIMULIEREN
AU2001281136A1 (en) 2000-08-04 2002-02-18 Board Of Regents, The University Of Texas System Detection and diagnosis of smoking related cancers
US20070212689A1 (en) 2003-10-30 2007-09-13 Bianchi Diana W Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid
US20090136502A1 (en) 2005-10-24 2009-05-28 Toshimitsu Arai Preventives/Remedies for Cancer
US20110195072A1 (en) 2006-09-12 2011-08-11 Anne Boulay Non-neuroendocrine cancer therapy
EP2599878A4 (en) 2010-07-26 2014-02-12 Astellas Pharma Inc NEW METHOD FOR DETECTING FUSED BODIES RET
EP2740742B1 (en) 2011-08-04 2018-03-14 National Cancer Center Fusion gene of kif5b gene and ret gene, and method for determining effectiveness of cancer treatment targeting fusion gene
WO2013028817A1 (en) * 2011-08-23 2013-02-28 Foundation Medicine , Inc. Novel kif5b-ret fusion molecules and uses thereof

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Publication number Publication date
JP2015504299A (ja) 2015-02-12
US20130116280A1 (en) 2013-05-09
KR20160052751A (ko) 2016-05-12
US10023855B2 (en) 2018-07-17
EP2773673A1 (en) 2014-09-10
KR20140092846A (ko) 2014-07-24
KR101660235B1 (ko) 2016-09-27
WO2013066047A1 (en) 2013-05-10
KR101625139B1 (ko) 2016-05-31
EP2773673B1 (en) 2019-12-04
EP2773673A4 (en) 2015-03-18

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