JP6367795B2 - リスペリドンまたはパリペリドンインプラント製剤 - Google Patents

リスペリドンまたはパリペリドンインプラント製剤 Download PDF

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Publication number
JP6367795B2
JP6367795B2 JP2015514533A JP2015514533A JP6367795B2 JP 6367795 B2 JP6367795 B2 JP 6367795B2 JP 2015514533 A JP2015514533 A JP 2015514533A JP 2015514533 A JP2015514533 A JP 2015514533A JP 6367795 B2 JP6367795 B2 JP 6367795B2
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risperidone
polymer
molecular weight
kda
composition
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Japanese (ja)
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JP2015518036A (ja
Inventor
グティエロ アドゥリス イボン
グティエロ アドゥリス イボン
フランコ ロドリゲス ギジェルモ
フランコ ロドリゲス ギジェルモ
Original Assignee
ラボラトリオス ファルマセウティコス ロビ，ソシエダッド アノニマ
ラボラトリオス ファルマセウティコス ロビ，ソシエダッド アノニマ
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Application filed by ラボラトリオス ファルマセウティコス ロビ，ソシエダッド アノニマ, ラボラトリオス ファルマセウティコス ロビ，ソシエダッド アノニマ filed Critical ラボラトリオス ファルマセウティコス ロビ，ソシエダッド アノニマ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015514533A 2012-05-31 2013-05-31 リスペリドンまたはパリペリドンインプラント製剤 Active JP6367795B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12170362.3A EP2529756B1 (en) 2011-05-31 2012-05-31 Risperidone and/or Paliperidone implant formulation
EP12170362.3 2012-05-31
PCT/EP2013/061320 WO2013178812A1 (en) 2012-05-31 2013-05-31 Risperidone or paliperidone implant formulation

Publications (2)

Publication Number Publication Date
JP2015518036A JP2015518036A (ja) 2015-06-25
JP6367795B2 true JP6367795B2 (ja) 2018-08-01

Family

ID=46147376

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015514533A Active JP6367795B2 (ja) 2012-05-31 2013-05-31 リスペリドンまたはパリペリドンインプラント製剤

Country Status (32)

Country Link
EP (2) EP2529756B1 (https=)
JP (1) JP6367795B2 (https=)
KR (1) KR101880716B1 (https=)
CN (1) CN104363923A (https=)
AU (1) AU2013269547B2 (https=)
BR (1) BR112014029209A2 (https=)
CA (1) CA2874765C (https=)
CL (1) CL2014003216A1 (https=)
CO (1) CO7160108A2 (https=)
CY (1) CY1124369T1 (https=)
DK (2) DK2529756T3 (https=)
EA (1) EA031819B1 (https=)
ES (1) ES2878112T3 (https=)
FI (1) FI2854858T3 (https=)
HR (2) HRP20260301T1 (https=)
IL (1) IL235849B (https=)
IN (1) IN2014DN10672A (https=)
LT (2) LT2529756T (https=)
MA (1) MA37664B1 (https=)
MX (1) MX374955B (https=)
MY (1) MY174999A (https=)
NZ (1) NZ703321A (https=)
PH (1) PH12014502667B1 (https=)
PL (2) PL2529756T3 (https=)
PT (2) PT2529756T (https=)
RS (1) RS62059B1 (https=)
SG (1) SG11201407961WA (https=)
SI (1) SI2529756T1 (https=)
SM (1) SMT202100448T1 (https=)
UA (1) UA119430C2 (https=)
WO (1) WO2013178812A1 (https=)
ZA (1) ZA201409299B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
EP2152315B1 (en) 2007-05-25 2016-01-06 Indivior UK Limited Sustained delivery formulations of risperidone compounds
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
EP2529757B1 (en) * 2011-05-31 2014-01-08 Laboratorios Farmaceuticos Rovi, S.A. Paliperidone implant formulation
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
LT2394664T (lt) 2010-05-31 2016-09-26 Laboratorios Farmaceuticos Rovi, S.A. Antipsichozinė injekcinė depozitinė kompozicija
PT2394663T (pt) 2010-05-31 2021-11-26 Farm Rovi Lab Sa Composições para implantes biodegradáveis injectáveis
LT2529756T (lt) * 2011-05-31 2021-07-26 Laboratorios Farmaceuticos Rovi, S.A. Risperidono ir (arba) paliperidono implantų kompozicija
HK1220628A1 (zh) 2013-03-11 2017-05-12 Durect Corporation 包含高粘度液体载体的可注射控制释放组合物
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN104922085B (zh) * 2015-06-01 2016-10-26 湖南赛沃药业有限公司 一种利培酮植入剂及其制备方法
CN109589304A (zh) * 2017-10-01 2019-04-09 万特制药(海南)有限公司 利培酮口服溶液及其制备方法
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
PE20210047A1 (es) 2018-06-12 2021-01-08 Farm Rovi Lab Sa Composicion inyectable
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
US12594236B2 (en) 2021-07-16 2026-04-07 Laboratorios Farmaceuticos Rovi, S.A. Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
US12318387B2 (en) 2021-07-16 2025-06-03 Laboratorios Farmaceuticos Rovi, S.A. Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
TW202313047A (zh) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 抗精神病可注射儲積型組合物
AU2023281232A1 (en) 2022-05-18 2024-10-24 Laboratorios Farmacéuticos Rovi, S.A. Prolonged-release injectable compositions for use in treatment with risperidone together with cyp2d6 enzyme inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
US7658998B2 (en) * 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
WO2005007122A2 (en) * 2003-07-18 2005-01-27 Oakwood Laboratories, L.L.C. Polymer stabilization
JP2008509144A (ja) 2004-08-04 2008-03-27 アルザ・コーポレーシヨン 上昇するゼロ次放出パターンを示す持続薬剤放出組成物、そのような組成物を製造する方法
JP5315336B2 (ja) 2007-04-19 2013-10-16 又欣 李 精神疾患治療用の新規化合物とその調剤及び使用
DK2167039T3 (en) * 2007-05-18 2017-01-09 Durect Corp Improved depot formulations
EP2152315B1 (en) 2007-05-25 2016-01-06 Indivior UK Limited Sustained delivery formulations of risperidone compounds
WO2009015828A1 (en) 2007-07-27 2009-02-05 Synthon B.V. Paliperidone derivatives
BRPI0821408A2 (pt) 2007-12-19 2015-06-16 Janssen Pharmaceutica Nv Regime de dosagem associado a ésteres de paliperidona injetáveis de longa ação
EP2485712A1 (en) 2009-10-06 2012-08-15 Ascendis Pharma A/S Subcutaneous paliperidone composition
EP2529757B1 (en) * 2011-05-31 2014-01-08 Laboratorios Farmaceuticos Rovi, S.A. Paliperidone implant formulation
LT2394664T (lt) 2010-05-31 2016-09-26 Laboratorios Farmaceuticos Rovi, S.A. Antipsichozinė injekcinė depozitinė kompozicija
PT2394663T (pt) * 2010-05-31 2021-11-26 Farm Rovi Lab Sa Composições para implantes biodegradáveis injectáveis
LT2529756T (lt) * 2011-05-31 2021-07-26 Laboratorios Farmaceuticos Rovi, S.A. Risperidono ir (arba) paliperidono implantų kompozicija

Also Published As

Publication number Publication date
CA2874765A1 (en) 2013-12-05
ZA201409299B (en) 2015-12-23
SI2529756T1 (sl) 2021-09-30
PH12014502667B1 (en) 2020-01-22
HRP20260301T1 (hr) 2026-04-10
SG11201407961WA (en) 2014-12-30
IN2014DN10672A (https=) 2015-08-28
BR112014029209A2 (pt) 2017-06-27
PT2529756T (pt) 2021-07-28
EA031819B1 (ru) 2019-02-28
HRP20211057T1 (hr) 2021-10-01
PH12014502667A1 (en) 2015-02-02
KR20150016964A (ko) 2015-02-13
CY1124369T1 (el) 2022-07-22
MX374955B (es) 2025-03-06
CN104363923A (zh) 2015-02-18
LT2529756T (lt) 2021-07-26
CL2014003216A1 (es) 2015-07-10
EP2529756A3 (en) 2013-08-07
EP2854858B1 (en) 2025-12-10
CO7160108A2 (es) 2015-01-15
EA201401346A1 (ru) 2015-04-30
RS62059B1 (sr) 2021-07-30
PL2854858T3 (pl) 2026-04-20
AU2013269547B2 (en) 2018-03-15
CA2874765C (en) 2020-06-02
AU2013269547A1 (en) 2015-01-22
DK2529756T3 (da) 2021-08-02
IL235849B (en) 2019-03-31
EP2529756B1 (en) 2021-05-19
MY174999A (en) 2020-06-01
EP2529756A2 (en) 2012-12-05
MA37664B1 (fr) 2016-11-30
WO2013178812A1 (en) 2013-12-05
NZ703321A (en) 2017-01-27
KR101880716B1 (ko) 2018-08-17
UA119430C2 (uk) 2019-06-25
SMT202100448T1 (it) 2021-09-14
PL2529756T3 (pl) 2021-11-15
EP2854858A1 (en) 2015-04-08
MX2014014483A (es) 2015-02-24
IL235849A0 (en) 2015-01-29
PT2854858T (pt) 2026-03-06
FI2854858T3 (fi) 2026-03-03
LT2854858T (lt) 2026-03-10
MA37664A1 (fr) 2016-03-31
ES2878112T3 (es) 2021-11-18
JP2015518036A (ja) 2015-06-25
DK2854858T3 (da) 2026-03-09

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