JP6336067B2 - 関節症の場合のペプスタチンの関節内適応 - Google Patents
関節症の場合のペプスタチンの関節内適応 Download PDFInfo
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- JP6336067B2 JP6336067B2 JP2016532244A JP2016532244A JP6336067B2 JP 6336067 B2 JP6336067 B2 JP 6336067B2 JP 2016532244 A JP2016532244 A JP 2016532244A JP 2016532244 A JP2016532244 A JP 2016532244A JP 6336067 B2 JP6336067 B2 JP 6336067B2
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- pepstatin
- intra
- arthropathy
- cathepsin
- treatment
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP13003923 | 2013-08-06 | ||
| EP13003923.3 | 2013-08-06 | ||
| PCT/EP2014/001861 WO2015018472A1 (de) | 2013-08-06 | 2014-07-07 | Intraartikuläre applikation von pepstatin bei arthrose |
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| JP2016527284A JP2016527284A (ja) | 2016-09-08 |
| JP2016527284A5 JP2016527284A5 (https=) | 2017-08-17 |
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| ES (1) | ES2759060T3 (https=) |
| IL (1) | IL243983B (https=) |
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| US6251928B1 (en) | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| EP0958293B1 (en) | 1997-02-04 | 2005-01-19 | The Regents Of The University Of California | Nanomolar, non-peptide inhibitors of cathepsin d |
| US5962506A (en) | 1997-07-07 | 1999-10-05 | Pharmacopeia, Inc. | Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases |
| US5986102A (en) | 1998-04-29 | 1999-11-16 | Pharmacopeia, Inc. | Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases |
| JP2000300266A (ja) | 1999-04-20 | 2000-10-31 | St Marianna Univ School Of Medicine | ポリペプチド及びｄｎａ |
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| US20050042213A1 (en) * | 2003-08-14 | 2005-02-24 | Insight Biopharmaceuticals Ltd. | Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof |
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| EP1745777A1 (en) | 2005-07-20 | 2007-01-24 | Speedel Experimenta AG | Amido-aminoalcohols as therapeutic compounds |
| US20070021400A1 (en) | 2005-07-20 | 2007-01-25 | Peter Herold | Amino alcohols as therapeutic compounds |
| GB0526614D0 (en) | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
| EP1867329A3 (en) | 2006-06-14 | 2008-05-07 | Speedel Experimenta AG | 5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamides as therapeutic compounds |
| EP1872780A3 (en) | 2006-06-14 | 2008-04-30 | Speedel Experimenta AG | Omega-Phenyloctanamides as therapeutic compounds |
| EP1987834A3 (en) | 2007-02-13 | 2008-11-19 | Speedel Experimenta AG | Substituted piperidines as therapeutic compounds |
| WO2008119772A1 (en) | 2007-03-30 | 2008-10-09 | Medivir Ab | Amide derivatives as inhibitors of aspartyl proteases |
| WO2009013293A1 (en) | 2007-07-24 | 2009-01-29 | Novartis Ag | Substituted cyclohexanecarboxamides useful as bace inhibitors |
| AU2012216230B2 (en) | 2011-02-08 | 2017-05-25 | Merck Patent Gmbh | Amino statin derivatives for the treatement of arthrosis |
| US20150225369A1 (en) * | 2012-08-29 | 2015-08-13 | Merck Patent Gmbh | Ddr2 inhibitors for the treatment of osteoarthritis |
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2014
- 2014-07-07 CA CA2920420A patent/CA2920420C/en active Active
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- 2014-07-07 WO PCT/EP2014/001861 patent/WO2015018472A1/de not_active Ceased
- 2014-07-07 EP EP14741803.2A patent/EP3030250B1/de active Active
- 2014-07-07 JP JP2016532244A patent/JP6336067B2/ja not_active Expired - Fee Related
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- 2014-07-07 CN CN201480044142.6A patent/CN105451754A/zh active Pending
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|---|---|
| US20160175381A1 (en) | 2016-06-23 |
| CA2920420A1 (en) | 2015-02-12 |
| EP3030250A1 (de) | 2016-06-15 |
| US9750784B2 (en) | 2017-09-05 |
| JP2016527284A (ja) | 2016-09-08 |
| CA2920420C (en) | 2021-11-23 |
| CN105451754A (zh) | 2016-03-30 |
| AU2014304950B2 (en) | 2019-09-12 |
| EP3030250B1 (de) | 2019-08-28 |
| AU2014304950A1 (en) | 2016-03-17 |
| IL243983A0 (en) | 2016-04-21 |
| IL243983B (en) | 2020-04-30 |
| ES2759060T3 (es) | 2020-05-07 |
| US20170348380A1 (en) | 2017-12-07 |
| WO2015018472A1 (de) | 2015-02-12 |
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