JP6332965B2 - アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法 - Google Patents

アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法 Download PDF

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Publication number
JP6332965B2
JP6332965B2 JP2013503634A JP2013503634A JP6332965B2 JP 6332965 B2 JP6332965 B2 JP 6332965B2 JP 2013503634 A JP2013503634 A JP 2013503634A JP 2013503634 A JP2013503634 A JP 2013503634A JP 6332965 B2 JP6332965 B2 JP 6332965B2
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Prior art keywords
azoline
peptide
library
sequence
patd
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Japanese (ja)
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JPWO2012121392A1 (ja
Inventor
裕明 菅
裕明 菅
佑樹 後藤
佑樹 後藤
悠美 伊藤
悠美 伊藤
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University of Tokyo NUC
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University of Tokyo NUC
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2013503634A 2011-03-09 2012-03-09 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法 Active JP6332965B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011052219 2011-03-09
JP2011052219 2011-03-09
PCT/JP2012/056181 WO2012121392A1 (ja) 2011-03-09 2012-03-09 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法

Related Child Applications (1)

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JP2017123617A Division JP6516382B2 (ja) 2011-03-09 2017-06-23 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法

Publications (2)

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JPWO2012121392A1 JPWO2012121392A1 (ja) 2014-07-17
JP6332965B2 true JP6332965B2 (ja) 2018-05-30

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JP2013503634A Active JP6332965B2 (ja) 2011-03-09 2012-03-09 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法
JP2017123617A Active JP6516382B2 (ja) 2011-03-09 2017-06-23 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法
JP2018219492A Pending JP2019073511A (ja) 2011-03-09 2018-11-22 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法

Family Applications After (2)

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JP2017123617A Active JP6516382B2 (ja) 2011-03-09 2017-06-23 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法
JP2018219492A Pending JP2019073511A (ja) 2011-03-09 2018-11-22 アゾリン化合物及びアゾール化合物のライブラリー、並びにその製造方法

Country Status (4)

Country Link
US (1) US10197567B2 (https=)
EP (2) EP2684952B1 (https=)
JP (3) JP6332965B2 (https=)
WO (1) WO2012121392A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2966174B1 (en) * 2013-03-07 2018-02-21 The University of Tokyo Method for producing compound containing heterocycle
EP3103881A4 (en) 2014-02-03 2017-10-25 The University of Tokyo Method for producing peptides having azole-derived skeleton

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2368026A1 (en) * 1999-03-22 2000-09-28 Bi-Huang Hu Oxazole and thiazole combinatorial libraries
US9365622B2 (en) * 2006-03-01 2016-06-14 University Of Utah Research Foundation Methods and compositions related to cyclic peptide synthesis
CN100532191C (zh) 2006-06-15 2009-08-26 李上 防倾覆水上救生设备
EP2141175B1 (en) 2007-03-26 2016-07-27 The University of Tokyo Process for synthesizing cyclic peptide compound

Also Published As

Publication number Publication date
JP2017160272A (ja) 2017-09-14
JP6516382B2 (ja) 2019-05-22
EP3460059A8 (en) 2019-06-05
JPWO2012121392A1 (ja) 2014-07-17
WO2012121392A8 (ja) 2013-08-29
EP2684952A1 (en) 2014-01-15
US10197567B2 (en) 2019-02-05
EP3460059A1 (en) 2019-03-27
US20140113830A1 (en) 2014-04-24
EP2684952A4 (en) 2015-01-07
JP2019073511A (ja) 2019-05-16
EP2684952B1 (en) 2018-12-05
WO2012121392A1 (ja) 2012-09-13

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