JP6324395B2 - 軟骨細胞を移植する方法 - Google Patents
軟骨細胞を移植する方法 Download PDFInfo
- Publication number
- JP6324395B2 JP6324395B2 JP2015539923A JP2015539923A JP6324395B2 JP 6324395 B2 JP6324395 B2 JP 6324395B2 JP 2015539923 A JP2015539923 A JP 2015539923A JP 2015539923 A JP2015539923 A JP 2015539923A JP 6324395 B2 JP6324395 B2 JP 6324395B2
- Authority
- JP
- Japan
- Prior art keywords
- cartilage
- cells
- derived
- chondrocytes
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Organic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Materials For Medical Uses (AREA)
- Polymers & Plastics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719902P | 2012-10-29 | 2012-10-29 | |
| US61/719,902 | 2012-10-29 | ||
| PCT/US2013/067349 WO2014070796A1 (en) | 2012-10-29 | 2013-10-29 | Methods of transplanting chondrocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534809A JP2015534809A (ja) | 2015-12-07 |
| JP2015534809A5 JP2015534809A5 (https=) | 2016-11-10 |
| JP6324395B2 true JP6324395B2 (ja) | 2018-05-16 |
Family
ID=50628009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539923A Active JP6324395B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞を移植する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9974885B2 (https=) |
| EP (1) | EP2911709B1 (https=) |
| JP (1) | JP6324395B2 (https=) |
| WO (1) | WO2014070796A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014052912A1 (en) | 2012-09-28 | 2014-04-03 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| US9914911B2 (en) | 2012-10-29 | 2018-03-13 | Scripps Health | Methods of reprogramming chondrocytes |
| EP2911709B1 (en) | 2012-10-29 | 2018-04-18 | Scripps Health | Methods of transplanting chondrocytes |
| EP3344256B1 (en) * | 2015-08-31 | 2020-08-05 | CorMedix Inc. | Compositions for the treatment of joints |
| MX2021007121A (es) * | 2018-12-19 | 2021-08-11 | Univ Minnesota | Metodos para generar y usar organoides y los tejidos en estos. |
| US20220064592A1 (en) * | 2020-09-03 | 2022-03-03 | Tokai University Educational System | Cell microsheet, syringe containing the cell microsheet, and production and use of the cell microsheet |
| DE102021202830A1 (de) * | 2021-03-23 | 2022-09-29 | Gelita Ag | Rekombinantes Typ II-Kollagen zur therapeutischen Verwendung |
| US20230330149A1 (en) * | 2022-04-14 | 2023-10-19 | Creative Medical Technologies, Inc. | Enhancement of cartilage regenerative activity of stem cell populations based on reduction of intra-articular cellular material |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399347A (en) * | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| CA2060223C (en) * | 1991-02-12 | 1999-07-20 | Clarence C. Lee | Injectable medical lubricating fluid composition and method of use |
| US5645851A (en) | 1994-02-28 | 1997-07-08 | Moore; Eugene R. | Product for alleviating the symptons of arthritis in mammals |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6025327A (en) * | 1997-08-08 | 2000-02-15 | Biocell Technology, Llc | Hydrolyzed collagen type II and use thereof |
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| US20030026786A1 (en) | 1999-06-04 | 2003-02-06 | Mark F. Pittenger | Chondrogenic differentiation of human mesenchymal stem cells |
| EP1254670A1 (en) * | 2001-05-03 | 2002-11-06 | Stichting Katholieke Universiteit | Type II collagen matrices for use in cartilage engineering |
| US6780841B2 (en) * | 2001-11-13 | 2004-08-24 | Biocell Technology, Llc | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US6852331B2 (en) | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| EP1781776A2 (en) | 2004-07-29 | 2007-05-09 | Stem Cell Innovations, Inc. | Differentiation of stem cells |
| CA2866468C (en) | 2004-09-24 | 2019-09-03 | Mesoblast, Inc. | Generating multipotential expanded mesenchymal precursor cell progeny (memp) from mesenchymal progenitor cells (mpc) and stimulation factor |
| KR20070085288A (ko) | 2004-09-24 | 2007-08-27 | 안지오블라스트 시스템스 인코퍼레이티드 | 간엽 전구세포의 증식 및/또는 생존성 증강 방법 |
| US20060189840A1 (en) * | 2005-02-18 | 2006-08-24 | Acorn Cardiovascular, Inc. | Transmyocardial delivery of cardiac wall tension relief |
| ES2329636B2 (es) | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| FR2900155B1 (fr) | 2006-04-21 | 2008-06-27 | Diana Naturals Sa | Hydrolisat de cartilage aviaire, procede d'obtention et utilisations |
| CN101721349B (zh) * | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| KR101091028B1 (ko) * | 2009-07-02 | 2011-12-09 | 아주대학교산학협력단 | 체내 주입형 하이드로젤 및 이의 생의학적 용도 |
| JP5636174B2 (ja) * | 2009-07-10 | 2014-12-03 | 学校法人近畿大学 | 間葉系細胞または軟骨細胞の製法ならびに発癌性の抑制方法 |
| CA2725728C (en) * | 2009-11-24 | 2014-01-28 | University Of Connecticut | Differentiation of human embryonic and induced pluripotent stem cells |
| KR100990436B1 (ko) | 2009-11-30 | 2010-10-29 | 동국대학교 산학협력단 | 중간엽 줄기세포를 DKK-1 또는 sFRP-1을 이용하여 연골세포로 분화시키는 방법 |
| AU2011208948B2 (en) | 2010-01-28 | 2016-05-05 | The University Of Queensland | Method for stem cell differentiation |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| US9029145B2 (en) | 2010-04-08 | 2015-05-12 | The University Court Of The University Of Edinburgh | Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof |
| CN101810855B (zh) | 2010-05-20 | 2012-06-13 | 广州创尔生物技术有限公司 | 一种ⅱ型胶原关节软骨修复液及其制备方法 |
| EP2598634A1 (en) | 2010-07-26 | 2013-06-05 | The University Of Manchester | Targeted differentiation of stem cells |
| CN101934092A (zh) * | 2010-08-27 | 2011-01-05 | 中国人民解放军第三军医大学第一附属医院 | 用于软骨再生修复的注射型软骨仿生基质材料及使用方法 |
| KR101340458B1 (ko) * | 2010-11-02 | 2013-12-11 | 서울대학교산학협력단 | 하이드로겔을 포함하는 연골 이식용 조성물 |
| US8663675B2 (en) * | 2010-11-18 | 2014-03-04 | Jalaledin Ghanavi | Injectable matrix having a polymer and a stem cell niche composed of cup-shaped nanoparticles containing growth factors or physiological agents for organ reconstruction |
| JP2014509517A (ja) | 2011-03-18 | 2014-04-21 | アンセルム(アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル) | 軟骨細胞分化培地および細胞の軟骨細胞分化を誘導するための方法 |
| WO2014052912A1 (en) | 2012-09-28 | 2014-04-03 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| US9914911B2 (en) | 2012-10-29 | 2018-03-13 | Scripps Health | Methods of reprogramming chondrocytes |
| EP2911709B1 (en) | 2012-10-29 | 2018-04-18 | Scripps Health | Methods of transplanting chondrocytes |
| WO2014157257A1 (ja) | 2013-03-25 | 2014-10-02 | 公益財団法人先端医療振興財団 | 細胞の選別方法 |
-
2013
- 2013-10-29 EP EP13852195.0A patent/EP2911709B1/en active Active
- 2013-10-29 US US14/438,583 patent/US9974885B2/en active Active
- 2013-10-29 JP JP2015539923A patent/JP6324395B2/ja active Active
- 2013-10-29 WO PCT/US2013/067349 patent/WO2014070796A1/en not_active Ceased
-
2018
- 2018-01-16 US US15/872,667 patent/US10179193B2/en active Active
- 2018-12-07 US US16/213,790 patent/US20190143000A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150283303A1 (en) | 2015-10-08 |
| EP2911709B1 (en) | 2018-04-18 |
| US10179193B2 (en) | 2019-01-15 |
| US20190143000A1 (en) | 2019-05-16 |
| JP2015534809A (ja) | 2015-12-07 |
| EP2911709A1 (en) | 2015-09-02 |
| WO2014070796A1 (en) | 2014-05-08 |
| US9974885B2 (en) | 2018-05-22 |
| US20180154046A1 (en) | 2018-06-07 |
| EP2911709A4 (en) | 2016-06-29 |
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