JP2015534809A5 - - Google Patents
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- Publication number
- JP2015534809A5 JP2015534809A5 JP2015539923A JP2015539923A JP2015534809A5 JP 2015534809 A5 JP2015534809 A5 JP 2015534809A5 JP 2015539923 A JP2015539923 A JP 2015539923A JP 2015539923 A JP2015539923 A JP 2015539923A JP 2015534809 A5 JP2015534809 A5 JP 2015534809A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- matrix
- ternary
- concentration
- cartilage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 17
- 210000000845 cartilage Anatomy 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 210000001612 chondrocyte Anatomy 0.000 claims 7
- 102000000503 Collagen Type II Human genes 0.000 claims 5
- 108010041390 Collagen Type II Proteins 0.000 claims 5
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 3
- 229940099552 hyaluronan Drugs 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 101100096242 Mus musculus Sox9 gene Proteins 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 239000004744 fabric Substances 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 210000000963 osteoblast Anatomy 0.000 claims 2
- 210000004663 osteoprogenitor cell Anatomy 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 claims 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 210000004207 dermis Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229940117828 polylactic acid-polyglycolic acid copolymer Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719902P | 2012-10-29 | 2012-10-29 | |
| US61/719,902 | 2012-10-29 | ||
| PCT/US2013/067349 WO2014070796A1 (en) | 2012-10-29 | 2013-10-29 | Methods of transplanting chondrocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534809A JP2015534809A (ja) | 2015-12-07 |
| JP2015534809A5 true JP2015534809A5 (https=) | 2016-11-10 |
| JP6324395B2 JP6324395B2 (ja) | 2018-05-16 |
Family
ID=50628009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539923A Active JP6324395B2 (ja) | 2012-10-29 | 2013-10-29 | 軟骨細胞を移植する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9974885B2 (https=) |
| EP (1) | EP2911709B1 (https=) |
| JP (1) | JP6324395B2 (https=) |
| WO (1) | WO2014070796A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014052912A1 (en) | 2012-09-28 | 2014-04-03 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| US9914911B2 (en) | 2012-10-29 | 2018-03-13 | Scripps Health | Methods of reprogramming chondrocytes |
| EP2911709B1 (en) | 2012-10-29 | 2018-04-18 | Scripps Health | Methods of transplanting chondrocytes |
| EP3344256B1 (en) * | 2015-08-31 | 2020-08-05 | CorMedix Inc. | Compositions for the treatment of joints |
| MX2021007121A (es) * | 2018-12-19 | 2021-08-11 | Univ Minnesota | Metodos para generar y usar organoides y los tejidos en estos. |
| US20220064592A1 (en) * | 2020-09-03 | 2022-03-03 | Tokai University Educational System | Cell microsheet, syringe containing the cell microsheet, and production and use of the cell microsheet |
| DE102021202830A1 (de) * | 2021-03-23 | 2022-09-29 | Gelita Ag | Rekombinantes Typ II-Kollagen zur therapeutischen Verwendung |
| US20230330149A1 (en) * | 2022-04-14 | 2023-10-19 | Creative Medical Technologies, Inc. | Enhancement of cartilage regenerative activity of stem cell populations based on reduction of intra-articular cellular material |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399347A (en) * | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| CA2060223C (en) * | 1991-02-12 | 1999-07-20 | Clarence C. Lee | Injectable medical lubricating fluid composition and method of use |
| US5645851A (en) | 1994-02-28 | 1997-07-08 | Moore; Eugene R. | Product for alleviating the symptons of arthritis in mammals |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6025327A (en) * | 1997-08-08 | 2000-02-15 | Biocell Technology, Llc | Hydrolyzed collagen type II and use thereof |
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| US20030026786A1 (en) | 1999-06-04 | 2003-02-06 | Mark F. Pittenger | Chondrogenic differentiation of human mesenchymal stem cells |
| EP1254670A1 (en) * | 2001-05-03 | 2002-11-06 | Stichting Katholieke Universiteit | Type II collagen matrices for use in cartilage engineering |
| US6780841B2 (en) * | 2001-11-13 | 2004-08-24 | Biocell Technology, Llc | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same |
| CA2412012C (en) | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US6852331B2 (en) | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| EP1781776A2 (en) | 2004-07-29 | 2007-05-09 | Stem Cell Innovations, Inc. | Differentiation of stem cells |
| CA2866468C (en) | 2004-09-24 | 2019-09-03 | Mesoblast, Inc. | Generating multipotential expanded mesenchymal precursor cell progeny (memp) from mesenchymal progenitor cells (mpc) and stimulation factor |
| KR20070085288A (ko) | 2004-09-24 | 2007-08-27 | 안지오블라스트 시스템스 인코퍼레이티드 | 간엽 전구세포의 증식 및/또는 생존성 증강 방법 |
| US20060189840A1 (en) * | 2005-02-18 | 2006-08-24 | Acorn Cardiovascular, Inc. | Transmyocardial delivery of cardiac wall tension relief |
| ES2329636B2 (es) | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| FR2900155B1 (fr) | 2006-04-21 | 2008-06-27 | Diana Naturals Sa | Hydrolisat de cartilage aviaire, procede d'obtention et utilisations |
| CN101721349B (zh) * | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
| KR101091028B1 (ko) * | 2009-07-02 | 2011-12-09 | 아주대학교산학협력단 | 체내 주입형 하이드로젤 및 이의 생의학적 용도 |
| JP5636174B2 (ja) * | 2009-07-10 | 2014-12-03 | 学校法人近畿大学 | 間葉系細胞または軟骨細胞の製法ならびに発癌性の抑制方法 |
| CA2725728C (en) * | 2009-11-24 | 2014-01-28 | University Of Connecticut | Differentiation of human embryonic and induced pluripotent stem cells |
| KR100990436B1 (ko) | 2009-11-30 | 2010-10-29 | 동국대학교 산학협력단 | 중간엽 줄기세포를 ＤＫＫ-1 또는 ｓＦＲＰ-1을 이용하여 연골세포로 분화시키는 방법 |
| AU2011208948B2 (en) | 2010-01-28 | 2016-05-05 | The University Of Queensland | Method for stem cell differentiation |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| US9029145B2 (en) | 2010-04-08 | 2015-05-12 | The University Court Of The University Of Edinburgh | Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof |
| CN101810855B (zh) | 2010-05-20 | 2012-06-13 | 广州创尔生物技术有限公司 | 一种ⅱ型胶原关节软骨修复液及其制备方法 |
| EP2598634A1 (en) | 2010-07-26 | 2013-06-05 | The University Of Manchester | Targeted differentiation of stem cells |
| CN101934092A (zh) * | 2010-08-27 | 2011-01-05 | 中国人民解放军第三军医大学第一附属医院 | 用于软骨再生修复的注射型软骨仿生基质材料及使用方法 |
| KR101340458B1 (ko) * | 2010-11-02 | 2013-12-11 | 서울대학교산학협력단 | 하이드로겔을 포함하는 연골 이식용 조성물 |
| US8663675B2 (en) * | 2010-11-18 | 2014-03-04 | Jalaledin Ghanavi | Injectable matrix having a polymer and a stem cell niche composed of cup-shaped nanoparticles containing growth factors or physiological agents for organ reconstruction |
| JP2014509517A (ja) | 2011-03-18 | 2014-04-21 | アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | 軟骨細胞分化培地および細胞の軟骨細胞分化を誘導するための方法 |
| WO2014052912A1 (en) | 2012-09-28 | 2014-04-03 | Scripps Health | Methods of differentiating stem cells into chondrocytes |
| US9914911B2 (en) | 2012-10-29 | 2018-03-13 | Scripps Health | Methods of reprogramming chondrocytes |
| EP2911709B1 (en) | 2012-10-29 | 2018-04-18 | Scripps Health | Methods of transplanting chondrocytes |
| WO2014157257A1 (ja) | 2013-03-25 | 2014-10-02 | 公益財団法人先端医療振興財団 | 細胞の選別方法 |
-
2013
- 2013-10-29 EP EP13852195.0A patent/EP2911709B1/en active Active
- 2013-10-29 US US14/438,583 patent/US9974885B2/en active Active
- 2013-10-29 JP JP2015539923A patent/JP6324395B2/ja active Active
- 2013-10-29 WO PCT/US2013/067349 patent/WO2014070796A1/en not_active Ceased
-
2018
- 2018-01-16 US US15/872,667 patent/US10179193B2/en active Active
- 2018-12-07 US US16/213,790 patent/US20190143000A1/en not_active Abandoned
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