JP6317690B2 - 経皮吸収シート、及びその製造方法 - Google Patents

経皮吸収シート、及びその製造方法 Download PDF

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Publication number
JP6317690B2
JP6317690B2 JP2015041385A JP2015041385A JP6317690B2 JP 6317690 B2 JP6317690 B2 JP 6317690B2 JP 2015041385 A JP2015041385 A JP 2015041385A JP 2015041385 A JP2015041385 A JP 2015041385A JP 6317690 B2 JP6317690 B2 JP 6317690B2
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Japan
Prior art keywords
needle
mold
drug
sheet
convex
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JP2015041385A
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English (en)
Japanese (ja)
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JP2016158930A (ja
JP2016158930A5 (enExample
Inventor
哲史 若松
哲史 若松
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Fujifilm Corp
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Fujifilm Corp
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Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Priority to JP2015041385A priority Critical patent/JP6317690B2/ja
Priority to PCT/JP2016/056002 priority patent/WO2016140174A1/ja
Priority to EP16758867.2A priority patent/EP3266493B1/en
Publication of JP2016158930A publication Critical patent/JP2016158930A/ja
Publication of JP2016158930A5 publication Critical patent/JP2016158930A5/ja
Priority to US15/694,409 priority patent/US10596361B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/026—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles characterised by the shape of the surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/22—Component parts, details or accessories; Auxiliary operations
    • B29C39/26—Moulds or cores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B81B1/006—Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
    • B81B1/008—Microtips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
    • B81B7/04—Networks or arrays of similar microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0058—Liquid or visquous
    • B29K2105/0073—Solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2883/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as mould material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Computer Hardware Design (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Micromachines (AREA)
JP2015041385A 2015-03-03 2015-03-03 経皮吸収シート、及びその製造方法 Active JP6317690B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2015041385A JP6317690B2 (ja) 2015-03-03 2015-03-03 経皮吸収シート、及びその製造方法
PCT/JP2016/056002 WO2016140174A1 (ja) 2015-03-03 2016-02-29 経皮吸収シート、及びその製造方法
EP16758867.2A EP3266493B1 (en) 2015-03-03 2016-02-29 Transdermal absorption sheet, and method for manufacturing same
US15/694,409 US10596361B2 (en) 2015-03-03 2017-09-01 Transdermal absorption sheet and method of producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015041385A JP6317690B2 (ja) 2015-03-03 2015-03-03 経皮吸収シート、及びその製造方法

Publications (3)

Publication Number Publication Date
JP2016158930A JP2016158930A (ja) 2016-09-05
JP2016158930A5 JP2016158930A5 (enExample) 2017-06-22
JP6317690B2 true JP6317690B2 (ja) 2018-04-25

Family

ID=56843757

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015041385A Active JP6317690B2 (ja) 2015-03-03 2015-03-03 経皮吸収シート、及びその製造方法

Country Status (4)

Country Link
US (1) US10596361B2 (enExample)
EP (1) EP3266493B1 (enExample)
JP (1) JP6317690B2 (enExample)
WO (1) WO2016140174A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200016018A (ko) * 2018-08-06 2020-02-14 주식회사 코스칼드바이오 생체 용해성 마이크로니들 어레이 및 이의 제작 방법

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504512B2 (en) * 2017-05-10 2022-11-22 Chee Yen Lim Method of fabricating microneedle patches
KR102604753B1 (ko) * 2018-05-18 2023-11-22 포항공과대학교 산학협력단 경피 투과형 약물 전달 패치의 제조 방법
JP2021522978A (ja) * 2018-05-18 2021-09-02 ポステック アカデミー−インダストリー ファンデーション 経皮透過型薬物伝達パッチおよびその製造方法
JP6823009B2 (ja) * 2018-05-30 2021-01-27 花王株式会社 微細中空突起具の製造方法、及び微細中空突起具
KR102227989B1 (ko) * 2018-09-18 2021-03-15 한국기계연구원 미세 구조체 기반 약물 주입장치 및 이의 제조 방법
JP7464465B2 (ja) * 2020-06-29 2024-04-09 花王株式会社 微細中空突起具

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
EP1789127A2 (en) * 2004-08-05 2007-05-30 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
CA2595894C (en) 2005-01-31 2013-09-10 Kanji Takada Percutaneously absorbable preparation, percutaneously absorbable preparation holding sheet, and percutaneously absorbable preparation holding equipment
KR100612891B1 (ko) * 2005-02-24 2006-08-14 삼성전자주식회사 마이크로 니들 및 그 제조방법
JP2008006178A (ja) 2006-06-30 2008-01-17 Fujifilm Corp マイクロニードルシートの製造方法及び製造装置
US8865288B2 (en) 2006-07-17 2014-10-21 University Of Utah Research Foundation Micro-needle arrays having non-planar tips and methods of manufacture thereof
WO2008020632A1 (en) 2006-08-18 2008-02-21 Toppan Printing Co., Ltd. Microneedle and microneedle patch
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
JP2009233808A (ja) * 2008-03-27 2009-10-15 Fujifilm Corp 中空ニードルシート及び中空ニードルシートの製造方法
JP5572310B2 (ja) 2008-12-19 2014-08-13 凸版印刷株式会社 針状体の製造方法
JP2010233674A (ja) 2009-03-30 2010-10-21 Fujifilm Corp マイクロニードルシート及びその使用方法並びに製造方法
JP5663792B2 (ja) 2009-08-07 2015-02-04 株式会社 メドレックス 剣山型マイクロニードルのアプリケータデバイス
JP5558772B2 (ja) 2009-10-08 2014-07-23 東レエンジニアリング株式会社 マイクロニードルシートのスタンパー及びその製造方法とそれを用いたマイクロニードルの製造方法
DE102010001667A1 (de) 2010-02-08 2011-08-11 Robert Bosch GmbH, 70469 Herstellungsverfahren für eine poröse Mikronadelanordnung mit Rückseitenanschluss und entsprechende poröse Mikronadelanordnung
JP5587647B2 (ja) * 2010-03-29 2014-09-10 東レエンジニアリング株式会社 マイクロニードルシートの製造方法
JP5770055B2 (ja) 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
JP2013153866A (ja) 2012-01-27 2013-08-15 Fujifilm Corp 経皮吸収シート及び経皮吸収シートの製造方法
JP6074889B2 (ja) 2012-02-08 2017-02-08 凸版印刷株式会社 マイクロニードルチップ
WO2014144973A1 (en) * 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10099043B2 (en) * 2013-07-16 2018-10-16 3M Innovative Properties Company Hollow microneedle array article
JP6285277B2 (ja) * 2014-05-15 2018-02-28 富士フイルム株式会社 経皮吸収シートおよび経皮吸収シートの製造方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200016018A (ko) * 2018-08-06 2020-02-14 주식회사 코스칼드바이오 생체 용해성 마이크로니들 어레이 및 이의 제작 방법
KR102166065B1 (ko) * 2018-08-06 2020-10-15 주식회사 코스칼드바이오 생체 용해성 마이크로니들 어레이 및 이의 제작 방법

Also Published As

Publication number Publication date
EP3266493B1 (en) 2019-12-11
WO2016140174A1 (ja) 2016-09-09
EP3266493A1 (en) 2018-01-10
JP2016158930A (ja) 2016-09-05
EP3266493A4 (en) 2018-03-07
US10596361B2 (en) 2020-03-24
US20170361080A1 (en) 2017-12-21

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