JP6315848B2 - Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法 - Google Patents

Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法 Download PDF

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JP6315848B2
JP6315848B2 JP2016501365A JP2016501365A JP6315848B2 JP 6315848 B2 JP6315848 B2 JP 6315848B2 JP 2016501365 A JP2016501365 A JP 2016501365A JP 2016501365 A JP2016501365 A JP 2016501365A JP 6315848 B2 JP6315848 B2 JP 6315848B2
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JP2016516702A5 (OSRAM
JP2016516702A (ja
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ロス，ブライアン，ディー．
ドルト，マルシャン ヴァン
ドルト，マルシャン ヴァン
ホワイトヘッド，クリストファー
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ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016501365A 2013-03-13 2014-03-12 Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法 Active JP6315848B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361779462P 2013-03-13 2013-03-13
US61/779,462 2013-03-13
PCT/US2014/023860 WO2014164942A1 (en) 2013-03-13 2014-03-12 Dual mek/pi3k inhibitors and therapeutic methods using the same

Publications (3)

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JP2016516702A JP2016516702A (ja) 2016-06-09
JP2016516702A5 JP2016516702A5 (OSRAM) 2018-04-12
JP6315848B2 true JP6315848B2 (ja) 2018-04-25

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JP2016501365A Active JP6315848B2 (ja) 2013-03-13 2014-03-12 Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法

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US (1) US9611258B2 (OSRAM)
EP (1) EP2968345B1 (OSRAM)
JP (1) JP6315848B2 (OSRAM)
CN (1) CN105358156A (OSRAM)
CA (1) CA2901613C (OSRAM)
WO (1) WO2014164942A1 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016001485A1 (en) 2014-06-30 2016-01-07 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
US9968604B2 (en) * 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
CA3004530A1 (en) 2015-11-07 2017-05-11 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
CA3029875C (en) * 2016-07-06 2023-12-19 The Regents Of The University Of Michigan Multifunctional inhibitors of mek/pi3k and mtor/mek/pi3k biological pathways and therapeutic methods using the same
CN110381997A (zh) 2016-12-12 2019-10-25 茂体外尔公司 用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物
JP7350336B2 (ja) * 2017-08-11 2023-09-26 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン ＭＥＫ／ＰＩ３Ｋ、ＪＡＫ／ＭＥＫ、ＪＡＫ／ＰＩ３Ｋ／ｍＴＯＲおよびＭＥＫ／ＰＩ３Ｋ／ｍＴＯＲの生物学的経路の阻害剤、および治療化合物のリンパ取り込み、生物学的利用能、および溶解性を改善する方法
AU2019322487B2 (en) 2018-03-19 2024-04-18 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
CA3166636A1 (en) * 2020-01-10 2021-07-15 Immuneering Corporation Mek inhibitors and therapeutic uses thereof
CN111135309B (zh) * 2020-01-15 2023-04-28 重庆大学 一种核壳结构的替拉扎明药物载体及其制备方法和应用
AR121078A1 (es) 2020-01-22 2022-04-13 Chugai Pharmaceutical Co Ltd Derivados de arilamida con actividad antitumoral
CA3245088A1 (en) * 2022-01-06 2023-07-13 Immuneering Corporation MEK IMMUNE ONCOLOGICAL INHIBITORS AND THEIR THERAPEUTIC USES
WO2024102859A1 (en) * 2022-11-09 2024-05-16 Immuneering Corporation Mek immune oncology inhibitors and therapeutic uses thereof
WO2025010287A2 (en) * 2023-07-03 2025-01-09 Immuneering Corporation Mek immune oncology inhibitors and therapeutic uses thereof
WO2025114495A1 (en) * 2023-11-28 2025-06-05 Universität Basel Pi3k inhibitors and use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960614B2 (en) * 2000-07-19 2005-11-01 Warner-Lambert Company Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids
AR059339A1 (es) 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
WO2008032060A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
WO2008032033A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
US8569378B2 (en) * 2007-07-20 2013-10-29 Toshiyuki Sakai p27 protein inducer
JP2011515462A (ja) * 2008-03-27 2011-05-19 アウククランド ウニセルビセス リミテッド 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
JP2011527703A (ja) * 2008-07-11 2011-11-04 ノバルティス アーゲー （ａ）ホスホイノシタイド３−キナーゼ阻害剤および（ｂ）Ｒａｓ／Ｒａｆ／Ｍｅｋ経路のモジュレーターの配合物
JP5766177B2 (ja) 2009-03-27 2015-08-19 ベトディーシー，インコーポレイテッド ピリミジニル及び１，３，５−トリアジニルベンゾイミダゾールスルホンアミド及びガンの療法におけるその使用
CA2987503C (en) 2009-07-07 2019-02-26 Mei Pharma, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
US20110166191A1 (en) * 2010-01-07 2011-07-07 Shijun Zhang 3-(2-amino-ethyl)-5-(3-cyclohexyl-propylidene)-thiazolidine-2,4-dione and its derivatives as multiple signaling pathway inhibitors and for the treatment of cancer
GB201007227D0 (en) * 2010-04-30 2010-06-16 Univ Basel Piperazinotriazines
EP3693017A1 (en) * 2010-12-14 2020-08-12 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer

Also Published As

Publication number Publication date
WO2014164942A1 (en) 2014-10-09
JP2016516702A (ja) 2016-06-09
EP2968345A1 (en) 2016-01-20
US20160002212A1 (en) 2016-01-07
CN105358156A (zh) 2016-02-24
US9611258B2 (en) 2017-04-04
CA2901613A1 (en) 2014-10-09
CA2901613C (en) 2020-10-20
EP2968345B1 (en) 2017-12-13
EP2968345A4 (en) 2016-08-17

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