JP6275152B2 - アレイ合成および生体分子解析のための、支持体、システム、および方法 - Google Patents

アレイ合成および生体分子解析のための、支持体、システム、および方法 Download PDF

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JP6275152B2
JP6275152B2 JP2015542794A JP2015542794A JP6275152B2 JP 6275152 B2 JP6275152 B2 JP 6275152B2 JP 2015542794 A JP2015542794 A JP 2015542794A JP 2015542794 A JP2015542794 A JP 2015542794A JP 6275152 B2 JP6275152 B2 JP 6275152B2
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coupling
amino acids
carboxylic acid
support
wafer
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JP2016503447A5 (https=
JP2016503447A (ja
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ジョン ジェイ． ラジャセカラン
ジョン ジェイ． ラジャセカラン
ヴァサンス ジャヤラマン
ヴァサンス ジャヤラマン
ティアンハオ ワン
ティアンハオ ワン
カン ベイ
カン ベイ
ハリー クリシュナン クリシュナムルティー
ハリー クリシュナン クリシュナムルティー
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ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー
ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー
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Priority claimed from PCT/US2013/025190 external-priority patent/WO2013119845A1/en
Priority claimed from PCT/US2013/062773 external-priority patent/WO2014052989A2/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Structural Engineering (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Photolithography (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015542794A 2012-11-14 2013-11-14 アレイ合成および生体分子解析のための、支持体、システム、および方法 Active JP6275152B2 (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201261726515P 2012-11-14 2012-11-14
US61/726,515 2012-11-14
US201261732221P 2012-11-30 2012-11-30
US61/732,221 2012-11-30
USPCT/US2013/025190 2013-02-07
PCT/US2013/025190 WO2013119845A1 (en) 2012-02-07 2013-02-07 Substrates, peptide arrays, and methods
US201361765584P 2013-02-15 2013-02-15
US61/765,584 2013-02-15
US201361805884P 2013-03-27 2013-03-27
US61/805,884 2013-03-27
US201361866512P 2013-08-15 2013-08-15
US61/866,512 2013-08-15
PCT/US2013/062773 WO2014052989A2 (en) 2012-09-28 2013-09-30 Methods, systems, and arrays for biomolecular analysis
USPCT/US2013/062773 2013-09-30
PCT/US2013/070207 WO2014078606A2 (en) 2012-11-14 2013-11-14 Substrates, systems, and methods for array synthesis and biomolecular analysis

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JP2016503447A JP2016503447A (ja) 2016-02-04
JP2016503447A5 JP2016503447A5 (https=) 2016-12-28
JP6275152B2 true JP6275152B2 (ja) 2018-02-07

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JP2018000969A Active JP6613325B2 (ja) 2012-11-14 2018-01-09 アレイ合成および生体分子解析のための、支持体、システム、および方法
JP2019200012A Active JP7159145B2 (ja) 2012-11-14 2019-11-01 アレイ合成および生体分子解析のための、支持体、システム、および方法
JP2022163696A Active JP7514280B2 (ja) 2012-11-14 2022-10-12 アレイ合成および生体分子解析のための、支持体、システム、および方法
JP2024104585A Pending JP2024124458A (ja) 2012-11-14 2024-06-28 アレイ合成および生体分子解析のための、支持体、システム、および方法

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JP2019200012A Active JP7159145B2 (ja) 2012-11-14 2019-11-01 アレイ合成および生体分子解析のための、支持体、システム、および方法
JP2022163696A Active JP7514280B2 (ja) 2012-11-14 2022-10-12 アレイ合成および生体分子解析のための、支持体、システム、および方法
JP2024104585A Pending JP2024124458A (ja) 2012-11-14 2024-06-28 アレイ合成および生体分子解析のための、支持体、システム、および方法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017509696A (ja) * 2014-02-21 2017-04-06 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 一段階ペプチドカップリングのためのアミノ酸の選択的光活性化
JP2018119136A (ja) * 2012-11-14 2018-08-02 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー アレイ合成および生体分子解析のための、支持体、システム、および方法
US11565231B2 (en) 2012-02-07 2023-01-31 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US11674956B2 (en) 2012-09-28 2023-06-13 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US12251674B2 (en) 2012-11-14 2025-03-18 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2956771B1 (en) 2013-02-15 2020-04-08 Vibrant Holdings, LLC Methods and compositions for amplified electrochemiluminescence detection
WO2016145434A1 (en) 2015-03-12 2016-09-15 Vibrant Holdings, Llc Polypeptide arrays and methods of attaching polypeptides to an array
EP3402897A4 (en) * 2015-12-28 2019-06-19 Vibrant Holdings, LLC SUBSTRATES, SYSTEMS AND METHODS FOR NUCLEINE ACIDIFICATION SYNTHESIS
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
EP3790985B1 (en) * 2018-05-09 2026-04-15 Vibrant Holdings, LLC Methods of synthesizing a polynucleotide array using photactivated agents
EP3802847A4 (en) * 2018-05-29 2022-03-09 Centrillion Technologies, Inc. INCREASING THE EFFICIENCY OF PHOTOCHEMICAL REACTIONS ON SUBSTRATES
JP7120547B2 (ja) * 2019-02-22 2022-08-17 国立研究開発法人理化学研究所 物質固定化剤、及び当該物質固定化剤を用いた物質固定化方法
US11752195B2 (en) * 2021-04-15 2023-09-12 Arizona Board Of Regents On Behalf Of Arizona State Univeristy Compositions and methods of use of synthetic peptides with Mycobacterium abscessus inhibitory activity

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352678A (en) * 1962-10-05 1967-11-14 Fuji Photo Film Co Ltd Diffusion transfer photographic materials
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5240811A (en) * 1991-04-15 1993-08-31 Ocg Microelectronic Materials, Inc. Photogenerated polycarbodiimides from poly(tetrazole-5-thiones) and use in the preparation of coatings and deep-UV photoresists
EP0702707A1 (en) * 1993-05-26 1996-03-27 Akzo Nobel N.V. Coating composition including a uv-deblockable basic catalyst
ATE165168T1 (de) * 1994-03-29 1998-05-15 Lepetit Spa Festphasenimmunoassay zum nachweis von inhibitoren von einem proteolytischen enzym
JP4503828B2 (ja) * 1998-02-11 2010-07-14 ユニバーシティー オブ ヒューストン 光生成試薬を用いる化学反応および生化学反応のための方法および装置
JP2001172259A (ja) * 1999-03-25 2001-06-26 Nisshinbo Ind Inc 蛍光性基含有カルボジイミド化合物前駆体及び蛍光性基含有カルボジイミド化合物並びにこれらの製造方法
JP4570363B2 (ja) * 2001-10-02 2010-10-27 ノースウエスタン ユニヴァーシティ タンパク質およびペプチドのナノアレイ
JP2003342354A (ja) * 2002-05-24 2003-12-03 Hokko Chem Ind Co Ltd 新規なボレート化合物およびエポキシ樹脂硬化促進剤
DE602004021604D1 (de) * 2003-08-06 2009-07-30 Mitsubishi Gas Chemical Co Ammensetzung
DE602005002571T2 (de) * 2004-02-16 2008-01-31 Mitsubishi Gas Chemical Co., Inc. Photobasengenerator und härtbare Zusammensetzung
JP4843955B2 (ja) * 2004-02-16 2011-12-21 三菱瓦斯化学株式会社 光塩基発生剤
US20070122842A1 (en) 2005-11-30 2007-05-31 Rajasekaran John J Massively parallel synthesis of proteinaceous biomolecules
US20070122841A1 (en) 2005-11-30 2007-05-31 Rajasekaran John J Massively parallel synthesis of proteinaceous biomolecules
US20070154946A1 (en) 2005-12-29 2007-07-05 Rajasekaran John J Massively parallel synthesis of biopolymeric arrays
WO2008118167A1 (en) * 2006-03-24 2008-10-02 The Regents Of The University Of Michigan Method for forming molecular sequences on surfaces
US9096953B2 (en) * 2006-09-29 2015-08-04 Intel Corporation Method for high throughput, high volume manufacturing of biomolecule micro arrays
US20080108149A1 (en) 2006-10-23 2008-05-08 Narayan Sundararajan Solid-phase mediated synthesis of molecular microarrays
US20100093554A1 (en) 2007-06-01 2010-04-15 Keting Chu Methods for identifying biomarkers, autoantibody signatures, and stratifying subject groups using peptide arrays
JP5120378B2 (ja) * 2007-06-06 2013-01-16 日立化成工業株式会社 感光性接着剤組成物、フィルム状接着剤、接着シート、接着剤パターンの形成方法、接着剤層付半導体ウェハ、半導体装置、及び、半導体装置の製造方法
KR101588912B1 (ko) * 2008-03-31 2016-01-26 산아프로 가부시키가이샤 광염기 발생제
JP2011017798A (ja) * 2009-07-07 2011-01-27 Jsr Corp 酸転写性樹脂組成物、バイオチップの製造方法及びバイオチップ
JP5521645B2 (ja) * 2010-02-26 2014-06-18 ぺんてる株式会社 ノック式ボールペン
JP6012767B2 (ja) * 2012-02-07 2016-10-25 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 基板、ペプチドアレイ、および方法
CA3088591C (en) * 2012-09-28 2023-01-03 Vibrant Holdings, Llc Inverted pillar plates for assaying microarrays and methods of using same.
CA2891651C (en) * 2012-11-14 2019-01-22 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis

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US11565231B2 (en) 2012-02-07 2023-01-31 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US12454771B2 (en) 2012-02-07 2025-10-28 Vibrant Holdings Llc Substrates, peptide arrays, and methods
US11674956B2 (en) 2012-09-28 2023-06-13 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US11815512B2 (en) 2012-09-28 2023-11-14 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
JP2018119136A (ja) * 2012-11-14 2018-08-02 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー アレイ合成および生体分子解析のための、支持体、システム、および方法
US12251674B2 (en) 2012-11-14 2025-03-18 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
JP2017509696A (ja) * 2014-02-21 2017-04-06 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 一段階ペプチドカップリングのためのアミノ酸の選択的光活性化

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JP2024124458A (ja) 2024-09-12
CA3027054A1 (en) 2014-05-22
EP4556467A3 (en) 2025-08-13
EP3617219A1 (en) 2020-03-04
CA3027054C (en) 2023-02-07
JP7159145B2 (ja) 2022-10-24
JP2023001123A (ja) 2023-01-04
JP2018119136A (ja) 2018-08-02
EP2920272A2 (en) 2015-09-23
WO2014078606A3 (en) 2014-08-07
JP2016503447A (ja) 2016-02-04
WO2014078606A2 (en) 2014-05-22
JP6613325B2 (ja) 2019-11-27
CA2891651A1 (en) 2014-05-22
CA2891651C (en) 2019-01-22
JP2020037698A (ja) 2020-03-12
EP4556467A2 (en) 2025-05-21
CA3183995A1 (en) 2014-05-22
EP3617219B1 (en) 2025-02-26
EP2920272B1 (en) 2019-08-21
JP7514280B2 (ja) 2024-07-10

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