JP6272834B2 - サイト特異的誘導とｌｃ／ｍｓ／ｍｓワークフローとを使用した脳腱黄色腫症バイオマーカーのパネルの解析 - Google Patents

サイト特異的誘導とｌｃ／ｍｓ／ｍｓワークフローとを使用した脳腱黄色腫症バイオマーカーのパネルの解析 Download PDF

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JP6272834B2
JP6272834B2 JP2015512143A JP2015512143A JP6272834B2 JP 6272834 B2 JP6272834 B2 JP 6272834B2 JP 2015512143 A JP2015512143 A JP 2015512143A JP 2015512143 A JP2015512143 A JP 2015512143A JP 6272834 B2 JP6272834 B2 JP 6272834B2
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Japan
Prior art keywords
cholesten
ketosterol
bile acid
ion
analyte
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JP2015512143A
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Japanese (ja)
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JP2015516578A5 (enExample
JP2015516578A (ja
Inventor
アンドレア デバーバー，
アンドレア デバーバー，
スブハシシュ プルカヤスタ，
スブハシシュ プルカヤスタ，
ロバート ディー． ステイナー，
ロバート ディー． ステイナー，
ミカル ウェインストック，
ミカル ウェインストック，
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Oregon Health and Science University
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Oregon Health and Science University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G01N2333/90248—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one of the donors, and incorporation of one atom of oxygen 1.14.13
    • G01N2333/90251—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one of the donors, and incorporation of one atom of oxygen 1.14.13 with a definite EC number (1.14.13.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015512143A 2012-05-18 2013-05-17 サイト特異的誘導とｌｃ／ｍｓ／ｍｓワークフローとを使用した脳腱黄色腫症バイオマーカーのパネルの解析 Expired - Fee Related JP6272834B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261649044P 2012-05-18 2012-05-18
US61/649,044 2012-05-18
PCT/IB2013/000961 WO2013171568A1 (en) 2012-05-18 2013-05-17 Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow

Publications (3)

Publication Number Publication Date
JP2015516578A JP2015516578A (ja) 2015-06-11
JP2015516578A5 JP2015516578A5 (enExample) 2016-07-07
JP6272834B2 true JP6272834B2 (ja) 2018-01-31

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JP2015512143A Expired - Fee Related JP6272834B2 (ja) 2012-05-18 2013-05-17 サイト特異的誘導とｌｃ／ｍｓ／ｍｓワークフローとを使用した脳腱黄色腫症バイオマーカーのパネルの解析

Country Status (6)

Country Link
US (1) US10078091B2 (enExample)
EP (1) EP2850430B1 (enExample)
JP (1) JP6272834B2 (enExample)
CN (1) CN104603617B (enExample)
CA (1) CA2873650A1 (enExample)
WO (1) WO2013171568A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503753A (ja) * 2012-01-05 2015-02-02 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド ケトステロイドとケトまたはアルデヒドを含む分析物との敏感度および特異度の強化
CN105785048B (zh) * 2016-04-15 2017-07-28 同济大学 基于轻同位素近同重标记的整体蛋白质定量分析方法
CN105866429B (zh) * 2016-05-06 2017-12-15 同济大学 基于自带电荷同位素试剂的生物分子标记和定量分析方法
JP7547315B2 (ja) * 2018-07-24 2024-09-09 エフ． ホフマン－ラ ロシュ アーゲー 質量分析のための試薬

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3029907B2 (ja) * 1991-12-20 2000-04-10 理化学研究所 抗肥満剤
AU2004209401A1 (en) 2003-01-30 2004-08-19 Applied Biosystems, Llc. Methods, mixtures, kits and compositions pertaining to analyte determination
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
CN101454488A (zh) 2006-05-26 2009-06-10 阿普里拉股份有限公司 用于羟基化化合物的标签试剂和方法
GB0713463D0 (en) * 2007-07-11 2007-08-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses
WO2008137767A1 (en) 2007-05-04 2008-11-13 Oregon Health & Science University Tandem mass spectrometry for detecting and/or screening for conditions associated with altered sterols
US20110003395A1 (en) * 2009-05-31 2011-01-06 Dh Technologies Development Pte. Ltd. Specific analysis of analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
US8372653B2 (en) * 2010-01-22 2013-02-12 Dh Technologies Development Pte. Ltd. Mass tag reagents for simultaneous quantitation and identification of small molecules

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Publication number Publication date
US10078091B2 (en) 2018-09-18
EP2850430A4 (en) 2016-02-10
CN104603617B (zh) 2017-04-12
CA2873650A1 (en) 2013-11-21
CN104603617A (zh) 2015-05-06
WO2013171568A1 (en) 2013-11-21
JP2015516578A (ja) 2015-06-11
EP2850430A1 (en) 2015-03-25
US20150323554A1 (en) 2015-11-12
EP2850430B1 (en) 2017-04-19

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