CN104603617B - 使用定点衍生化和lc/ms/ms工作流程分析一组脑腱黄瘤病生物 - Google Patents

使用定点衍生化和lc/ms/ms工作流程分析一组脑腱黄瘤病生物 Download PDF

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Publication number
CN104603617B
CN104603617B CN201380026048.3A CN201380026048A CN104603617B CN 104603617 B CN104603617 B CN 104603617B CN 201380026048 A CN201380026048 A CN 201380026048A CN 104603617 B CN104603617 B CN 104603617B
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Prior art keywords
ketosterol
cholesten
bile acid
labeled
ion
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Expired - Fee Related
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CN201380026048.3A
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English (en)
Chinese (zh)
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CN104603617A (zh
Inventor
A·迪巴贝尔
S·普卡雅斯特哈
R·D·施泰纳
M·魏茵斯托克
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DH Technologies Development Pte Ltd
Oregon Health and Science University
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DH Technologies Development Pte Ltd
Oregon Health and Science University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G01N2333/90248—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one of the donors, and incorporation of one atom of oxygen 1.14.13
    • G01N2333/90251—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one of the donors, and incorporation of one atom of oxygen 1.14.13 with a definite EC number (1.14.13.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201380026048.3A 2012-05-18 2013-05-17 使用定点衍生化和lc/ms/ms工作流程分析一组脑腱黄瘤病生物 Expired - Fee Related CN104603617B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261649044P 2012-05-18 2012-05-18
US61/649,044 2012-05-18
PCT/IB2013/000961 WO2013171568A1 (en) 2012-05-18 2013-05-17 Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow

Publications (2)

Publication Number Publication Date
CN104603617A CN104603617A (zh) 2015-05-06
CN104603617B true CN104603617B (zh) 2017-04-12

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CN201380026048.3A Expired - Fee Related CN104603617B (zh) 2012-05-18 2013-05-17 使用定点衍生化和lc/ms/ms工作流程分析一组脑腱黄瘤病生物

Country Status (6)

Country Link
US (1) US10078091B2 (enExample)
EP (1) EP2850430B1 (enExample)
JP (1) JP6272834B2 (enExample)
CN (1) CN104603617B (enExample)
CA (1) CA2873650A1 (enExample)
WO (1) WO2013171568A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104040343A (zh) * 2012-01-05 2014-09-10 Dh科技发展私人贸易有限公司 增强含有酮类固醇和酮基或醛的分析物的灵敏度和特异性
CN105785048B (zh) * 2016-04-15 2017-07-28 同济大学 基于轻同位素近同重标记的整体蛋白质定量分析方法
CN105866429B (zh) * 2016-05-06 2017-12-15 同济大学 基于自带电荷同位素试剂的生物分子标记和定量分析方法
WO2020020849A1 (en) 2018-07-24 2020-01-30 F. Hoffmann-La Roche Ag Reagent for mass spectrometry

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141075A1 (en) * 2009-05-31 2010-12-09 Dh Technologies Development Pte. Ltd. Specific analysis of ketone and aldehyde analytes using reagent compounds labeling strategies, and mass spectrometry workflow
US8158435B2 (en) * 2007-05-04 2012-04-17 Oregon Health & Science University Tandem mass spectrometry for detecting and/or screening for conditions associated with altered sterols

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3029907B2 (ja) * 1991-12-20 2000-04-10 理化学研究所 抗肥満剤
JP4613299B2 (ja) 2003-01-30 2011-01-12 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 分析物分析に関する方法、混合物、キット、および組成物
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
CA2667854C (en) 2006-05-26 2015-04-07 Applied Biosystems, Llc Tagging reagents and methods for hydroxylated compounds
GB0713463D0 (en) * 2007-07-11 2007-08-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses
US8372653B2 (en) 2010-01-22 2013-02-12 Dh Technologies Development Pte. Ltd. Mass tag reagents for simultaneous quantitation and identification of small molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158435B2 (en) * 2007-05-04 2012-04-17 Oregon Health & Science University Tandem mass spectrometry for detecting and/or screening for conditions associated with altered sterols
WO2010141075A1 (en) * 2009-05-31 2010-12-09 Dh Technologies Development Pte. Ltd. Specific analysis of ketone and aldehyde analytes using reagent compounds labeling strategies, and mass spectrometry workflow

Also Published As

Publication number Publication date
WO2013171568A1 (en) 2013-11-21
CN104603617A (zh) 2015-05-06
EP2850430A1 (en) 2015-03-25
JP6272834B2 (ja) 2018-01-31
EP2850430B1 (en) 2017-04-19
EP2850430A4 (en) 2016-02-10
US20150323554A1 (en) 2015-11-12
JP2015516578A (ja) 2015-06-11
CA2873650A1 (en) 2013-11-21
US10078091B2 (en) 2018-09-18

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