JP6258922B2 - 制御性b細胞の製造及び使用方法 - Google Patents
制御性b細胞の製造及び使用方法 Download PDFInfo
- Publication number
- JP6258922B2 JP6258922B2 JP2015509008A JP2015509008A JP6258922B2 JP 6258922 B2 JP6258922 B2 JP 6258922B2 JP 2015509008 A JP2015509008 A JP 2015509008A JP 2015509008 A JP2015509008 A JP 2015509008A JP 6258922 B2 JP6258922 B2 JP 6258922B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- protein
- isolated
- cell
- ril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/13—B-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2312—Interleukin-12 (IL-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2327—Interleukin-27 (IL-27)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2335—Interleukin-35 (IL-35)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/65—MicroRNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637915P | 2012-04-25 | 2012-04-25 | |
| US61/637,915 | 2012-04-25 | ||
| PCT/US2013/036175 WO2013162905A1 (en) | 2012-04-25 | 2013-04-11 | Methods of producing and using regulatory b-cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516156A JP2015516156A (ja) | 2015-06-11 |
| JP2015516156A5 JP2015516156A5 (enExample) | 2016-05-19 |
| JP6258922B2 true JP6258922B2 (ja) | 2018-01-10 |
Family
ID=48183014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509008A Active JP6258922B2 (ja) | 2012-04-25 | 2013-04-11 | 制御性b細胞の製造及び使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9629897B2 (enExample) |
| EP (1) | EP2841562B1 (enExample) |
| JP (1) | JP6258922B2 (enExample) |
| AU (1) | AU2013252771B2 (enExample) |
| CA (1) | CA2871499C (enExample) |
| WO (1) | WO2013162905A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015526520A (ja) * | 2012-08-31 | 2015-09-10 | プリンシピア バイオファーマ インコーポレイテッド | Itk阻害剤としてのベンズイミダゾール誘導体 |
| WO2018013897A1 (en) * | 2016-07-15 | 2018-01-18 | Board Of Regents, The University Of Texas System | Regulatory b cells and uses thereof |
| GB201707238D0 (en) | 2017-05-05 | 2017-06-21 | Univ Oxford Innovation Ltd | Composition |
| EP4302768A3 (en) * | 2017-06-22 | 2024-05-01 | Board Of Regents, The University Of Texas System | Methods for producing regulatory immune cells and uses thereof |
| WO2019165447A1 (en) * | 2018-02-26 | 2019-08-29 | Claudia Zylberberg | Immune cell activation |
| CA3136551A1 (en) | 2019-04-12 | 2020-10-15 | Board Of Regents, The University Of Texas System | Methods for producing regulatory b cells and uses thereof |
| CA3143998A1 (en) | 2019-06-18 | 2020-12-24 | Charles E. EGWUAGU | Interleukin-27 producing b-cells and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008500812A (ja) | 2004-03-18 | 2008-01-17 | ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ グラスゴウ | 免疫抑制サイトカイン |
| AU2006261527B2 (en) | 2005-05-16 | 2012-11-22 | Prometic Pharma Smt Limited | Purine derivatives and their use for treatment of autoimmune diseases |
| WO2009131712A2 (en) * | 2008-04-25 | 2009-10-29 | Duke University Medical Center | Regulatory b cells and their uses |
| US8592364B2 (en) * | 2010-02-11 | 2013-11-26 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | CCR7 ligand delivery and co-delivery in immunotherapy |
| WO2012082771A1 (en) * | 2010-12-13 | 2012-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Cardiac glycosides for treating autoimmune disease |
-
2013
- 2013-04-11 EP EP13718448.7A patent/EP2841562B1/en active Active
- 2013-04-11 JP JP2015509008A patent/JP6258922B2/ja active Active
- 2013-04-11 WO PCT/US2013/036175 patent/WO2013162905A1/en not_active Ceased
- 2013-04-11 CA CA2871499A patent/CA2871499C/en active Active
- 2013-04-11 AU AU2013252771A patent/AU2013252771B2/en active Active
- 2013-04-11 US US14/396,475 patent/US9629897B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2871499A1 (en) | 2013-10-31 |
| AU2013252771A1 (en) | 2014-10-30 |
| JP2015516156A (ja) | 2015-06-11 |
| WO2013162905A1 (en) | 2013-10-31 |
| AU2013252771B2 (en) | 2017-06-08 |
| EP2841562A1 (en) | 2015-03-04 |
| CA2871499C (en) | 2021-08-17 |
| EP2841562B1 (en) | 2020-06-03 |
| US20150110737A1 (en) | 2015-04-23 |
| WO2013162905A8 (en) | 2014-01-23 |
| US9629897B2 (en) | 2017-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6258922B2 (ja) | 制御性b細胞の製造及び使用方法 | |
| Liu et al. | Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression | |
| Boniface et al. | From interleukin‐23 to T‐helper 17 cells: human T‐helper cell differentiation revisited | |
| JP4638876B2 (ja) | Gitrリガンド及びgitrリガンド関連分子及び抗体及びその使用 | |
| Morel et al. | Dendritic cells, T cell tolerance and therapy of adverse immune reactions | |
| US20170159057A1 (en) | Compositions and methods for modulation of rorgammat functions | |
| Sasaoka et al. | Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells | |
| Park et al. | NF-κB activation in T helper 17 cell differentiation | |
| JP2015525069A (ja) | 免疫抑制細胞、並びにその作成方法及び使用方法 | |
| JP2025111489A (ja) | Interleukin-27産生b細胞及びその使用 | |
| WO2010003002A2 (en) | Modulation of follicular helper t cells | |
| CN107002037A (zh) | 用于调节th‑gm细胞功能的方法和组合物 | |
| EP2170394A1 (en) | Regulatory t cells in adipose tissue | |
| JP2004208548A (ja) | 免疫反応の抗原特異的抑制 | |
| KR102569644B1 (ko) | Gdf15를 유효성분으로 함유하는 면역질환의 예방 및 치료용 조성물 | |
| Alakhras | Cell-Type Specific Function of STAT4 in an Animal Model of Multiple Sclerosis | |
| JP6739106B2 (ja) | 自己免疫疾患の治療用ペプチド断片 | |
| Hu | The roles of STRA6, EFNB1/B2 and ARMC5 in T cell function and autoimmune diseases | |
| Chang et al. | The pro-and anti-inflammatory potential of IL-12: the dual role of Th1 cells | |
| Zgaga-Griesz et al. | Aberrant expression of the co-chaperone HDJ2 in rheumatoid arthritis | |
| Perry | Genetic dissection of murine lupus susceptibility locus SLE1C identifies estrogen-related receptor gamma as a novel regulator of autoimmunity | |
| Wilson | Alterations in T cell functions mediated by SOCS1 deficiency: Implications for SLE development and revelation of a novel biological target | |
| Löytömäki | Immunopathogenesis of Asthma and Atopic Diseases–The specific Role of a selected Panel of Genes in human T helper Cell Differentiation | |
| Karlsson | Ex vivo-generated inducible regulatory T cells cure colitis | |
| Sabatos | Tim-3 regulation of the T helper 1 (Th1) immune response |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD01 | Notification of change of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7426 Effective date: 20150713 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150713 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160324 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160324 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170117 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170413 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170614 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20171107 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20171207 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6258922 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |