JP6253986B2 - コレクション及びその使用方法 - Google Patents

コレクション及びその使用方法 Download PDF

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Publication number
JP6253986B2
JP6253986B2 JP2013539286A JP2013539286A JP6253986B2 JP 6253986 B2 JP6253986 B2 JP 6253986B2 JP 2013539286 A JP2013539286 A JP 2013539286A JP 2013539286 A JP2013539286 A JP 2013539286A JP 6253986 B2 JP6253986 B2 JP 6253986B2
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seq
antibody
collection
germline
sequence
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Japanese (ja)
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JP2014500725A5 (enExample
JP2014500725A (ja
Inventor
ウルリンガー，シュテファーニエ
ティラー，トーマス
シュスター，イングリット
シュタルク，イボンヌ
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Morphosys GmbH
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Morphosys GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2013539286A 2010-11-19 2011-11-18 コレクション及びその使用方法 Active JP6253986B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41536710P 2010-11-19 2010-11-19
EP10191910.8 2010-11-19
US61/415,367 2010-11-19
EP10191910 2010-11-19
US201161494452P 2011-06-08 2011-06-08
US61/494,452 2011-06-08
PCT/EP2011/070473 WO2012066129A1 (en) 2010-11-19 2011-11-18 A collection and methods for its use

Publications (3)

Publication Number Publication Date
JP2014500725A JP2014500725A (ja) 2014-01-16
JP2014500725A5 JP2014500725A5 (enExample) 2015-01-15
JP6253986B2 true JP6253986B2 (ja) 2017-12-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013539286A Active JP6253986B2 (ja) 2010-11-19 2011-11-18 コレクション及びその使用方法

Country Status (18)

Country Link
US (3) US8728981B2 (enExample)
EP (1) EP2640742B1 (enExample)
JP (1) JP6253986B2 (enExample)
KR (1) KR101938021B1 (enExample)
CN (1) CN103237809B (enExample)
AU (1) AU2011331129B2 (enExample)
CA (1) CA2816558C (enExample)
DK (1) DK2640742T3 (enExample)
ES (1) ES2696548T3 (enExample)
HR (1) HRP20181811T1 (enExample)
IL (1) IL226364B (enExample)
MX (1) MX353795B (enExample)
NZ (1) NZ609707A (enExample)
PL (1) PL2640742T3 (enExample)
RU (1) RU2603080C2 (enExample)
SG (2) SG10201509257VA (enExample)
WO (1) WO2012066129A1 (enExample)
ZA (1) ZA201303566B (enExample)

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CN102993305B (zh) 2012-11-16 2015-05-13 上海赛伦生物技术有限公司 人源抗人表皮生长因子受体抗体及其编码基因与应用
JP6621750B2 (ja) * 2013-09-18 2019-12-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒスチジン操作軽鎖抗体およびそれを生成するための遺伝子改変非ヒト動物
US10684289B2 (en) 2013-12-09 2020-06-16 Adimab, Llc Polyclonal mixtures of antibodies, and methods of making and using them
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ES2996699T3 (en) * 2016-04-12 2025-02-13 Medimmune Llc Immune repertoire mining
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CN115667307A (zh) 2020-05-20 2023-01-31 居里研究所 合成的单域文库
EP4154004A1 (en) 2020-06-08 2023-03-29 Immundiagnostik AG Improved method and test system for in-vitro determination of drug antibodies in blood
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Also Published As

Publication number Publication date
IL226364B (en) 2020-11-30
CA2816558C (en) 2020-12-29
US8367586B2 (en) 2013-02-05
JP2014500725A (ja) 2014-01-16
ZA201303566B (en) 2014-07-30
EP2640742B1 (en) 2018-08-15
AU2011331129A1 (en) 2013-05-23
KR20140015274A (ko) 2014-02-06
US8728981B2 (en) 2014-05-20
RU2013126025A (ru) 2014-12-27
IL226364A0 (en) 2013-07-31
PL2640742T3 (pl) 2019-01-31
AU2011331129B2 (en) 2016-10-06
EP2640742A1 (en) 2013-09-25
HRP20181811T1 (hr) 2018-12-28
MX353795B (es) 2018-01-30
CN103237809A (zh) 2013-08-07
US20120129717A1 (en) 2012-05-24
WO2012066129A1 (en) 2012-05-24
US20130236902A1 (en) 2013-09-12
US9541559B2 (en) 2017-01-10
DK2640742T3 (en) 2018-12-03
US20140206575A1 (en) 2014-07-24
MX2013005614A (es) 2013-11-21
CN103237809B (zh) 2016-09-07
KR101938021B1 (ko) 2019-01-11
RU2603080C2 (ru) 2016-11-20
NZ609707A (en) 2014-12-24
ES2696548T3 (es) 2019-01-16
SG189950A1 (en) 2013-06-28
CA2816558A1 (en) 2012-05-24
SG10201509257VA (en) 2015-12-30

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