JP6249962B2 - 抗体およびエンドグリコシダーゼの組合せ治療上の使用 - Google Patents
抗体およびエンドグリコシダーゼの組合せ治療上の使用 Download PDFInfo
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Description
薬剤と治療用抗体が同時、個別または連続的に使用するための組合せ調製物として存在する。
(a)対象に前記薬剤を投与するステップ、および次いで、
(b)場合によっては一定時間間隔後、対象に前記治療用抗体を投与するステップを含む。
(a)薬剤を用いてex vivoで対象由来の血液を処置するステップ、
(b)血液を対象に戻すステップ、および
(c)対象に前記治療用抗体を投与するステップを含む。
(a)治療有効量の内因性血清抗体のFc受容体結合を低減するEndoS、および
(b)治療有効量の治療用抗体、好ましくはEndoSのエンドグリコシダーゼ活性に耐性がある治療用抗体、および
(c)薬学的に許容される担体または希釈剤を含む、
がん、感染および/または自己免疫疾患の治療方法において使用するための医薬組成物も提供する。
(a)治療有効量の内因性血清抗体のFc受容体結合を低減するEndoS、および
(b)治療有効量のEndoSのエンドグリコシダーゼ活性に耐性があるオリゴマンノースタイプ糖型の治療用抗体、および
(c)薬学的に許容される担体または希釈剤を含む、
がん、感染および/または自己免疫疾患の治療方法において使用するための医薬組成物も提供する。
(a)配列番号1のアミノ酸配列、
(b)配列番号1のアミノ酸配列と少なくとも50%の同一性を有しIgGエンドグリコシダーゼ活性を有するその変異体、または
(c)IgGエンドグリコシダーゼ活性を有する(a)または(b)いずれかの断片
を含むことができる。
(a)配列番号2のアミノ酸配列、
(b)配列番号2のアミノ酸配列と少なくとも50%の同一性を有しIgGエンドグリコシダーゼ活性を有するその変異体、または
(c)IgGエンドグリコシダーゼ活性を有する(a)または(b)いずれかの断片
を含むことができる。
EndoSポリペプチドは、配列番号2において示す配列からなり得る。
「バイセクティングN−アセチルグルコサミン」を含有する糖型であり、β−マンノース残基と1−4結合したβ−N−アセチルグルコサミンを含有する糖型は、複合タイプまたはハイブリッドタイプのグリカンを生成することができGlcNAcトランスフェラーゼIII(GnTIIIとしても知られる、およびUDP−N−アセチルグルコサミン:β−Dマンノシドβ(1,4)−N−アセチルグルコサミニルトランスフェラーゼ)を発現する真核生物発現系における発現によって作製することができる(例えば米国特許第7897842号)。
1.(i)内因性血清抗体のFc受容体結合を低減する薬剤、および
(ii)薬剤に耐性がある治療用抗体
を含む組成物。
2.治療用抗体の効能の増大において使用するための、実施形態1に記載の組成物。
3.がん、感染および/または自己免疫疾患の治療において使用するための、実施形態1に記載の組成物。
4.薬剤がエンドグリコシダーゼ、プロテアーゼまたはプロテイン−N−グリカナーゼから選択される、実施形態1から3に記載の組成物。
5.エンドグリコシダーゼがエンドグリコシダーゼSもしくはエンドグリコシダーゼF3もしくはエンドグリコシダーゼEbetaから選択される、実施形態4に記載の組成物。
6.治療用抗体の効能の増大において使用するための、内因性血清抗体のFc受容体結合を低減する薬剤、および薬剤に耐性がある治療用抗体。
7.実施形態6では、薬剤はエンドグリコシダーゼ、プロテアーゼまたはプロテイン−N−グリカナーゼから選択される。
8.実施形態7では、エンドグリコシダーゼはエンドグリコシダーゼS、エンドグリコシダーゼF3およびエンドグリコシダーゼEbetaから選択される。
9.内因性血清抗体のFc受容体結合を低減する薬剤に耐性がある治療用抗体。
10.抗体のFcドメインが無グリコシル化状態でありFc受容体と結合することができる、実施形態9に記載の治療用抗体。
11.抗体のFcドメインが薬剤の活性に耐性がある1つまたは複数の糖型を含む、実施形態9に記載の治療用抗体。
12.Fcドメインの各グリカンが少なくとも5個のマンノース残基を含有する、実施形態9、10または11に記載の治療用抗体。
13.糖型がオリゴマンノースタイプの糖型である、実施形態11に記載の治療用抗体。
14.Fcドメインの各グリカンが2個のみのGlcNAc残基と3個以上のマンノース残基を含有する、実施形態13に記載の治療用抗体。
15.Fcドメインの各グリカンがMan5GlcNAc2、Man8GlcNAc2、もしくはMan9GlcNAc2を含有する、実施形態13に記載の治療用抗体。
16.オリゴマンノースタイプの糖型がオリゴマンノースタイプのグリカンの混合物である、実施形態13に記載の治療用抗体。
17.Fcドメインの各グリカンが5〜20個のマンノース残基を含有する、実施形態13または14に記載の治療用抗体。
18.糖型がハイブリッドタイプの糖型である、実施形態11に記載の治療用抗体。
19.糖型がβ−マンノース残基と1−4結合した少なくとも1個のβ−N−アセチルグルコサミン残基(「バイセクティングN−アセチルグルコサミン」)を含有する、実施形態11に記載の治療用抗体。
20.糖型がβ−マンノース残基と1−4結合した2個のβ−N−アセチルグルコサミン残基(「バイセクティングN−アセチルグルコサミン」)を含有する、実施形態11に記載の治療用抗体。
21.糖型がガラクトースとα2−6結合したシアル酸もしくはシアル酸を含有する、実施形態11に記載の治療用抗体。
22.抗体介在療法の効能を増大するための医薬品の製造における、内因性血清抗体のFc受容体結合を低減する薬剤、および薬剤に耐性がある治療用抗体の使用。
23.医薬品ががん、感染および/または自己免疫疾患の治療用である、実施形態22に記載の使用。
24.薬剤がEndoSであり、治療用抗体がオリゴマンノースタイプのグリカンを含むFcドメインを有する、実施形態22に記載の使用。
25.薬剤がEndoSであり、治療用抗体がハイブリッドタイプのグリカンを含むFcドメインを有する、実施形態22に記載の使用。
26.薬剤がEndoSであり、治療用抗体がβ−マンノース残基と1−4結合したβ−N−アセチルグルコサミン残基を含むFcドメインを有する、実施形態22に記載の使用。
27.薬剤がEndoSであり、治療用抗体がシアル酸を含むFcドメインを有する、実施形態22に記載の使用。
28.抗体介在療法の効能を増大するための方法であって、内因性血清抗体のFc受容体結合を低減する薬剤、および薬剤に耐性がある治療用抗体を対象に投与するステップを含む方法。
29.がん、感染および/または自己免疫疾患を治療するための、内因性血清抗体のFc受容体結合を低減する薬剤、および薬剤に耐性がある治療用抗体を対象に投与するステップを含む、実施形態28に記載の方法。
30.がん、感染および/または自己免疫疾患の治療において使用するための、
(i)治療有効量の内因性血清抗体のFc受容体結合を低減する薬剤、および
(ii)治療有効量の薬剤に耐性がある治療用抗体
を含むキット。
配列番号1は、化膿性連鎖球菌(S.pyogenes)AP1から単離したEndoSのアミノ酸配列である。
配列番号2は、シグナル配列を含む、化膿性連鎖球菌(S.pyogenes)AP1から単離したEndoSのアミノ酸配列である。
実施例
図8は、本発明の少なくとも1つの態様の原理を示す。特に図8は、どのようにしてEndoSが、「正常」Fcグリコシル化を除去することにより、FcγRに対する大量血清抗体のアフィニティーを無効にするかを示す概略図である。しかしながらEndoSは、グリカン操作型(オリゴマンノースタイプ)抗体に対しては影響がなく、FcRの活性化が実施される。生理的条件下において大部分のFcRは「無関係な」、典型的には血清IgFcによって結合する。これは、利用可能なFc受容体(FcγR)の有効濃度に強い制約を課す。この実施形態では、Endo−Sを使用して、グリカン操作型(オリゴマンノースタイプ)モノクローナル抗体ではなく、FcγRに対する無関係な血清抗体のアフィニティーを有意に低下させる。
EndoSを使用してFcγRIIIaと血清IgGの結合を低減することが可能であることを実証するため、以下の実験を実施した。PBS中2.5μg/mLのFcγRIIIa(158Val変異体;R and D systems、Minneapolis、U.S.A.)を、4℃で一晩、高結合マイクロタイタープレート(3690、Corning、NY、U.S.A.)にコーティングした。コーティングしたプレートは0.05%Tween20を含有するPBS(Sigma−aldrich、U.S.A.)で洗浄し、PBS中3%BSAで室温において2時間ブロッキングした。ヒト血清(H4522、Sigma−Aldrich、U.S.A.)またはMan9GlcNAc2もしくはMan5GlcNAc2を有する組換えヒトIgG1糖型の連続希釈液を次いで加え(PBS中に0.1mg/mLの開始濃度)、室温において2時間結合させた。プレートは0.05%Tweenを含有するPBSで5回洗浄し、ネズミIgGFabに特異的なHRP結合Fab断片(ab98659、Abcam、Cambridge、UK)を使用して結合を検出した。TMB基質(Thermo Scientific、Rockford、IL、U.S.A.)を、製造者の指示に従い発色に使用した。2M H2SO4の添加により発色を停止させ、Spectramax M5(Molecular Devices、California、U.S.A.)マルチウエルプレートリーダーにおいて450nmで吸光度を測定した。37℃で一晩、1μg/mLのEndoSまたはPBSと共に血清をインキュベートした。対照血清サンプルはPBSで擬似処置し、37℃で一晩インキュベートした。データを処理し、Prism(GraphPadソフトウェア、California、U.S.A.)を使用してプロットした。みかけのアフィニティーは、ELISA結合曲線上の最大結合の半分に相当するオリゴマンノースタイプmAbの濃度として計算した。正常ヒト血清の結合は、標識抗ヒトFabを使用して検出した。これらの結果は図1中に示し、ヒト血清IgGのEndoS処置はFcγRIIIa結合の低減をもたらすことを明らかに実証する。
バイセクティンググリカンとシアル酸構造がEndoSに耐性があることを実証するため、ヒト血清IgGで見られたN結合グリカンの組成分析を、材料および方法のセクション中に記載したようにEndoS消化の前(a)と後(b)に実施した。天然血清Igで見られた主なニュートラル2触角状構造(neutral bi-antennary structures)(m/z1559、1721、1883)は、EndoSに曝されたIgGには全く存在しなかった。対照的に、対応するバイセクティング構造(図2Aおよび2B中のm/z1762、1925、および2087)はEndo−S消化前に小集団を示したが、EndoS消化後にはIgGにおいて最も多量の種に対応した。
EndoSに耐性があるオリゴマンノースタイプ抗体を作製することが可能であることを実証するため、以下の実験を実施した。
タンパク質の発現およびIgG1オリゴマンノースタイプ糖型の精製
Man9GlcNAc2およびMan5GlcNAc2
ヒトIgG1Fc(残基240〜440、Edelman et alのナンバリングに従う、GenBank受託番号J00228)をpHLsecベクターにクローニングし、それぞれ1:1.5の質量比でポリエチレンイミン(PEI)と混合したDNAと共に、以前に記載されたように(Aricescu et al. Acta Crystallogr D Biol Crystallogr.2006 Oct;62(Pt10):1243-50.Epub 2006 Sep 19)、ヒト胚腎臓細胞において一過的に発現させた。Man9GlcNAc2糖型は、5μMのキフネンシン、クラスIα−マンノシダーゼ阻害剤の存在下でヒト胚腎臓293T細胞における一過的発現により得て(Chang VT, Crispin M, Aricescu AR, Harvey DJ, Nettleship JE, Fennelly JA, Yu C, Boles KS, Evans EJ, Stuart DI, Dwek RA, Jones EY, Owens RJ, Davis SJ. Structure. 2007 Mar;15(3):267-73)、未熟オリゴマンノースタイプN結合グリカンを有するIgG−Fc、Man9GlcNAc2を生成した。Man5GlcNAc2糖型は、GlcNAcトランスフェラーゼI欠損ヒト胚腎臓293S細胞における一過的発現により得た(Reeves, P.J., N. Callewaert, et al.(2002).Proc Natl Acad Sci USA99(21):13419-13424)。細胞上澄はトランスフェクション後5日で浄化し、IgG−Fcは、Chelating Sepharose Fast Flow Ni2+−アガロースビーズ(GE Healthcare、Buckinghamshire、UK)を使用して、固定化金属イオンアフィニティークロマトグラフィーにより精製した。IgG−Fcは、75μgmL−1エンドグリコシダーゼHを使用して、12時間25℃で部分的に脱グリコシル化状態にし、次いでサイズ排除クロマトグラフィーにより精製した。タンパク質純度はSDS−PAGE分析によって評価し、脱グリコシル化IgGの典型的収量は20mgL−1細胞培養物であった。
オリゴ糖を、クーマシーブルー染色還元SDS−PAGEゲルから切除した約10μgの標的糖タンパク質を含有するバンドから切り離し、水とアセトニトリルで交互に洗浄し、真空遠心分離で乾燥させ、次に100単位/mlのPNGaseF(New England Biolabs、MA、U.S.A.)で再水和し、37℃で12時間インキュベートした。酵素により切り離したN結合グリカンは水で溶出させた。エンドグリコシダーゼによるグリカンの消化は、(Genovis AB、Lund、Swedenから購入可能、さらにProfessor Ben Davis、CRL、University of Oxfordから入手可能な)1μgの組換えEndoS、または1μlのEndoH(500U/μl、New England Biolabs、MA、U.S.A.)を加えることによって行い、37℃で12時間インキュベートした。
前述の方法によって作製したグリカンの水溶液を、Nafion117膜で洗浄した。正イオンMALDI−TOF質量スペクトルを、ディレイドエクストラクションおよび窒素レーザー(337nm)を備えるShimazu AXIMA TOF MALDI TOF/TOFで記録した。加速電圧は20kVであり、パルス電圧は3200kVであり、ディレイドエクストラクションイオンソースに関するディレイは500nsであった。ステンレススチールターゲットプレートにおいてマトリックス溶液(アセトニトリル中に2,5−ジヒドロキシ安息香酸の0.3μL飽和溶液)に0.5μLの水溶液サンプルを加えることによりサンプルを調製し、室温でそれを乾燥させた。次いでサンプル/マトリックス混合物をエタノールから再結晶化した。
細胞系SKBR3(HER2の発現が高い細胞系)由来の細胞をマウスに皮下導入する。EndoSと、EndoSに耐性がありHER2を対象とする治療用抗体(例えばハーセプチン)を、4週間の間、週当たり30mg/Kgの用量で静脈内に導入する。対照マウスには(i)EndoSまたは(ii)治療用抗体のいずれも与えない。生成する腫瘍のサイズはカリパーにより測定する。
乳がん対象を、生理食塩水溶液中に15mgのEndoSで静脈内治療する。患者のIgGグリコシル化レベルは患者IgGサンプルの精製によってモニタリングし、SDS−PAGEによってIgG質量を評価する(IgGの脱グリコシル化はIgGの質量の低下をもたらす)。
乳がん対象の血液を250mL/1時間の割合で4時間EndoS用カラムに通し、対象に戻す。このとき、グリコシル化内因性血清IgGのレベルは開始レベルの50%未満に低下する。対象は後に体重1kg当たり2mgのトラスツズマブで静脈内治療する。
Claims (14)
- (i)内因性血清抗体のFc受容体結合を酵素による分解によって低減する、抗体の治療効能を増大させる方法の使用のための薬剤であって、前記薬剤がエンドグリコシダーゼ、プロテアーゼまたはプロテイン−N−グリカナーゼであり、前記抗体の作用形態はFc:FcR相互作用を利用するものであり、前記方法は、
(a)対象に前記薬剤を投与するステップ、その後
(b)一定時間間隔後、対象に前記抗体を投与するステップを含む、
薬剤。 - 前記方法は疾患の治療のためである請求項1に記載の薬剤。
- 疾患ががん、感染または自己免疫疾患である、請求項2に記載の薬剤。
- がんが急性リンパ芽球性白血病、急性骨髄性白血病、副腎皮質癌、AIDS関連がん、AIDS関連リンパ腫、肛門がん、虫垂がん、小児期小脳もしくは大脳における星状細胞腫、基底細胞癌、肝外胆管がん、膀胱がん、骨がん、骨肉腫/悪性線維組織球腫、脳幹グリオーマ、脳がん、脳腫瘍、小児期星状細胞腫、脳腫瘍、大脳星状細胞腫/悪性グリオーマ、脳腫瘍、上衣細胞腫、脳腫瘍、髄芽細胞腫、脳腫瘍、テント上原始神経外胚葉性腫瘍、脳腫瘍、視経路および視床下部グリオーマ、乳がん、気管支腺腫/カルチノイド、バーキットリンパ腫、カルチノイド腫瘍、胃腸部のカルチノイド腫瘍、未知の原発性癌、中枢神経系リンパ腫、小児期星状細胞腫、大脳星状細胞腫/悪性グリオーマ、子宮頸がん、慢性リンパ性白血病、慢性骨髄性白血病 慢性骨髄増殖性疾患、結腸がん、皮膚T細胞リンパ腫、線維形成性小円形細胞腫瘍、子宮内膜がん、上衣細胞腫、食道がん、ユーイング肉腫ファミリー腫瘍のユーイング肉腫、頭蓋外胚細胞腫瘍、小児性腺外胚細胞腫瘍、肝外胆管がん、眼部がん、眼内メラノーマ、眼部がん、網膜芽細胞腫、胆嚢がん、胃腸(胃)がん、消化管カルチノイド腫瘍、消化管間質腫瘍(GIST)、胚細胞腫瘍:頭蓋外、腺外、または卵巣、妊娠栄養膜腫瘍、脳幹のグリオーマ、グリオーマ、小児期大脳星状細胞腫、グリオーマ、小児期視経路および視床下部、胃カルチノイド、ヘアリーセル白血病、頭頚部がん、心臓がん、肝細胞(肝臓)がん、ホジキンリンパ腫、下咽頭がん、視床下部および視経路グリオーマ、眼内メラノーマ、膵島細胞癌(膵内分泌腺)、カポジ肉腫、腎臓がん(腎細胞がん)、咽頭がん、白血病(Leukemias)、急性リンパ芽球性白血病(急性リンパ性白血病とも呼ばれる)、急性骨髄性白血病(急性骨髄性白血病(acute myelogenous leukemia)とも呼ばれる)、慢性リンパ芽球性白血病(慢性リンパ性白血病とも呼ばれる)、慢性骨髄性白血病(慢性骨髄性白血病(chronic myeloid leukemia)とも呼ばれる)、ヘアリ細胞白血病、唇および口腔がん、脂肪肉腫、(原発性)肝がん、非小細胞肺がん、小細胞肺がん、リンパ腫(Lymphomas)、AIDS関連リンパ腫、バーキットリンパ腫、皮膚T細胞リンパ腫、ホジキンリンパ腫、非ホジキンリンパ腫(旧分類法のホジキン以外の全リンパ腫)、原発性中枢神経系リンパ腫、ヴァルデンストレームマクログロブリン血症、骨の悪性線維組織球腫/骨肉腫、髄芽細胞腫、メラノーマ、眼内(眼)メラノーマ、メルケル細胞癌、中皮腫、成人悪性中皮腫、原発不明転移性扁平上皮性頚部がん、口腔がん、多発性内分泌腫瘍症、多発性メラノーマ/形質細胞性腫瘍、菌状息肉症、骨髄異形成症候群、骨髄異形成/骨髄増殖性疾患、骨髄性白血病、慢性骨髄性白血病、成人急性骨髄性白血病、小児急性ミエローマ、多発性(骨髄のがん)、骨髄増殖性疾患、鼻腔および副鼻腔がん、鼻咽頭癌、神経芽細胞腫、非ホジキンリンパ腫、非小細胞肺がん、口腔がん、中咽頭がん、骨肉腫/骨の悪性線維組織球腫、卵巣がん、卵巣上皮がん(表面上皮−間質腫瘍)、卵巣胚細胞腫瘍、悪性の可能性が低い卵巣腫瘍、膵臓がん、膵島細胞がん、副鼻腔および鼻腔がん、上皮小体がん、陰茎がん、咽頭がん、クロム親和性細胞腫、松果体星状細胞腫、松果体胚細胞腫、松果体芽細胞腫およびテント上原始神経外胚葉性腫瘍、下垂体腺腫、形質細胞性腫瘍/多発性ミエローマ、胸膜肺芽細胞腫、中枢神経系原発性リンパ腫、前立腺がん、直腸がん、腎細胞癌(腎臓がん)、腎盂および尿管、移行上皮細胞がん、網膜芽細胞腫、横紋筋肉腫、唾液腺がん、肉腫、ユーイング肉腫ファミリー腫瘍、カポジ肉腫、肉腫、軟質組織、肉腫、子宮、セザリー症候群、皮膚がん(非メラノーマ)、皮膚がん(メラノーマ)、皮膚腫瘍、メルケル細胞、小細胞肺がん、小腸がん、軟質組織肉腫、扁平上皮細胞癌、原発不明転移性扁平上皮性頚部がん、胃がん、テント上原始神経外胚葉性腫瘍、皮膚T細胞リンパ腫−菌状息肉症およびセザリー症候群参照、精巣がん、咽頭がん、胸腺腫、胸腺腫および胸腺癌、甲状腺がん、甲状腺がん、腎盂および尿管の移行上皮細胞がん、栄養膜腫瘍、尿管および腎盂の移行上皮細胞がん 尿道がん、子宮がん、子宮内膜、子宮肉腫、膣がん、視経路および視床下部グリオーマ、外陰がん、ヴァルデンストレームマクログロブリン血症またはウィルムス腫瘍(腎臓がん)である、請求項3に記載の薬剤。
- がんが、膀胱がん、肺がん、乳がん、メラノーマ、結腸がん、直腸がん、非ホジキンリンパ腫、子宮内膜がん、膵臓がん、腎臓(腎細胞)がん、前立腺がん、白血病、甲状腺がんまたは食道がんである、請求項3に記載の薬剤。
- 薬剤と抗体が、連続的に使用するための組合せ調製物として存在する、請求項1から5のいずれか一項に記載の薬剤。
- 一定時間間隔が1〜2、1〜5、1〜10または1〜20日である、請求項1から6のいずれか一項に記載の薬剤。
- 方法が、
(a)薬剤を用いてex vivoで対象由来の血液を処置するステップ、
(b)処置済み血液を対象に戻すステップ、その後
(c)対象に前記抗体を投与するステップを含む、
請求項1から7のいずれか一項に記載の薬剤。 - エンドグリコシダーゼがエンドグリコシダーゼS(EndoS)もしくはエンドグリコシダーゼF3もしくはエンドグリコシダーゼEbetaであり、またはプロテアーゼがIdeSである、請求項1〜8のいずれかに記載の薬剤。
- 薬剤がEndoSまたはIdeSである、請求項1〜9のいずれか一項に記載の薬剤。
- 抗体が、アバゴモマブ、アブシキシマブ、アクトキスマブ、アダリムマブ、アデカツムマブ、アフェリモマブ、アフツズマブ、アラシズマブペゴール、ALD518、アレムツズマブ、アリロクマブ、アルツモマブペンテテート、アマツキシマブ、アナツモマブマフェナトクス、アンルキンズマブ、アポリズマブ、アルシツモマブ、アセリズマブ、アチヌマブ、アトリズマブ(=トシリズマブ)、アトロリムマブ、バピネウズマブ、バシリキシマブ、バビツキシマブ、ベクツモマブ、ベリムマブ、ベンラリズマブ、ベルチリムマブ、ベシレソマブ、ベバシズマブ、ベズロトキスマブ、ビシロマブ、ビマグルマブ、ビバツズマブメルタンシン、ブリナツモマブ、ブロソズマブ、ブレンツキシマブベドチン、ブリアキヌマブ、ブロダルマブ、カナキヌマブ、カンツズマブメルタンシン、カンツズマブラヴタンシン、カプラシズマブ、カプロマブペンデタイド、カルルマブ、カツマキソマブ、CC49、セデリズマブ、セルトリズマブペゴール、セツキシマブ、Ch.14.18、シタツズマブボガトックス、シクスツムマブ、クラザキズマブ、クレノリキシマブ、クリバツズマブテトラキセタン、コナツムマブ、コンシズマブ、クレネズマブ、CR6261、ダセツズマブ、ダクリズマブ、ダロツズマブ、ダラツムマブ、デムシズマブ、デノスマブ、デツモマブ、ドルリモマブアリトックス、ドロジツマブ、デュリゴツマブ、デュピルマブ、デュシジツマブ、エクロメキシマブ、エクリズマブ、エドバコマブ、エドレコロマブ、エファリズマブ、エファングマブ、エロツズマブ、エルシリモマブ、エナバツズマブ、エンリモマブペゴール、エノキズマブ、エノチクマブ、エンシツキシマブ、エピツモマブシツキセタン、エプラツズマブ、エルリズマブ、エルツマキソマブ、エタラシズマブ、エトロリズマブ、エボロクマブ、エクスビビルマブ、ファノレソマブ、ファラリモマブ、ファルレツズマブ、ファシヌマブ、FBTA05、フェルビズマブ、フェザキヌマブ、フィクラツズマブ、フィジツムマブ、フラボツマブ、フォントリズマブ、フォラルマブ、フォラビルマブ、フレソリムマブ、フルラヌマブ、フツキシマブ、ガリキシマブ、ガニツマブ、ガンテネルマブ、ガビリモマブ、ゲムツズマブオゾガマイシン、ゲボキズマブ、ジレンツキシマブ、グレムバツムマブベドチン、ゴリムマブ、ゴミリキシマブ、GS6624、イバリズマブ、イブリツモマブチウキセタン、イクルクマブ、イゴボマブ、イムシロマブ、イムガツズマブ、インクラクマブ、インダツキシマブラヴタンシン、インフリキシマブ、インテツムマブ、イノリモマブ、イノツズマブオゾガマイシン、イピリムマブ、イラツムマブ、イトリズマブ、イクセキズマブ、ケリキシマブ、ラベツズマブ、ラムパリズマブ、レブリキズマブ、レマレソマブ、レルデリムマブ、レキサツムマブ、リビビルマブ、リゲリズマブ、リンツズマブ、リリルマブ、ロデルシズマブ、ロルボツズマブメルタンシン、ルカツムマブ、ルミリキシマブ、マパツムマブ、マスリモマブ、マブリリムマブ、マツズマブ、メポリズマブ、メテリムマブ、ミラツズマブ、ミンレツモマブ、ミツモマブ、モガムリズマブ、モロリムマブ、モタビズマブ、モキセツモマブパスドトックス、ムロモナブ−CD3、ナコロマブタフェナトックス、ナミルマブ、ナプツモマブエスタフェナトクス、ナルナツマブ、ナタリズマブ、ネバクマブ、ネシツムマブ、ネレリモマブ、ネスバクマブ、ニモツズマブ、ニボルマブ、ノフェツモマブメルペンタン、オカラツズマブ、オクレリズマブ、オズリモマブ、オファツムマブ、オララツマブ、オロキズマブ、オマリズマブ、オナルツズマブ、オポルツズマブモナトックス、オレゴボマブ、オルチクマブ、オテリキシズマブ、オキセルマブ、オザネズマブ、オゾラリズマブ、パギバキシマブ、パリビズマブ、パニツムマブ、パノバキュマブ、パルサツズマブ、パスコリズマブ、パテクリズマブ、パトリツマブ、ペンツモマブ、ペラキズマブ、ペルツズマブ、ペキセリズマブ、ピジリズマブ、ピナツズマブベドチン、ピンツモマブ、プラクルマブ、ポラツズマブベドチン、ポネズマブ、プリリキシマブ、プリトキサキシマブ、プリツムマブ、PRO140、クイリズマブ、ラコツモマブ、ラドレツマブ、ラフィビルマブ、ラムシルマブ、ラニビズマブ、ラキシバキュマブ、レガビルマブ、レスリズマブ、リロツムマブ、リツキシマブ、ロバツムマブ、ロレズマブ、ロモソズマブ、ロンタリズマブ、ロベリズマブ、ルプリズマブ、サマリズマブ、サリルマブ、サツモマブペンデチド、セクキヌマブ、セリバンツマブ、セトキサキシマブ、セビルマブ、シブロツズマブ、シファリムマブ、シルツキシマブ、シムツズマブ、シプリズマブ、シルクマブ、ソラネズマブ、ソリトマブ、ソネプシズマブ、ソンツズマブ、スタムルマブ、スレソマブ、スビズマブ、タバルマブ、タカツズマブテトラキセタン、タドシズマブ、タリズマブ、タネズマブ、タプリツモマブパプトックス、テフィバズマブ、テリモマブアリトックス、テナツモマブ、テネリキシマブ、テプリズマブ、テプロツムマブ、TGN1412、チシリムマブ(=トレメリムマブ)、チルドラキズマブ、チガツズマブ、TNX−650、トシリズマブ(=アトリズマブ)、トラリズマブ、トシツモマブ、トラロキヌマブ、トラスツズマブ、TRBS07、トレガリズマブ、トレメリムマブ、ツコツズマブセルモロイキン、ツビルマブ、ウブリツキシマブ、ウレルマブ、ウルトキサズマブ、ウステキヌマブ、バパリキシマブ、バテリズマブ、ベドリズマブ、ベルツズマブ、ベパリモマブ、ベセンクマブ、ビシリズマブ、ボロシキシマブ、ボレセツズマブマフォドチン、ボツムマブ、ザルツムマブ、ザノリムマブ、ザツキシマブ、ジラリムマブまたはゾリモマブアリトックスである、請求項1から10のいずれか一項に記載の薬剤。
- 抗体がトラスツズマブである、請求項11に記載の薬剤。
- 前記抗体が前記薬剤に耐性がある、請求項1〜12のいずれか一項に記載の薬剤。
- 前記薬剤が、
(i)前記抗体のFcドメインが無グリコシル化状態または非グリコシル化状態であり、Fc受容体と結合することができる、
(ii)抗体のFcドメインが薬剤の活性に耐性がある1つまたは複数の糖型を含む、
(iii)抗体のFcドメインがオリゴマンノースタイプの糖型を含む、または
(iv)Fcドメインの各グリカンが少なくとも5個のマンノース残基を含有する
請求項13に記載の薬剤。
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KR102494193B1 (ko) | 2014-05-28 | 2023-01-31 | 아카데미아 시니카 | 항-tnf-알파 글리코항체 및 이의 용도 |
GB201413240D0 (en) * | 2014-07-25 | 2014-09-10 | Hansa Medical Ab | Method |
GB201502306D0 (en) | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
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JP6752203B2 (ja) * | 2015-07-16 | 2020-09-09 | 第一三共株式会社 | 新規EndoS変異酵素 |
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