JP6235855B2 - The composition for hair containing Usbenia mallow or Bukuryo, and caffeine or cacao butter. - Google Patents

Description

  The present invention relates to a hair composition, a melanin production promoter, and a composition for improving gray hair. More particularly, the present invention relates to a hair composition containing Usbene or Mulberry and caffeine or cacao butter. In addition, the present invention relates to a melanin production promoter and a composition for improving gray hair, which contains usvenia mallow.

  Rich and well-colored hair is important for daily life. Alopecia, thinning hair, and loss of hair volume caused by hair loss, thinning and weakening of the hair and making it easier to cut have a significant impact on the appearance of humans. Such symptoms can be caused by various factors such as genetic predisposition, environmental predisposition, aging, stress and the like. However, the detailed mechanism has not been clarified yet.

  In hair, hair matrix cells existing in the root part of the hair grow, so that the hair pulp, fur, and hair cuticle constituting the hair are made and the hair gradually grows. For this reason, it is important to grow hair matrix cells in order to increase and grow strong hair.

  In addition, melanocytes are present around the hair matrix cells, and the color of the hair is maintained by producing melanin. In order to prevent and improve gray hair, it is important that melanocytes work actively. Recently, it has been found that SCF (stem cell growth factor) proliferates melanocytes and is effective in preventing white hair and improving white hair (Non-Patent Documents 1 and 2).

  Some herbs and herbal medicines are known to be effective for hair growth and white hair prevention. For example, it is known that usbeneering is effective in improving hair loss (Patent Document 1). Further, Bukuryo has been reported to maintain and extend the growth phase of hair by maintaining the division and proliferation activity of hair epithelial cells (Patent Document 2).

JP-T-2004-67634 JP-A-10-265349

Kei Kurita: J Invest Dermatol, 125, 538-544, 2005 Emi K: Nature, 416, 854-860, 2002

  However, the hair composition to which these herbs and herbal medicines are added alone does not have a sufficient hair-growth effect, and further improvement has been desired. In addition, it has been desired to find a substance derived from nature and having a stronger white hair preventing effect and white hair improving effect.

  As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention have an excellent hair-growth effect in which a hair composition containing (a) usvenia oyster or bukuro, and (b) caffeine or cocoa butter is excellent. As a result, the present invention has been completed. In addition, the present inventors have found that usvenia oysters are effective in preventing and improving gray hair, and have completed the present invention.

  That is, this invention relates to the composition for hair containing (a) usvenia oyster or bukuro, and (b) caffeine or cacao butter.

  The content of the component (a) is preferably 0.000001 to 10% by weight in terms of solid content based on the total amount of the hair composition, and the content of the component (b) is the hair composition It is preferable to set it as 0.000001-10 weight% in conversion of solid content on the basis of the total amount of a thing.

  The blending weight ratio (in terms of solid content) of the component (a) and the component (b) can be (a) :( b) = 0.00010001-100: 1.

  The present invention also relates to a hair-restoring agent comprising (a) usvenia oyster or bukuro, and (b) caffeine or cocoa butter.

  The present invention also relates to a melanin production promoter containing usbnia mallow.

  The melanin production promoter preferably further contains caffeine or cocoa butter.

  Furthermore, the present invention relates to a composition for improving gray hair, which contains usvenia oysters.

  The white hair improving composition preferably further contains caffeine or cocoa butter.

  The composition for hair of the present invention has a high hair matrix cell growth effect and an excellent hair growth effect. In addition, the melanin production promoter and the gray hair improving composition of the present invention promote SCF production in keratinocytes and melanin production in melanocytes, and have excellent white hair prevention and white hair improvement effects.

It is the graph which showed the KGF (keratinocyte growth factor) production promotion effect in the hair papilla cell of Usbenia mallow and caffeine. It is the graph which showed the KGF (keratinocyte growth factor) production promotion effect in a hair papilla cell of Bukuryo and caffeine. It is the graph which showed the KGF (keratinocyte growth factor) production promotion effect in the hair papilla cell of a usbania mallow and cacao butter. It is the graph which showed the SCF production promotion effect in a normal human keratinocyte of a Usbenia mallow. It is the graph which showed the melanin production promotion effect in the B16 mouse | mouth melanoma cell of a Usbenia mallow.

  The composition for hair of the present invention contains (a) usvenia oyster or bukuro, and (b) caffeine or cocoa butter.

  In the present invention, the component (a) is a solid matter, a dry matter, or an extract obtained from a common species of the common mallow (generally known as Malva sylvestris). Usbania is a perennial plant native to Europe that grows in the wild, but is also cultivated for use as herbs and herbal medicines.

  In the present invention, in the case of using Usbania mushroom as an extract, the extraction method is not particularly limited, but all or part of the dried material of Usbania mushroom, or the dried product is crushed and pulverized. The powder is extracted with a solvent. The extract of Ussobnia mallow may be used as it is, or may be diluted or concentrated. Alternatively, in the case of obtaining an extract of Ussobnia mallow, it is possible to use Ussua mallow preserved by lyophilization. Commercially available products can be used for these usbeneering oysters. Examples of commercially available products of Usvenia oyster include trade name: Usvenia oyster extract LA, Usvenia oyster extract BG, or Mallow Moisture (both manufactured by Maruzen Pharmaceutical Co., Ltd.).

  In the present invention, the component (a) Bukuryu refers to a herbal medicine obtained from the sclerotia of the genus Anatake of the genus Salnocosiaceae (scientific name is also referred to as Poria cocos (Fr.) Wolf, Matsuhodo) or an extract obtained therefrom. Bukuryo parasites such as pine (genus Pinus) and fir (genus Abies), which are hosts, are formed after the trees wither. Bukuryo contains polysaccharides such as Pakiman and triterpenoids such as bricoic acid as active ingredients, so it is incorporated into herbal medicines for the purpose of diuresis, antibacterial activity, intestinal relaxation and the like.

  In the present invention, in the case of using bukkaku as an extract, the extraction method of the bucurium extract is not particularly limited, but a dried product of the whole or a part of the mycorrhiza of bucurium, or a dried product thereof. Extracted with a solvent from the crushed and ground powder. The extract of Bukuryu may be used as it is, or may be diluted or concentrated. Alternatively, in order to obtain an extract of bukkake, it is also possible to use bukuro stored by freeze-drying. Commercially available products can be used for these bukuro. Examples of commercially available products of Bukuryo include trade name: Falco Rex Bukuryo E or Falco Rex Bukuryo B (both manufactured by Ichimaru Falcos Co., Ltd.).

  Examples of the solvent used for the extraction of Ussnia mallow or bryophyll include water, alcohol, or a mixture thereof. Water, methanol, ethanol, 1,3-butylene glycol, propylene glycol, glycerin, or a mixture thereof is preferable, and water is used. More preferred is ethanol or ethanol-containing water.

  There are no particular limitations on the part of the common carp used for extraction, but examples include flowers, leaves, stems, roots, and the like, with flowers and leaves being preferred.

  Although the extraction method is not particularly limited, for example, there is a method in which all or a part of Usbunia mushroom or Buddleae is cut, crushed, an extraction solvent is added, room temperature to heating, and then the extract of Usbunia mushroom or Buddleia is extracted. Can be mentioned. Moreover, normal conditions can apply for extraction conditions, Although it is not limited, The method of immersing the dried material of Usvenia mushroom or a horse chestnut in a solvent, for example at 3-100 degreeC, or heat-refluxing is employable. It is also possible to increase the extraction efficiency by adding an acid, an alkali, or an enzyme to the black-spotted mallow or bukkake before adding the extraction solvent.

  In the present invention, the content of the component (a) Usvenia oyster is based on the total amount of the hair composition in terms of solid content, from the viewpoint of hair growth effect, white hair improvement effect, feeling of use, formulation stability, coloring and odor. The content may be 0.000001 to 10% by weight, preferably 0.00001 to 5% by weight, and more preferably 0.0005 to 2% by weight.

  In the present invention, the content of the component (a) Bukuryo is 0.000001 to in terms of solid content, based on the total amount of the hair composition, from the viewpoint of hair growth effect, feeling of use, formulation stability, coloring and odor. The amount can be 10% by weight, preferably 0.00001 to 5% by weight, and more preferably 0.0005 to 2% by weight.

  In the present invention, the component (b) caffeine means caffeine (1,3,7-trimethylxanthine) or a mixture of caffeine and a caffeine derivative such as theophylline or theobromine. Caffeine can be obtained by extraction from tea leaves, coffee beans, guarana, cocoa and the like containing caffeine. The extracted caffeine may be used as it is, or may be used as a diluted solution or a concentrated solution. Caffeine can be a synthetic product. Commercially available caffeine can also be used. As a commercial product of caffeine, for example, trade name: anhydrous caffeine (manufactured by Shizuoka Caffeine Industry) and the like can be mentioned.

  In the present invention, the content of caffeine as the component (b) is 0.0000001 to 10% by weight, preferably 0, based on the total amount of the hair composition, from the viewpoint of the hair-growth effect, the feeling of use and the preparation stability. The amount can be 0.0005 to 5% by weight, more preferably 0.00001 to 2% by weight.

  In the present invention, the component (b) cocoa butter (also referred to as cocoa butter) refers to a fat component obtained from cocoa seeds. It is known to contain oleic acid, stearic acid, palmitic acid and the like as active ingredients. Cocoa butter can generally be obtained by roasting cacao seeds and then grinding and pressing. A commercially available cocoa butter can also be used. Examples of commercially available cocoa butter include trade name: cocoa butter (manufactured by Daito Cacao Corporation).

  In the present invention, the content of the cocoa butter as the component (b) is 0.0000001 to 10% by weight, preferably 0, based on the total amount of the hair composition, from the viewpoint of the hair-growing effect, feeling of use, and formulation stability. The amount can be 0.0005 to 5% by weight, more preferably 0.00001 to 2% by weight.

  In the present invention, the blending weight ratio (in terms of solid content) of components (a) and (b) is in terms of solid content, based on the total amount of the composition for hair, from the viewpoint of hair growth effect, usability, and formulation stability. (A) :( b) = 0.00010001-100: 1, preferably (a) :( b) = 0.0001-1000: 1, more preferably (a) :( b) = 0.001 100: 1

  In addition, the present inventors have newly found that usvenia mallow has an SCF production effect and a melanin production effect. For example, when a melanin production promoter or a composition for improving gray hair containing usbeneia is applied to the scalp, the production of SCF in keratinocytes or the like is promoted, the progression of white hair is suppressed, or white hair is prevented or improved. In addition, melanin production in melanin-producing cells is promoted, and gray hair is prevented / improved. Therefore, usvenia mallow is suitable for a melanin production promoter or a composition for improving gray hair.

  In the present invention, the melanin production promoter refers to a drug having an effect of promoting melanin production in cells capable of producing melanin such as melanocytes or melanoma cells. In addition, the melanin production promoter in the present invention includes a drug that can activate the proliferation of melanocytes by promoting SCF production in normal cells.

  In the present invention, the composition for improving white hair refers to a composition for hair that can prevent white hair and / or improve white hair by promoting proliferation of melanocytes and / or promoting melanin production from melanocytes. Showing things.

  The melanin production promoter containing usbnia mallow and caffeine or cacao butter has the effect of promoting melanin production by containing usbnia mallow in addition to the hair-growth effect. In addition, a hair composition containing usvenia oyster and caffeine or cacao butter is suitable as a hair composition for improving white hair having a hair growth effect.

  The hair composition, the melanin production promoter or the gray hair improving composition of the present invention is particularly limited as long as it is a known form of cosmetics used for hair, pharmaceuticals used for hair, or quasi drugs. Although it is not a thing, for example, hair on sheets of liquids, suspensions, emulsions, creams, ointments, granules, tablets, capsules, gels, liniments, lotions, aerosols, powders, nonwoven fabrics, etc. And a sheet agent impregnated with the composition for use. Among them, the liquid, suspension, emulsion, cream, ointment, granule, tablet, capsule, gel, lotion, and gel are preferably used. By setting it as this form, the composition for hair of this invention can fully exhibit the hair growth effect. Moreover, the melanin production promoter or the composition for improving gray hair of the present invention can sufficiently exhibit the effect of preventing and improving gray hair.

  More detailed and specific forms of the hair composition, melanin production promoter or gray hair improving composition of the present invention include hair restorer, shampoo, rinse, treatment, conditioner, hair pack, hair cream, hair liquid, hair styling. Materials, hair nicks, permanent agents, hair color agents and the like.

  In addition, as a more detailed and specific form of the hair composition, melanin production promoter or gray hair improving composition of the present invention, a dosage form may be mentioned, which may be taken orally, for example, a capsule. , Tablets, granules, gels, syrups, chewing gums and the like can be formulated by known methods.

  Moreover, as a usage form of the composition for hair of this invention, it can use by apply | coating or spraying directly on the skin or hair of the scalp which wants to grow hair, for example.

  Moreover, as a usage form of the melanin production promoter or the gray hair improving composition of the present invention, for example, it can be used by directly applying or spraying on the skin or hair of a site where it is desired to improve gray hair or a site where white hair is desired to be prevented. it can.

The effective dosage of the hair composition, melanin production promoter or gray hair improving composition of the present invention is about 0.0001 to 10 mg / per unit area once per unit area in terms of solid content when applied to the skin. cm ² .

  When the hair composition, melanin production promoter or gray hair improving composition of the present invention is taken orally, it is about 0.0001 to 10 mg per adult day in terms of solid content.

  By applying the composition for hair of the present invention to the hair in the above-mentioned form, the hair growth effect provides the hair with elasticity, makes it difficult to cut the hair, makes the hair thicker, reduces hair removal, or smoothes the finger. Is expected to be.

  By applying the melanin production promoter or the gray hair improving composition of the present invention to the hair in the above-described form, glossy black hair can be obtained due to white hair prevention / improvement effect, and the gray hair does not increase or the gray hair returns to black hair. It is expected.

  The hair composition, the melanin production promoter or the white hair improving composition of the present invention is a known group that can be used as a cosmetic or as a medicine, quasi-drug, etc., as long as the effects of the present invention are not impaired. The composition can be mixed with an agent or a carrier. In addition, the hair composition, melanin production promoter or gray hair improving composition of the present invention includes, for example, surfactants, oils, alcohols, thickeners, preservatives, antioxidants, antioxidants, Preservatives, chelating agents, pH adjusters, stabilizers, solubilizers, suspending agents, isotonic agents, buffers, soothing agents, dispersants, fragrances, colorants, pigments, water, and other additives Can be blended. An additive can be used individually by 1 type or in combination of 2 or more types.

  Bases or carriers include liquid paraffin, squalane, gelled hydrocarbons (such as plastibase), ozokerite, α-olefin oligomers, hydrocarbons such as light liquid paraffin; methyl polysiloxane, cross-linked methyl polysiloxane, highly polymerized methyl Polysiloxane, Cyclic silicone, Alkyl-modified silicone, Cross-linked alkyl-modified silicone, Amino-modified silicone, Polyether-modified silicone, Polyglycerin-modified silicone, Cross-linked polyether-modified silicone, Cross-linked alkyl polyether-modified silicone, Silicone / alkyl chain copolymer Modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, Silicone oil such as phenyl-modified silicone, silicone resin; polyethylene glycol; dioxane; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate Esters; lower alcohols such as ethanol and isopropanol; glycol ethers such as diethylene glycol monomethyl ether and diethylene glycol monoethyl ether; polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, isoprene glycol, pentanediol And polyhydric alcohols such as hexanediol; aqueous bases such as water.

  A base or a support | carrier can be used individually by 1 type or in combination of 2 or more types.

  Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Sorbitan fatty acid esters; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hardened Hardened castor oil derivatives such as castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80; polyoxyethylene (20) sorbitan (polysorbate 20) monolaurate, monostearate Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan (polysorbate 60), polyoxyethylene monooleate (20) sorbitan (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; Glyceryl alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; polyoxyethylene / methylpolysiloxane copolymer; Silicone surfactants such as lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone; laurate, Amphoteric surfactants such as luminate, cocoyl glutamate, palm oil methylalanine salt, acylmethyltaurine salt, anionic surfactant such as polyoxyethylene lauryl sulfate, lauryl diaminoethylglycine salt, coconut oil fatty acid betaine salt Agents and the like.

  Examples of the oil include natural animal and plant oils, hydrocarbon oils, ester oils, silicone oils, higher alcohols, higher fatty acids, animals and plants, and synthetic essential oils.

  Examples of natural animal and plant oils and fats include avocado oil, linseed oil, almond oil, olive oil, cacao oil, beef tallow, giraffe oil, wheat germ oil, sesame oil, rice germ oil, rice bran oil, safflower oil, soybean oil, evening primrose oil , Camellia oil, corn oil, rapeseed oil, horse fat, persic oil, palm oil, palm kernel oil, castor oil, sunflower oil, pork fat, grape oil, jojoba oil, macadamia nut oil, mink oil, cottonseed oil, molasses, palm oil , Hardened coconut oil, peanut oil, lanolin, egg yolk oil, rosehip oil and the like.

  Examples of the hydrocarbon oil include paraffinic hydrocarbons and olefinic hydrocarbons, and examples include squalane, squalene, ceresin, paraffin, pristane, microcrystalline wax, liquid paraffin, and petroleum jelly.

  As ester oils, synthetic esters, esters of higher alcohols and higher fatty acids are used, for example, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, isostearyl isostearate, Trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, Oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate, cetyl lactate Tetradecyl lactate, isopril pyr myristate, octyldodecyl myristate, cetyl myristate, myristyl myristate, octyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, 12-hydroxystearin Examples thereof include cholesteryl acid, phytosteryl oleate, diisostearyl malate, paramethoxycinnamate, and pentarosyl tetrarosinate.

  Examples of the silicone oil include dimethylpolysiloxane, highly polymerized methylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclohexasiloxane, stearoxysilicone, etc. Higher alkoxy-modified silicone, alkyl-modified silicone, higher fatty acid ester-modified silicone, and the like.

  Examples of the higher alcohol include octyldodecanol, isostearyl alcohol, oleyl alcohol, and behenyl alcohol.

  As the higher fatty acid, a saturated or unsaturated linear or branched fatty acid having 12 to 22 carbon atoms can be used. For example, isostearic acid, oxystearic acid, oleic acid, stearic acid, palmitic acid, behenic acid, Examples include myristic acid, lauric acid, lanolinic acid, linoleic acid, and linolenic acid.

  Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl methacrylate methacrylate. Copolymer, polyethylene glycol, bentonite, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (acryloyldimethyltaurine ammonium / vinylpyrrolidone) copolymer, and the like.

  Preferable examples of the preservative include paraoxybenzoates, chlorobutanol, benzyl alcohol, phenethyl alcohol, dehydroacetic acid, sorbic acid and the like.

  Preferable examples of the antioxidant include sulfite and ascorbic acid.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.

  Preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzyl paraoxybenzoate, paraoxybenzoate Examples include methyl benzoate and phenoxyethanol.

  Examples of the chelating agent include EDTA / disodium salt, EDTA / calcium disodium salt, and the like.

  Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.) ) And organic bases (such as triethanolamine, diisopropanolamine, and triisopropanolamine).

  Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

  Preferable examples of the solubilizer include polyethylene glycol, propylene glycol, D-mannitol, benzyl benzoate, ethanol, trisaminomethane, cholesterol, triethanolamine, sodium carbonate, sodium citrate and the like.

  Suitable examples of the suspending agent include surfactants such as stearyltriethanolamine, sodium lauryl sulfate, laurylaminopropionic acid, lecithin, benzalkonium chloride, benzethonium chloride, glyceryl monostearate; for example, polyvinyl alcohol, Examples thereof include hydrophilic polymers such as polyvinylpyrrolidone, sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, and hydroxypropylcellulose.

  Preferable examples of the isotonic agent include sodium chloride, glycerin, D-mannitol and the like.

  Preferable examples of the buffer include buffer solutions such as phosphate, acetate, carbonate, citrate and the like.

  Preferable examples of the soothing agent include benzyl alcohol.

  Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, and organic acid.

  Examples of the colorant include inorganic pigments and natural pigments.

  The hair composition, melanin production promoter or white hair improving composition of the present invention can contain other active ingredients as long as the effects of the present invention are not impaired. Specific examples of active ingredients include, for example, moisturizing ingredients, pearl luster imparting agents, conditioning agents, scrub agents, blood circulation promoting components, astringent components, UV absorbing components, UV scattering components, cleaning components, antibacterial components, anti-inflammatory agents, vitamins Class, peptide or derivative thereof, amino acid or derivative thereof, cell activation component and the like.

  As moisturizing ingredients, polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol and diglycerin; sugars such as trehalose, xylitol and oligosaccharides; sodium hyaluronate, heparin-like Substances, high molecular compounds such as sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan; amino acids such as glycine, aspartic acid, arginine; natural moisturizing factors such as sodium lactate, urea, sodium pyrrolidone carboxylate; ceramide , Lipids such as cholesterol and phospholipids; plant extract extracts such as chamomile extract, hamamelis extract, tea extract and perilla extract.

  Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

  Examples of the conditioning agent include cationized cellulose, cationized starch, cationized fenugreek gum, cationized guar gum, cationized tara gum, cationized locust bean gum, cationized xanthan gum, diallyl quaternary ammonium salt / acrylamide copolymer, polyquaternium , Vinyl imidazolium trichloride / vinyl pyrrolidone copolymer, hydroxyethyl cellulose / dimethyldiallylammonium chloride copolymer, vinyl pyrrolidone / quaternized dimethylaminoethyl methacrylate copolymer, polyvinyl pyrrolidone / alkylamino acrylate copolymer, polyvinyl pyrrolidone / Alkylamino acrylate / vinyl caprolactam copolymer, vinyl pyrrolidone / methacrylamidopropyl chloride Trimethyl ammonium copolymer, alkyl acrylamide / acrylate / alkylaminoalkyl acrylamide / polyethylene glycol methacrylate copolymers, adipic acid / dimethylaminohydroxypropyl ethylene triamine copolymer and Ageraru.

  Examples of scrubbing agents include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride granules, olive kernel powder, dried seawater granules, candelilla wax, walnut shell powder, cherries kernel powder, coral powder, charcoal powder, Examples include hasp shell powder, polyethylene powder, and silicic anhydride.

  Examples of the blood circulation promoter include acetylcholine, ictamol, caffeine, capsaicin, cantalis tincture, gamma oryzanol, ginger tincture, gingeron, cephalanthin, assembly extract, tannic acid, red pepper tincture, trazoline, tocopherol nicotinate, benzyl nicotinate Examples include esters.

  Examples of the astringent component include zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, zinc sulfocolate and tannic acid.

  Examples of the ultraviolet absorbing component include octyl triazone, diethylaminohydroxybenzoyl hexyl benzoate, dimethoxybenzylidene dioxoimidazolidine propionate octyl, paramethoxycinnamate 2-ethylhexyl, t-butylmethoxydibenzoylmethane, phenylbenzimidazolesulfonic acid, Examples include octyl methoxycinnamate and ethylhexyl methoxycinnamate.

  Examples of ultraviolet scattering components include hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zinc oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, silicic anhydride, and other inorganic compounds. Coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and with silicon oil and fatty acid aluminum salts, etc. Processed ones are listed.

  Cleaning ingredients include soaps such as alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts, amino acid-based interfaces such as sodium cocoyl glutamate, sodium cocoyl methyl taurate, etc. Activator, ether sulfate ester salt such as sodium laureth sulfate, ether carboxylate salt such as sodium lauryl ether acetate, sulfosuccinate ester salt such as sodium alkylsulfosuccinate ester, coconut oil fatty acid monoethanolamide, coconut oil fatty acid ethanolamide Fatty acid alkanolamides, monoalkyl phosphates such as sodium lauryl phosphate, sodium polyoxyethylene lauryl ether phosphate, coconut oil Fatty acid amidopropyldimethylaminoacetic acid betaine, lauryldimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, laurylhydroxysulfobetaine and lauroylamidoethylhydroxyethylcarboxymethylbetaine hydroxypropyl phosphate Examples include betaine-type amphoteric surfactants such as sodium, and amino acid-type amphoteric surfactants such as sodium laurylaminopropionate.

  Antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101 , Photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoolamine, miconazole and the like.

  Examples of anti-inflammatory agents include glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, and hydrocortisone.

  Vitamins such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenine dinucleotide Vitamin B2 such as riboflavin butyrate, riboflavin tetrabutyrate, sodium riboflavin 5′-phosphate, riboflavin tetranicotinate; nicotinic acid dl-α-tocopherol, benzyl nicotinate, methyl nicotinate, β-nicotinic acid β- Nicotinic acids such as butoxyethyl, nicotinic acid 1- (4-methylpheny-BR> J-ethyl); ascorbigen-A, ascorbic acid stearate, ascorbyl palmitate, dipalmitin Vitamin C such as L-ascorbyl acid; Vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol; Vitamin K such as phylloquinone, farnoquinone, γ-oryzanol, dibenzoylthiamine, dibenzoylthiamine hydrochloride; thiamine Hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diline Vitamin B1 such as acid ester, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5 -Vitamin B6 such as pyridoxal phosphate and pyridoxamine hydrochloride; Vitamin B12 such as cyanocobalamin, hydroxocobalamin and deoxyadenosylcobalamin; Folic acids such as folic acid and pteroylglutamic acid; Nicotinic acids such as nicotinic acid and nicotinamide; Pantothenic acids such as acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthecine, D-panthetin, coenzyme A, pantothenyl ethyl ether; biotins such as biotin and bioticin; ascorbic acid and sodium ascorbate , Vitamin C which are ascorbic acid derivatives such as dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate; carnitine, ferulic acid, α-lipo , And the like vitamin-like effect factors such as orotic acid.

  Peptides or derivatives thereof include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide , Conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, hydrolyzed soy protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide Acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

  As amino acids or their derivatives, betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine Leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and the like.

  Cell activation components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid, vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids, α-hydroxy acids such as glycolic acid and lactic acid, tannins, Examples include flavonoids, saponins, allantoin, and photosensitizer 301.

  Next, the present invention will be specifically described with reference to test examples and examples, but the present invention is not limited to the following examples.

  Usbenia oyster extract LA (manufactured by Maruzen Pharmaceuticals Co., Ltd .; 0.4% in terms of solid content) was used for Usvenia oyster.

  Fukurokubu Fukuryo E (manufactured by Ichimaru Falcos Co., Ltd .; solid content conversion 0.13%) was used for Bukuryo.

  As the caffeine, commercially available anhydrous caffeine (manufactured by Shizuoka Caffeine Industry) was used. As cocoa butter, commercially available Lipobutter Refind Cocoa (manufactured by Shima Trading Co., Ltd.) or cocoa butter (manufactured by Daito Cacao Co., Ltd.) was used.

(Test Example 1) Hair-growth effect of usvenia mallow and caffeine In order to examine the hair-growth effect of usbena mallow and caffeine, the following experiment was conducted.

That is, human hair follicular dermal papilla cells (HFDPC, manufactured by Toyobo Co., Ltd.) are transferred to a 48-well plate (Corning Co., Ltd.) using a hair papilla cell growth medium (TMTPGM-250, manufactured by Toyobo Co., Ltd.). 12,500 cells / 0.5 mL / well was seeded and cultured at 37 ° C. under 5% CO ₂ -95% air for 48 hours. Thereafter, the culture solution was discarded, and TMTPGM-250 was used to test each concentration (in W / V, caffeine alone, 0.0001%, 0.001%, 0.01%, V / V) Samples were prepared to be 0.001%, 0.01%, 0.1%, both caffeine and usbnia mallow, and test samples containing 0.0005% caffeine and 0.005% caffeine, respectively. 0.5 ml of each test sample dissolved in 005% and 0.05% usbnia oyster) was added to each well, and cultured for 24 hours under conditions of 37 ° C. and 5% CO ₂ -95% air. The liquid was sampled (supposed as a supernatant protein). The amount of KGF protein contained in the supernatant protein (100 ul each) was quantified using a KGF Human ELISA Kit Quantikine (96 well) (manufactured by R & D Systems). The amount of KGF secretion when the control was 100% was calculated.

  As is clear from the results in FIG. 1, the hair composition containing euglena or caffeine alone has a concentration-dependent hair-growth effect. The hair composition containing both usbeneer and caffeine showed a synergistic hair-growth effect even when each component was contained at a low concentration.

(Test Example 2) Hair growth effect of Bukuryo and caffeine By the same method as in Test Example 1, the hair growth effect of Bukuryo and caffeine was examined.

  The test sample of caffeine alone is 0.0001% at W / V, the test sample of Bukuryo alone is 0.001% at V / V, and the test sample containing both caffeine and bukuro is caffeine. 0.00005% and Bukuryu were adjusted to 0.0005%.

  As is apparent from the results of FIG. 2, the hair composition containing both bukuro and caffeine showed a synergistic hair-growth effect when each component was contained at a low concentration.

(Test Example 3) Hair-growth effect of Usvenia oyster and cocoa butter By the same method as Test Example 1, the hair-growth effect of Usbeneia oyster and cocoa butter was examined.

  The test sample of Usbeneia oyster alone is V / V, 0.001%, 0.01%, 0.1%, and the test sample of cocoa butter is W / V, 0.0001%, 0.001%, Test samples containing 0.01%, Usvenia mallow and cocoa butter are prepared to be 0.0005% Usubania and 0.00005% cacao butter, 0.005% Usbenioa and 0.0005% cacao butter, respectively. It was prepared so that it might become 0.05% of usvenia oysters and 0.005% of cacao butter.

  As is clear from the results of FIG. 3, the hair composition containing both the mussels and cacao butter was found to have a synergistic hair growth effect when each component was contained at a low concentration.

(Test Example 4) SCF production promoting effect of Usbenia mallow In order to examine the SCF production promoting effect of Usbenia mallow, the following experiment was conducted.

That is, normal human newborn foreskin keratinocytes (normal human keratinocytes: NHEK, manufactured by Kurashiki Boseki Co., Ltd.) were used on a 96-well plate (Corning Co., Ltd.) on 5,000 cells / The cells were seeded at 0.2 mL / well, and cultured for 48 hours under conditions of 37 ° C. and 5% CO ₂ -95% air. Then the culture medium was discarded, the addition of test sample dissolved in 0.01% or 0.1% malva sylvestris in Humedia-KG2 (V / V) into each well by 0.2mL, 37 ℃, 5% CO 2 - The cells were cultured for 48 hours under the condition of 95% air. The supernatant was discarded, washed with PBS, fixed with ethanol at −30 ° C. for 20 minutes, washed with PBS, and then blocked with 2% BSA / PBS for 1 hour and a half. Thereafter, the mixture is reacted with the primary antibody Anti-SCF antibody (manufactured by abcam) for 2 hours, washed with PBS, and then reacted with the secondary antibody HRP-Goat Anti-Rabbit IgG (H + L) Conjugate (manufactured by zymed) for 1.5 hours. It was. After washing with PBS, the reaction was allowed to proceed for 5 minutes with TMB Substrate (manufactured by Dako), the reaction was stopped with 2N sulfuric acid, and the absorbance was measured at 450 nm. The amount of SCF produced when the control was 100% was calculated.

  As is clear from the results of FIG. 4, the hair composition containing the euglena was observed to promote SCF production.

(Test Example 5) Melanin production promotion effect of Usbania mallow In order to investigate the melanin production promotion effect of Usbania mallow, the following experiment was conducted.

That is, mouse-derived B16-F10 melanoma cells (distributed from American Type Culture Collection (ATCC), ATCC number: CRL-6475) were added to a 6-well plate (manufactured by Corning) using 10% FBS-containing DMEM (GIBCO). 000 cells / 2 ml / well were seeded and cultured at 37 ° C. under 5% CO ₂ -95% air for 24 hours. Thereafter, the culture solution is discarded, and 1 mL of a test sample in which Usvenia oysters are dissolved in DMEM in 0.01% or 0.1% (V / V) is added to each well, and at 37 ° C., 5% CO ₂ -95% air. It was cultured for 48 hours under the conditions. Thereafter, the culture supernatant was removed, washed twice with PBS (−) (GIBCO), 4N NaOH was added, and the mixture was heated at 60 ° C. for 2 hours. Two hours later, the cell extract was transferred to a 96-well plate (manufactured by Corning) in an amount of 0.1 mL, the absorbance at 475 nm was measured with a microplate reader, and the amount of melanin produced when the control was 100% was calculated.

  As is clear from the results of FIG. 5, the melanin production promoter or hair composition containing ususnia mallow was recognized to promote melanin production.

(Hair composition formulation example 1)
The following components were mixed and dissolved to obtain a lotion. The unit of the numerical value in each of the following formulation examples is indicated by “% by weight” where the total amount is 100.

[Table 1]
Usenia oyster extract 1
Caffeine 2
Assembly extract 0.1
Dipotassium glycyrrhizinate 0.1
l-Menthol 0.2
Concentrated glycerin 3
Ethanol 10
Polyoxyethylene hydrogenated castor oil 40 1
Purified water balance

(Hair composition formulation example 2)
The following components were mixed and dissolved to obtain a gel.

[Table 2]
Usvenia mallow extract 0.5
Assembly extract 0.05
Cocoa butter 1
Dipotassium glycyrrhizinate 0.2
l-Menthol 0.5
Concentrated glycerin 2
Ethanol 5
1,3-Butylene glycol 5
Isopropyl palmitate 0.5
Polyoxyethylene hydrogenated castor oil 40 4
Triethanolamine 0.2
Carboxyvinyl polymer 0.7
Purified water balance

(Composition example 3 for hair composition)
Each component was mixed and dissolved, and filled into an aerosol can so that the adjusted chemical solution and LP gas were 1: 1 to obtain an aerosol agent.

[Table 3]
Bukuryu extract 0.3
Assembly extract 0.4
Caffeine 0.5
Dipotassium glycyrrhizinate 0.05
l-Menthol 0.1
Concentrated glycerin 1
Ethanol 30
1,3-butylene glycol 1
Polyoxyethylene hydrogenated castor oil 40 1
Purified water balance

  Formulation examples 1 to 3 of the above hair composition exhibit excellent hair-growth effects.

(Melanin production promoter / composition example 1 for improving gray hair)
The following components were mixed and dissolved to obtain a lotion.

[Table 4]
Usenia oyster extract 1
Dipotassium glycyrrhizinate 0.1
l-Menthol 0.2
Concentrated glycerin 3
Ethanol 15
Polyoxyethylene hydrogenated castor oil 40 1
Purified water balance

(Melanin production promoter / Composition example 2 for improving gray hair)
The following components were mixed and dissolved to obtain a lotion.

[Table 5]
Usenia oyster extract 1
Assembly extract 0.1
Cocoa butter 0.2
Dipotassium glycyrrhizinate 0.1
l-Menthol 0.2
Concentrated glycerin 3
Ethanol 40
Polyoxyethylene hydrogenated castor oil 40 4
Purified water balance

(Melanin production promoter / composition example 3 for improving white hair)
The following components were mixed and dissolved to obtain a hair gel.

[Table 6]
Usvenia mallow extract 0.5
Assembly extract 0.05
Caffeine 0.1
Dipotassium glycyrrhizinate 0.2
l-Menthol 0.5
Concentrated glycerin 2
Ethanol 5
1,3-Butylene glycol 5
Isopropyl palmitate 0.5
Polyoxyethylene hydrogenated castor oil 40 4
Triethanolamine 0.2
Carboxyvinyl polymer 0.7
Purified water balance

  Formulation example 1 of the above composition for promoting melanin production / improving gray hair has an excellent effect of improving / preventing gray hair. Formulation Examples 2-3 of the melanin production promoter / white hair improving composition have excellent hair growth effects and white hair improvement / prevention effects.

Claims (5)

A composition for hair containing (a) ausbeneia mushroom , bukuro, or an extract thereof , and (b) caffeine or cocoa butter.   The component (a) is contained in an amount of 0.000001 to 10% by weight in terms of solid content based on the total amount of the hair composition, and the component (b) is added in an amount of 0.001 on the basis of the total amount of the hair composition. The hair composition according to claim 1, which contains 000001 to 10% by weight.   The hair composition according to claim 1 or 2, wherein a blending weight ratio (in terms of solid content) of the component (a) and the component (b) is (a) :( b) = 0.000001 to 100,000: 1. The melanin production promoter which contains a Usbenia mallow or its extract as an active ingredient .   Furthermore, the melanin production promoter of Claim 4 containing caffeine or cacao butter.

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