JP6234466B2 - 予測因子を用いて同定された患者サブ集団における癌の処置のためのマシチニブの使用 - Google Patents

予測因子を用いて同定された患者サブ集団における癌の処置のためのマシチニブの使用 Download PDF

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JP6234466B2
JP6234466B2 JP2015535036A JP2015535036A JP6234466B2 JP 6234466 B2 JP6234466 B2 JP 6234466B2 JP 2015535036 A JP2015535036 A JP 2015535036A JP 2015535036 A JP2015535036 A JP 2015535036A JP 6234466 B2 JP6234466 B2 JP 6234466B2
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pain
masitinib
gemcitabine
treatment
patients
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JP2015532296A (ja
JP2015532296A5 (OSRAM
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モウッシー，アライン
キネト，ジーン‐ピエール
ピクエマル，デイビッド
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エービー サイエンス
エービー サイエンス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015535036A 2012-10-04 2013-10-04 予測因子を用いて同定された患者サブ集団における癌の処置のためのマシチニブの使用 Active JP6234466B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306214 2012-10-04
EP12306214.3 2012-10-04
PCT/EP2013/070741 WO2014053650A1 (en) 2012-10-04 2013-10-04 Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors

Publications (3)

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JP2015532296A JP2015532296A (ja) 2015-11-09
JP2015532296A5 JP2015532296A5 (OSRAM) 2016-11-10
JP6234466B2 true JP6234466B2 (ja) 2017-11-22

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JP2015535036A Active JP6234466B2 (ja) 2012-10-04 2013-10-04 予測因子を用いて同定された患者サブ集団における癌の処置のためのマシチニブの使用

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Country Link
US (1) US10238649B2 (OSRAM)
EP (1) EP2903616B8 (OSRAM)
JP (1) JP6234466B2 (OSRAM)
KR (1) KR102149483B1 (OSRAM)
CN (1) CN104968347A (OSRAM)
AR (1) AR092899A1 (OSRAM)
AU (1) AU2013326463B2 (OSRAM)
BR (1) BR112015007144A2 (OSRAM)
CA (1) CA2886979C (OSRAM)
DK (1) DK2903616T3 (OSRAM)
EA (1) EA037368B1 (OSRAM)
ES (1) ES2656640T3 (OSRAM)
IL (1) IL238107B (OSRAM)
MX (1) MX369999B (OSRAM)
NZ (1) NZ706420A (OSRAM)
SG (1) SG11201502626PA (OSRAM)
SI (1) SI2903616T1 (OSRAM)
TW (1) TWI609686B (OSRAM)
WO (1) WO2014053650A1 (OSRAM)
ZA (1) ZA201503054B (OSRAM)

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TW201514311A (zh) * 2013-10-04 2015-04-16 Ab Science 用於判定胰臟癌預後之方法
MX2016014574A (es) * 2014-05-08 2017-02-23 Oncoethix Gmbh El uso de compuestos de tienotriazolodiazepina para el tratamiento de cancer de mama triple-negativo.
ES2954860T3 (es) * 2014-10-24 2023-11-27 Launx Biomedical Co Ltd Uso de azelnidipina en la preparación de una composición medicinal para el tratamiento de cánceres
EP3824908A1 (en) 2015-04-10 2021-05-26 Capsugel Belgium NV Abiraterone acetate lipid formulations
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
CA3018635C (en) * 2016-03-25 2023-09-26 Ab Science Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation
CN107267454B (zh) * 2016-04-07 2025-05-23 内蒙古原生元生物科技有限公司 一种脐血nk细胞的体外扩增方法及其试剂盒与应用
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
KR20190109479A (ko) * 2017-02-01 2019-09-25 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
AU2019216351B2 (en) * 2018-01-31 2024-07-25 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
US20210398672A1 (en) * 2018-10-29 2021-12-23 Northwestern University Big Data-Driven Personalized Management of Chronic Pain
WO2020115108A1 (en) * 2018-12-06 2020-06-11 Sørlandet Sykehus Hf Egfr inhibitors and their use in the treatment of neuroathic pain
WO2020115261A1 (en) * 2018-12-07 2020-06-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating melanoma
NZ784949A (en) 2019-08-12 2025-09-26 Deciphera Pharmaceuticals Llc Ripretinib for treating gastrointestinal stromal tumors
KR20250057151A (ko) 2019-12-30 2025-04-28 데시페라 파마슈티칼스, 엘엘씨 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의조성물
CN114214396A (zh) * 2020-06-30 2022-03-22 宁波市康宁医院(宁波市精神疾病预防控制中心、宁波市微循环与莨菪类药研究所) Gabrd甲基化作为抗海洛因复吸靶点的应用

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US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
ATE375342T1 (de) 2002-08-02 2007-10-15 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren
US20090298061A1 (en) * 2005-07-29 2009-12-03 Siemens Healthcare Diagnostics Inc. Diagnostic Methods for the Prediction of Therapeutic Success, Recurrence Free and Overall Survival in Cancer Therapy
WO2008115300A1 (en) * 2006-12-01 2008-09-25 Apocell, Inc. C-kit phosphorylation in cancer
ES2606505T3 (es) 2007-01-12 2017-03-24 Ab Science Tratamiento de combinación de cánceres sólidos con antimetabolitos e inhibidores de tirosina quinasa
US8153792B2 (en) 2007-02-13 2012-04-10 Ab Science Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
US20120264639A1 (en) 2009-11-04 2012-10-18 Jen Jen Yeh Methods and compositions for predicting survival in subjects with cancer
US20120309706A1 (en) 2010-02-01 2012-12-06 Ab Science Combined treatment of pancreatic cancer with gemcitabine and masitinib
WO2012170640A1 (en) 2011-06-07 2012-12-13 The Trustees Of Columbia University In The City Of New York Methods and compositions for trail-drug combination therapy

Also Published As

Publication number Publication date
MX369999B (es) 2019-11-28
CA2886979C (en) 2021-01-05
DK2903616T3 (da) 2018-01-29
WO2014053650A1 (en) 2014-04-10
ZA201503054B (en) 2016-11-30
EP2903616A1 (en) 2015-08-12
MX2015004264A (es) 2015-10-12
KR102149483B1 (ko) 2020-08-28
CN104968347A (zh) 2015-10-07
ES2656640T3 (es) 2018-02-27
NZ706420A (en) 2018-08-31
EP2903616B8 (en) 2018-02-07
AU2013326463B2 (en) 2018-01-18
AR092899A1 (es) 2015-05-06
CA2886979A1 (en) 2014-04-10
EA037368B1 (ru) 2021-03-19
EP2903616B1 (en) 2017-12-13
KR20150092739A (ko) 2015-08-13
EA201500373A1 (ru) 2016-02-29
SI2903616T1 (en) 2018-02-28
BR112015007144A2 (pt) 2017-12-12
TW201414475A (zh) 2014-04-16
US10238649B2 (en) 2019-03-26
JP2015532296A (ja) 2015-11-09
IL238107B (en) 2018-03-29
TWI609686B (zh) 2018-01-01
AU2013326463A1 (en) 2015-04-16
SG11201502626PA (en) 2015-05-28
US20150272945A1 (en) 2015-10-01

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