JP6228121B2 - リソソームエキソサイトーシス活性のレベルを検出する方法及び組成物並びに使用方法 - Google Patents
リソソームエキソサイトーシス活性のレベルを検出する方法及び組成物並びに使用方法 Download PDFInfo
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- JP6228121B2 JP6228121B2 JP2014528515A JP2014528515A JP6228121B2 JP 6228121 B2 JP6228121 B2 JP 6228121B2 JP 2014528515 A JP2014528515 A JP 2014528515A JP 2014528515 A JP2014528515 A JP 2014528515A JP 6228121 B2 JP6228121 B2 JP 6228121B2
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- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/16—Serine-type carboxypeptidases (3.4.16)
- C12Y304/16005—Carboxypeptidase C (3.4.16.5), i.e. carboxypeptidase Y
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- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
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- Biomedical Technology (AREA)
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- Wood Science & Technology (AREA)
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- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529675P | 2011-08-31 | 2011-08-31 | |
| US61/529,675 | 2011-08-31 | ||
| US201161544855P | 2011-10-07 | 2011-10-07 | |
| US61/544,855 | 2011-10-07 | ||
| PCT/US2012/052629 WO2013033074A2 (en) | 2011-08-31 | 2012-08-28 | Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526904A JP2014526904A (ja) | 2014-10-09 |
| JP2014526904A5 JP2014526904A5 (cg-RX-API-DMAC7.html) | 2017-06-29 |
| JP6228121B2 true JP6228121B2 (ja) | 2017-11-08 |
Family
ID=46881159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528515A Active JP6228121B2 (ja) | 2011-08-31 | 2012-08-28 | リソソームエキソサイトーシス活性のレベルを検出する方法及び組成物並びに使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9399791B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2751279B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6228121B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012300252B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2847057C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1119689T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2751279T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2653918T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20171909T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE037829T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2751279T (cg-RX-API-DMAC7.html) |
| PL (1) | PL2751279T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2751279T (cg-RX-API-DMAC7.html) |
| SI (1) | SI2751279T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013033074A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102123763B (zh) | 2008-08-19 | 2014-10-08 | 什诺波特有限公司 | 富马酸氢甲酯的前体药物、其药物组合物、及其使用方法 |
| JP6228121B2 (ja) * | 2011-08-31 | 2017-11-08 | セント ジュード チルドレンズ リサーチ ホスピタル | リソソームエキソサイトーシス活性のレベルを検出する方法及び組成物並びに使用方法 |
| JP2015527372A (ja) | 2012-08-22 | 2015-09-17 | ゼノポート,インコーポレイティド | 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法 |
| JP2015526476A (ja) | 2012-08-22 | 2015-09-10 | ゼノポート,インコーポレイティド | メチル水素フマレートの経口剤形およびそのプロドラッグ |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| TW201516020A (zh) | 2013-09-06 | 2015-05-01 | Xenoport Inc | (n,n-二乙基胺甲醯基)甲基(2e)丁-2-烯-1,4-二酸甲酯之晶形、合成方法及用途 |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| US10695338B2 (en) | 2015-05-07 | 2020-06-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Cancer treatment via repositioned tricyclic anti-depressant-like drugs as anti-cancer agents and new combinations of such drugs |
| CN108367018A (zh) * | 2015-10-30 | 2018-08-03 | 奥特吉尼克斯制药公司 | 用于治疗淀粉样变性病的方法和组合物 |
| WO2017161360A2 (en) * | 2016-03-18 | 2017-09-21 | Nant Holdings Ip, Llc | Multimodal vector for dendritic cell infection |
| MA46145B1 (fr) * | 2017-01-04 | 2020-04-30 | Ericsson Telefon Ab L M | Procédé, station de base et équipement utilisateur permettant d'émettre et de recevoir des informations de système |
| US20220364101A1 (en) | 2019-07-05 | 2022-11-17 | Tokushima University | Modified neuraminidase |
| WO2023147605A2 (en) * | 2022-01-31 | 2023-08-03 | Sens Research Foundation | Senescent cell surface markers |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769331A (en) | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
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| SI2751279T1 (en) | 2018-01-31 |
| US20180057854A1 (en) | 2018-03-01 |
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| US20200087704A1 (en) | 2020-03-19 |
| US9840727B2 (en) | 2017-12-12 |
| US20140193392A1 (en) | 2014-07-10 |
| PL2751279T3 (pl) | 2018-03-30 |
| ES2653918T3 (es) | 2018-02-09 |
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| HUE037829T2 (hu) | 2018-09-28 |
| CA2847057A1 (en) | 2013-03-07 |
| US10533208B2 (en) | 2020-01-14 |
| WO2013033074A3 (en) | 2013-04-25 |
| US20220406435A1 (en) | 2022-12-22 |
| DK2751279T3 (da) | 2017-11-20 |
| JP2014526904A (ja) | 2014-10-09 |
| AU2012300252A1 (en) | 2014-03-20 |
| EP2751279B1 (en) | 2017-10-04 |
| PT2751279T (pt) | 2017-12-29 |
| HRP20171909T1 (hr) | 2018-01-26 |
| WO2013033074A2 (en) | 2013-03-07 |
| AU2012300252B2 (en) | 2017-10-19 |
| CA2847057C (en) | 2019-06-11 |
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