JP6222584B2 - 細胞ベースの組織解析 - Google Patents
細胞ベースの組織解析 Download PDFInfo
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- JP6222584B2 JP6222584B2 JP2015559269A JP2015559269A JP6222584B2 JP 6222584 B2 JP6222584 B2 JP 6222584B2 JP 2015559269 A JP2015559269 A JP 2015559269A JP 2015559269 A JP2015559269 A JP 2015559269A JP 6222584 B2 JP6222584 B2 JP 6222584B2
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/695—Preprocessing, e.g. image segmentation
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00138—Slides
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Theoretical Computer Science (AREA)
- Immunology (AREA)
- Multimedia (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Signal Processing (AREA)
- Quality & Reliability (AREA)
- Dispersion Chemistry (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361769049P | 2013-02-25 | 2013-02-25 | |
| US61/769,049 | 2013-02-25 | ||
| US13/934,237 US9488639B2 (en) | 2013-02-25 | 2013-07-03 | Cell-based tissue analysis |
| US13/934,237 | 2013-07-03 | ||
| PCT/US2014/018322 WO2014131013A1 (en) | 2013-02-25 | 2014-02-25 | Cell-based tissue analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507759A JP2016507759A (ja) | 2016-03-10 |
| JP2016507759A5 JP2016507759A5 (enExample) | 2017-03-30 |
| JP6222584B2 true JP6222584B2 (ja) | 2017-11-01 |
Family
ID=51391913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559269A Expired - Fee Related JP6222584B2 (ja) | 2013-02-25 | 2014-02-25 | 細胞ベースの組織解析 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9488639B2 (enExample) |
| EP (1) | EP2946190A4 (enExample) |
| JP (1) | JP6222584B2 (enExample) |
| SG (1) | SG11201506644XA (enExample) |
| WO (1) | WO2014131013A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9589172B1 (en) * | 2013-02-25 | 2017-03-07 | Flagship Biosciences, Inc. | Systems and methods for interactive image analysis of digital pathology images |
| US9424459B1 (en) * | 2013-02-25 | 2016-08-23 | Flagship Biosciences, Inc. | Computerized methods for cell-based pattern recognition |
| US9412006B1 (en) * | 2013-02-25 | 2016-08-09 | Flagship Biosciences, Inc. | Continuous tissue analysis scoring scheme based on cell classifications |
| TW201520906A (zh) * | 2013-11-29 | 2015-06-01 | Univ Nat Taiwan Science Tech | 影像註冊方法 |
| EP3108448B1 (en) | 2014-02-21 | 2019-05-15 | Ventana Medical Systems, Inc. | Group sparsity model for image unmixing |
| US9785752B1 (en) * | 2014-02-25 | 2017-10-10 | Flagship Biosciences, Inc. | Method for stratifying and selecting candidates for receiving a specific therapeutic approach |
| US9725766B1 (en) | 2014-07-29 | 2017-08-08 | Flagship Biosciences, Inc. | Methods for measuring and reporting vascularity in a tissue sample |
| US9298968B1 (en) * | 2014-09-12 | 2016-03-29 | Flagship Biosciences, Inc. | Digital image analysis of inflammatory cells and mediators of inflammation |
| JP2018505392A (ja) * | 2014-12-10 | 2018-02-22 | ネオゲノミクス ラボラトリーズ, インコーポレイテッド | 自動化されたフローサイトメトリ分析方法及びシステム |
| US20180040120A1 (en) * | 2014-12-29 | 2018-02-08 | Flagship Biosciences, Inc. | Methods for quantitative assessment of mononuclear cells in muscle tissue sections |
| EP3251052B1 (en) * | 2015-01-31 | 2024-07-17 | Ventana Medical Systems, Inc. | Quality control of automated whole-slide analysis |
| CN118319236A (zh) | 2015-02-02 | 2024-07-12 | 史赛克公司 | 用于表征受试者的组织的方法和系统 |
| EP3054279A1 (en) * | 2015-02-06 | 2016-08-10 | St. Anna Kinderkrebsforschung e.V. | Methods for classification and visualization of cellular populations on a single cell level based on microscopy images |
| WO2017051229A1 (en) | 2015-09-23 | 2017-03-30 | Novadaq Technologies Inc. | Methods and systems for management of data derived from medical imaging |
| US10796130B2 (en) * | 2015-12-22 | 2020-10-06 | Nikon Corporation | Image processing apparatus |
| AU2017226252A1 (en) * | 2016-03-01 | 2018-07-26 | Ventana Medical Systems, Inc. | Improved image analysis algorithms using control slides |
| WO2017171720A1 (en) * | 2016-03-29 | 2017-10-05 | Flagship Biosciences, Inc. | Digital image analysis of inflammatory cells and mediators of inflammation |
| WO2017174267A1 (en) * | 2016-04-06 | 2017-10-12 | F. Hoffmann-La Roche Ag | Spatial index creation for ihc image analysis |
| WO2018005413A1 (en) * | 2016-06-30 | 2018-01-04 | Konica Minolta Laboratory U.S.A., Inc. | Method and system for cell annotation with adaptive incremental learning |
| WO2018009202A1 (en) * | 2016-07-07 | 2018-01-11 | Flagship Biosciences Inc. | Continuous tissue analysis scoring scheme based on cell classifications |
| CA3021481A1 (en) * | 2016-07-29 | 2018-02-01 | Novadaq Technologies ULC | Methods and systems for characterizing tissue of a subject utilizing machine learning |
| EP3523779A1 (en) | 2016-10-07 | 2019-08-14 | Ventana Medical Systems, Inc. | Digital pathology system and associated workflow for providing visualized whole-slide image analysis |
| US10504224B1 (en) * | 2016-12-31 | 2019-12-10 | Flagship Biosciences, Inc. | Method for detecting immunostaining below the threshold of visual perception |
| WO2019009893A1 (en) * | 2017-07-05 | 2019-01-10 | Flagship Biosciences Inc. | METHODS OF MEASURING AND REPORTING VASCULARITY IN A TISSUE SAMPLE |
| SE542402C2 (en) | 2018-07-02 | 2020-04-21 | Cellavision Ab | Method and apparatus for training a neural network classifier to classify an image depicting one or more objects of a biological sample |
| US12223753B2 (en) | 2019-04-02 | 2025-02-11 | Deutsches Rheuma-Forschungszentrum Berlin | Cytometry data analysis |
| EP3876193A1 (de) * | 2020-03-02 | 2021-09-08 | Euroimmun Medizinische Labordiagnostika AG | Bildverarbeitungsverfahren zum anzeigen von zellen mehrerer gesamtbilder |
| EP4295307A4 (en) * | 2021-02-16 | 2024-12-18 | Verily Life Sciences LLC | Systems and methods for biomarker detection in digitized pathology samples |
| GB2607606A (en) * | 2021-06-08 | 2022-12-14 | Solentim Ltd | Calibration apparatus and method |
| WO2024194921A1 (ja) * | 2023-03-17 | 2024-09-26 | 日本電気株式会社 | 病理診断支援装置、病理診断支援方法、及び、記録媒体 |
| CN118376792B (zh) * | 2024-04-16 | 2025-04-15 | 北京菲诺维康生物科技有限公司 | 一种检测组织目标蛋白表达结果的校准方法 |
| CN119673278B (zh) * | 2024-11-29 | 2025-08-08 | 陆桂新 | 基于单细胞的数据库可视化方法 |
| CN119919732B (zh) * | 2025-01-06 | 2025-09-09 | 北京协同创新研究院 | 基于偏振图像的免疫细胞分类方法及系统、免疫环境评估方法及系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0797069B2 (ja) * | 1993-05-14 | 1995-10-18 | 財団法人東京都神経科学総合研究所 | 顕微鏡用連続薄切片の収拾保持方法とその装置 |
| WO2001020044A2 (en) * | 1999-09-17 | 2001-03-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health | Signal counting for in situ hybridization |
| EP1135680A4 (en) * | 1999-09-24 | 2004-12-15 | Ventana Med Syst Inc | HIGH-PERFORMANCE SYSTEM FOR EVALUATING THE CLINICAL BENEFIT OF TARGET MOLECULAR MOLECULES IN TISSUE SAMPLES |
| AT411066B (de) * | 2000-10-24 | 2003-09-25 | Steiner Georg E | Verfahren und anordnung zur untersuchung von zellen |
| CN1615143A (zh) | 2002-01-14 | 2005-05-11 | 亨利·福特卫生系统 | 来自骨髓基质细胞的用于形成血管并产生血管生成和营养因子的物质 |
| US7181055B2 (en) | 2003-08-15 | 2007-02-20 | Holger Lange | Systems and methods for registering reflectance and fluorescence hyperspectral imagery |
| US7899624B2 (en) * | 2005-07-25 | 2011-03-01 | Hernani Del Mundo Cualing | Virtual flow cytometry on immunostained tissue-tissue cytometer |
| CN101484806A (zh) * | 2006-05-17 | 2009-07-15 | 协乐民公司 | 一种对组织进行自动分析的方法 |
| WO2008115547A1 (en) | 2007-03-19 | 2008-09-25 | Sti Medical Systems, Llc | A method of automated image color calibration |
| US8787651B2 (en) * | 2010-09-28 | 2014-07-22 | Flagship Biosciences, LLC | Methods for feature analysis on consecutive tissue sections |
| AU2012230858A1 (en) * | 2011-03-23 | 2013-10-17 | Hologic, Inc. | Method for automatically seeding previously-classified images among images of objects of interest from a specimen |
| US20120270752A1 (en) * | 2011-04-22 | 2012-10-25 | Ge Global Research | Analyzing the expression of biomarkers in cells with moments |
| US9311521B2 (en) * | 2011-07-28 | 2016-04-12 | Medetect Ab | Method for providing images of a tissue section |
-
2013
- 2013-07-03 US US13/934,237 patent/US9488639B2/en active Active
-
2014
- 2014-02-25 JP JP2015559269A patent/JP6222584B2/ja not_active Expired - Fee Related
- 2014-02-25 EP EP14754443.1A patent/EP2946190A4/en not_active Withdrawn
- 2014-02-25 WO PCT/US2014/018322 patent/WO2014131013A1/en not_active Ceased
- 2014-02-25 SG SG11201506644XA patent/SG11201506644XA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2946190A1 (en) | 2015-11-25 |
| SG11201506644XA (en) | 2015-09-29 |
| US9488639B2 (en) | 2016-11-08 |
| US20150004630A1 (en) | 2015-01-01 |
| EP2946190A4 (en) | 2016-11-23 |
| JP2016507759A (ja) | 2016-03-10 |
| WO2014131013A1 (en) | 2014-08-28 |
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