JP6181279B2 - ドライパウダー吸入器の内部でブリスターを締め付けるための方法及び装置 - Google Patents
ドライパウダー吸入器の内部でブリスターを締め付けるための方法及び装置 Download PDFInfo
- Publication number
- JP6181279B2 JP6181279B2 JP2016500611A JP2016500611A JP6181279B2 JP 6181279 B2 JP6181279 B2 JP 6181279B2 JP 2016500611 A JP2016500611 A JP 2016500611A JP 2016500611 A JP2016500611 A JP 2016500611A JP 6181279 B2 JP6181279 B2 JP 6181279B2
- Authority
- JP
- Japan
- Prior art keywords
- blister
- inhaler according
- housing
- vibrating member
- flow path
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/001—Details of inhalators; Constructional features thereof with means for agitating the medicament using ultrasonic means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0061—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using pre-packed dosages having an insert inside
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0063—Storages for pre-packed dosages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0083—Timers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/587—Lighting arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Description
1)第一のチャンバーの圧電素子への係合の確実性が向上。
2)より高い平均圧電頻度及び低いインピーダンスで測定された、より低い減衰。
3)合成噴流のより高いピーク引き出し気体速度。
4)より小さな第一のチャンバーの動き。振動モードのシフトを避けるようである。
5)より高い平均エアロゾル性能とより低いばらつき。
Claims (14)
- ハウジングの内部に保持される個別にアドレス可能な複数のブリスターを納めるためのハウジング、当該個別にアドレス可能な複数のブリスターの各々は特定された量の薬剤を収容し、前記ブリスターは第一のドーム形状の面及び第二の平らな面を有する;
前記ハウジングの内部に振動部材;
前記ブリスターと連絡する流路を規定するチャンバー;
貯蔵位置と投薬位置との間で選択されたブリスターを動かす機構;及び
前記第一のドーム形状の面の少なくとも一部を係合し包囲するため、また、前記振動部材に隣接する投薬位置にブリスターを締め付けるための、ブリスター締め付け部材、当該ブリスター締め付け部材は、前記ブリスターのドーム形状の面と周縁接触するようにされたボールジョイントを含み、それによって前記ブリスターに3回転自由度を与え、前記ブリスターと前記振動部材とが適切に係合されることが確実になる;
を含む、薬剤吸入器。 - 前記ブリスターの平らな面が、前記振動部材と接触して位置している、請求項1に記載の吸入器。
- 前記ブリスター締め付け部材が、ブリスターのドーム形状の面の、ドームの基部よりもドームの頂部近くを係合する、請求項1又は2に記載の吸入器。
- 次の構成の1又は複数を特徴とする、請求項1〜3のいずれか1項に記載の吸入器。
(a)前記振動部材が圧電変換器である;
(b)前記薬剤がドライパウダー又は液体を含む;
(c)さらに前記ブリスターに対して前記振動部材を押し付けるスプリングを含む;
(d)さらに使用者の息を検知するためのフローセンサ、及び、前記振動部材をアクチベートするための電子回路を含む;
(e)さらにバッテリとプリント回路基板とを含む;
(f)さらに前記ハウジングの内部に収容された穿孔部材を含む;及び
(g)さらにバッテリ及びマイクロプロセッサを含み、当該マイクロプロセッサはフローセンサからのシグナルを受容し、振動部材のアクチベーションを制御する。 - 前記複数のブリスターがカセット上に配置され、当該カセットはハウジングの内部に回転可能に備えられている、請求項4に記載の吸入器。
- さらに回転可能に備えられたディスクを含み、当該ディスクは、前記複数の個別のブリスターの一つの、当該個別のブリスターが前記振動部材と穿孔部材との間に締め付けられる投薬位置への移動を調節する、請求項4又は5に記載の吸入器。
- さらに、前記回転ディスクが、前記投薬位置にある前記ブリスターを前記穿孔部材が穿孔する前記穿孔部材の動き、及び/又は、前記振動部材が前記投薬位置でブリスターと接触するようにする前記振動部材の動き、を調節する、請求項6に記載の吸入器。
- 前記ディスクの回転が、ハウジングから突出するレバーアームを用いることによって使用者によってコントロールされる、請求項6に記載の吸入器。
- 前記ハウジングに取り付けられ、前記流路と連絡するマウスピースを含む、請求項1〜8のいずれか1項に記載の吸入器。
- さらに前記ハウジングに枢動可能に接続された、前記マウスピースを覆うカバーを含み、さらに前記回転ディスクと前記カバーとを接続するリンク機構を含み、前記ディスクの枢動が前記カバーの開閉を行う、請求項9に記載の吸入器。
- さらに、一端がマウスピースに接続された流路を含み、当該流路は選択されたブリスターの前記第一の面がフィットする開口を有し、前記ブリスターは前記流路に対して定位置に保持され;また、
選択されたブリスターを動かすための前記機構がレバーアームを含み、当該レバーアームの動きが、選択されたブリスターを、使用者によって脱凝集され吸入されるように、前記振動部材と前記穿孔部材との間に引き込むようにする;
請求項9に記載の吸入器。 - 前記複数の個別のブリスターが円形平面に配置され、前記ブリスターの平面は前記カートリッジの平面に垂直であり、また、前記ディスクがさらに前記回転可能に備えられたカセットの動きを調整する、請求項6〜11のいずれか1項に記載の吸入器。
- 次の構成の1又は両方を特徴とする、請求項12に記載の吸入器。
(a)さらに、前記複数の個別のブリスターの一つの操作位置への動きと前記レバーアームの動きとを連係するディスクを含む;
(b)前記穿孔部材が流路の逆側に位置し、さらに、前記選択されたブリスターに対して前記振動部材を押し付けるスプリングを含む。 - 前記選択されたブリスターを動かす機構が、前記選択されたブリスターを放射状の方向に動かすようにされている、請求項11〜13のいずれか1項に記載の吸入器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/840,577 US8985101B2 (en) | 2009-05-21 | 2013-03-15 | Method and device for clamping a blister within a dry powder inhaler |
US13/840,577 | 2013-03-15 | ||
PCT/US2014/020371 WO2014149691A1 (en) | 2013-03-15 | 2014-03-04 | Method and device for clamping a blister within a dry powder inhaler |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016511067A JP2016511067A (ja) | 2016-04-14 |
JP6181279B2 true JP6181279B2 (ja) | 2017-08-16 |
Family
ID=51580643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016500611A Expired - Fee Related JP6181279B2 (ja) | 2013-03-15 | 2014-03-04 | ドライパウダー吸入器の内部でブリスターを締め付けるための方法及び装置 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8985101B2 (ja) |
JP (1) | JP6181279B2 (ja) |
AR (1) | AR095577A1 (ja) |
CA (1) | CA2903980C (ja) |
IL (1) | IL241238B (ja) |
MX (1) | MX360743B (ja) |
NZ (1) | NZ629001A (ja) |
TW (1) | TW201505671A (ja) |
UY (1) | UY35480A (ja) |
WO (1) | WO2014149691A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8985101B2 (en) * | 2009-05-21 | 2015-03-24 | Microdose Therapeutx, Inc. | Method and device for clamping a blister within a dry powder inhaler |
ES2745552T3 (es) | 2015-07-20 | 2020-03-02 | Pearl Therapeutics Inc | Sistemas de administración de aerosol |
EP3519025B1 (en) * | 2016-09-30 | 2022-11-23 | De Motu Cordis Pty Ltd | Delivery device |
WO2018071443A1 (en) | 2016-10-11 | 2018-04-19 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2517482A (en) | 1949-04-09 | 1950-08-01 | Sharp & Dohme Inc | Inhaler |
GB1182779A (en) | 1966-09-17 | 1970-03-04 | Fisons Pharmaceuticals Ltd | Inhalation Device |
US3507277A (en) | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
GB1268051A (en) | 1968-06-07 | 1972-03-22 | Fisons Pharmaceuticals Ltd | Inhalation device |
US3653380A (en) | 1970-02-16 | 1972-04-04 | American Cyanamid Co | Aerosol powder dosage dispensing device |
US3831606A (en) | 1971-02-19 | 1974-08-27 | Alza Corp | Auto inhaler |
IT941426B (it) | 1971-07-17 | 1973-03-01 | Isf Spa | Inalatore a camera di turbinio per sostanze medicamentose polveriformi |
US3795244A (en) | 1973-02-02 | 1974-03-05 | Syntex Corp | Inhalation device |
YU41046B (en) | 1974-08-22 | 1986-10-31 | Schering Ag | Medicine inholating device |
US3948264A (en) | 1975-05-21 | 1976-04-06 | Mead Johnson & Company | Inhalation device |
US4094317A (en) | 1976-06-11 | 1978-06-13 | Wasnich Richard D | Nebulization system |
US4452239A (en) | 1980-03-25 | 1984-06-05 | Hilal Malem | Medical nebulizing apparatus |
CA1224992A (en) | 1982-10-08 | 1987-08-04 | Robert E. Newell | Device for administering medicament to patients |
US5260321A (en) | 1984-11-12 | 1993-11-09 | Sandoz Ltd. | Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins |
US4733797A (en) | 1986-09-22 | 1988-03-29 | Haber Terry M | Dosage sealing, monitoring and dispensing assembly |
IT1228460B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore monouso con capsula pre-forata |
GB8909891D0 (en) | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
US5110008A (en) | 1989-09-29 | 1992-05-05 | Moulding Jr Thomas S | Dispenser adapted to isolate the dispensed objects by compression between two moveable structures |
SK280967B6 (sk) | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Inhalačný prístroj |
GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
YU48707B (sh) | 1990-03-02 | 1999-07-28 | Glaxo Group Limited | Aparat za inhaliranje - inhalator |
GB9021433D0 (en) | 1990-10-02 | 1990-11-14 | Atomic Energy Authority Uk | Power inhaler |
US6629646B1 (en) | 1991-04-24 | 2003-10-07 | Aerogen, Inc. | Droplet ejector with oscillating tapered aperture |
ES2141108T3 (es) | 1991-07-02 | 2000-03-16 | Inhale Inc | Metodo y dispositivo para proporcionar medicamentos en aerosol. |
NZ256825A (en) | 1992-10-16 | 1998-02-26 | Sheiman Ultrasonic Research Fo | Ultrasonic nebuliser has a tube in the upper part of a holding chamber and an ultrasonic transducer |
US5429302A (en) | 1993-05-19 | 1995-07-04 | Fisons Corporation | Nebulizing element and device |
US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
US5709202A (en) * | 1993-05-21 | 1998-01-20 | Aradigm Corporation | Intrapulmonary delivery of aerosolized formulations |
US5349947A (en) | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
DK0714314T3 (da) | 1993-08-18 | 1999-06-23 | Fisons Plc | Inhalator med åndedrætsregulering |
JPH10506028A (ja) | 1994-08-30 | 1998-06-16 | アール.ピー.シェーラー リミテッド | 眼球治療装置 |
US5503869A (en) | 1994-10-21 | 1996-04-02 | Glaxo Wellcome Inc. | Process for forming medicament carrier for dry powder inhalator |
US6457654B1 (en) | 1995-06-12 | 2002-10-01 | Georgia Tech Research Corporation | Micromachined synthetic jet actuators and applications thereof |
US5758823A (en) | 1995-06-12 | 1998-06-02 | Georgia Tech Research Corporation | Synthetic jet actuator and applications thereof |
US6209538B1 (en) | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5647357A (en) | 1995-09-08 | 1997-07-15 | Respironics, Inc. | Respiratory mask facial seal |
US5694920A (en) | 1996-01-25 | 1997-12-09 | Abrams; Andrew L. | Inhalation device |
US6026809A (en) | 1996-01-25 | 2000-02-22 | Microdose Technologies, Inc. | Inhalation device |
US6312909B1 (en) | 1996-03-29 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the diagnosis prevention and treatment of tumor progression |
US5699649A (en) | 1996-07-02 | 1997-12-23 | Abrams; Andrew L. | Metering and packaging device for dry powders |
US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
GB9626263D0 (en) | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
SE9700424D0 (sv) | 1997-02-07 | 1997-02-07 | Astra Ab | Powder inhaler |
US5823434A (en) | 1997-05-05 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Navy | Electromechanical driver for an aerosol dispensing apparatus which dispenses a medicated vapor into the lungs of a patient |
US6237590B1 (en) | 1997-09-18 | 2001-05-29 | Delsys Pharmaceutical Corporation | Dry powder delivery system apparatus |
CA2334590C (en) | 1998-06-12 | 2009-08-18 | Microdose Technologies, Inc. | Inhalation device |
US6142146A (en) | 1998-06-12 | 2000-11-07 | Microdose Technologies, Inc. | Inhalation device |
US6152130A (en) | 1998-06-12 | 2000-11-28 | Microdose Technologies, Inc. | Inhalation device with acoustic control |
AU4514299A (en) | 1998-06-15 | 2000-01-05 | Karl Holm | Inhalation device |
GB2343122B (en) | 1998-10-26 | 2003-01-08 | Medic Aid Ltd | Improvements in and relating to nebulisers |
US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
US6328033B1 (en) | 1999-06-04 | 2001-12-11 | Zohar Avrahami | Powder inhaler |
CA2635489A1 (en) | 2000-02-11 | 2001-08-16 | Respironics Respiratory Drug Delivery (Uk) Ltd | Drug delivery apparatus |
US8820316B2 (en) | 2000-02-11 | 2014-09-02 | Respironics Respiratory Drug Delivery (Uk) Ltd | Drug delivery apparatus |
DE10011120A1 (de) | 2000-03-09 | 2001-09-13 | Pfeiffer Erich Gmbh & Co Kg | Spender für Medien |
US6971383B2 (en) | 2001-01-24 | 2005-12-06 | University Of North Carolina At Chapel Hill | Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods |
US6759159B1 (en) | 2000-06-14 | 2004-07-06 | The Gillette Company | Synthetic jet for admitting and expelling reactant air |
US7080644B2 (en) | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
FR2813214B1 (fr) * | 2000-08-29 | 2003-05-02 | Valois Sa | Dispositif de distribution de produit fluide ameliore |
US6622720B2 (en) | 2000-12-18 | 2003-09-23 | Xerox Corporation | Using capillary wave driven droplets to deliver a pharmaceutical product |
US6546927B2 (en) * | 2001-03-13 | 2003-04-15 | Aerogen, Inc. | Methods and apparatus for controlling piezoelectric vibration |
EP1446172B1 (en) | 2001-09-06 | 2010-04-14 | MicroDose Therapeutx, Inc. | Inhalation device type DPI |
JP4261351B2 (ja) | 2001-09-19 | 2009-04-30 | アドヴェント ファーマセウティカルズ プロプライエタリー リミテッド | 吸入器 |
US7093595B2 (en) * | 2001-10-08 | 2006-08-22 | Eli Lilly And Company | Portable medication inhalation kit |
US6722581B2 (en) | 2001-10-24 | 2004-04-20 | General Electric Company | Synthetic jet actuators |
EP1487407A4 (en) | 2002-03-12 | 2010-08-25 | Microdose Therapeutx Inc | SITE SPECIFICITY ADMINISTRATION OF MEDICAMENTS SIMULTANEOUSLY TAKEN BY INHALATION |
SE524957C2 (sv) | 2002-04-12 | 2004-11-02 | Microdrug Ag | Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament |
SE524990C2 (sv) | 2002-04-12 | 2004-11-09 | Microdrug Ag | Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver |
EP1499276A2 (en) | 2002-04-29 | 2005-01-26 | Glaxo Group Limited | Alerting system |
US6889690B2 (en) | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
SI1534366T1 (sl) | 2002-06-27 | 2014-04-30 | Oriel Therapeutics, Inc. | Sistem za polnjenje doze s suhim praškom in ustrezni postopek |
GB0217196D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
US6962266B2 (en) | 2002-10-04 | 2005-11-08 | Ecolab Inc. | Method and apparatus for using a unit dose dispenser |
GB2395437C (en) | 2002-11-20 | 2010-10-20 | Profile Respiratory Systems Ltd | Improved inhalation method and apparatus |
EP1617820B1 (en) | 2003-04-14 | 2018-03-21 | Vectura Limited | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
EP1468748A1 (en) | 2003-04-15 | 2004-10-20 | Microflow Engineering SA | Low-cost liquid droplet spray device and nozzle body |
US8012136B2 (en) | 2003-05-20 | 2011-09-06 | Optimyst Systems, Inc. | Ophthalmic fluid delivery device and method of operation |
GB0315509D0 (en) | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
GB2407042B (en) | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
US7377277B2 (en) | 2003-10-27 | 2008-05-27 | Oriel Therapeutics, Inc. | Blister packages with frames and associated methods of fabricating dry powder drug containment systems |
US7451761B2 (en) | 2003-10-27 | 2008-11-18 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances |
SE0303570L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
SE0303269L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Medicinsk produkt |
JP2007512898A (ja) | 2003-12-03 | 2007-05-24 | マイクロドラッグ アクチェンゲゼルシャフト | 湿度に過敏な薬剤向けの予め計量されたドライパウダー吸入器 |
AU2005209199B2 (en) | 2004-01-16 | 2008-09-11 | Biodel Inc. | Sublingual drug delivery device |
US7607435B2 (en) | 2004-01-21 | 2009-10-27 | Battelle Memorial Institute | Gas or liquid flow sensor |
US7538473B2 (en) | 2004-02-03 | 2009-05-26 | S.C. Johnson & Son, Inc. | Drive circuits and methods for ultrasonic piezoelectric actuators |
RU2363502C2 (ru) | 2004-02-06 | 2009-08-10 | Майкродоуз Текнолоджиз, Инк. | Блистерная упаковка, предназначенная для применения с ингаляционным устройством |
EP1718353B1 (en) | 2004-02-24 | 2019-12-11 | MicroDose Therapeutx, Inc. | Synthetic jet based medicament delivery apparatus |
US8474452B2 (en) | 2004-02-24 | 2013-07-02 | Microdose Therapeutx, Inc. | Directional flow sensor inhaler |
DE102005005540B4 (de) | 2005-02-07 | 2007-10-04 | Pari GmbH Spezialisten für effektive Inhalation | In verschiedenen Moden ansteuerbare Inhalationstherapievorrichtung |
US7987845B2 (en) | 2006-01-31 | 2011-08-02 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
KR20080108995A (ko) | 2006-02-20 | 2008-12-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 흡입기 |
US8196576B2 (en) | 2007-02-28 | 2012-06-12 | Microdose Therapeutx, Inc. | Inhaler |
US20100252032A1 (en) | 2007-07-06 | 2010-10-07 | Boehringer Ingelheim International Gmbh | Inhaler |
US8297280B2 (en) | 2007-07-20 | 2012-10-30 | Canon Kabushiki Kaisha | Inhaler |
GB0800709D0 (en) | 2008-01-16 | 2008-02-20 | Dunne Stephen T | Double jet impinging nozzle |
DK2570147T3 (da) | 2008-06-13 | 2018-01-29 | Mannkind Corp | Tørpulverinhalator og system til lægemiddelindgivelse |
DE102009005048A1 (de) | 2009-01-13 | 2010-07-15 | Borm, Hans-Jürgen | Verfahren und Einrichtung zur automatischen Ermittlung eines inspiratorischen Leckagevolumens bei der maschinellen Beatmung |
US8985101B2 (en) | 2009-05-21 | 2015-03-24 | Microdose Therapeutx, Inc. | Method and device for clamping a blister within a dry powder inhaler |
EP2432536B1 (en) * | 2009-05-21 | 2018-07-04 | MicroDose Therapeutx, Inc. | Rotary cassette system for dry powder inhaler |
RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
EP2585151B1 (en) | 2010-06-24 | 2018-04-04 | Boehringer Ingelheim International GmbH | Nebulizer |
-
2013
- 2013-03-15 US US13/840,577 patent/US8985101B2/en not_active Expired - Fee Related
-
2014
- 2014-03-04 JP JP2016500611A patent/JP6181279B2/ja not_active Expired - Fee Related
- 2014-03-04 CA CA2903980A patent/CA2903980C/en not_active Expired - Fee Related
- 2014-03-04 NZ NZ629001A patent/NZ629001A/en not_active IP Right Cessation
- 2014-03-04 MX MX2015011741A patent/MX360743B/es active IP Right Grant
- 2014-03-04 WO PCT/US2014/020371 patent/WO2014149691A1/en active Application Filing
- 2014-03-14 TW TW103109273A patent/TW201505671A/zh unknown
- 2014-03-17 AR ARP140101201A patent/AR095577A1/es unknown
- 2014-03-17 UY UY0001035480A patent/UY35480A/es not_active Application Discontinuation
-
2015
- 2015-09-07 IL IL241238A patent/IL241238B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
NZ629001A (en) | 2017-04-28 |
TW201505671A (zh) | 2015-02-16 |
UY35480A (es) | 2015-09-30 |
JP2016511067A (ja) | 2016-04-14 |
WO2014149691A1 (en) | 2014-09-25 |
CA2903980A1 (en) | 2014-09-25 |
US8985101B2 (en) | 2015-03-24 |
IL241238B (en) | 2020-05-31 |
US20130213392A1 (en) | 2013-08-22 |
IL241238A0 (en) | 2015-11-30 |
MX2015011741A (es) | 2016-01-15 |
MX360743B (es) | 2018-11-15 |
AR095577A1 (es) | 2015-10-28 |
CA2903980C (en) | 2017-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5752679B2 (ja) | 乾燥粉末吸入器のための回転カセットシステム | |
JP3790423B2 (ja) | 薬剤のデリバリの引き金となる吸入活性化流れ分割手段を有する乾燥粉末薬剤吸入器 | |
RU2427392C2 (ru) | Ингаляционное устройство с регулируемой дозой | |
US6550477B1 (en) | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament | |
US20100154794A1 (en) | Inhaler Flow Channel | |
JP2007522840A (ja) | 吸入装置とともに用いられるブリスターパック | |
JP6181279B2 (ja) | ドライパウダー吸入器の内部でブリスターを締め付けるための方法及び装置 | |
TWI832021B (zh) | 乾粉吸入器及監控器和乾粉吸入器之套件 | |
KR102235192B1 (ko) | 흡입 장치 | |
AU2014221279A1 (en) | Rotary cassette system for dry powder inhaler | |
CN114949483B (zh) | 一种干粉吸入器及其制造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20151109 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20161026 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170124 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170621 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170719 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6181279 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |