JP6174014B2 - 哺乳動物乳頭の治療方法及び関連する組成物 - Google Patents
哺乳動物乳頭の治療方法及び関連する組成物 Download PDFInfo
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- JP6174014B2 JP6174014B2 JP2014513626A JP2014513626A JP6174014B2 JP 6174014 B2 JP6174014 B2 JP 6174014B2 JP 2014513626 A JP2014513626 A JP 2014513626A JP 2014513626 A JP2014513626 A JP 2014513626A JP 6174014 B2 JP6174014 B2 JP 6174014B2
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- topical composition
- citrate
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- methylene blue
- hydroxybenzoate
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Landscapes
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| US201161491053P | 2011-05-27 | 2011-05-27 | |
| US61/491,053 | 2011-05-27 | ||
| PCT/US2012/039707 WO2012166655A1 (en) | 2011-05-27 | 2012-05-25 | Method of treating a mammalian teat and related compositions |
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| US8757092B2 (en) | 2011-03-22 | 2014-06-24 | Eco-Composites Llc | Animal bedding and associated method for preparing the same |
| US9737047B2 (en) | 2011-03-22 | 2017-08-22 | Ccd Holdings Llc | Method for the treatment, control, minimization, and prevention of bovine mastitis |
| CN103997886B (zh) * | 2011-05-27 | 2017-07-18 | 祖雷克斯农业医药有限公司 | 处理哺乳动物乳头的方法及相关组合物 |
| WO2014153293A1 (en) * | 2013-03-18 | 2014-09-25 | Aqua Access Llc | Methods and apparatuses related to treatment in milking facilities |
| US10646461B2 (en) * | 2013-06-10 | 2020-05-12 | Naeem Uddin | Broad spectrum pharmacological composition for treatment of various infections and diseases and methods of use |
| BR122018076176B1 (pt) | 2014-12-18 | 2021-06-01 | Ecolab Usa Inc | Método para formar ácido peroxifórmico, método para tratar uma superfície, método para tratar um biofilme em uma superfície e método para desinfetar uma superfície da pele |
| JP6433826B2 (ja) * | 2015-03-09 | 2018-12-05 | 株式会社トクヤマ | 家畜用乳頭パック材料、及び乳用家畜の乳房炎予防方法 |
| ES2949838T3 (es) * | 2015-05-06 | 2023-10-03 | Zoetis Services Llc | Formulación de hidrogel con adherencia leve |
| KR101988240B1 (ko) * | 2017-02-27 | 2019-06-12 | 주식회사 디알나노 | 피부질환에 사용되는 메틸렌 블루 복합체 및 이의 용도 |
| US20210069143A1 (en) * | 2017-06-02 | 2021-03-11 | Zurex Pharma, Inc. | Low-alcohol antimicrobial composition and use thereof |
| BR112019025855A2 (pt) * | 2017-06-09 | 2020-07-14 | Zoetis Broomhill Ip Limited | composição veterinária intramamária |
| EP3806637A1 (en) | 2018-06-15 | 2021-04-21 | Ecolab USA Inc. | On site generated performic acid compositions for teat treatment |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| IL291111B2 (en) * | 2019-09-06 | 2024-01-01 | Consejo Nacional De Investigaciones Cientificas Y Tecn | Pharmaceutical composition for topical wound treatment |
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| US4022199A (en) * | 1975-09-24 | 1977-05-10 | Fetty Walter W | Method of preventing the spread and control of mastitis |
| US5618841A (en) * | 1994-07-06 | 1997-04-08 | Kross; Robert | Composition of iodophor teat dip for the prevention of mastitis and a process for using the same |
| GT199800140A (es) * | 1997-09-12 | 2000-02-29 | Composicion farmaceutica antimastitica a base de extractos de origen natural y procedimientos para fabricarla. | |
| US6749869B1 (en) * | 1997-09-26 | 2004-06-15 | Ecolab | Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection |
| US6436444B1 (en) * | 1997-09-26 | 2002-08-20 | Ecolab Inc. | Acidic aqueous chlorite teat dip providing shelf life sanitizing capacity and tissue protection |
| US6440442B1 (en) * | 1998-06-29 | 2002-08-27 | Hydromer, Inc. | Hydrophilic polymer blends used for dry cow therapy |
| RU2262699C2 (ru) * | 2003-12-15 | 2005-10-20 | Уральская государственная академия ветеринарной медицины | Средство для диагностики субклинического мастита у крупного рогатого скота |
| US20080095735A1 (en) * | 2005-01-31 | 2008-04-24 | Kross Robert D | Skin-Protective Polymer For Use In Teat Care Compositions |
| US7749529B2 (en) * | 2005-02-08 | 2010-07-06 | Ash Access Technology, Inc. | Catheter lock solution comprising citrate and a paraben |
| US20100010086A1 (en) | 2006-08-04 | 2010-01-14 | Ash Stephen R | Antimicrobial therapy for indwelling catheters and for sanitizing surfaces |
| CN100512874C (zh) * | 2007-02-28 | 2009-07-15 | 新疆农垦科学院 | 奶牛乳头涂膜保护剂及其生产方法 |
| US20080226748A1 (en) * | 2007-03-16 | 2008-09-18 | Stevenson Randal D | Stabilized Chlorine Dioxide and Hypochlorous Acid in a Liquid Biocide |
| US8389583B2 (en) * | 2008-05-23 | 2013-03-05 | Zurex Pharma, Inc. | Antimicrobial compositions and methods of use |
| CN101732726B (zh) * | 2008-11-10 | 2012-02-01 | 周庆民 | 奶牛乳头保护膜成膜剂及其制备方法 |
| EP2332587A1 (de) * | 2009-12-12 | 2011-06-15 | Bayer MaterialScience AG | Polyurethan-Dispersionen zur Versiegelung von Zitzen der Milchdrüse bei milchliefernden Tieren |
| CN101804058A (zh) * | 2010-04-22 | 2010-08-18 | 中国农业科学院兰州畜牧与兽药研究所 | 一种用于防治奶牛干奶期乳房炎的药物及制备方法 |
| CN101837074B (zh) * | 2010-05-27 | 2011-08-10 | 东北农业大学 | 一种防治奶牛乳房炎的药剂及其制剂方法 |
| CN103997886B (zh) * | 2011-05-27 | 2017-07-18 | 祖雷克斯农业医药有限公司 | 处理哺乳动物乳头的方法及相关组合物 |
-
2012
- 2012-05-25 CN CN201280037382.4A patent/CN103997886B/zh not_active Expired - Fee Related
- 2012-05-25 EP EP12792615.2A patent/EP2713707A4/en not_active Withdrawn
- 2012-05-25 WO PCT/US2012/039707 patent/WO2012166655A1/en not_active Ceased
- 2012-05-25 RU RU2013158178A patent/RU2632225C2/ru not_active IP Right Cessation
- 2012-05-25 US US13/481,537 patent/US9040023B2/en not_active Expired - Fee Related
- 2012-05-25 JP JP2014513626A patent/JP6174014B2/ja not_active Expired - Fee Related
- 2012-05-25 CA CA2840061A patent/CA2840061A1/en not_active Abandoned
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2015
- 2015-05-22 US US14/720,368 patent/US10098908B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2713707A1 (en) | 2014-04-09 |
| RU2632225C2 (ru) | 2017-10-03 |
| WO2012166655A1 (en) | 2012-12-06 |
| RU2013158178A (ru) | 2015-07-10 |
| CN103997886A (zh) | 2014-08-20 |
| US9040023B2 (en) | 2015-05-26 |
| CA2840061A1 (en) | 2012-12-06 |
| US20150250816A1 (en) | 2015-09-10 |
| US20120301407A1 (en) | 2012-11-29 |
| US10098908B2 (en) | 2018-10-16 |
| EP2713707A4 (en) | 2015-01-07 |
| CN103997886B (zh) | 2017-07-18 |
| JP2014522403A (ja) | 2014-09-04 |
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