JP6165744B2 - Ｒａｓアンタゴニストによる悪性および非悪性疾患の治療 - Google Patents
Ｒａｓアンタゴニストによる悪性および非悪性疾患の治療 Download PDFInfo
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- JP6165744B2 JP6165744B2 JP2014534755A JP2014534755A JP6165744B2 JP 6165744 B2 JP6165744 B2 JP 6165744B2 JP 2014534755 A JP2014534755 A JP 2014534755A JP 2014534755 A JP2014534755 A JP 2014534755A JP 6165744 B2 JP6165744 B2 JP 6165744B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161544471P | 2011-10-07 | 2011-10-07 | |
| US61/544,471 | 2011-10-07 | ||
| PCT/US2012/058900 WO2013052765A1 (en) | 2011-10-07 | 2012-10-05 | Malignant and non-malignant disease treatment with ras antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528453A JP2014528453A (ja) | 2014-10-27 |
| JP2014528453A5 JP2014528453A5 (https=) | 2015-11-26 |
| JP6165744B2 true JP6165744B2 (ja) | 2017-07-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534755A Expired - Fee Related JP6165744B2 (ja) | 2011-10-07 | 2012-10-05 | Ｒａｓアンタゴニストによる悪性および非悪性疾患の治療 |
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| Country | Link |
|---|---|
| US (1) | US9309203B2 (https=) |
| EP (1) | EP2763681B1 (https=) |
| JP (1) | JP6165744B2 (https=) |
| CN (1) | CN103906518B (https=) |
| AU (1) | AU2012318471B9 (https=) |
| CA (1) | CA2849421C (https=) |
| ES (1) | ES2642843T3 (https=) |
| IL (1) | IL231757A (https=) |
| MX (1) | MX364551B (https=) |
| RU (1) | RU2632097C2 (https=) |
| WO (1) | WO2013052765A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9738614B2 (en) | 2011-10-07 | 2017-08-22 | Pisces Therapeutics, Llc | Malignant and non-malignant disease treatment with Ras antagonists |
| CN103304499B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| CN103304500B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 新型抗糖尿病化合物、其制备方法和用途 |
| CN103304501B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| CN103304498B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一种抗糖尿病化合物、其制备方法和用途 |
| CN103304503B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| KR20160091920A (ko) | 2013-11-18 | 2016-08-03 | 예일 유니버시티 | 트랜스포존 조성물 및 이의 이용 방법 |
| WO2016056606A1 (ja) * | 2014-10-07 | 2016-04-14 | 国立大学法人京都大学 | ベンゾイソチアゾロピリミジン誘導体またはその塩、およびウイルス感染阻害剤ならびに医薬品 |
| JP6875745B2 (ja) * | 2016-02-16 | 2021-05-26 | 国立大学法人大阪大学 | 線維化を治療するための医薬組成物 |
| TR201920922A2 (tr) * | 2019-12-20 | 2020-06-22 | Ankara Ueniversitesi | 3/4-((2E,6E)-3,7,11-Trimetildodeka-2,6,10-trieniltiyo)benzamid Türevi Bileşikler |
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| IL107587A (en) | 1993-11-12 | 1998-08-16 | Univ Ramot | Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation |
| AU4723897A (en) * | 1996-10-24 | 1998-05-15 | Kyowa Hakko Kogyo Co. Ltd. | 1,4-benzoquinone derivatives |
| JP2001513890A (ja) | 1997-02-26 | 2001-09-04 | サイレオス コーポレーション | リポタンパク質の膜アンカーを標的とする薬剤スクリーニング法 |
| GEP20043214B (en) * | 1999-01-21 | 2004-04-26 | Bristol Myers Squibb Company Us | Complex of Ras-Farnesyltransferase Inhibitor and Sulfobutylether-7- Beta – Cyclodextrin or 2-Hydroxypropyl- Beta – Cyclodextrina and Pharmaceutical Compositions Containing the Same |
| US20050119237A1 (en) | 1999-06-18 | 2005-06-02 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Non-malignant disease treatment with Ras antagonists |
| JP2003502365A (ja) * | 1999-06-18 | 2003-01-21 | サイリオス・コーポレイション | Ｒａｓアンタゴニストによる非悪性疾患処置 |
| US20020115696A1 (en) * | 1999-06-18 | 2002-08-22 | Yoel Kloog | Treatment of post-angioplasty restenosis and atherosclerosis with ras antagonists |
| US20070054886A1 (en) | 2003-05-23 | 2007-03-08 | Ramot At Tel Aviv University, Ltd. | Ras antagonists for treating neurodegenerative disorders |
| ES2414861T3 (es) * | 2004-08-18 | 2013-07-23 | Kadmon Corporation, Llc | Uso del FTS para el tratamiento de trastornos malignos |
| WO2007064448A2 (en) | 2005-11-28 | 2007-06-07 | Ramot At Tel Aviv University, Ltd. | Cancer treatment using fts and 2-deoxyglucose |
| EP1986625B1 (en) | 2006-02-10 | 2012-08-01 | Ramot at Tel-Aviv University Ltd. | Treatment of ovarian cancer |
| CA2648518C (en) | 2006-04-11 | 2012-06-26 | Ramot At Tel Aviv University Ltd. | Treatment of hematological malignancies with fts and a bcr-abl tyrosine kinase inhibitor |
| WO2007144889A2 (en) | 2006-06-14 | 2007-12-21 | Ramot At Tel Aviv University Ltd. | Treatment of neurofibromatosis |
| WO2008075342A1 (en) | 2006-12-19 | 2008-06-26 | Ramot At Tel Aviv University Ltd. | Treatment of lung cancer |
| WO2009048541A2 (en) * | 2007-10-05 | 2009-04-16 | Purdue Research Foundation | Compounds and methods for use in treating neoplasia and cancer |
| US8338481B2 (en) * | 2009-01-28 | 2012-12-25 | Ramot At Tel-Aviv University Ltd. | Alkoxyalkyl S-prenylthiosalicylates for treatment of cancer |
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2012
- 2012-10-05 CA CA2849421A patent/CA2849421C/en not_active Expired - Fee Related
- 2012-10-05 JP JP2014534755A patent/JP6165744B2/ja not_active Expired - Fee Related
- 2012-10-05 RU RU2014118430A patent/RU2632097C2/ru active
- 2012-10-05 WO PCT/US2012/058900 patent/WO2013052765A1/en not_active Ceased
- 2012-10-05 ES ES12838578.8T patent/ES2642843T3/es active Active
- 2012-10-05 AU AU2012318471A patent/AU2012318471B9/en not_active Ceased
- 2012-10-05 MX MX2014004126A patent/MX364551B/es active IP Right Grant
- 2012-10-05 US US14/350,303 patent/US9309203B2/en not_active Expired - Fee Related
- 2012-10-05 CN CN201280048941.1A patent/CN103906518B/zh not_active Expired - Fee Related
- 2012-10-05 EP EP12838578.8A patent/EP2763681B1/en not_active Not-in-force
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2014
- 2014-03-27 IL IL231757A patent/IL231757A/en active IP Right Grant
Also Published As
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|---|---|
| RU2014118430A (ru) | 2015-11-20 |
| IL231757A0 (en) | 2014-05-28 |
| US20140249163A1 (en) | 2014-09-04 |
| CA2849421A1 (en) | 2013-04-11 |
| MX364551B (es) | 2019-04-30 |
| EP2763681B1 (en) | 2017-08-16 |
| EP2763681A4 (en) | 2015-04-15 |
| AU2012318471B2 (en) | 2017-05-04 |
| JP2014528453A (ja) | 2014-10-27 |
| AU2012318471A1 (en) | 2014-05-22 |
| EP2763681A1 (en) | 2014-08-13 |
| AU2012318471B9 (en) | 2017-06-01 |
| MX2014004126A (es) | 2014-07-28 |
| ES2642843T3 (es) | 2017-11-20 |
| CA2849421C (en) | 2020-04-28 |
| WO2013052765A1 (en) | 2013-04-11 |
| IL231757A (en) | 2017-07-31 |
| US9309203B2 (en) | 2016-04-12 |
| CN103906518A (zh) | 2014-07-02 |
| RU2632097C2 (ru) | 2017-10-02 |
| CN103906518B (zh) | 2020-03-13 |
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