JP6165586B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition in which a natural component having a vasodilatory effect and γ oryzanol are combined.

  In recent years, due to an uneven diet, the necessary nutrients have been insufficient, and due to health consciousness, it has become common to take in nutrients that are difficult to ingest with diet alone. In addition, the average life expectancy is about 80 years old for both men and women, and dietary supplements that can be easily consumed are particularly popular among elderly people who cannot increase the amount of meals as the population ages.

  Nutritional supplements are also available in a wide variety of products for different purposes, especially for women, products released for beauty and skin care are popular, and those containing collagen, chondroitin sulfate, and ceramide have been reported ( For example, see Patent Documents 1 and 2). In addition, it has been used as a herbal medicine since ancient times, such as carrots, coconut, daikon, cinnamon, cinnamon, acid jinjin, chenseed, cordyceps, etc. Also, products containing ginger for the purpose of antioxidant, metabolism promotion and blood circulation promotion are still popular (see, for example, Patent Document 4).

  On the other hand, with the westernization of the diet, patients with hyperlipidemia are increasing, and in such patients, lipids adhere to blood vessels, causing clogging of blood vessels, and in some cases, death. For the purpose of preventing the deterioration of the vascular condition, dietary supplements containing natural ingredients having a vasodilatory effect are used. For example, Tansan leaves have vasodilation, increased cerebral blood flow, anticoagulation and blood pressure lowering action. Chicken blood wisteria has blood circulation improvement and hematopoiesis promoting action, and Yamako has action of vasodilation, blood pressure lowering, blood fat reduction, and dietary supplements containing these are known (see, for example, Patent Document 5) ).

  Nutritional supplements that are expected to have a vasodilatory effect are often provided in tablets for ease of consumption. As a problem of tablets, tableting troubles such as lamination and capping may occur at the time of production (for example, Patent Documents 6 and 7). Conditions that do not cause tableting troubles such as adjustment had to be studied, and complicated work was required.

  In dietary supplements, discoloration such as discoloration and browning over time has become an issue, and it has been reported that additives such as vitamins can improve discoloration, but it cannot be used depending on the composition, or it affects the flavor, etc. There has been a demand for a more versatile discoloration improvement technique (for example, Patent Documents 7 and 8).

JP 2009-073735 A JP 2013-138632 A JP 2002-275075 A JP 2007-222116 A JP 2002-233331 A JP 2007-181441 A JP 2013-179905 A Japanese Patent Laid-Open No. 4-166061

  The present invention has been made under such circumstances, and in an oral composition containing a natural ingredient having a vasodilatory effect, the tableting troubles such as tablet lamination and capping are improved, and after the production, It is an object of the present invention to provide an oral composition in which γ-oryzanol is combined with a natural ingredient having a vasodilatory effect in order to suppress discoloration.

The present inventors have advanced research to provide an oral composition that can improve tableting troubles such as lamination and capping, and surprisingly have been identified as an oral composition containing a natural ingredient having a vasodilatory effect. It was found that by adding the lipids, a significant tableting trouble-improving effect and further, discoloration with time was prevented. In particular, by adding γ-orizanol, which is an ester obtained by condensing ferulic acid and sterol, the inventors have found that tableting problems are improved significantly and discoloration is improved, thereby completing the present invention. The oral composition of the present invention can not only solve problems in tablet production such as cracks and cracks, but also improve discoloration after production, without studying the conventional complicated tableting problems.
<1> An oral composition containing a natural ingredient having a vasodilatory effect and γ oryzanol.
<2> The oral composition according to <1>, wherein the natural component having a vasodilatory effect includes at least one selected from the group consisting of chicken blood wisteria, tansan, and yamako.
<3> The oral composition according to <1> or <2>, which is in the form of a tablet.

  Hereinafter, although the composition for oral use of this invention is demonstrated, the technical scope of this invention is not limited only to the following specific embodiments.

An embodiment of the present invention is an oral composition containing a natural ingredient having a vasodilatory effect and γ oryzanol.
The composition for oral administration according to this embodiment is a finding obtained by the present inventors, which is a tableting disorder such as lamination and capping during tablet production by combining a natural component having a vasodilatory effect and a specific lipid. Can be improved, and further discoloration after production can be suppressed.

(1) Natural component having vasodilator effect The vasodilator effect of the present invention means an effect of expanding blood vessels to increase blood volume, an effect of increasing blood flow, etc., and FMD (blood flow dependent vasodilator reaction). It can be measured by measurement, ultrasonic measurement, blood flow measurement device or the like.
The natural component having a vasodilator effect of the present invention is not particularly limited as long as it is a commercially available natural component and has a vasodilator effect. For example, chicken blood wisteria, tansan, yamako, garlic, ginger, crust, ginseng It can be illustrated. Of these, chicken blood wisteria, tansan, and yamako are preferable, and chicken blood wisteria is particularly preferable.
These natural components include roots, stems, branches, leaves, seeds, whole plants of plants that have a vasodilatory effect, or an extract extracted with a polar solvent such as ethanol or water. Preferable examples include those obtained by drying and powdering, those obtained by purifying these pulverized products, extracts, dried products, etc. by partitioning between columns and solutions to increase the active ingredients.
For chicken blood rattle, Spatholobus of legumes
An extract or dried product of suberectus can be used, and it is particularly preferable to use a product obtained by drying a stem, a product extracted with a polar solvent such as water, or a product obtained by drying the extract.
As for Dansan, the Labiatae plant Salvia
An extract or dried product of miltiorrhiza can be used, and it is particularly preferable to use a product obtained by drying leaves, a product extracted with a polar solvent such as water, or a product obtained by drying the extract.
As a mountain checker, the Rosaceae Crataegus
An extract or dried product of cuneata can be used, and it is particularly preferable to use a product obtained by drying a fruit, a product extracted with a polar solvent such as water, or a product obtained by drying the extract.
In addition, natural ingredients that may have a vasodilatory effect are prepared as an oral composition, a certain amount is ingested, and the degree of vasodilation before and after ingestion is measured by FMD (blood flow-dependent vasodilator response) or ultrasound A natural component having a high degree of vasodilation may be selected and used by measurement.

  The natural component of the present invention can be contained in the composition for oral use within the range usually used, but is preferably 0.1 to 90% by mass, more preferably 0.5 to 70% by mass, Preferably it is 1-60 mass%. If it exceeds the upper limit, there may be a problem in tableting suitability, and if it is less than the lower limit, a vasodilator action is required.

(2) γ oryzanol As the γ oryzanol of the present invention, commercially available γ oryzanol can be used. Examples thereof include γ-oryzanol (manufactured by Oriza Oil Co., Ltd.) and oryzanol (manufactured by Okayasu Shoten Co., Ltd.)
In addition, roots, stems, branches, leaves, seeds, whole plants of γ-oryzanol-containing plants are crushed or dried as they are, extracts extracted with polar solvents such as ethanol and water, and the extracts are dried and powdered It is also possible to use what has been made.
It is known that brown rice epidermis / brown rice germ-derived vegetable oil and rice bran contain γ oryzanol, and as γ oryzanol, a part of the plant containing γ oryzanol, extracted oil, and the like can also be used.

The γ-oryzanol of the present invention can be contained in an oral composition within a range that is usually used, but preferably contains 0.001 to 50% by mass, more preferably 0.01 to 20% by mass. More preferably, it is 0.1-10 mass%. When using the plant extract containing (gamma) oryzanol, it is preferable to contain an extract so that (gamma) oryzanol may become said content. For example, in the case of commercially available rice germ oil gamma (manufactured by Tsukino Food Industry Co., Ltd.), it is preferably exemplified that 0.001 to 10% by mass is contained.
If it exceeds the upper limit, there may be a problem in tableting suitability, and if it is less than the lower limit, the effect of improving the tableting failure may not be exhibited. Therefore, it is preferably contained in the above range.

(3) Oral composition of the present invention The oral composition of the present invention is characterized by containing a natural component having a vasodilatory effect and γ oryzanol. With such a configuration, it is possible to improve tableting troubles such as lamination and capping during tablet production, and to suppress discoloration after production.
In the oral composition of the present invention, in addition to the above-mentioned components, any component used in normal foods, nutritional supplements, medical foods, and the like can be contained. Examples of such optional components include surfactants such as sucrose fatty acid esters, glycerin monofatty acid esters and sorbitan fatty acid esters, starches that may be pregelatinized, crystalline cellulose, excipients such as lactose, hydroxypropylcellulose, and the like. Examples thereof include binders such as gum arabic, sugar alcohol and reduced maltose water, lubricants such as magnesium stearate, zinc stearate and calcium stearate, and plasticizers such as triethyl citrate and monoglyceride caprate. In addition, it is preferably used as a tablet, and when used as a tablet, it is preferable to apply a coating such as sugar coating to make it easy.

Hereinafter, the present invention will be described in detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

An oral composition of the present invention was prepared according to Table 1 below. Tablets were prepared by granulating reduced maltose, crystalline cellulose, and sucrose fatty acid ester into γ oryzanol, a natural component having a vasodilatory effect shown in Table 1, and then tableting to prepare a tablet-like oral composition.

<Comparative example>
In the same manner as in Table 1, an oral composition of a comparative example was prepared according to Table 2 below.

<Test Example 1>
Table 3 shows the number of tablets with lamination and capping among the 100 tablets produced in Examples 1 to 4 and Comparative Examples 1 to 4.

  The results in Table 3 clearly show that tableting troubles such as lamination and capping are remarkably improved in the tablet containing γ-oryzanol as a natural ingredient having vasodilation in the examples. Further, it is clear that the tableting failure cannot be improved by adding safflower oil, which is an oil component other than γ oryzanol, instead of γ oryzanol.

<Experimental example 2> For the tablets of Examples 1 to 4 and Comparative Examples 1 to 3, when 100 tablets without any tableting trouble were selected and stored at 30 ° C for 1 month, stored at 50 ° C for 1 week The presence or absence of discoloration was confirmed visually, and the results are shown in Table 4. The following criteria were used for judgment.
(Criteria)
No change → ○, finally recognized color change → △, obvious color change → ×

  From the results of Table 4, it can be seen that the discoloration with time is remarkably improved in the example as compared with the comparative example. Further, it is apparent that discoloration is not suppressed even when safflower oil, which is an oil component other than γ oryzanol, is added instead of γ oryzanol.

  According to the present invention, tableting troubles such as lamination and capping during tablet production can be improved, and further discoloration after production can be suppressed.

Claims (2)

An oral composition containing a natural component having a vasodilatory effect and γ oryzanol, the natural component having a vasodilatory effect comprising at least one selected from the group consisting of chicken blood wisteria, tansan, and Yamako Oral composition characterized by the above-mentioned. The oral composition according to claim 1, characterized in that it is in the form of a tablet.