JP2013043854A - Preparation containing crude drug - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a preparation containing a crude drug, which reduces a peculiar taste of combination of dried crude drug extract, is taken without water and has an improved administration feeling.SOLUTION: The preparation containing a crude drug, which has improved dose feeling, uses a dried crude drug extract, vegetable hard wax as a tableting improving additive and powdery reducing maltose thick malt syrup, erythritol and sucralose as administration feeling improving additives without water.

Description

  The present invention relates to a crude drug-containing preparation used for pharmaceuticals, health foods, foods and the like.

  Conventionally, when taking herbal medicine-containing preparations used for pharmaceuticals, health foods, foods, etc. without water, there is a resistance to the unique taste unique to herbal medicines. For this reason, gel addition using a thickener and water (Patent Document 1) has been used. However, filling into a container that is easy to chew and packaging in which water does not evaporate are required.

  Moreover, although there exists what added the capsaicin containing material which is a corrigent (patent document 2), this is not common because a target crude drug is restricted to a wind-proof sansho.

  On the other hand, as a product in which a sweetener is added to a crude drug-containing preparation, a product containing stevia (Patent Document 3) is used. There is a tendency to prolong, which is not preferable.

  In addition, the one added with erythritol (Patent Document 4) has a disadvantage that the rise of the taste is quick, but the effect immediately disappears.

  Further, in the direct tableting method, Patent Document 5 is a blend of erythritol and lactitol, and Patent Document 6 is a blend of erythritol and sorbitol, both of which produce sweetener tableting granules. is there.

Japanese Patent Laid-Open No. 9-12463 JP 2009-84217 A JP-A-9-110708 JP-A-8-27033 JP 2008-271829 A JP 2006-335686 A

  The present invention, when producing a herbal medicine-containing preparation widely used in pharmaceuticals, health foods, etc., by a direct tableting method, has excellent tableting properties even with a preparation containing a wide range of herbal medicine dry extract and water. It is an object of the present invention to provide a herbal medicine-containing preparation that can be taken without a peculiarity and relaxes the unique taste unique to herbal medicines.

  In order to solve the above-mentioned problem, the present invention provides a vegetable hard wax as a tableting property improving additive to a herbal medicine dry extract, and powdered reduced maltose starch syrup and erythritol as a taking property improving additive without water. Using sucralose.

  And even if the blending ratio of the crude drug dried extract was in a wide range of 50 to 85% by mass of the whole preparation, a preparation having good moldability and good feeling of administration was produced by a direct tableting method.

  As described above, in the present invention, since vegetable hard wax was used as a tableting property improving additive at the end of dry crude drugs, the surface of the tablet was smoothly glossed, and sticking (a part of the tablet was damaged during tableting). ) And capping (a phenomenon in which the upper and lower sides of the tablet peel off into a flake form during tableting) and the compression moldability of the preparation containing the herbal medicine was remarkably improved.

  In addition, the herbal medicine-containing preparation has a unique taste unique to herbal medicine, and those who are not good at it need to take it with a large amount of water etc. and are inconvenient for portability when going out. The use of reduced maltose syrup, erythritol, and sucralose in the form of a pill can significantly improve the dosing ability because it can be taken without water due to relaxation of the taste and increased saliva. The combination of powdered reduced maltose syrup and erythritol and sucralose is a powdered reduced maltose syrup with a sweetness close to mellow sugar with no aftertaste. It has double sweetness and can be formulated in a small amount. For this reason, the sweetness rises quickly and the sweetness lasts before you feel the unique taste of herbal medicine.

  In the present invention, the dosage form of the preparation is a tablet or a lozenge. Tablets include dosage forms such as orally disintegrating tablets that disintegrate with a small amount of water such as saliva, chewable tablets that chew in the mouth, and buccal tablets that are oral preparations.

Furthermore, lactose, starch, calcium stearate, magnesium stearate, talc, crystalline cellulose, sucrose, light anhydrous silicic acid, etc. may be used as other additives during the manufacture of tablets and lozenges. You may add the particle | grains which gave the lasting or enteric functionality covered with the soluble film.
The tablet shape includes a disk type, a ring type, a concave lens type, a convex lens type, a polygonal type, an oblong type, and an oval type.

  The direct tableting method in the present invention includes a direct powder compression method in which powder is directly compressed to produce tablets and troches, and a dry granule compression method in which powder and granules are directly compressed to produce tablets and troches.

The herbal medicine dried extract used in the present invention is: Shakuyakukanzo-to (herbal medicine ingredients peony, licorice), Kakkonto (herbal medicine ingredients kakon, mao, taisou, keihi, peony, licorice, ginger) Kakkon, Maoh, Taisou, Keihi, Peonies, Kanzo, Shokyo, Jiou) Shoseiryu (herbal medicines Maou, Peonies, Kanzo, Keihi, Saishin, Goshi, Hange, Kankyo), Daisaikoto (herbal medicines Psycho, Hange) , Syougyo, Ogon, Taiso, Pheasant, Daio, Peonies), Sho-saiko-to (herbal medicine Psycho, Hange, Ogon, Carrot, Taisou, Licorice, Ginger), Hanatsushinshinto (Herbal medicine ingredient Hange, Ogon, Carrot, Licorice, Taiso, Auren, Kankyo), yellow ream Poisonous hot water (herbal medicine ingredients: Auren, Aubaku, Ogon, Sanshishi), wind-proof scented powder (herbal medicine ingredients: Kyo, Bakujutsu, licorice, Ogon, Gypsophila, Diou, Toki, peonies, senkyu, Sangishi, Forsythia, mint, crab, bowfish, Maoh, Shokyo, Kaseki, Bowsho), Hachimi-jio-gan (Ryokan, Sangshuyu, Sanyaku, Takusha, Bukryo, Boppi, Keihi, Bushi), Hakuho-to (Herbal medicinal ingredients Bowie, Ogi, Taiso, Kanzo) , Peanuts, shrimp), Hochuekkito (herbal medicine ingredients carrots, carrots, toki, chimpi, taiso, sandalwood, psycho, licorice, shouma, shrimp) one or more herbal ingredients selected from the group consisting of Is used as a powder. Of these, Kampo prescriptions are used as “hot water” or “stock” in which the herbal medicine component groups constituting each prescription are collectively extracted.
In addition to the spray drying method, the freeze drying method and the evaporation drying method are also recommended for the production of the crude drug dried extract of the present invention.

  As a typical vegetable hard wax, carnauba wax which is a wax obtained from a leaf of carnauba palm having a high melting point is used. In the case of the direct hitting method, a powder of 60 mesh (250 μm) or less is usually used, and the blending in the preparation is desirably in the range of 0.2% by mass to 10% by mass of the whole preparation.

  Powdered reduced maltose syrup is made of maltitol, D-sorbitol and oligosaccharide alcohol in the standard for pharmaceutical additives (supplemented in 2003 version). The powder containing 75.0-80.0% by mass into a fine powder is used, and the compounding ratio in the formulation is preferably in the range of 1-20% by mass with respect to the total amount of herbal dry extract.

  In addition, erythritol is, for example, a white crystal or crystalline powder containing 98.0% by mass or more of erythritol when quantifying a dry product in the standard for pharmaceutical additives (2003 version). Is preferably in the range of 1 to 20% by mass with respect to the total amount of the crude drug dry extract.

  Furthermore, sucralose is a fine powdery white to light gray white crystalline powder containing 98.0 to 102.0% by mass of sucralose with respect to the dehydrated product when quantified in the standard for pharmaceutical additives (2003 edition supplement). The type is used, and the blending ratio in the preparation is desirably a blending ratio range of 5% by mass or less with respect to the total blended amount of the crude drug.

In the tableting test by the direct tableting method, the rotation speed of the tableting machine A (collect 45, manufactured by Kikusui Seisakusho Co., Ltd.) is 25 rpm, the tableting pressure is 500 to 2000 kg, the diameter of the punch is 10 mmφ, and the tableting machine B (VIRGO 0512SS2AZ, Kikusui Seisakusho Co., Ltd.) was tableted with a rotation speed of 12 rpm, a tableting pressure of 2 to 4 tons and a punch diameter of 15 mmφ, and tableting properties such as sticking and capping tableting troubles and tablet appearance were observed with the naked eye. Further, the tablet quality was measured by tablet hardness (TANAKA hardness meter). In addition, applicability was evaluated by a sensory test.
Regarding the evaluation of tableting property, those having no sticking or capping were evaluated as “good”, and those having a tableting failure or those incapable of tableting were determined as “bad”.
As for the tablet appearance, a smooth surface with a glossy tablet surface was defined as “good”, and a non-glossy or powdery surface was defined as “bad”.
The sensory test was conducted with 6 panelists (5 men and 1 woman). In the section of feeling of taking, “+” mark indicates that it cannot be taken without water, and “±” mark and “−” mark indicate that it can be taken without water.
In the following experimental examples and examples, “part” means part by mass and “%” means mass% unless otherwise specified.

  Next, the present invention will be described with reference to experimental examples and examples.

Experimental example

(Experimental example 1)
As a dry extract of herbal medicine dried by spray, Daisaikoto dried extract (manufactured by Nippon Powder Chemical Co., Ltd., active ingredient ratio: Psycho 6 parts, Hange 4 parts, Shogyo 1 part, Ogon 3 parts, Taiso 3 parts, Pheasant 2 parts Carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.), Neusilin FL-1 (magnesium aluminate metasilicate manufactured by Fuji Chemical Industry Co., Ltd.), lactose hydrate in the ratios shown in Table 1 (Manufactured by DMV), potato starch (manufactured by Matsutani Chemical Co., Ltd.), talc (manufactured by Matsumura Sangyo Co., Ltd.), magnesium stearate (manufactured by NOF Corporation), powdered sugar (manufactured by Nissin Sugar Co., Ltd.), powdered Reduced maltose syrup (Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), Stevi MZ (stevia extract purified product manufactured by Maruzen Pharmaceutical Co., Ltd.), Sucralose FP Co., Ltd.) and erythritol (Mitsubishi Chemical Foods Co., Ltd.) are mixed with powder to prepare each powder sample from Sample 1 to Sample 6, and these sample powders are produced by a single-handed manual press tableting machine (Shimadzu Corporation). (Manufactured by Seisakusho Co., Ltd.), a tableting test by a direct tableting method was performed as follows.

Using 100 g of a powder sample, tableting was performed at a tableting pressure of 3 tons at a weight of 500 mg per tablet, and the evaluation results are shown in Table 1.
There was no problem with either tablet in tableting property and tablet appearance, but sample 2 without sample sweetener, sample 2 using powdered sugar as sweetener, and sample 4 using Stevi MZ were poor in taking feeling. It was. The result showed that powdered reduced maltose starch syrup, sucralose, and erythritol are preferable from the viewpoint of ingestion at a sweetener addition rate of 10% by mass relative to the dry extract.

(Experimental example 2)
Spray dried dried kakukonyu dried extract (manufactured by Nippon Powdery Chemicals Co., Ltd., raw drug ratio: 8 parts of kakon, 4 parts of mao, 4 parts of taiso, 3 parts of kehi, 3 parts of peonies, 2 parts of licorice, show Carnauba wax (manufactured by Freund Sangyo Co., Ltd.), potato starch (manufactured by Matsutani Chemical Co., Ltd.), magnesium stearate (manufactured by NOF Corporation), and powdered reduced maltose syrup Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd., sucralose (manufactured by San-Ei Gen FFI Co., Ltd.), erythritol (manufactured by Mitsubishi Chemical Foods Co., Ltd.) were mixed in powders, and samples 10 and 11 were used as comparative examples and sample 12 without carnauba wax. A sample 13 having a blending ratio of 12% by mass of carnauba wax was prepared. These sample powders were subjected to a tableting test by the direct tableting method as follows.
Using 2 kg of the powder sample, the mass per tablet was tableted with the tableting machine A with the blended amount of Kakkonto dry extract constant, and the evaluation results are shown in Table 3.
Samples 10 and 11 of the present invention were good in tableting property and ingestion feeling. Sample 12 not containing Carnauba wax, which is a comparative example, was powdery in the mouth and inferior in feeling to be taken. Moreover, the sample 13 containing 12% by mass of carnauba wax was poor in wetness in the mouth and inferior in feeling of administration.

(Experimental example 3)
Using spray-dried glaze licorice-dried extract (Alps Yakuhin Co., Ltd., raw drug ratio: 1 part peony, 1 part licorice), carnauba wax (Freund Sangyo Co., Ltd.), potato starch (Matsuya) at the ratios shown in Table 3 Chemical Co., Ltd.), magnesium stearate (manufactured by NOF Corporation), powdered reduced maltose syrup (Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), sucralose (manufactured by Saneigen FFI Co., Ltd.), erythritol (Mitsubishi Chemical) Foods Co., Ltd.) was mixed with powder to prepare Samples 20 and 21 as comparative examples, Sample 22 to which 40% by weight of herbal dry extract was added, and Document 23 to which 88% by weight of herbal dry extract was added. These sample powders were subjected to a tableting test by the direct tableting method as follows.
Using 2 kg of the powder sample, the weight per tablet was tableted with the tableting machine A with the blended amount of the glaze licorice-dried extract constant, and the evaluation results are shown in Table 3.
Samples 20 and 21 of the present invention were good in tableting properties and ingestion feeling. Sample 22 to which 40% by mass of crude herbal extract, which is a comparative example, was added had poor powder flow at the time of tableting due to the effect of potato starch as an additive, and the taste became powdery and the feeling of taking was poor. Therefore, in the samples 20, 21, and 23, the herbal medicine dry extract addition rate was set to 50% by mass or more. Moreover, although the sample 23 to which 88% by mass of the crude drug dry extract as a comparative example was added had no problem in tableting property, tablet appearance, and feeling of administration, since the ratio of the crude drug dry extract addition was large and the range of the sweetener addition rate was narrow. The herbal medicine dry extract addition rate was 85% by mass or less.

Example 1
As the dried herbal medicine dried extract, Shakuyakukanzoto dry extract (Alps Yakuhin Co., Ltd., raw drug ratio: 1 part peony, 1 part licorice) 24 kg, Carnauba wax (Ogi Pharmaceutical Co., Ltd.) 320 g, potato starch (Matsutani Chemical) 5.38 kg, made by magnesium stearate (manufactured by NOF Corporation), 1.2 kg of powdered reduced maltose syrup (Amalty MR100, manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), sucralose (manufactured by Saneigen FFI Corporation) ) 120 g, 1.2 kg of erythritol (Mitsubishi Chemical Foods Co., Ltd.) 1.2 kg in a Laedige mixer (Matsuzaka Giken Co., Ltd.) and mixed for 5 minutes, and the resulting powder is vibrating sieve (manufactured by Asano Iron Works Co., Ltd., 42 After sieving with a mesh wire mesh), 32kg of mixed powder is compressed into a tableting machine B using a 15mmφ mortar and punch. A tableting pressure 4 t Te, to give tablets each weighing mass 1.08 g. The obtained tablet had a thickness of 4.3 mm, a hardness of 36 kg or more, and a disintegration time of 44 to 48 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 2)
As a dry extract of herbal medicines that have been spray-dried, Dokukatsu Kakkonto dry extract (manufactured by Nippon Powdery Chemicals Co., Ltd., active pharmaceutical ingredients ratio: 2 parts of dokukatsu, 5 parts of kakon, 2 parts of mao, 1 part of taiso, 3 parts of kehi, 3 parts of peonies, 1 part of licorice, 0.5 part of gyoza, 4 parts of Ziou) 38 kg, 510 g of carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.), 8.12 kg of potato starch (manufactured by Matsutani Chemical Co., Ltd.), magnesium stearate (manufactured by NOF Corporation) 380 g, 1.9 kg of powdered reduced maltose syrup (Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.), 190 g of sucralose (manufactured by Saneigen FFI Co., Ltd.), 1.9 kg of erythritol (manufactured by Mitsubishi Chemical Foods Co., Ltd.) Put in a Gemixer (Matsuzaka Giken Co., Ltd.) and mix for 5 minutes. Sieving with a 42 mesh wire mesh, manufactured by Asano Tekkosho Co., Ltd.) 50kg of the mixed powder was tableted with a tableting machine B using a 15mmφ mortar and punch with a tableting pressure of 4 tons, each tablet having a mass of 1.22g Got. The obtained tablet had a thickness of 5.1 mm, a hardness of 33 kg, and a disintegration time of 40 minutes to 44 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 3)
Spray dried dried kakukonto dry extract (manufactured by Nippon Powder Co., Ltd., active pharmaceutical ingredients ratio: 8 parts of kakon, 4 parts of mao, 4 parts of taiso, 3 parts of kehi, 3 parts of peonies, 2 parts of licorice, ginger 1 part) 43.4 kg, Carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.) 600 g, potato starch (manufactured by Matsutani Chemical Co., Ltd.) 1.1 kg, magnesium stearate (manufactured by NOF Corporation) 450 g, powdered reduced maltose syrup candy (Mitsubishi) Shoji Foodtech Co., Ltd. Amarty MR100 (2.2 kg), Sucralose (San-Eigen FFI Co., Ltd.) 220 g, Erythritol (Mitsubishi Chemical Foods Co., Ltd.) 2.2 kg were added to the Redige Mixer (Matsuzaka Giken Co., Ltd.) And mixed for 5 minutes, and the resulting powder was shaken (42-inch gold, manufactured by Asano Tekkosho Co., Ltd.). ) After sieving, at a tableting pressure of 4 ton mixed powder at using tabletting machine B a mortar-pestle for 15mmφ of 60 kg, to give tablets each weighing mass 1g. The obtained tablet had a thickness of 4.3 mm, a hardness of 34 kg, and a disintegration time of 29 minutes to 32 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 4)
As a dried crude drug extract, the dried herb extract from Gyokukankanzoto (Alps Yakuhin Co., Ltd., raw drug ratio: 1 part peony, 1 part licorice) 24 kg, 300 g carnauba wax (Ogi Pharmaceutical Co., Ltd.), potato starch (Matsutani Chemical) 5.2 kg, Magnesium stearate (manufactured by NOF Corporation) 180 g, powdered reduced maltose syrup (Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.) 1.2 kg, sucralose (manufactured by Saneigen FFI Corporation) ) 240 g, erythritol (Mitsubishi Chemical Foods Co., Ltd.) 1.2 kg was placed in a Laedige mixer (Matsuzaka Giken Co., Ltd.) and mixed for 5 minutes, and the resulting powder was shaken (Asano Iron Works Co., Ltd., 42 After sieving with a mesh wire mesh), 32kg of mixed powder is put into a tableting machine A using a 10mmφ mortar and punch. Tableting pressure was tableted in two tons to give tablets each weighing mass 360 mg. The obtained tablets had a thickness of 5.0 mm, a hardness of 10.1 kg, and a disintegration time of 41 to 44 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 5)
As a spray-dried crude drug dried extract, Hosei Koreito dried extract (Alps Yakuhin Co., Ltd., raw drug ratio: Bowie 10 parts, Ogi 10 parts, Taiso 6 parts, licorice 3 parts, Sandalwood 6 parts, Showa 2 Part) 31.5 kg, Carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.) 2.3 kg, potato starch (manufactured by Matsutani Chemical Co., Ltd.) 7.6 kg, magnesium stearate (manufactured by NOF Corporation) 340 g, powdered reduced maltose syrup candy ( 1.6 kg of Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd., 160 g of sucralose (manufactured by Saneigen FFI Co., Ltd.) and 1.6 kg of erythritol (manufactured by Mitsubishi Chemical Foods Co., Ltd.) And mixed for 5 minutes, and the resulting powder is shaken (42 mesh, manufactured by Asano Tekkosho Co., Ltd.). After sieved with a net), a tableting pressure 2 tons in tabletting machine A with mortar-pestle for 10mmφ a mixed powder of 45 kg, to give tablets each weighing mass 450 mg. The obtained tablet had a thickness of 5.6 mm, a hardness of 25 kg, and a disintegration time of 44 minutes to 49 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 6)
As a dry extract of herbal medicine dried by spray, Daisaikoto dried extract (manufactured by Nippon Powder Chemical Co., Ltd., active ingredient ratio: Psycho 6 parts, Hange 4 parts, Shogyo 1 part, Ogon 3 parts, Taiso 3 parts, Pheasant 2 parts , 1 part of Daio, 3 parts of Peonies) 31.5 kg, 2.3 kg of Carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.), 7.6 kg of potato starch (manufactured by Matsutani Chemical Co., Ltd.), 340 g of magnesium stearate (manufactured by NOF Corporation), A powdered reduced maltose syrup (Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.) 1.6 kg, 160 g of sucralose (manufactured by Saneigen FFI Co., Ltd.), 1.6 kg of erythritol (manufactured by Mitsubishi Chemical Foods Co., Ltd.) (Matsuzaka Giken Co., Ltd.) and mixed for 5 minutes, and the resulting powder is vibrating sieve (Asano Tekko Co., Ltd.) After sieving with a 42 mesh wire mesh, a 45 kg mixed powder was tableted with a tableting machine A using a 10 mmφ mortar and punch with a tableting pressure of 2 tons to obtain a tablet with a tablet weight of 450 mg. The obtained tablet had a thickness of 5.7 mm, a hardness of 25 kg, and a disintegration time of 14 to 16 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 7)
Spray dried dried herbal medicine, Shosaikoto dried extract (manufactured by Alps Pharmaceutical Co., Ltd., active ingredient ratio: Psycho 7 parts, Hange 5 parts, Ogon 3 parts, carrot 3 parts, Taiso 3 parts, Licorice 2 parts, Shaw 1 part) 31.5 kg, Carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.) 2.3 kg, potato starch (manufactured by Matsutani Chemical Co., Ltd.) 7.6 kg, magnesium stearate (manufactured by NOF Corporation) 340 g, powdered reduced maltose Mizuame (Amarti MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.) 1.6kg, Sucralose (manufactured by Saneigen FFI Co., Ltd.) 160g, Erythritol (manufactured by Mitsubishi Chemical Foods Co., Ltd.) 1.6kg, Ladige Mixer (Matsuzaka Giken Co., Ltd.) And the resulting powder is mixed with a vibrating sieve (manufactured by Asano Iron Works, 42 mesh). After sieved in Interview wire mesh), at a tableting pressure 2 tons in tabletting machine A with mortar-pestle for 10mmφ a mixed powder of 45 kg, to give tablets each weighing mass 450 mg. The obtained tablet had a thickness of 5.7 mm, a hardness of 14 kg, and a disintegration time of 60 minutes or more. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

(Example 8)
As a herbal medicine dried extract that has been spray-dried, a wind-proof scented powder dried extract (manufactured by Alps Yakuhin Co., Ltd., active pharmaceutical ingredient ratio: 6 parts of Kyoku, 6 parts of peacock, 6 parts of licorice, 6 parts of ogon, 6 parts of gypsum, 4) 5 parts, 3.6 parts of Toki, 3.6 parts of peony, 3.6 parts of Senkyu, 3.6 parts of Sashishi, 3.6 parts of Forsythia, 3.6 parts of mint, 3.6 parts of Keigai, 3.6 parts of Bow Fu , Mao 3.6 parts, Showa 1.2 parts, Kasseki 9 parts, Bow show 4.5 parts) 31.5 kg, Carnauba wax (Ogi Pharmaceutical Co., Ltd.) 2.3 kg, Potato starch (Matsuya Chemical Co., Ltd.) 7 .6 kg, Magnesium stearate (manufactured by NOF Corporation) 340 g, powdered reduced maltose syrup (Amalty MR100, manufactured by Mitsubishi Corporation Foodtech Co., Ltd.) 1.6 kg, SC 160 g of loin (manufactured by San-Ei Gen FFI Co., Ltd.) and 1.6 kg of erythritol (manufactured by Mitsubishi Chemical Foods Co., Ltd.) were placed in a Laedige mixer (manufactured by Matsuzaka Giken Co., Ltd.) and mixed for 5 minutes. (Shinsei Co., Ltd., 42 mesh wire mesh), sieved 45 kg of mixed powder using a 10 mmφ mortar and punch with tableting machine A at a tableting pressure of 2 tons, 1 tablet weight 450 mg Got. The obtained tablets had a thickness of 5.6 mm, a hardness of 10 kg, and a disintegration time of 53 to 59 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

Example 9
As a dried crude drug extract, Hochuekkito dried extract (manufactured by Nippon Powder Chemical Co., Ltd., ratio of crude drug: 4 parts of ogi, 4 parts of carrot, 3 parts of touki, 2 parts of chimpi, 2 parts of peanut, 4 peanuts Part, psycho 2 parts, licorice 1.5 parts, ginger 1 part, ginger 0.5 part) 31.5 kg, carnauba wax (manufactured by Ogi Pharmaceutical Co., Ltd.) 2.3 kg, potato starch (manufactured by Matsutani Chemical Co., Ltd.) 6 kg, Magnesium stearate (manufactured by NOF Corporation) 340 g, powdered reduced maltose syrup (Amalty MR100 manufactured by Mitsubishi Corporation Foodtech Co., Ltd.) 1.6 kg, sucralose (manufactured by Saneigen FFI Corporation) 160 g, erythritol (Mitsubishi) 1.6kg of Chemical Foods Co., Ltd.) is put in a Laedige mixer (Matsuzaka Giken Co., Ltd.) and mixed for 5 minutes. The obtained powder was sieved with a vibration sieve (manufactured by Asano Iron Works Co., Ltd., 42 mesh wire mesh), and then 45 kg of the mixed powder was tableted with a tableting machine A with a tableting machine A using a 10 mmφ mortar and punch, A tablet with a mass of 450 mg was obtained. The thickness of the obtained tablet was 5.6 mm, the hardness was 20 kg, and the disintegration time was 14 to 16 minutes. When the tablets were put in the mouth and chewed, they had a flavor and sweetness peculiar to herbal medicines and could be swallowed without difficulty due to the generation of saliva.

Claims (6)

  A herbal medicine-containing preparation comprising a herbal dry wax blended with a vegetable hard wax, powdered maltose starch syrup, erythritol and sucralose.   The herbal medicine-containing preparation according to claim 1, wherein the blending ratio of the dried crude drug is in the range of 50 to 85 mass% of the whole preparation.   Herbal medicine dried extract is shakuyaku kanzo-yu, kakkon-yu, sotsukatsu-katsune-yu, kosei-ryu, dai-saiko-yu, koshi-saiko-yu, hanatsu-jinshin-yu, kanren-deto-yu The herbal medicine-containing preparation according to claim 1 or 2, wherein the herbal medicine is one or more herbal ingredients selected from the group consisting of Hosei Koreito and Hochuekkito.   Herbal medicine dry extracts are herbal medicines such as Shakuyaku Kanzo-yu, Kakkon-to, Dokatsu-Kakkon-to, Dai-saiko-to, Sho-saiko-to, Fufutsu-san-san, Hochuekki-to, Hozen-ko-to The herbal medicine-containing preparation according to claim 1 or 2, wherein the herbal medicine component group constituting the prescription is extracted at once.   The herbal medicine-containing preparation according to claim 1 or 2, wherein the vegetable hard wax is carnauba wax.   The herbal medicine-containing preparation according to any one of claims 1 to 5, which is produced by a direct tableting method.