JP6146990B2 - 重水素化されたｃｆｔｒ増強物質 - Google Patents

重水素化されたｃｆｔｒ増強物質 Download PDF

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JP6146990B2
JP6146990B2 JP2012251831A JP2012251831A JP6146990B2 JP 6146990 B2 JP6146990 B2 JP 6146990B2 JP 2012251831 A JP2012251831 A JP 2012251831A JP 2012251831 A JP2012251831 A JP 2012251831A JP 6146990 B2 JP6146990 B2 JP 6146990B2
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compound
deuterium
pharmaceutically acceptable
mmol
acid
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JP2014097964A5 (show.php
JP2014097964A (ja
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アダム ジェイ． モーガン
アダム ジェイ． モーガン
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コンサート ファーマシューティカルズ インコーポレイテッド
コンサート ファーマシューティカルズ インコーポレイテッド
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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JP2012251831A 2012-11-16 2012-11-16 重水素化されたｃｆｔｒ増強物質 Active JP6146990B2 (ja)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
JP2018188474A (ja) * 2018-08-13 2018-11-29 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質

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EP3219705B1 (en) 2005-12-28 2020-03-11 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
JP2013525371A (ja) 2010-04-22 2013-06-20 バーテックス ファーマシューティカルズ インコーポレイテッド シクロアルキルカルボキサミド−インドール化合物の製造方法
HUE039062T2 (hu) 2014-04-15 2018-12-28 Vertex Pharma Gyógyszerészeti készítmények cisztás fibrózis transzmembrán konduktancia regulátor által mediált betegségek kezelésére
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
EP3317274A4 (en) 2015-06-30 2019-05-08 Eiger Group International, Inc. USE OF CHLOROQUIN AND CLEMIZOL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY AND CANCER DISEASES
HUP1600270A2 (hu) 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Ivacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadott készítményei
US10206915B2 (en) 2016-04-25 2019-02-19 Druggability Technologies Ip Holdco Limited Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US10383865B2 (en) 2016-04-25 2019-08-20 Druggability Technologies Ip Holdco Limited Pharmaceutical combination composition comprising complex formulations of Ivacaftor and Lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
HUP1600271A2 (hu) 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei
JP6802899B2 (ja) * 2016-07-25 2020-12-23 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ，Ｉｎｃ． 置換ボロン酸化合物、該化合物を含む医薬組成物およびその使用
KR102720000B1 (ko) * 2017-12-01 2024-10-21 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막관통 조절 인자의 제조 방법
CN115304595A (zh) * 2020-01-10 2022-11-08 康圣博施医药有限公司 药物的治疗组合以及其使用方法

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* Cited by examiner, † Cited by third party
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ES2293638T3 (es) * 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
PL372968A1 (en) * 2002-04-08 2005-08-08 Pfizer Inc. Tropane derivatives as ccr5 modulators
WO2004000854A1 (en) * 2002-06-20 2003-12-31 Ic Vec Limited Sulfur-containing phospholipid derivatives
RS56873B1 (sr) * 2004-06-24 2018-04-30 Vertex Pharma Modulatori atp-vezujućih kasetnih transportera
MX349159B (es) * 2011-05-18 2017-07-14 Concert Pharmaceuticals Inc Derivados deuterados de ivacaftor.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
JP2018188474A (ja) * 2018-08-13 2018-11-29 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質

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