JP6130387B2 - 強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ - Google Patents

強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ Download PDF

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JP6130387B2
JP6130387B2 JP2014539995A JP2014539995A JP6130387B2 JP 6130387 B2 JP6130387 B2 JP 6130387B2 JP 2014539995 A JP2014539995 A JP 2014539995A JP 2014539995 A JP2014539995 A JP 2014539995A JP 6130387 B2 JP6130387 B2 JP 6130387B2
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nucleic acid
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マレク ファハム
マレク ファハム
ビクトリア カールトン
ビクトリア カールトン
マーティン ムーアヘッド
マーティン ムーアヘッド
チャンビャオ チェン
チャンビャオ チェン
トーマス アズベリー
トーマス アズベリー
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アダプティヴ バイオテクノロジーズ コーポレーション
アダプティヴ バイオテクノロジーズ コーポレーション
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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JP2014539995A 2011-11-04 2012-10-25 強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ Active JP6130387B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161556125P 2011-11-04 2011-11-04
US61/556,125 2011-11-04
US201161561234P 2011-11-17 2011-11-17
US61/561,234 2011-11-17
PCT/US2012/061977 WO2013066726A1 (en) 2011-11-04 2012-10-25 T-cell receptor clonotypes shared among ankylosing spondylitis patients

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JP2014533102A JP2014533102A (ja) 2014-12-11
JP2014533102A5 JP2014533102A5 (enExample) 2015-12-10
JP6130387B2 true JP6130387B2 (ja) 2017-05-17

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US (2) US20150252422A1 (enExample)
EP (1) EP2773773B1 (enExample)
JP (1) JP6130387B2 (enExample)
ES (1) ES2619713T3 (enExample)
WO (1) WO2013066726A1 (enExample)

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US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
EP2719774B8 (en) 2008-11-07 2020-04-22 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
HUE029424T2 (en) 2009-01-15 2017-02-28 Adaptive Biotechnologies Corp Adaptive immunity profiling and a method for producing monoclonal antibodies
RU2539032C2 (ru) 2009-06-25 2015-01-10 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения искусственного иммунитета
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
AU2012325791B2 (en) 2011-10-21 2018-04-05 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
ES2867924T3 (es) 2011-12-09 2021-10-21 Adaptive Biotechnologies Corp Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2823060B1 (en) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
DK2831276T3 (da) 2012-05-08 2016-08-01 Adaptive Biotechnologies Corp Sammensætninger og fremgangsmåde til at måle og kalibrere amplifikations-bias i multipleks-PCR-reaktioner
US20160002731A1 (en) 2012-10-01 2016-01-07 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US9708657B2 (en) * 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3132059B1 (en) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
ES2858306T3 (es) 2015-02-24 2021-09-30 Adaptive Biotechnologies Corp Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
CN107345240A (zh) * 2016-05-12 2017-11-14 眭维国 T细胞抗原受体β链CDR3的处理方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements

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US5667967A (en) * 1990-05-01 1997-09-16 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor varible transcripts as disease related markers
AU736742B2 (en) * 1996-06-03 2001-08-02 Governors Of The University Of Alberta, The Methods for detection of rearranged DNA
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KR101323827B1 (ko) * 2010-01-08 2013-10-31 키스트 유럽 에프게엠베하 강직성척추염 진단용 프라이머 및 이를 이용한 강직성 척추염 진단 방법

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EP2773773B1 (en) 2017-01-11
EP2773773A1 (en) 2014-09-10
ES2619713T3 (es) 2017-06-26
EP2773773A4 (en) 2015-07-22
JP2014533102A (ja) 2014-12-11
US20170191132A1 (en) 2017-07-06
WO2013066726A1 (en) 2013-05-10
US20150252422A1 (en) 2015-09-10

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