JP6125529B2 - 修正された組織固定繊維 - Google Patents
修正された組織固定繊維 Download PDFInfo
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- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
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Description
第1の断面積を有する少なくとも1つの部分と、
第2の断面積を有する少なくとも1つの部分と、を含む、組織固定繊維に関し、
第2の断面積は、第1の断面積より小さく、第2の断面積を有する少なくとも1つの部分は、第1の断面積を有する少なくとも1つの部分の中間にある。
A1=π/4・D1 2
A2=π/4・D2 2
D2 2=A2/A1 ・D1 2
D2=D1 ・(A2/A1)1/2
A1=π・D1minor/2・D1major/2
A2=π・D2minor/2・D2major/2
D2minor=A2/A1 ・D1minor ・D1major/D2major
繊維を延伸することにより繊維直径を減少させる方法は、実質的に均一な大きな断面積、例えば、完全な円形又は他の非円形の断面形状(例えば、楕円形若しくは矩形など)を備えて製造された繊維を使用する。繊維は、種々の高分子材料から標準的な固形押出成形として製造され得る。本発明での使用に好適な非吸収性材料には、ポリアミド(例えば、ポリヘキサメチレンアジパミド(ナイロン66)、ポリヘキサメチレンセバカミド(ナイロン610)、ポリカプラミド(ナイロン6)、ポリドデカンアミド(ナイロン12)及びポリヘキサメチレンイソフタルアミド(ナイロン61)、それらのコポリマー及びブレンド)、ポリエステル(例えば、ポリエチレンテレフタレート、ポリブチルテレフタレート、それらのコポリマー及びブレンド)、フルオロポリマー(例えば、ポリテトラフルオロエチレン及びポリフッ化ビニリデン)ポリ(ヘキサフルオロプロピレン−VDF)、ポリアリールエーテルケトン、ポリオレフィン(例えば、アイソタクチック及びシンジオタクチックポリプロピレン並びにそれらのブレンドを含むポリプロピレン、並びにヘテロタクチックポリプロピレン及び/又はポリエチレンと配合された主にアイソタクチック又はシンジオタクチックポリプロピレンから構成されるブレンド(例えば、その内容全体が参照により本明細書に組み込まれる、1985年12月10日に発行され、Ethicon,Inc.に譲渡された、米国特許第4,557,264号に記載されるもの))、及びそれらの組み合わせが挙げられるが、これらに限定されない。
延伸比=(VB/VA)*(VC/VB)*(VD/VC)又は(VD/VA)
VO1=VO2
pD1 2*L1/4=pD4 2*L4/4
D1 2*L1=D4 2*L4
L1/L4=D4 2/D1 2
1/3=D4 2/(0.065)2
(1/3)*(0.065)2=D4 2
0.094cm(0.037インチ)=D4
断面積又は直径が減少した固定繊維を製造するための第2の方法は、ePTFEなどの膨張型繊維形態を圧縮することによる。ePTFEなどの材料を使用する場合、局部的ヒンジ点は、材料の体積圧縮及び再焼結を用いることにより作製される。ePTFEは、自由体積が独立気泡発泡構造と同様に配置される発泡テフロン材料として形成される。この材料は、ペースト押し出しにより形成され、次に焼結処理が施されて、材料の結節を結合させ、十分な強度と高い柔軟性とを有する繊維を作製する。より大きな断面積又は形状を有する繊維を作製すると、良好な耐荷重面を有する材料を提供し、可撓性を損なうことなく荷重時に組織を切断しにくい。前述したように、未修正の繊維を使用する問題点の1つは、前述した繊維のように単一穿刺位置の場所における材料の体積に関する。これらの個別の位置では、比較的非圧縮性の独立気泡発泡体様の構造は、嵩高すぎることがあり、(図3に示すように)組織の治癒時に穿刺開口部につっかえ棒をすることがある。この組織につっかえ棒をすることは、特に血管分布が不十分な組織で、病原体に十分な進入路を与える恐れがある。
(1) 第1の断面積を有する少なくとも2つの部分と、
第2の断面積を有する少なくとも1つの部分と、を含む、一体構造の組織固定繊維であって、
前記第2の断面積が、前記第1の断面積より小さく、前記第2の断面積を有する少なくとも1つの部分が、前記第1の断面積を有する少なくとも2つの部分の中間にある、繊維。
(2) 前記第2の断面積を有する少なくとも1つの部分が、弧を更に含む、実施態様1に記載の繊維。
(3) 前記第2の断面積を有する少なくとも1つの部分が、刻み目を更に含む、実施態様1に記載の繊維。
(4) 前記第1の断面積の前記第2の断面積に対する割合が、4:1〜10:1に及ぶ、実施態様1に記載の繊維。
(5) 前記第1の断面積の前記第2の断面積に対する割合が、6:1〜9:1に及ぶ、実施態様4に記載の繊維。
(7) 前記繊維が、生体吸収性材料及び非生体吸収性材料の組み合わせから構成される、実施態様1に記載の繊維。
(8) 前記繊維が、ポリアミド、ポリエステル、フルオロポリマー、ポリアリールエーテルケトン、ポリオレフィン、及びそれらの組み合わせからなる群から選択される生体適合性ポリマーから構成される、実施態様1に記載の繊維。
(9) 前記ポリアミドが、ポリヘキサメチレンアジパミド(ナイロン66)、ポリヘキサメチレンセバカミド(ナイロン610)、ポリカプラミド(ナイロン6)、ポリドデカンアミド(ナイロン12)、ポリヘキサメチレンイソフタルアミド(ナイロン61)、及びそれらの組み合わせからなる群から選択される、実施態様8に記載の繊維。
(10) 前記ポリエステルが、ポリエチレンテレフタレート、ポリブチルテレフタレート、及びそれらの組み合わせからなる群から選択される、実施態様8に記載の繊維。
(12) 前記ポリオレフィンが、ポリプロピレン、アイソタクチックポリプロピレン、シンジオタクチックポリプロピレン、及びそれらの組み合わせ、並びに主にアイソタクチック又はシンジオタクチックポリプロピレンのヘテロタクチックポリプロピレン及び/又はポリエチレンとの組み合わせからなる群から選択される、実施態様8に記載の繊維。
(13) 前記繊維が、脂肪族ポリエステル、トリメチレンカーボネートのアルキル誘導体、δ−バレロラクトン、β−ブチロラクトン、γ−ブチロラクトン、ε−デカラクトン、ヒドロキシブチレート、ヒドロキシバレレート、1,4−ジオキセパン−2−オン(その二量体の1,5,8,12−テトラオキサシクロテトラデカン−7,14−ジオンを含む)、1,5−ジオキセパン−2−オン、6,6−ジメチル−1,4−ジオキサン−2−オン、及びそれらのポリマーブレンドからなる群から選択される生体吸収性ポリマーから構成される、実施態様1に記載の繊維。
(14) 前記脂肪族ポリマーが、乳酸、d−、l−及びメソラクチド、グリコリド、グリコール酸、ε−カプロラクトン、p−ジオキサノン(1,4−ジオキサン−2−オン)、トリメチレンカーボネート(1,3−ジオキサン−2−オン)、及びそれらの組み合わせのホモポリマー及びコポリマーからなる群から選択される、実施態様13に記載の繊維。
(15) 前記繊維が、ポリ(ヘキサフルオロプロピレン−VDF)又はポリプロピレンである、実施態様1に記載の繊維。
Claims (15)
- 体組織を通して取り付けられることにより体組織を固定するための一体構造の繊維であって、
第1の断面積を有する少なくとも2つの部分と、
第2の断面積を有する少なくとも1つの部分と、
前記第1の断面積を有する少なくとも2つの部分と、前記第2の断面積を有する少なくとも1つの部分との間の移行部分と、
を含み、
前記第2の断面積が、前記第1の断面積より小さく、前記第2の断面積を有する少なくとも1つの部分が、前記第1の断面積を有する少なくとも2つの部分の中間にあり、前記移行部分は、前記第1の断面積を有する少なくとも2つの部分から前記第2の断面積を有する少なくとも1つの部分へと断面積が連続的に減少する、繊維。 - 前記第2の断面積を有する少なくとも1つの部分が、弧を更に含む、請求項1に記載の繊維。
- 前記第2の断面積を有する少なくとも1つの部分が、刻み目を更に含む、請求項1に記載の繊維。
- 前記第1の断面積の前記第2の断面積に対する割合が、4:1〜10:1に及ぶ、請求項1に記載の繊維。
- 前記第1の断面積の前記第2の断面積に対する割合が、6:1〜9:1に及ぶ、請求項4に記載の繊維。
- 前記第1の断面積の前記第2の断面積に対する割合が、9:1である、請求項4に記載の繊維。
- 前記繊維が、生体吸収性材料及び非生体吸収性材料の組み合わせから構成される、請求項1に記載の繊維。
- 前記繊維が、ポリアミド、ポリエステル、フルオロポリマー、ポリアリールエーテルケトン、ポリオレフィン、及びそれらの組み合わせからなる群から選択される生体適合性ポリマーから構成される、請求項1に記載の繊維。
- 前記ポリアミドが、ポリヘキサメチレンアジパミド(ナイロン66)、ポリヘキサメチレンセバカミド(ナイロン610)、ポリカプラミド(ナイロン6)、ポリドデカンアミド(ナイロン12)、ポリヘキサメチレンイソフタルアミド(ナイロン61)、及びそれらの組み合わせからなる群から選択される、請求項8に記載の繊維。
- 前記ポリエステルが、ポリエチレンテレフタレート、ポリブチルテレフタレート、及びそれらの組み合わせからなる群から選択される、請求項8に記載の繊維。
- 前記フルオロポリマーが、ポリテトラフルオロエチレン、ポリフッ化ビニリデン、ポリ(ヘキサフルオロプロピレン−VDF)、及びそれらの組み合わせからなる群から選択される、請求項8に記載の繊維。
- 前記ポリオレフィンが、ポリプロピレン、アイソタクチックポリプロピレン、シンジオタクチックポリプロピレン、及びそれらの組み合わせ、並びに主にアイソタクチック又はシンジオタクチックポリプロピレンのヘテロタクチックポリプロピレン及び/又はポリエチレンとの組み合わせからなる群から選択される、請求項8に記載の繊維。
- 前記繊維が、脂肪族ポリエステル、トリメチレンカーボネートのアルキル誘導体、δ−バレロラクトン、β−ブチロラクトン、γ−ブチロラクトン、ε−デカラクトン、ヒドロキシブチレート、ヒドロキシバレレート、1,4−ジオキセパン−2−オン(その二量体の1,5,8,12−テトラオキサシクロテトラデカン−7,14−ジオンを含む)、1,5−ジオキセパン−2−オン、6,6−ジメチル−1,4−ジオキサン−2−オン、及びそれらのポリマーブレンドからなる群から選択される生体吸収性ポリマーから構成される、請求項1に記載の繊維。
- 前記脂肪族ポリマーが、乳酸、d−、l−及びメソラクチド、グリコリド、グリコール酸、ε−カプロラクトン、p−ジオキサノン(1,4−ジオキサン−2−オン)、トリメチレンカーボネート(1,3−ジオキサン−2−オン)、及びそれらの組み合わせのホモポリマー及びコポリマーからなる群から選択される、請求項13に記載の繊維。
- 前記繊維が、ポリ(ヘキサフルオロプロピレン−VDF)又はポリプロピレンである、請求項1に記載の繊維。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/314,704 | 2011-12-08 | ||
US13/314,704 US10470760B2 (en) | 2011-12-08 | 2011-12-08 | Modified tissue securement fibers |
PCT/US2012/067708 WO2013085880A1 (en) | 2011-12-08 | 2012-12-04 | Modified tissue securement fibers |
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JP2015507101A JP2015507101A (ja) | 2015-03-05 |
JP6125529B2 true JP6125529B2 (ja) | 2017-05-10 |
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JP2014545976A Active JP6125529B2 (ja) | 2011-12-08 | 2012-12-04 | 修正された組織固定繊維 |
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US (1) | US10470760B2 (ja) |
EP (1) | EP2787897A1 (ja) |
JP (1) | JP6125529B2 (ja) |
AU (1) | AU2012348061B2 (ja) |
CA (1) | CA2857178A1 (ja) |
WO (1) | WO2013085880A1 (ja) |
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US8556797B2 (en) * | 2008-07-31 | 2013-10-15 | Ethicon, Inc. | Magnetic implants for treating obstructive sleep apnea and methods therefor |
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US8800567B2 (en) | 2008-12-01 | 2014-08-12 | Ethicon, Inc. | Implant systems and methods for treating obstructive sleep apnea |
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US8371308B2 (en) | 2009-02-17 | 2013-02-12 | Ethicon, Inc. | Magnetic implants and methods for treating an oropharyngeal condition |
US9877862B2 (en) * | 2009-10-29 | 2018-01-30 | Ethicon, Inc. | Tongue suspension system with hyoid-extender for treating obstructive sleep apnea |
US9326886B2 (en) | 2009-10-29 | 2016-05-03 | Ethicon, Inc. | Fluid filled implants for treating obstructive sleep apnea |
US9974683B2 (en) | 2009-10-30 | 2018-05-22 | Ethicon, Inc. | Flexible implants having internal volume shifting capabilities for treating obstructive sleep apnea |
US8905033B2 (en) | 2011-09-28 | 2014-12-09 | Ethicon, Inc. | Modular tissue securement systems |
US9161855B2 (en) | 2011-10-24 | 2015-10-20 | Ethicon, Inc. | Tissue supporting device and method |
US8973582B2 (en) | 2011-11-30 | 2015-03-10 | Ethicon, Inc. | Tongue suspension device and method |
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WO2013085880A1 (en) | 2013-06-13 |
US10470760B2 (en) | 2019-11-12 |
CA2857178A1 (en) | 2013-06-13 |
JP2015507101A (ja) | 2015-03-05 |
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