JP6098020B2 - 凹部を有するマイクロフルイディック構造体 - Google Patents
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- B01L2200/06—Fluid handling related problems
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- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- Chemical Kinetics & Catalysis (AREA)
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Description
2 マイクロフルイディックコンポーネント
3 マイクロフルイディック構造体
4 マイクロフルイディックコンポーネント
5 マイクロフルイディック構造体
6 マイクロフルイディックコンポーネント
7 マイクロフルイディック構造体
8 マイクロフルイディックコンポーネント
10 キャビティ
11 入口開口部
12 出口開口部
13 凹部
14 凹部の第1の領域(停止エッジ)
15 凹部の第2の領域(ランプ)
15′ 別の設計例の第2の領域
15″ 別の設計例の第2の領域(凹状丸形部分)
15′″ 別の設計例の第2の領域(凸状丸形部分)
16 充填チャネル
17 通気チャネル
18 別のマイクロチャネル
19 キャビティのベース
20 凹部のベース
21 カバー
22 凹部の境界エッジ
23 凹部の境界エッジ
24 毛管停止部
30 キャビティ
31 凹部
32 凹部の第1の領域(停止エッジ)
33 凹部の第2の領域(ランプ)
40 キャビティ
41 凹部
42 凹部の第1の領域(停止エッジ)
43 凹部の第2の領域(ランプ)
50 キャビティ
51 バー
52 カバー
53 凹部のベース
α 角度
β 角度
B 凹部の幅
F 液体
L 凹部の長手方向広がり
R ランプ状移行領域
S 到来する液体の流れ方向
Claims (9)
- 少なくとも1つの入口開口部(11)及び少なくとも1つの出口開口部(12)を備えた少なくとも1つのキャビティ(10,30,40)を有するマイクロフルイディック構造体(1,3,5)であって、前記キャビティ(10,30,40)には液体(F)が充填されるようになっており又はこのような液体が前記キャビティ(10,30,40)を通って流れるようになっており、前記液体(F)が前記キャビティ(10,30,40)中を流れているときに前記液体(F)を少なくとも一時的に停止させると共に/或いは少なくとも部分的に逸らす少なくとも1つの要素(13,31,41)が前記キャビティ(10,30,40)内に設けられているマイクロフルイディック構造体において、
前記少なくとも1つの要素(13,31,41)は、前記キャビティ(10,30,40)の壁(19)に設けられた凹部(13,31,41)によって形成され、前記凹部(13,31,41)は、前記液体(F)を少なくとも一時的に停止させると共に/或いは少なくとも部分的に逸らす少なくとも1つの第1の領域(14,32,42)と、前記液体(F)が好ましくは前記凹部(13,31,41)中に流れるようにする少なくとも1つの第2の領域(15,15′,15″,15′″,33,43)とを有し、
前記少なくとも1つの凹部(13,31,41)は、細長い形態のものであり、前記少なくとも1つの第1の領域(14,32,42)は、到来する液体(F)に向き、前記少なくとも1つの第2の領域(15,33,43)は、到来する液体(F)から見て遠くに位置している、
ことを特徴とするマイクロフルイディック構造体。 - 前記第2の領域(15,33,43)は、ランプ状移行部(R)によって形成され、前記ランプ状移行部は、前記キャビティ(10)のベース高さ位置(19)から始まって、前記凹部(13)のベース高さ位置(20)まで延びている、
請求項1記載のマイクロフルイディック構造体(1,3,5)。 - 前記ランプ状移行部(R)は、前記凹部(13)の境界エッジ(23)から始まっていて、前記キャビティ(10)の前記ベース平面(19)と約10°〜60°の角度αをなしている、
請求項1又は2記載のマイクロフルイディック構造体(1,3,5)。 - 前記ランプ状移行部(R)は、前記凹部(13)の境界エッジ(23)から始まっていて、前記キャビティ(10)の前記ベース平面(19)と約45°の角度αをなしている、
請求項1又は2記載のマイクロフルイディック構造体(1,3,5)。 - 前記第1の領域(14,32,42)は、前記凹部(13)の境界エッジ(22)によって形成され、前記境界エッジ(22)を形成するせばまり状態の壁が、120°未満の角度βをなしている、
請求項1〜4のいずれか1項に記載のマイクロフルイディック構造体(1,3,5)。 - 前記第1の領域(14,32,42)は、前記凹部(13)の境界エッジ(22)によって形成され、前記境界エッジ(22)を形成するせばまり状態の壁が約90°の角度βをなしている、
請求項1〜4のいずれか1項に記載のマイクロフルイディック構造体(1,3,5)。 - 前記キャビティ(10,30,40)の側壁から始まって交互に配置された複数個の凹部(13,31,41)が設けられている、
請求項1〜6のいずれか1項に記載のマイクロフルイディック構造体(1,3)。 - 前記少なくとも1つの第1の領域(14,32,42)は、前記少なくとも1つの凹部(13,31,41)の長手方向側部の実質的に長さ(L)全体にわたって延び、前記少なくとも1つの第2の領域(15,33,43)は、別の長手方向側部の長さ(L)の一部だけにわたって延びている、
請求項1〜7のいずれか1項に記載のマイクロフルイディック構造体(1,5)。 - 請求項1〜8のいずれか1項に記載のマイクロフルイディック構造体(1,3,5)を少なくとも1つ有するマイクロフルイディックプラットホーム(2,4,6)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11172775.6 | 2011-07-05 | ||
EP11172775 | 2011-07-05 | ||
PCT/EP2012/062863 WO2013004673A1 (de) | 2011-07-05 | 2012-07-02 | Mikrofluidische struktur mit vertiefungen |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014521056A JP2014521056A (ja) | 2014-08-25 |
JP6098020B2 true JP6098020B2 (ja) | 2017-03-22 |
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Application Number | Title | Priority Date | Filing Date |
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JP2014517765A Active JP6098020B2 (ja) | 2011-07-05 | 2012-07-02 | 凹部を有するマイクロフルイディック構造体 |
Country Status (4)
Country | Link |
---|---|
US (2) | US20140227148A1 (ja) |
EP (1) | EP2729251B1 (ja) |
JP (1) | JP6098020B2 (ja) |
WO (1) | WO2013004673A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6240785B2 (ja) * | 2013-12-20 | 2017-11-29 | スリーエム イノベイティブ プロパティズ カンパニー | サンプルの濃縮及び検出のためのシステム及び方法 |
US10357909B2 (en) * | 2014-05-30 | 2019-07-23 | Absolute Exhibits, Inc. | Thermoset in-mold finishing film |
TWI499637B (zh) * | 2014-06-20 | 2015-09-11 | Ind Tech Res Inst | 發泡體及包含其之發光裝置 |
GB201617869D0 (en) | 2016-10-21 | 2016-12-07 | Blacktrace Holdings Limited | A microfluidic device |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4271119A (en) * | 1979-07-23 | 1981-06-02 | Eastman Kodak Company | Capillary transport device having connected transport zones |
US4618476A (en) * | 1984-02-10 | 1986-10-21 | Eastman Kodak Company | Capillary transport device having speed and meniscus control means |
DE10313201A1 (de) * | 2003-03-21 | 2004-10-07 | Steag Microparts Gmbh | Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält |
DE10360220A1 (de) | 2003-12-20 | 2005-07-21 | Steag Microparts Gmbh | Mikrostrukturierte Anordnung zur blasenfreien Befüllung zumindest eines Systems zur Ableitung von Flüssigkeiten, Vorrichtung mit einer solchen Anordnung und Befüllungsverfahren |
DE102004027422A1 (de) * | 2004-06-04 | 2005-12-29 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen |
EP1616619A1 (de) * | 2004-07-17 | 2006-01-18 | Tecan Trading AG | Vorrichtung und Verfahren zum Bereitstellen einer Hybridisierkammer und zum Beeinflussen von Luftblasen in derselben |
DE502006009183D1 (de) | 2005-01-27 | 2011-05-12 | Boehringer Ingelheim Micropart | Verwendung einer Vorrichtung zur Untersuchung von Probenflüssigkeit |
DE102005017653A1 (de) * | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit |
JP4685611B2 (ja) * | 2005-12-02 | 2011-05-18 | 株式会社エンプラス | 微小流体装置 |
-
2012
- 2012-07-02 JP JP2014517765A patent/JP6098020B2/ja active Active
- 2012-07-02 WO PCT/EP2012/062863 patent/WO2013004673A1/de active Application Filing
- 2012-07-02 EP EP12732642.9A patent/EP2729251B1/de active Active
- 2012-07-02 US US14/127,341 patent/US20140227148A1/en not_active Abandoned
-
2015
- 2015-05-22 US US14/719,503 patent/US9409171B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20150251182A1 (en) | 2015-09-10 |
WO2013004673A1 (de) | 2013-01-10 |
JP2014521056A (ja) | 2014-08-25 |
US9409171B2 (en) | 2016-08-09 |
EP2729251A1 (de) | 2014-05-14 |
EP2729251B1 (de) | 2018-11-14 |
US20140227148A1 (en) | 2014-08-14 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |