JP6092883B2 - 無効赤血球生成を処置するための方法および組成物 - Google Patents

無効赤血球生成を処置するための方法および組成物 Download PDF

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Publication number
JP6092883B2
JP6092883B2 JP2014537186A JP2014537186A JP6092883B2 JP 6092883 B2 JP6092883 B2 JP 6092883B2 JP 2014537186 A JP2014537186 A JP 2014537186A JP 2014537186 A JP2014537186 A JP 2014537186A JP 6092883 B2 JP6092883 B2 JP 6092883B2
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actriib
polypeptide
seq
gdf trap
amino acid
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JP2014530253A5 (show.php
JP2014530253A (ja
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ジャスバー シーラー,
ジャスバー シーラー,
ロバート スコット ピアソール,
ロバート スコット ピアソール,
ラビンドラ クマール,
ラビンドラ クマール,
ナガ ベンカタ サイ ラジャセカール スラガニ,
ナガ ベンカタ サイ ラジャセカール スラガニ,
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アクセルロン ファーマ, インコーポレイテッド
アクセルロン ファーマ, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103Receptor protein serine/threonine kinase (2.7.11.30)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2014537186A 2011-10-17 2012-10-17 無効赤血球生成を処置するための方法および組成物 Active JP6092883B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161547932P 2011-10-17 2011-10-17
US61/547,932 2011-10-17
PCT/US2012/060650 WO2013059347A1 (en) 2011-10-17 2012-10-17 Methods and compositions for treating ineffective erythropoiesis

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JP2017022176A Division JP6383821B2 (ja) 2011-10-17 2017-02-09 無効赤血球生成を処置するための方法および組成物

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JP2014530253A JP2014530253A (ja) 2014-11-17
JP2014530253A5 JP2014530253A5 (show.php) 2015-12-10
JP6092883B2 true JP6092883B2 (ja) 2017-03-08

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JP2014537186A Active JP6092883B2 (ja) 2011-10-17 2012-10-17 無効赤血球生成を処置するための方法および組成物
JP2017022176A Active JP6383821B2 (ja) 2011-10-17 2017-02-09 無効赤血球生成を処置するための方法および組成物
JP2018147507A Active JP6796626B2 (ja) 2011-10-17 2018-08-06 無効赤血球生成を処置するための方法および組成物
JP2020140889A Pending JP2020186277A (ja) 2011-10-17 2020-08-24 無効赤血球生成を処置するための方法および組成物

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JP2017022176A Active JP6383821B2 (ja) 2011-10-17 2017-02-09 無効赤血球生成を処置するための方法および組成物
JP2018147507A Active JP6796626B2 (ja) 2011-10-17 2018-08-06 無効赤血球生成を処置するための方法および組成物
JP2020140889A Pending JP2020186277A (ja) 2011-10-17 2020-08-24 無効赤血球生成を処置するための方法および組成物

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US (4) US20130243743A1 (show.php)
EP (3) EP3520805B1 (show.php)
JP (4) JP6092883B2 (show.php)
KR (4) KR20220075438A (show.php)
CN (3) CN107693776A (show.php)
AU (4) AU2012326207B2 (show.php)
BR (3) BR122019023174B1 (show.php)
CA (1) CA2852683A1 (show.php)
DK (2) DK3520805T3 (show.php)
EA (2) EA034563B1 (show.php)
ES (3) ES3010483T3 (show.php)
HK (2) HK1250341A1 (show.php)
WO (1) WO2013059347A1 (show.php)

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EP2797620B1 (en) 2019-04-24
ES2741477T3 (es) 2020-02-11
BR122019023166B1 (pt) 2021-02-23
AU2017201580B2 (en) 2018-07-12
JP2018165287A (ja) 2018-10-25
JP6796626B2 (ja) 2020-12-09
JP6383821B2 (ja) 2018-08-29
WO2013059347A1 (en) 2013-04-25
EP2797620A1 (en) 2014-11-05
US20170137791A1 (en) 2017-05-18
BR112014009528A2 (pt) 2017-05-09
AU2018247262B2 (en) 2020-12-24
HK1203413A1 (en) 2015-10-30
KR20190105113A (ko) 2019-09-11
EP3520805A1 (en) 2019-08-07
AU2020286229A1 (en) 2021-01-07
EP2797620A4 (en) 2015-05-20
EA202090053A2 (ru) 2020-04-30
DK3520805T3 (da) 2021-04-19
KR20220075438A (ko) 2022-06-08
KR102079482B1 (ko) 2020-02-19
BR112014009528A8 (pt) 2019-12-10
US20170327800A1 (en) 2017-11-16
EP3875104B1 (en) 2025-01-22
EP3875104A1 (en) 2021-09-08
HK1250341A1 (zh) 2018-12-14
JP2017101060A (ja) 2017-06-08
EP3520805B1 (en) 2021-03-10
JP2014530253A (ja) 2014-11-17
CA2852683A1 (en) 2013-04-25
CN103987403A (zh) 2014-08-13
DK3875104T3 (da) 2025-02-03
HK1252940A1 (zh) 2019-06-06
AU2012326207A1 (en) 2014-05-15
EA202090053A3 (ru) 2020-06-30
EA201490809A1 (ru) 2014-09-30
AU2018247262A1 (en) 2018-11-01
US20130243743A1 (en) 2013-09-19
JP2020186277A (ja) 2020-11-19
ES3010483T3 (en) 2025-04-03
KR20140084211A (ko) 2014-07-04
BR122019023174B1 (pt) 2021-02-23
EA034563B1 (ru) 2020-02-20
KR20200019261A (ko) 2020-02-21
BR112014009528B1 (pt) 2020-12-29
ES2869168T3 (es) 2021-10-25
CN103987403B (zh) 2017-12-01
AU2012326207B2 (en) 2016-12-15
AU2017201580A1 (en) 2017-03-30
CN107837390A (zh) 2018-03-27
US20210207107A1 (en) 2021-07-08
CN107693776A (zh) 2018-02-16

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