JP6087289B2 - Napi2b輸送体に対するヒト化モノクローナル抗体の相補性決定領域に由来する抗腫瘍ペプチド - Google Patents

Napi2b輸送体に対するヒト化モノクローナル抗体の相補性決定領域に由来する抗腫瘍ペプチド Download PDF

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JP6087289B2
JP6087289B2 JP2013543901A JP2013543901A JP6087289B2 JP 6087289 B2 JP6087289 B2 JP 6087289B2 JP 2013543901 A JP2013543901 A JP 2013543901A JP 2013543901 A JP2013543901 A JP 2013543901A JP 6087289 B2 JP6087289 B2 JP 6087289B2
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トラバッソス,ルイス,ロドルフォ,ラジャ,ガバグリア
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レセプタ バイオファーマ エス.エー.
レセプタ バイオファーマ エス.エー.
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069Reproductive system, e.g. ovaria, uterus, testes, prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2013543901A 2010-12-14 2011-12-14 Napi2b輸送体に対するヒト化モノクローナル抗体の相補性決定領域に由来する抗腫瘍ペプチド Active JP6087289B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42285610P 2010-12-14 2010-12-14
US61/422,856 2010-12-14
PCT/IB2011/003053 WO2012080822A2 (en) 2010-12-14 2011-12-14 Antitumor peptide derived from a complementarity determining region of a humanized monoclonal antibody to napi2b transporter

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JP2014510699A JP2014510699A (ja) 2014-05-01
JP2014510699A5 JP2014510699A5 (enExample) 2015-02-05
JP6087289B2 true JP6087289B2 (ja) 2017-03-01

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JP2013543901A Active JP6087289B2 (ja) 2010-12-14 2011-12-14 Napi2b輸送体に対するヒト化モノクローナル抗体の相補性決定領域に由来する抗腫瘍ペプチド

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US (2) US9193797B2 (enExample)
EP (1) EP2654769B1 (enExample)
JP (1) JP6087289B2 (enExample)
BR (1) BR112013015001B1 (enExample)
CO (1) CO6721014A2 (enExample)
ES (1) ES2804476T3 (enExample)
PT (1) PT2654769T (enExample)
WO (1) WO2012080822A2 (enExample)

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Publication number Priority date Publication date Assignee Title
JP6980384B2 (ja) * 2013-12-16 2021-12-15 ジェネンテック, インコーポレイテッド 1−(クロロメチル)−2,3−ジヒドロ−1h−ベンゾ[e]インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法
CN105491524B (zh) * 2015-12-11 2019-04-26 小米科技有限责任公司 一种确定目标便携设备位置的方法和装置
JP7194180B2 (ja) * 2017-07-01 2022-12-21 レセプタ バイオファーマ エッシ ア ペプチドを使用する方法及び樹状細胞を調節する方法
CN111492246A (zh) * 2017-09-20 2020-08-04 梅尔莎纳医疗公司 用于预测对napi2b靶向疗法的响应的组合物和方法
WO2022032228A1 (en) 2020-08-07 2022-02-10 The Broad Institute, Inc. Therapeutic targeting of phosphate dysregulation in cancer via the xpr1:kidins220 protein complex
KR102822203B1 (ko) 2020-12-29 2025-06-18 삼성전자주식회사 전력 공급 장치를 이용하여 오디오 출력 장치를 찾는 방법 및 그 전력 공급 장치
CN116514926B (zh) * 2023-06-25 2023-08-29 烟台药物研究所 一种抗肿瘤阳离子两亲肽及其应用

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GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
US5827498A (en) * 1994-06-07 1998-10-27 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
US6689753B1 (en) 1999-11-05 2004-02-10 Axonyx, Inc. β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide
WO2005040219A1 (en) * 2003-10-28 2005-05-06 Novo Nordisk A/S Laminin-5 gamma2-binding peptides, related compositions, and use thereof
BRPI0907648B1 (pt) * 2008-01-29 2022-01-11 Institute Of Molecular Biology And Genetics National Academy Of Science Of Ukraine Anticorpo isolado humanizado, usos de um anticorpo, métodos para preparar um anticorpo, para gerar anticorpos imunorreativos com slc34a2 e para triar ou identificar agentes ou compostos que modulam slc34a2, composições, ácido nucleico isolado, e, microorganismo hospedeiro

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Publication number Publication date
CO6721014A2 (es) 2013-07-31
BR112013015001A8 (pt) 2018-04-17
US20130315902A1 (en) 2013-11-28
ES2804476T3 (es) 2021-02-08
US20160108132A1 (en) 2016-04-21
PT2654769T (pt) 2020-07-16
US9896512B2 (en) 2018-02-20
BR112013015001A2 (pt) 2017-12-19
US9193797B2 (en) 2015-11-24
BR112013015001B1 (pt) 2021-10-13
EP2654769B1 (en) 2020-04-15
WO2012080822A2 (en) 2012-06-21
JP2014510699A (ja) 2014-05-01
EP2654769A4 (en) 2017-10-25
WO2012080822A9 (en) 2016-08-11
EP2654769A2 (en) 2013-10-30

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